Q9HNI9 - HALSA - GREMLIN Contacts

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Q9HNI9 - Transport protein

UniProt:	Q9HNI9	Sequences: MSTKPNEGLLARFGFGVDPDDKYEARLYRIKRNRTKNRIIWALALIAFLVLFEVALELVNFSLLEISAYWSQFVGSLRDFFPLTSLFGVVPFVDVGQYYSFLAAHENPSIPLAAVETLGIAFAGTVLGAPLALTFGVLGSERVTPFPLNFLFRGVMSSIRSIPALVWALIFIPLGGLSPFTATLAIGTDTIGNLGRLFTDALEEVEDGPIEGVESTGASRPQVILFGMLSQMVRPFIAWSMYILEINVRVAVTMGLINAGGIGEILMLQRQTRSWHNMMATIIVIFVLVVSVEMLSQRIRSRIRGNESTSVLRLFVRTIKQFPSKTREALT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	331 (254)
Sequences:	60370 (43065)
Seq/√Len:	2702.2

ECOLI - PROW POTH CYSW TAUC SSUC PSTA YEHY PSTC PHNE YDCU POTI CYST YDCV POTC UGPA YEHW YCJO YCJP POTB UGPE DPPC MALG METI THIP OPPC MALF MODB DDPC GSID YNJC
BACSU - SSUC OPUAB YTLD ARAP YTEP GANP YQGH MDXF AMYD LPLB YESQ OPUCD YURM OPUCB YESP OPUBD YQGI YURN OPUBB MDXG GANQ AMYC DPPC ARAQ OPPC YTCP APPC METP LPLC YVGM YXEN TCYL TCYB
HALSA - Q9HNI9 Q9HML6 Q9HS11 Q9HP01 Q9HP02 Q9HPK3 Q9HHQ6 Q9HR05 Q9HHQ7 Q9HMT4 Q9HMW2 Q9HMI1
SULSO - Q97UF3 Q97YY2 Q97UZ0 Q97YY3 Q97UY9 Q97ZC1 Q97UH2 Q97UF4 Q97ZT6 Q97UG3 Q97ZT7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
222_Q	226_F	3.253	1.00
214_E	223_V	2.891	1.00
219_S	222_Q	2.853	1.00
115_V	119_G	2.740	1.00
221_P	225_L	2.692	1.00
127_L	187_G	2.476	1.00
123_A	183_T	2.424	1.00
210_I	228_M	2.403	1.00
54_V	58_L	2.402	1.00
199_T	203_E	2.305	1.00
54_V	57_E	2.216	1.00
202_L	228_M	2.091	1.00
214_E	220_R	2.067	1.00
112_L	115_V	2.067	1.00
210_I	223_V	2.063	1.00
74_V	78_R	2.042	1.00
264_E	268_L	2.025	1.00
218_A	222_Q	2.016	1.00
220_R	223_V	2.015	1.00
56_L	60_N	1.975	1.00
111_P	115_V	1.971	1.00
202_L	232_M	1.955	1.00
54_V	62_S	1.902	1.00
141_E	210_I	1.890	1.00
57_E	61_F	1.888	1.00
129_A	240_S	1.880	1.00
119_G	123_A	1.869	1.00
251_A	261_G	1.863	1.00
130_P	134_T	1.851	1.00
125_T	240_S	1.842	1.00
213_V	223_V	1.840	1.00
209_P	231_Q	1.796	1.00
140_S	203_E	1.783	1.00
114_A	262_I	1.777	1.00
208_G	211_E	1.743	1.00
78_R	82_P	1.711	1.00
194_L	243_I	1.711	1.00
62_S	65_E	1.645	1.00
251_A	255_G	1.624	1.00
198_F	236_F	1.623	1.00
53_E	57_E	1.606	1.00
213_V	218_A	1.601	1.00
205_V	209_P	1.592	1.00
149_N	199_T	1.583	1.00
222_Q	225_L	1.570	1.00
57_E	60_N	1.570	1.00
75_G	78_R	1.541	1.00
81_F	84_T	1.521	1.00
140_S	202_L	1.514	1.00
137_V	202_L	1.507	1.00
135_F	195_G	1.491	1.00
58_L	61_F	1.474	1.00
57_E	62_S	1.450	1.00
274_S	277_N	1.450	1.00
178_S	181_T	1.445	1.00
182_A	186_I	1.442	1.00
133_L	198_F	1.431	1.00
132_A	194_L	1.425	1.00
75_G	79_D	1.418	1.00
82_P	85_S	1.413	1.00
142_R	220_R	1.413	1.00
213_V	227_G	1.409	1.00
