GREMLIN Database
Q9HNI9 - Transport protein
UniProt: Q9HNI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (254)
Sequences: 60370 (43065)
Seq/√Len: 2702.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_Q226_F3.2531.00
214_E223_V2.8911.00
219_S222_Q2.8531.00
115_V119_G2.7401.00
221_P225_L2.6921.00
127_L187_G2.4761.00
123_A183_T2.4241.00
210_I228_M2.4031.00
54_V58_L2.4021.00
199_T203_E2.3051.00
54_V57_E2.2161.00
202_L228_M2.0911.00
214_E220_R2.0671.00
112_L115_V2.0671.00
210_I223_V2.0631.00
74_V78_R2.0421.00
264_E268_L2.0251.00
218_A222_Q2.0161.00
220_R223_V2.0151.00
56_L60_N1.9751.00
111_P115_V1.9711.00
202_L232_M1.9551.00
54_V62_S1.9021.00
141_E210_I1.8901.00
57_E61_F1.8881.00
129_A240_S1.8801.00
119_G123_A1.8691.00
251_A261_G1.8631.00
130_P134_T1.8511.00
125_T240_S1.8421.00
213_V223_V1.8401.00
209_P231_Q1.7961.00
140_S203_E1.7831.00
114_A262_I1.7771.00
208_G211_E1.7431.00
78_R82_P1.7111.00
194_L243_I1.7111.00
62_S65_E1.6451.00
251_A255_G1.6241.00
198_F236_F1.6231.00
53_E57_E1.6061.00
213_V218_A1.6011.00
205_V209_P1.5921.00
149_N199_T1.5831.00
222_Q225_L1.5701.00
57_E60_N1.5701.00
75_G78_R1.5411.00
81_F84_T1.5211.00
140_S202_L1.5141.00
137_V202_L1.5071.00
135_F195_G1.4911.00
58_L61_F1.4741.00
57_E62_S1.4501.00
274_S277_N1.4501.00
178_S181_T1.4451.00
182_A186_I1.4421.00
133_L198_F1.4311.00
132_A194_L1.4251.00
75_G79_D1.4181.00
82_P85_S1.4131.00
142_R220_R1.4131.00
213_V227_G1.4091.00
146_F149_N1.4011.00
71_S75_G1.4001.00
183_T187_G1.3931.00
136_G140_S1.3771.00
113_A265_I1.3661.00
80_F83_L1.3541.00
136_G198_F1.3431.00
201_A235_P1.3381.00
116_E259_A1.3381.00
46_I50_V1.3271.00
77_L80_F1.3251.00
241_M296_S1.3191.00
139_G195_G1.3161.00
212_G216_T1.3031.00
294_M298_R1.2831.00
33_N37_N1.2711.00
191_I195_G1.2631.00
137_V224_I1.2621.00
141_E220_R1.2581.00
79_D83_L1.2571.00
135_F152_F1.2491.00
33_N36_K1.2471.00
105_H108_P1.2441.00
48_F60_N1.2301.00
77_L81_F1.2221.00
70_W74_V1.2121.00
119_G179_P1.2041.00
131_L134_T1.2031.00
109_S112_L1.2001.00
41_W45_L1.1941.00
116_E119_G1.1841.00
298_R302_R1.1821.00
201_A204_E1.1781.00
80_F84_T1.1751.00
210_I214_E1.1741.00
266_L281_T1.1721.00
72_Q75_G1.1691.00
180_F184_L1.1661.00
43_L47_A1.1661.00
80_F85_S1.1561.00
131_L191_I1.1531.00
145_P149_N1.1501.00
138_L142_R1.1501.00
37_N41_W1.1501.00
136_G202_L1.1441.00
142_R146_F1.1431.00
238_A242_Y1.1391.00
124_G247_N1.1391.00
71_S74_V1.1391.00
262_I288_L1.1321.00
156_M195_G1.1221.00
79_D84_T1.1191.00
42_A45_L1.1111.00
79_D82_P1.1071.00
61_F64_L1.1071.00
112_L116_E1.0981.00
133_L224_I1.0971.00
81_F85_S1.0951.00
39_I43_L1.0901.00
149_N203_E1.0881.00
48_F52_F1.0871.00
219_S223_V1.0851.00
42_A46_I1.0831.00
49_L53_E1.0801.00
132_A198_F1.0771.00
45_L57_E1.0691.00
