Q9HNI7 - HALSA - GREMLIN Contacts

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Q9HNI7 - Possible phosphate binding protein

UniProt:	Q9HNI7	Sequences: MDRRNFLKTAGAAGTIGISGLSGCLGVLGGGGEDADVRFVLTPAESDVNVKEQYAGVFDYLESETGASIEPKVAADHQAVLQALENDQADIADASPTLAVVGDNASVTDVVGIRVAYGASRYFSTITTQPDSPIDSLSDLADETVVFGARLSTSGSLFPLQMLADAGLDVGDAPEGEVTDFTGKWSNDHNTAIEQLLERDEYMAAGTGAFVSLPHVPQSQLPEQVMNISSDADTAGTEDPELQLLAASDPIPRAPLLARRSWEGSVRSDVQTALLDATESDLKGSNASDELWFTGVAEATIDDYEPIRNVKNTLNLKFGN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	320 (271)
Sequences:	3248 (2475)
Seq/√Len:	150.4

ECOLI - PHND
HALSA - Q9HNI7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
192_A	205_A	4.451	1.00
55_A	59_D	3.841	1.00
109_D	267_R	3.756	1.00
140_L	204_A	3.703	1.00
36_D	70_E	3.159	1.00
40_V	89_A	3.028	1.00
146_V	202_Y	2.920	1.00
128_T	243_Q	2.765	1.00
264_G	268_S	2.724	1.00
300_T	303_D	2.638	1.00
135_D	243_Q	2.556	1.00
272_T	276_D	2.500	1.00
196_L	205_A	2.472	1.00
268_S	272_T	2.406	1.00
305_E	308_R	2.397	1.00
64_E	276_D	2.380	1.00
133_P	243_Q	2.302	1.00
305_E	309_N	2.293	1.00
99_A	301_I	2.284	1.00
38_R	70_E	2.280	1.00
129_Q	200_D	2.233	1.00
301_I	308_R	2.214	1.00
38_R	90_D	2.174	1.00
123_F	247_A	2.148	1.00
271_Q	298_E	2.102	1.00
128_T	132_S	2.077	1.00
147_F	185_W	2.073	1.00
36_D	68_S	2.067	1.00
169_D	179_T	2.025	1.00
195_Q	202_Y	1.997	1.00
135_D	139_D	1.966	1.00
299_A	303_D	1.931	1.00
111_V	258_A	1.870	1.00
36_D	67_A	1.800	1.00
121_R	250_P	1.790	1.00
136_S	139_D	1.765	1.00
145_V	206_G	1.764	1.00
55_A	58_F	1.761	1.00
144_T	203_M	1.755	1.00
143_E	203_M	1.725	1.00
126_I	206_G	1.716	1.00
60_Y	64_E	1.713	1.00
184_K	202_Y	1.695	1.00
156_S	185_W	1.691	1.00
59_D	62_E	1.691	1.00
123_F	209_A	1.689	1.00
21_L	24_C	1.684	1.00
302_D	305_E	1.675	1.00
148_G	155_G	1.674	1.00
37_V	91_I	1.647	1.00
161_Q	165_D	1.642	1.00
65_T	69_I	1.625	1.00
263_E	266_V	1.615	1.00
87_D	261_S	1.611	1.00
268_S	271_Q	1.607	1.00
115_V	295_G	1.601	1.00
162_M	246_A	1.577	1.00
85_E	106_S	1.550	1.00
103_D	301_I	1.548	1.00
301_I	305_E	1.533	1.00
127_T	196_L	1.520	1.00
130_P	243_Q	1.517	1.00
258_A	267_R	1.500	1.00
84_L	94_A	1.482	1.00
131_D	243_Q	1.466	1.00
156_S	160_L	1.465	1.00
144_T	182_T	1.458	1.00
91_I	270_V	1.421	1.00
238_E	241_E	1.412	1.00
280_S	283_K	1.391	1.00
94_A	257_L	1.387	1.00
95_S	153_T	1.358	1.00
186_S	192_A	1.356	1.00
145_V	181_F	1.355	1.00
115_V	297_A	1.355	1.00
60_Y	277_A	1.349	1.00
282_L	286_N	1.343	1.00
76_D	79_A	1.339	1.00
138_S	166_A	1.315	1.00
18_I	21_L	1.314	1.00
38_R	72_K	1.313	1.00
81_L	102_G	1.305	1.00
59_D	63_S	1.302	1.00
113_I	299_A	1.281	1.00
