GREMLIN Database
Q9HNJ2 - Uncharacterized protein
UniProt: Q9HNJ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (173)
Sequences: 15630 (10979)
Seq/√Len: 834.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_T48_D4.1891.00
106_T115_S4.0571.00
52_V63_L3.0571.00
93_T100_A2.9961.00
101_A118_T2.7461.00
95_Q100_A2.7291.00
93_T102_D2.6361.00
26_T49_Q2.4851.00
103_V114_V2.4571.00
37_A69_A2.4161.00
102_D119_E2.3911.00
51_V116_L2.3031.00
118_T121_A2.1791.00
24_T46_A2.1401.00
25_T45_D2.0951.00
39_E43_H1.9871.00
49_Q75_V1.9411.00
103_V116_L1.9151.00
18_F172_Y1.8981.00
21_V45_D1.8681.00
78_Y89_A1.8641.00
149_S152_R1.7861.00
28_V123_F1.7821.00
90_D160_L1.7271.00
67_V85_T1.7131.00
21_V25_T1.7011.00
90_D159_E1.6721.00
155_G159_E1.6201.00
26_T51_V1.5941.00
89_A92_D1.5921.00
161_L188_E1.5761.00
65_A69_A1.5521.00
40_I47_L1.5301.00
37_A70_F1.4871.00
99_Q118_T1.4821.00
39_E42_A1.4811.00
115_S122_L1.4811.00
37_A41_R1.4761.00
102_D117_V1.4481.00
64_D68_D1.3931.00
77_A105_F1.3861.00
33_Y65_A1.3821.00
117_V122_L1.3761.00
73_P86_H1.3721.00
154_I158_R1.3571.00
104_V117_V1.3531.00
38_D42_A1.3431.00
75_V86_H1.3351.00
111_P152_R1.3281.00
49_Q73_P1.2931.00
28_V53_T1.2871.00
159_E162_A1.2731.00
110_A113_H1.2661.00
158_R191_L1.2641.00
47_L72_G1.2291.00
86_H92_D1.2231.00
64_D67_V1.2151.00
106_T156_S1.2101.00
74_D77_A1.2101.00
47_L70_F1.2031.00
34_D38_D1.1631.00
104_V160_L1.1491.00
80_D112_D1.1461.00
171_F179_F1.1371.00
90_D105_F1.1281.00
152_R155_G1.1271.00
18_F123_F1.1221.00
63_L74_D1.1211.00
150_R154_I1.1171.00
122_L164_M1.1041.00
181_G185_A1.0971.00
25_T47_L1.0881.00
41_R69_A1.0871.00
75_V88_L1.0861.00
117_V168_V1.0771.00
38_D41_R1.0701.00
150_R153_L1.0671.00
27_L47_L1.0651.00
113_H125_G1.0531.00
91_G102_D1.0491.00
108_G156_S1.0421.00
36_V39_E1.0351.00
170_E178_V1.0331.00
158_R162_A1.0221.00
135_F141_G1.0201.00
115_S127_V1.0131.00
33_Y37_A1.0011.00
53_T125_G0.9971.00
80_D83_L0.9941.00
106_T127_V0.9911.00
22_G98_D0.9841.00
77_A80_D0.9841.00
33_Y62_Q0.9741.00
30_A50_V0.9731.00
88_L114_V0.9711.00
36_V40_I0.9631.00
19_L39_E0.9621.00
77_A81_H0.9511.00
124_A171_F0.9411.00
57_T61_Q0.9401.00
65_A68_D0.9401.00
51_V101_A0.9341.00
127_V160_L0.9291.00
78_Y81_H0.9261.00
122_L171_F0.9251.00
162_A191_L0.9061.00
26_T96_V0.9021.00
96_V99_Q0.9011.00
79_A89_A0.9001.00
188_E191_L0.8961.00
95_Q98_D0.8941.00
139_S142_R0.8901.00
183_V187_A0.8881.00
158_R161_L0.8851.00
127_V153_L0.8651.00
20_V28_V0.8541.00
79_A82_P0.8501.00
76_Y86_H0.8481.00
22_G97_G0.8441.00
113_H127_V0.8381.00
151_E155_G0.8361.00
145_M150_R0.8361.00
63_L67_V0.8341.00
99_Q121_A0.8311.00
17_A36_V0.8291.00
24_T49_Q0.8281.00
117_V164_M0.8241.00
81_H87_A0.8231.00
78_Y87_A0.8221.00
166_D182_D0.8181.00
138_G183_V0.8161.00
81_H112_D0.8131.00
27_L30_A0.8101.00
88_L116_L0.8031.00
138_G187_A0.8001.00
127_V156_S0.7971.00
19_L27_L0.7941.00
15_C31_G0.7921.00