146_F	149_N	1.401	1.00
71_S	75_G	1.400	1.00
183_T	187_G	1.393	1.00
136_G	140_S	1.377	1.00
113_A	265_I	1.366	1.00
80_F	83_L	1.354	1.00
136_G	198_F	1.343	1.00
201_A	235_P	1.338	1.00
116_E	259_A	1.338	1.00
46_I	50_V	1.327	1.00
77_L	80_F	1.325	1.00
241_M	296_S	1.319	1.00
139_G	195_G	1.316	1.00
212_G	216_T	1.303	1.00
294_M	298_R	1.283	1.00
33_N	37_N	1.271	1.00
191_I	195_G	1.263	1.00
137_V	224_I	1.262	1.00
141_E	220_R	1.258	1.00
79_D	83_L	1.257	1.00
135_F	152_F	1.249	1.00
33_N	36_K	1.247	1.00
105_H	108_P	1.244	1.00
48_F	60_N	1.230	1.00
77_L	81_F	1.222	1.00
70_W	74_V	1.212	1.00
119_G	179_P	1.204	1.00
131_L	134_T	1.203	1.00
109_S	112_L	1.200	1.00
41_W	45_L	1.194	1.00
116_E	119_G	1.184	1.00
298_R	302_R	1.182	1.00
201_A	204_E	1.178	1.00
80_F	84_T	1.175	1.00
210_I	214_E	1.174	1.00
266_L	281_T	1.172	1.00
72_Q	75_G	1.169	1.00
180_F	184_L	1.166	1.00
43_L	47_A	1.166	1.00
80_F	85_S	1.156	1.00
131_L	191_I	1.153	1.00
145_P	149_N	1.150	1.00
138_L	142_R	1.150	1.00
37_N	41_W	1.150	1.00
136_G	202_L	1.144	1.00
142_R	146_F	1.143	1.00
238_A	242_Y	1.139	1.00
124_G	247_N	1.139	1.00
71_S	74_V	1.139	1.00
262_I	288_L	1.132	1.00
156_M	195_G	1.122	1.00
79_D	84_T	1.119	1.00
42_A	45_L	1.111	1.00
79_D	82_P	1.107	1.00
61_F	64_L	1.107	1.00
112_L	116_E	1.098	1.00
133_L	224_I	1.097	1.00
81_F	85_S	1.095	1.00
39_I	43_L	1.090	1.00
149_N	203_E	1.088	1.00
48_F	52_F	1.087	1.00
219_S	223_V	1.085	1.00
42_A	46_I	1.083	1.00
49_L	53_E	1.080	1.00
132_A	198_F	1.077	1.00
45_L	57_E	1.069	1.00
60_N	64_L	1.065	1.00
39_I	42_A	1.064	1.00
96_G	106_E	1.063	1.00
73_F	77_L	1.056	1.00
76_S	79_D	1.054	1.00
69_Y	72_Q	1.047	1.00
179_P	183_T	1.041	1.00
197_L	239_W	1.041	1.00
123_A	126_V	1.040	1.00
124_G	128_G	1.033	1.00
128_G	190_T	1.024	1.00
45_L	49_L	1.021	1.00
73_F	76_S	1.019	1.00
45_L	48_F	1.011	1.00
239_W	243_I	1.009	1.00
148_L	151_L	1.008	1.00
298_R	301_S	1.007	1.00
76_S	80_F	1.007	1.00
194_L	239_W	1.006	1.00
205_V	231_Q	1.005	1.00
57_E	72_Q	1.001	1.00
56_L	61_F	1.000	1.00
141_E	224_I	1.000	1.00
57_E	65_E	0.999	1.00
55_A	58_L	0.998	1.00
126_V	130_P	0.997	1.00
181_T	185_A	0.995	1.00
140_S	199_T	0.988	1.00
72_Q	76_S	0.988	1.00
205_V	232_M	0.982	1.00
78_R	81_F	0.982	1.00
238_A	300_R	0.981	1.00
139_G	152_F	0.973	1.00
40_I	44_A	0.969	1.00
54_V	65_E	0.963	1.00
38_R	42_A	0.962	1.00
74_V	77_L	0.956	1.00
147_P	150_F	0.953	1.00
121_A	244_L	0.949	1.00
148_L	152_F	0.946	1.00
109_S	265_I	0.943	1.00
154_G	157_S	0.940	1.00
134_T	137_V	0.934	1.00
133_L	232_M	0.934	1.00
52_F	56_L	0.933	1.00
194_L	198_F	0.929	1.00
107_N	111_P	0.928	1.00
142_R	148_L	0.923	1.00