126_I	204_A	1.280	1.00
83_A	89_A	1.258	1.00
145_V	204_A	1.248	1.00
13_A	16_I	1.245	1.00
82_Q	85_E	1.234	1.00
99_A	103_D	1.231	1.00
62_E	68_S	1.226	1.00
275_L	298_E	1.222	1.00
40_V	80_V	1.221	1.00
146_V	186_S	1.213	1.00
165_D	309_N	1.210	1.00
193_I	207_T	1.202	1.00
266_V	270_V	1.198	1.00
150_R	185_W	1.182	1.00
281_D	284_G	1.173	1.00
168_L	180_D	1.163	1.00
128_T	245_L	1.162	1.00
97_T	311_K	1.155	1.00
193_I	215_H	1.155	1.00
91_I	262_W	1.147	1.00
57_V	277_A	1.137	1.00
99_A	255_P	1.137	1.00
158_F	251_I	1.136	1.00
122_Y	154_S	1.130	1.00
61_L	65_T	1.118	0.99
193_I	205_A	1.094	0.99
65_T	266_V	1.090	0.99
158_F	310_V	1.084	0.99
244_L	247_A	1.080	0.99
123_F	250_P	1.077	0.99
148_G	185_W	1.075	0.99
266_V	269_D	1.074	0.99
141_A	168_L	1.069	0.99
107_V	260_R	1.065	0.99
147_F	183_G	1.059	0.99
12_A	15_T	1.050	0.99
60_Y	273_A	1.050	0.99
126_I	140_L	1.045	0.99
67_A	266_V	1.045	0.99
110_V	299_A	1.041	0.99
91_I	258_A	1.034	0.99
65_T	273_A	1.031	0.99
153_T	158_F	1.028	0.99
64_E	273_A	1.023	0.99
126_I	145_V	1.021	0.99
34_D	67_A	1.020	0.99
146_V	195_Q	1.016	0.99
37_V	69_I	1.015	0.99
265_S	268_S	1.010	0.99
14_G	17_G	1.004	0.99
134_I	143_E	0.998	0.99
19_S	22_S	0.995	0.99
159_P	206_G	0.993	0.99
39_F	58_F	0.983	0.99
103_D	308_R	0.978	0.99
161_Q	310_V	0.973	0.99
259_R	262_W	0.972	0.99
155_G	189_H	0.970	0.98
208_G	254_A	0.970	0.98
144_T	184_K	0.965	0.98
271_Q	275_L	0.965	0.98
39_F	93_D	0.963	0.98
15_T	18_I	0.958	0.98
162_M	166_A	0.957	0.98
87_D	259_R	0.954	0.98
278_T	295_G	0.952	0.98
194_E	199_R	0.951	0.98
58_F	274_L	0.951	0.98
17_G	20_G	0.949	0.98
124_S	248_S	0.949	0.98
11_G	17_G	0.947	0.98
193_I	196_L	0.944	0.98
283_K	286_N	0.943	0.98
90_D	259_R	0.941	0.98
87_D	90_D	0.941	0.98
20_G	24_C	0.937	0.98
122_Y	152_S	0.935	0.98
17_G	21_L	0.933	0.98
81_L	98_L	0.932	0.98
43_P	77_H	0.932	0.98
127_T	207_T	0.927	0.98
112_G	275_L	0.925	0.98
133_P	143_E	0.912	0.98
258_A	262_W	0.912	0.98
99_A	304_Y	0.902	0.98
79_A	83_A	0.901	0.98
196_L	242_L	0.883	0.97
97_T	157_L	0.883	0.97
270_V	274_L	0.879	0.97
12_A	17_G	0.877	0.97
152_S	189_H	0.874	0.97
129_Q	203_M	0.873	0.97
170_V	178_V	0.872	0.97
85_E	105_A	0.871	0.97
168_L	181_F	0.870	0.97
248_S	251_I	0.862	0.97
95_S	98_L	0.858	0.97
191_T	194_E	0.854	0.97
125_T	209_A	0.854	0.97
80_V	89_A	0.852	0.97
164_A	169_D	0.852	0.97
196_L	202_Y	0.851	0.97
111_V	256_L	0.850	0.97
100_V	308_R	0.843	0.96
154_S	208_G	0.842	0.96
77_H	189_H	0.837	0.96
129_Q	241_E	0.836	0.96
285_S	289_D	0.835	0.96
265_S	269_D	0.835	0.96
58_F	62_E	0.824	0.96
132_S	135_D	0.823	0.96
58_F	71_P	0.822	0.96
252_P	306_P	0.820	0.96
35_A	67_A	0.817	0.96
37_V	65_T	0.814	0.96