60_N64_L1.0651.00
39_I42_A1.0641.00
96_G106_E1.0631.00
73_F77_L1.0561.00
76_S79_D1.0541.00
69_Y72_Q1.0471.00
179_P183_T1.0411.00
197_L239_W1.0411.00
123_A126_V1.0401.00
124_G128_G1.0331.00
128_G190_T1.0241.00
45_L49_L1.0211.00
73_F76_S1.0191.00
45_L48_F1.0111.00
239_W243_I1.0091.00
148_L151_L1.0081.00
298_R301_S1.0071.00
76_S80_F1.0071.00
194_L239_W1.0061.00
205_V231_Q1.0051.00
57_E72_Q1.0011.00
56_L61_F1.0001.00
141_E224_I1.0001.00
57_E65_E0.9991.00
55_A58_L0.9981.00
126_V130_P0.9971.00
181_T185_A0.9951.00
140_S199_T0.9881.00
72_Q76_S0.9881.00
205_V232_M0.9821.00
78_R81_F0.9821.00
238_A300_R0.9811.00
139_G152_F0.9731.00
40_I44_A0.9691.00
54_V65_E0.9631.00
38_R42_A0.9621.00
74_V77_L0.9561.00
147_P150_F0.9531.00
121_A244_L0.9491.00
148_L152_F0.9461.00
109_S265_I0.9431.00
154_G157_S0.9401.00
134_T137_V0.9341.00
133_L232_M0.9341.00
52_F56_L0.9331.00
194_L198_F0.9291.00
107_N111_P0.9281.00
142_R148_L0.9231.00
43_L46_I0.9231.00
253_T257_I0.9151.00
41_W57_E0.9121.00
251_A254_M0.9101.00
134_T138_L0.9101.00
187_G191_I0.9061.00
38_R41_W0.9021.00
150_F154_G0.8991.00
151_L155_V0.8941.00
46_I58_L0.8911.00
300_R304_R0.8891.00
265_I268_L0.8861.00
124_G186_I0.8841.00
106_E280_A0.8841.00
267_M271_Q0.8811.00
218_A223_V0.8771.00
50_V54_V0.8761.00
41_W44_A0.8751.00
265_I269_Q0.8751.00
205_V210_I0.8651.00
130_P133_L0.8621.00
265_I281_T0.8491.00
220_R224_I0.8421.00
268_L271_Q0.8381.00
178_S182_A0.8351.00
269_Q277_N0.8321.00
131_L187_G0.8281.00
62_S70_W0.8261.00
53_E56_L0.8201.00
180_F183_T0.8191.00
147_P151_L0.8131.00
186_I247_N0.8111.00
207_D211_E0.8091.00
133_L236_F0.8061.00
279_M282_I0.7931.00
122_F126_V0.7921.00
299_I302_R0.7901.00
275_W279_M0.7891.00
153_R199_T0.7881.00
120_I124_G0.7851.00
111_P114_A0.7781.00
150_F153_R0.7751.00
216_T227_G0.7741.00
118_L122_F0.7731.00
268_L272_T0.7721.00
289_V293_E0.7721.00
127_L130_P0.7631.00
201_A232_M0.7621.00
47_A51_L0.7621.00
141_E207_D0.7611.00
171_F185_A0.7511.00
53_E60_N0.7501.00
139_G153_R0.7491.00
142_R145_P0.7491.00
97_Q274_S0.7491.00
44_A47_A0.7471.00
104_A108_P0.7461.00
151_L154_G0.7451.00
179_P182_A0.7441.00
245_E289_V0.7391.00
128_G243_I0.7351.00
269_Q278_M0.7311.00
37_N40_I0.7281.00
76_S84_T0.7251.00
149_N153_R0.7251.00
69_Y73_F0.7211.00
261_G264_E0.7211.00
54_V60_N0.7211.00
225_L229_L0.7211.00
155_V159_I0.7181.00
231_Q234_R0.7151.00
225_L228_M0.7131.00
267_M270_R0.7111.00
207_D210_I0.7101.00
291_S295_L0.7091.00
184_L187_G0.7081.00
128_G132_A0.7061.00
47_A54_V0.7041.00
243_I247_N0.6971.00
117_T263_G0.6971.00
127_L183_T0.6951.00
123_A127_L0.6941.00
108_P112_L0.6931.00
129_A236_F0.6881.00
56_L59_V0.6861.00
51_L58_L0.6791.00
125_T247_N0.6781.00
119_G122_F0.6771.00
115_V118_L0.6751.00
295_L299_I0.6741.00
233_V237_I0.6741.00