43_L	46_I	0.923	1.00
253_T	257_I	0.915	1.00
41_W	57_E	0.912	1.00
251_A	254_M	0.910	1.00
134_T	138_L	0.910	1.00
187_G	191_I	0.906	1.00
38_R	41_W	0.902	1.00
150_F	154_G	0.899	1.00
151_L	155_V	0.894	1.00
46_I	58_L	0.891	1.00
300_R	304_R	0.889	1.00
265_I	268_L	0.886	1.00
124_G	186_I	0.884	1.00
106_E	280_A	0.884	1.00
267_M	271_Q	0.881	1.00
218_A	223_V	0.877	1.00
50_V	54_V	0.876	1.00
41_W	44_A	0.875	1.00
265_I	269_Q	0.875	1.00
205_V	210_I	0.865	1.00
130_P	133_L	0.862	1.00
265_I	281_T	0.849	1.00
220_R	224_I	0.842	1.00
268_L	271_Q	0.838	1.00
178_S	182_A	0.835	1.00
269_Q	277_N	0.832	1.00
131_L	187_G	0.828	1.00
62_S	70_W	0.826	1.00
53_E	56_L	0.820	1.00
180_F	183_T	0.819	1.00
147_P	151_L	0.813	1.00
186_I	247_N	0.811	1.00
207_D	211_E	0.809	1.00
133_L	236_F	0.806	1.00
279_M	282_I	0.793	1.00
122_F	126_V	0.792	1.00
299_I	302_R	0.790	1.00
275_W	279_M	0.789	1.00
153_R	199_T	0.788	1.00
120_I	124_G	0.785	1.00
111_P	114_A	0.778	1.00
150_F	153_R	0.775	1.00
216_T	227_G	0.774	1.00
118_L	122_F	0.773	1.00
268_L	272_T	0.772	1.00
289_V	293_E	0.772	1.00
127_L	130_P	0.763	1.00
201_A	232_M	0.762	1.00
47_A	51_L	0.762	1.00
141_E	207_D	0.761	1.00
171_F	185_A	0.751	1.00
53_E	60_N	0.750	1.00
139_G	153_R	0.749	1.00
142_R	145_P	0.749	1.00
97_Q	274_S	0.749	1.00
44_A	47_A	0.747	1.00
104_A	108_P	0.746	1.00
151_L	154_G	0.745	1.00
179_P	182_A	0.744	1.00
245_E	289_V	0.739	1.00
128_G	243_I	0.735	1.00
269_Q	278_M	0.731	1.00
37_N	40_I	0.728	1.00
76_S	84_T	0.725	1.00
149_N	153_R	0.725	1.00
69_Y	73_F	0.721	1.00
261_G	264_E	0.721	1.00
54_V	60_N	0.721	1.00
225_L	229_L	0.721	1.00
155_V	159_I	0.718	1.00
231_Q	234_R	0.715	1.00
225_L	228_M	0.713	1.00
267_M	270_R	0.711	1.00
207_D	210_I	0.710	1.00
291_S	295_L	0.709	1.00
184_L	187_G	0.708	1.00
128_G	132_A	0.706	1.00
47_A	54_V	0.704	1.00
243_I	247_N	0.697	1.00
117_T	263_G	0.697	1.00
127_L	183_T	0.695	1.00
123_A	127_L	0.694	1.00
108_P	112_L	0.693	1.00
129_A	236_F	0.688	1.00
56_L	59_V	0.686	1.00
51_L	58_L	0.679	1.00
125_T	247_N	0.678	1.00
119_G	122_F	0.677	1.00
115_V	118_L	0.675	1.00
295_L	299_I	0.674	1.00
233_V	237_I	0.674	1.00
276_H	280_A	0.673	1.00
54_V	63_L	0.669	1.00
41_W	47_A	0.668	1.00
198_F	232_M	0.663	1.00
41_W	53_E	0.663	1.00
32_R	35_T	0.661	1.00
46_I	54_V	0.661	1.00
97_Q	277_N	0.661	1.00
250_V	254_M	0.660	1.00
120_I	179_P	0.657	1.00
49_L	73_F	0.657	1.00
32_R	36_K	0.657	1.00
264_E	267_M	0.657	1.00
201_A	205_V	0.655	1.00
79_D	85_S	0.654	1.00
159_I	192_G	0.653	1.00
135_F	191_I	0.651	1.00
124_G	187_G	0.651	1.00
211_E	214_E	0.651	1.00
129_A	133_L	0.648	1.00
198_F	202_L	0.648	1.00
221_P	224_I	0.646	1.00