132_S	243_Q	0.813	0.96
42_T	98_L	0.810	0.95
16_I	19_S	0.808	0.95
288_S	291_L	0.806	0.95
74_A	83_A	0.806	0.95
149_A	152_S	0.804	0.95
144_T	202_Y	0.800	0.95
11_G	15_T	0.798	0.95
109_D	260_R	0.796	0.95
19_S	24_C	0.795	0.95
279_E	282_L	0.791	0.95
162_M	165_D	0.785	0.95
282_L	285_S	0.784	0.95
281_D	285_S	0.783	0.95
82_Q	86_N	0.782	0.94
186_S	195_Q	0.779	0.94
83_A	88_Q	0.777	0.94
141_A	180_D	0.773	0.94
93_D	256_L	0.773	0.94
154_S	254_A	0.771	0.94
264_G	267_R	0.768	0.94
104_N	308_R	0.768	0.94
46_S	49_N	0.763	0.94
128_T	133_P	0.762	0.94
163_L	204_A	0.761	0.94
188_D	191_T	0.760	0.94
9_T	14_G	0.754	0.93
125_T	247_A	0.753	0.93
138_S	141_A	0.749	0.93
94_A	98_L	0.745	0.93
163_L	168_L	0.744	0.93
130_P	240_P	0.741	0.93
267_R	271_Q	0.739	0.93
74_A	79_A	0.734	0.92
127_T	242_L	0.734	0.92
61_L	273_A	0.732	0.92
152_S	155_G	0.732	0.92
77_H	152_S	0.731	0.92
111_V	271_Q	0.731	0.92
122_Y	148_G	0.729	0.92
10_A	14_G	0.721	0.92
153_T	251_I	0.720	0.92
147_F	206_G	0.719	0.92
279_E	283_K	0.718	0.92
65_T	270_V	0.716	0.91
14_G	19_S	0.716	0.91
170_V	181_F	0.714	0.91
61_L	69_I	0.712	0.91
37_V	262_W	0.710	0.91
19_S	23_G	0.709	0.91
124_S	159_P	0.692	0.90
178_V	181_F	0.692	0.90
24_C	34_D	0.687	0.90
95_S	189_H	0.684	0.89
122_Y	189_H	0.683	0.89
148_G	189_H	0.683	0.89
293_F	296_V	0.682	0.89
51_K	55_A	0.682	0.89
208_G	211_V	0.682	0.89
14_G	24_C	0.681	0.89
103_D	109_D	0.678	0.89
10_A	15_T	0.677	0.89
12_A	19_S	0.675	0.89
124_S	206_G	0.675	0.89
10_A	16_I	0.674	0.89
209_A	247_A	0.670	0.88
192_A	196_L	0.669	0.88
263_E	267_R	0.665	0.88
259_R	263_E	0.665	0.88
258_A	270_V	0.660	0.88
74_A	80_V	0.658	0.88
146_V	192_A	0.657	0.88
109_D	271_Q	0.653	0.87
138_S	218_Q	0.651	0.87
262_W	266_V	0.649	0.87
42_T	94_A	0.646	0.87
99_A	257_L	0.645	0.87
84_L	257_L	0.645	0.87
13_A	17_G	0.642	0.86
169_D	178_V	0.642	0.86
130_P	133_P	0.639	0.86
126_I	245_L	0.636	0.86
113_I	303_D	0.635	0.86
165_D	249_D	0.634	0.86
113_I	297_A	0.628	0.85
11_G	18_I	0.628	0.85
262_W	267_R	0.626	0.85
278_T	281_D	0.626	0.85
97_T	148_G	0.623	0.85
96_P	153_T	0.623	0.85
64_E	280_S	0.617	0.84
115_V	120_S	0.616	0.84
113_I	304_Y	0.614	0.84
162_M	249_D	0.612	0.84
24_C	31_G	0.611	0.83
95_S	154_S	0.610	0.83
207_T	211_V	0.606	0.83
195_Q	201_E	0.603	0.83
122_Y	153_T	0.603	0.83
64_E	272_T	0.601	0.82
13_A	21_L	0.600	0.82
37_V	67_A	0.600	0.82
95_S	208_G	0.598	0.82
12_A	21_L	0.597	0.82
125_T	212_S	0.594	0.82
129_Q	133_P	0.594	0.82
166_A	181_F	0.593	0.82
40_V	79_A	0.593	0.82
122_Y	155_G	0.593	0.82
146_V	196_L	0.592	0.82
96_P	254_A	0.592	0.82
128_T	204_A	0.591	0.81
98_L	153_T	0.588	0.81
128_T	135_D	0.587	0.81