276_H280_A0.6731.00
54_V63_L0.6691.00
41_W47_A0.6681.00
198_F232_M0.6631.00
41_W53_E0.6631.00
32_R35_T0.6611.00
46_I54_V0.6611.00
97_Q277_N0.6611.00
250_V254_M0.6601.00
120_I179_P0.6571.00
49_L73_F0.6571.00
32_R36_K0.6571.00
264_E267_M0.6571.00
201_A205_V0.6551.00
79_D85_S0.6541.00
159_I192_G0.6531.00
135_F191_I0.6511.00
124_G187_G0.6511.00
211_E214_E0.6511.00
129_A133_L0.6481.00
198_F202_L0.6481.00
221_P224_I0.6461.00
204_E207_D0.6451.00
77_L83_L0.6431.00
71_S76_S0.6411.00
162_I167_W0.6401.00
61_F65_E0.6381.00
277_N281_T0.6371.00
65_E71_S0.6361.00
53_E61_F0.6351.00
261_G265_I0.6311.00
164_A189_D0.6311.00
46_I49_L0.6261.00
224_I229_L0.6261.00
36_K40_I0.6251.00
78_R83_L0.6241.00
168_A172_I0.6241.00
41_W46_I0.6241.00
139_G199_T0.6221.00
44_A48_F0.6221.00
50_V73_F0.6171.00
129_A134_T0.6151.00
213_V216_T0.6111.00
198_F201_A0.6101.00
37_N42_A0.6081.00
41_W60_N0.6061.00
186_I250_V0.6021.00
232_M235_P0.6001.00
110_I281_T0.5981.00
70_W73_F0.5961.00
51_L55_A0.5951.00
295_L298_R0.5941.00
75_G83_L0.5911.00
146_F150_F0.5891.00
160_R192_G0.5871.00
243_I246_I0.5871.00
138_L148_L0.5871.00
128_G194_L0.5861.00
223_V228_M0.5841.00
185_A189_D0.5831.00
233_V236_F0.5821.00
96_G105_H0.5811.00
55_A60_N0.5761.00
76_S83_L0.5701.00
34_R37_N0.5681.00
78_R84_T0.5681.00
183_T186_I0.5671.00
182_A185_A0.5601.00
52_F114_A0.5581.00
129_A198_F0.5561.00
45_L54_V0.5521.00
292_V296_S0.5521.00
182_A254_M0.5521.00
128_G187_G0.5511.00
145_P150_F0.5511.00
250_V253_T0.5501.00
40_I43_L0.5451.00
52_F55_A0.5441.00
235_P239_W0.5421.00
121_A247_N0.5421.00
229_L236_F0.5421.00
60_N63_L0.5401.00
209_P227_G0.5401.00
153_R195_G0.5401.00
152_F156_M0.5381.00
48_F56_L0.5381.00
210_I220_R0.5381.00
252_V255_G0.5371.00
54_V64_L0.5351.00
125_T244_L0.5341.00
98_Y277_N0.5301.00
45_L58_L0.5301.00
211_E215_S0.5291.00
75_G80_F0.5291.00
44_A57_E0.5291.00
180_F187_G0.5281.00
157_S160_R0.5251.00
46_I60_N0.5231.00
60_N65_E0.5211.00
164_A167_W0.5201.00
72_Q77_L0.5201.00
32_R37_N0.5201.00
48_F51_L0.5181.00
51_L57_E0.5181.00
179_P186_I0.5141.00
129_A194_L0.5141.00
152_F195_G0.5131.00
190_T246_I0.5121.00
49_L61_F0.5111.00
263_G266_L0.5081.00
97_Q110_I0.5031.00
178_S185_A0.5001.00
41_W56_L0.5001.00
287_V291_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d31C 2 0.6949 100 0.417 Contact Map
2onkC 2 0.7039 100 0.425 Contact Map
4tquM 1 0.7553 100 0.459 Contact Map
3rlfF 1 0.8429 100 0.48 Contact Map
3rlfG 1 0.7885 100 0.493 Contact Map
4tquN 1 0.7855 100 0.501 Contact Map
3tuiA 2 0.6133 100 0.528 Contact Map
4ymuD 2 0.6254 100 0.539 Contact Map
4pypA 1 0.6586 73.7 0.926 Contact Map
1pw4A 1 0.6737 70.7 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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