204_E	207_D	0.645	1.00
77_L	83_L	0.643	1.00
71_S	76_S	0.641	1.00
162_I	167_W	0.640	1.00
61_F	65_E	0.638	1.00
277_N	281_T	0.637	1.00
65_E	71_S	0.636	1.00
53_E	61_F	0.635	1.00
261_G	265_I	0.631	1.00
164_A	189_D	0.631	1.00
46_I	49_L	0.626	1.00
224_I	229_L	0.626	1.00
36_K	40_I	0.625	1.00
78_R	83_L	0.624	1.00
168_A	172_I	0.624	1.00
41_W	46_I	0.624	1.00
139_G	199_T	0.622	1.00
44_A	48_F	0.622	1.00
50_V	73_F	0.617	1.00
129_A	134_T	0.615	1.00
213_V	216_T	0.611	1.00
198_F	201_A	0.610	1.00
37_N	42_A	0.608	1.00
41_W	60_N	0.606	1.00
186_I	250_V	0.602	1.00
232_M	235_P	0.600	1.00
110_I	281_T	0.598	1.00
70_W	73_F	0.596	1.00
51_L	55_A	0.595	1.00
295_L	298_R	0.594	1.00
75_G	83_L	0.591	1.00
146_F	150_F	0.589	1.00
160_R	192_G	0.587	1.00
243_I	246_I	0.587	1.00
138_L	148_L	0.587	1.00
128_G	194_L	0.586	1.00
223_V	228_M	0.584	1.00
185_A	189_D	0.583	1.00
233_V	236_F	0.582	1.00
96_G	105_H	0.581	1.00
55_A	60_N	0.576	1.00
76_S	83_L	0.570	1.00
34_R	37_N	0.568	1.00
78_R	84_T	0.568	1.00
183_T	186_I	0.567	1.00
182_A	185_A	0.560	1.00
52_F	114_A	0.558	1.00
129_A	198_F	0.556	1.00
45_L	54_V	0.552	1.00
292_V	296_S	0.552	1.00
182_A	254_M	0.552	1.00
128_G	187_G	0.551	1.00
145_P	150_F	0.551	1.00
250_V	253_T	0.550	1.00
40_I	43_L	0.545	1.00
52_F	55_A	0.544	1.00
235_P	239_W	0.542	1.00
121_A	247_N	0.542	1.00
229_L	236_F	0.542	1.00
60_N	63_L	0.540	1.00
209_P	227_G	0.540	1.00
153_R	195_G	0.540	1.00
152_F	156_M	0.538	1.00
48_F	56_L	0.538	1.00
210_I	220_R	0.538	1.00
252_V	255_G	0.537	1.00
54_V	64_L	0.535	1.00
125_T	244_L	0.534	1.00
98_Y	277_N	0.530	1.00
45_L	58_L	0.530	1.00
211_E	215_S	0.529	1.00
75_G	80_F	0.529	1.00
44_A	57_E	0.529	1.00
180_F	187_G	0.528	1.00
157_S	160_R	0.525	1.00
46_I	60_N	0.523	1.00
60_N	65_E	0.521	1.00
164_A	167_W	0.520	1.00
72_Q	77_L	0.520	1.00
32_R	37_N	0.520	1.00
48_F	51_L	0.518	1.00
51_L	57_E	0.518	1.00
179_P	186_I	0.514	1.00
129_A	194_L	0.514	1.00
152_F	195_G	0.513	1.00
190_T	246_I	0.512	1.00
49_L	61_F	0.511	1.00
263_G	266_L	0.508	1.00
97_Q	110_I	0.503	1.00
178_S	185_A	0.500	1.00
41_W	56_L	0.500	1.00
287_V	291_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3d31C	2	0.6949	100	0.417	Contact Map
2onkC	2	0.7039	100	0.425	Contact Map
4tquM	1	0.7553	100	0.459	Contact Map
3rlfF	1	0.8429	100	0.48	Contact Map
3rlfG	1	0.7885	100	0.493	Contact Map
4tquN	1	0.7855	100	0.501	Contact Map
3tuiA	2	0.6133	100	0.528	Contact Map
4ymuD	2	0.6254	100	0.539	Contact Map
4pypA	1	0.6586	73.7	0.926	Contact Map
1pw4A	1	0.6737	70.7	0.927	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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