128_T	140_L	0.587	0.81
93_D	254_A	0.586	0.81
10_A	13_A	0.582	0.80
84_L	89_A	0.582	0.80
20_G	23_G	0.581	0.80
30_G	33_E	0.578	0.80
241_E	244_L	0.578	0.80
18_I	22_S	0.577	0.80
94_A	189_H	0.576	0.80
101_V	151_L	0.574	0.80
16_I	20_G	0.572	0.79
208_G	212_S	0.571	0.79
90_D	261_S	0.571	0.79
255_P	304_Y	0.570	0.79
148_G	186_S	0.568	0.79
50_V	73_V	0.567	0.79
80_V	95_S	0.567	0.79
33_E	263_E	0.566	0.79
17_G	22_S	0.566	0.79
39_F	256_L	0.565	0.78
163_L	180_D	0.564	0.78
208_G	253_R	0.564	0.78
206_G	246_A	0.563	0.78
118_G	122_Y	0.563	0.78
169_D	218_Q	0.563	0.78
158_F	248_S	0.559	0.78
189_H	255_P	0.558	0.78
108_T	257_L	0.557	0.77
59_D	268_S	0.557	0.77
127_T	205_A	0.556	0.77
98_L	254_A	0.555	0.77
288_S	296_V	0.552	0.77
77_H	95_S	0.550	0.77
17_G	32_G	0.549	0.76
10_A	20_G	0.549	0.76
129_Q	132_S	0.548	0.76
45_E	190_N	0.548	0.76
81_L	94_A	0.547	0.76
107_V	112_G	0.546	0.76
140_L	143_E	0.546	0.76
41_L	71_P	0.546	0.76
202_Y	205_A	0.545	0.76
44_A	154_S	0.544	0.76
149_A	185_W	0.542	0.76
34_D	68_S	0.541	0.75
42_T	54_Y	0.539	0.75
269_D	272_T	0.538	0.75
77_H	98_L	0.538	0.75
49_N	52_E	0.537	0.75
102_G	108_T	0.536	0.75
153_T	208_G	0.536	0.75
157_L	310_V	0.535	0.75
9_T	16_I	0.532	0.74
139_D	166_A	0.532	0.74
193_I	242_L	0.532	0.74
16_I	30_G	0.532	0.74
93_D	96_P	0.531	0.74
60_Y	280_S	0.531	0.74
277_A	283_K	0.530	0.74
72_K	83_A	0.530	0.74
52_E	55_A	0.530	0.74
54_Y	71_P	0.528	0.74
193_I	221_L	0.527	0.74
57_V	274_L	0.525	0.73
269_D	273_A	0.524	0.73
148_G	207_T	0.524	0.73
76_D	190_N	0.521	0.73
152_S	208_G	0.521	0.73
9_T	12_A	0.521	0.73
273_A	277_A	0.520	0.73
11_G	16_I	0.519	0.72
45_E	95_S	0.517	0.72
114_R	293_F	0.517	0.72
262_W	265_S	0.517	0.72
153_T	157_L	0.517	0.72
84_L	106_S	0.517	0.72
40_V	71_P	0.516	0.72
54_Y	95_S	0.515	0.72
37_V	266_V	0.513	0.72
264_G	272_T	0.512	0.71
11_G	30_G	0.512	0.71
10_A	17_G	0.511	0.71
212_S	253_R	0.511	0.71
141_A	163_L	0.511	0.71
140_L	245_L	0.511	0.71
134_I	139_D	0.510	0.71
44_A	254_A	0.509	0.71
157_L	304_Y	0.508	0.71
143_E	204_A	0.507	0.71
99_A	305_E	0.506	0.71
65_T	68_S	0.504	0.70
62_E	65_T	0.501	0.70
99_A	308_R	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ekiA	1	0.8313	100	0.369	Contact Map
3myuA	1	0.7969	100	0.419	Contact Map
3v83A	6	0.8688	100	0.426	Contact Map
1h45A	1	0.825	100	0.435	Contact Map
2d3iA	1	0.8313	100	0.44	Contact Map
1blfA	1	0.9219	100	0.442	Contact Map
1ryoA	1	0.8438	100	0.444	Contact Map
1iejA	1	0.8344	100	0.446	Contact Map
1cb6A	1	0.9125	100	0.449	Contact Map
3mc2A	1	0.8313	100	0.457	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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