124_A173_A0.7891.00
88_L103_V0.7871.00
106_T113_H0.7871.00
35_G39_E0.7871.00
161_L191_L0.7851.00
185_A189_R0.7781.00
21_V39_E0.7761.00
186_V190_A0.7751.00
19_L25_T0.7751.00
100_A119_E0.7741.00
35_G38_D0.7731.00
77_A114_V0.7681.00
172_Y178_V0.7681.00
105_F114_V0.7671.00
137_D177_G0.7671.00
26_T101_A0.7661.00
142_R145_M0.7581.00
50_V72_G0.7561.00
13_F57_T0.7541.00
138_G182_D0.7421.00
111_P147_G0.7391.00
101_A116_L0.7381.00
93_T119_E0.7351.00
25_T48_D0.7291.00
88_L92_D0.7261.00
50_V63_L0.7211.00
49_Q76_Y0.7181.00
135_F142_R0.7181.00
15_C174_G0.7131.00
102_D164_M0.7101.00
104_V115_S0.7091.00
76_Y81_H0.7021.00
140_F143_T0.7001.00
27_L40_I0.7001.00
186_V189_R0.6991.00
27_L66_V0.6931.00
84_R87_A0.6911.00
138_G141_G0.6901.00
145_M148_Q0.6841.00
62_Q65_A0.6831.00
89_A105_F0.6801.00
22_G99_Q0.6801.00
30_A63_L0.6781.00
49_Q86_H0.6781.00
21_V43_H0.6711.00
79_A105_F0.6701.00
128_V171_F0.6691.00
55_Q112_D0.6661.00
123_F172_Y0.6651.00
104_V159_E0.6651.00
24_T97_G0.6621.00
67_V74_D0.6551.00
115_S160_L0.6541.00
33_Y36_V0.6541.00
165_P168_V0.6531.00
185_A188_E0.6531.00
9_G14_T0.6481.00
126_D175_H0.6441.00
73_P85_T0.6391.00
76_Y80_D0.6331.00
121_A172_Y0.6311.00
71_D74_D0.6251.00
171_F181_G0.6221.00
88_L94_V0.6221.00
28_V51_V0.6171.00
166_D185_A0.6161.00
34_D65_A0.6151.00
155_G158_R0.6051.00
60_V63_L0.6031.00
16_N176_G0.5991.00
66_V70_F0.5941.00
25_T40_I0.5941.00
11_A17_A0.5931.00
52_V60_V0.5901.00
146_P149_S0.5901.00
34_D37_A0.5881.00
117_V166_D0.5881.00
50_V66_V0.5861.00
104_V122_L0.5841.00
11_A14_T0.5821.00
121_A170_E0.5771.00
18_F174_G0.5751.00
25_T46_A0.5751.00
74_D86_H0.5751.00
135_F140_F0.5681.00
96_V101_A0.5671.00
137_D178_V0.5661.00
20_V26_T0.5641.00
94_V97_G0.5611.00
135_F138_G0.5601.00
10_A15_C0.5591.00
30_A62_Q0.5581.00
9_G16_N0.5441.00
16_N174_G0.5411.00
153_L157_L0.5401.00
135_F139_S0.5361.00
74_D78_Y0.5321.00
55_Q80_D0.5301.00
55_Q76_Y0.5301.00
68_D71_D0.5291.00
20_V118_T0.5281.00
28_V116_L0.5261.00
52_V74_D0.5261.00
16_N177_G0.5261.00
27_L36_V0.5211.00
51_V94_V0.5181.00
143_T153_L0.5181.00
16_N187_A0.5171.00
152_R156_S0.5151.00
157_L161_L0.5141.00
105_F112_D0.5131.00
107_P156_S0.5131.00
42_A45_D0.5131.00
161_L181_G0.5101.00
156_S159_E0.5101.00
153_L156_S0.5091.00
67_V71_D0.5061.00
144_D148_Q0.5061.00
74_D81_H0.5051.00
33_Y69_A0.5041.00
41_R44_V0.5011.00
147_G153_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qh5A 1 0.9317 100 0.283 Contact Map
4yslA 2 0.9561 100 0.295 Contact Map
3r2uA 4 0.9512 100 0.296 Contact Map
2qedA 1 0.9317 100 0.303 Contact Map
2gcuA 3 0.9561 100 0.304 Contact Map
4efzA 2 0.9512 100 0.306 Contact Map
3tp9A 2 0.9463 100 0.311 Contact Map
2p18A 1 0.9317 100 0.316 Contact Map
1xm8A 1 0.9317 100 0.319 Contact Map
2zo4A 1 0.9366 100 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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