GREMLIN Database
HIS5 - Imidazole glycerol phosphate synthase subunit HisH
UniProt: Q9HNI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (193)
Sequences: 3863 (2523)
Seq/√Len: 181.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_S113_D3.1821.00
14_V40_V3.1421.00
97_S118_R2.8631.00
38_S45_A2.7281.00
173_T181_A2.7011.00
142_H184_A2.6721.00
209_R213_D2.5571.00
120_V162_A2.4491.00
42_D45_A2.3241.00
30_L53_V2.2461.00
14_V49_A2.1121.00
122_F179_F2.1111.00
97_S108_D2.1051.00
60_F111_G1.9931.00
47_D76_D1.9921.00
96_S116_P1.9921.00
95_L161_A1.9571.00
174_D178_R1.9331.00
145_V182_V1.8671.00
172_E178_R1.8621.00
28_R31_E1.8371.00
77_A82_R1.8341.00
136_L153_A1.8031.00
52_I77_A1.8021.00
63_G89_L1.7951.00
155_F181_A1.7921.00
27_T31_E1.7661.00
77_A80_E1.7291.00
95_L183_V1.6401.00
99_E120_V1.6401.00
170_V184_A1.6261.00
206_R209_R1.6221.00
147_G210_N1.6041.00
171_A182_V1.5991.00
144_L191_F1.5841.00
160_Y177_E1.5711.00
151_E203_T1.5551.00
101_A107_G1.5531.00
119_N161_A1.5311.00
15_V27_T1.5181.00
153_A203_T1.5161.00
169_V180_P1.5141.00
126_V176_G1.4881.00
35_A212_V1.4861.00
78_A114_L1.4691.00
148_V151_E1.4581.00
182_V193_T1.4531.00
71_R75_T1.4501.00
75_T114_L1.4441.00
13_I212_V1.4251.00
30_L35_A1.3901.00
122_F160_Y1.3831.00
153_A207_I1.3791.00
168_H185_N1.3791.00
23_L39_I1.3681.00
44_G48_D1.3671.00
27_T39_I1.3661.00
96_S117_G1.3641.00
94_L190_V1.3611.00
99_E118_R1.3471.00
27_T37_V1.3401.00
163_P169_V1.3351.00
14_V46_L1.3141.00
116_P168_H1.3071.00
32_R205_L1.2981.00
61_G101_A1.2961.00
120_V160_Y1.2941.00
87_I208_L1.2861.00
40_V45_A1.2831.00
15_V30_L1.2821.00
136_L171_A1.2621.00
97_S110_R1.2581.00
61_G107_G1.2581.00
130_H179_F1.2531.00
143_P184_A1.2521.00
115_I168_H1.2321.00
91_M192_G1.2131.00
46_L73_A1.2121.00
61_G109_A1.2081.00
193_T207_I1.2071.00
123_T177_E1.2061.00
206_R210_N1.2051.00
31_E36_D1.2011.00
73_A77_A1.1971.00
135_E150_G1.1871.00
146_G213_D1.1781.00
147_G206_R1.1551.00
137_A178_R1.1301.00
68_G71_R1.1301.00
76_D80_E1.1281.00
99_E108_D1.1261.00
94_L114_L1.1141.00
139_T172_E1.1131.00
40_V49_A1.1101.00
44_G47_D1.0881.00
14_V52_I1.0701.00
165_D168_H1.0671.00
18_Y21_G1.0641.00
95_L119_N1.0581.00
174_D177_E1.0491.00
34_S37_V1.0481.00
67_A71_R1.0441.00
144_L210_N1.0210.99
31_E37_V1.0080.99
131_M156_V1.0040.99
43_P47_D1.0020.99
46_L49_A1.0010.99
30_L37_V0.9810.99
24_R28_R0.9790.99
91_M161_A0.9790.99
96_S118_R0.9770.99
173_T179_F0.9710.99
95_L117_G0.9700.99
160_Y180_P0.9660.99
137_A150_G0.9620.99
135_E152_Y0.9610.99
74_L114_L0.9590.99
148_V210_N0.9490.99
95_L115_I0.9480.99
142_H191_F0.9480.99
101_A109_A0.9470.99
59_A101_A0.9390.99
99_E121_R0.9370.99
54_L84_L0.9340.99
136_L181_A0.9230.99
84_L114_L0.9160.99
57_V89_L0.9140.99
137_A174_D0.9030.99
15_V37_V0.9000.99
85_F193_T0.8990.99
142_H170_V0.8980.99
184_A191_F0.8970.99
116_P164_D0.8890.99
118_R162_A0.8810.98
138_V149_D0.8810.98
170_V182_V0.8790.98
76_D79_D0.8750.98
47_D77_A0.8700.98
130_H157_H0.8680.98
78_A84_L0.8650.98
155_F173_T0.8580.98
13_I35_A0.8520.98
46_L77_A0.8450.98
72_D75_T0.8400.98
19_G66_N0.8380.98
40_V70_F0.8300.98
45_A48_D0.8280.98
24_R27_T0.8150.97
30_L212_V0.8110.97
30_L208_L0.8060.97
69_P72_D0.8060.97
122_F128_V0.8020.97
43_P46_L0.8020.97
126_V175_Y0.7970.97
60_F93_M0.7940.97
51_G211_F0.7940.97
162_A177_E0.7840.97
96_S115_I0.7810.97
141_D146_G0.7790.97
63_G93_M0.7760.97
33_A212_V0.7720.97
13_I51_G0.7710.97
64_M109_A0.7710.97
125_T176_G0.7690.96
115_I183_V0.7630.96
72_D76_D0.7570.96
43_P73_A0.7550.96
57_V91_M0.7550.96
171_A181_A0.7540.96
75_T79_D0.7490.96
137_A172_E0.7490.96
64_M71_R0.7480.96
110_R113_D0.7420.96
16_V54_L0.7420.96
84_L94_L0.7400.96
29_G33_A0.7390.96
46_L70_F0.7320.95
17_D41_G0.7300.95
163_P180_P0.7220.95
67_A70_F0.7140.95
146_G206_R0.7040.94
14_V45_A0.7030.94
130_H134_N0.7010.94
136_L207_I0.6970.94
40_V73_A0.6970.94
114_L190_V0.6940.94
130_H173_T0.6930.94
52_I73_A0.6890.94
43_P72_D0.6860.93
61_G65_E0.6850.93
60_F109_A0.6850.93
116_P185_N0.6850.93
136_L151_E0.6820.93
52_I74_L0.6800.93
51_G83_P0.6760.93
14_V38_S0.6720.93
116_P165_D0.6670.92
101_A108_D0.6610.92
84_L190_V0.6600.92
139_T178_R0.6560.92
40_V46_L0.6560.92
30_L33_A0.6550.92
33_A205_L0.6540.92
81_G189_N0.6530.92
16_V52_I0.6480.91
138_V171_A0.6450.91
59_A109_A0.6440.91
131_M152_Y0.6440.91
20_L24_R0.6390.91
37_V53_V0.6370.91
41_G68_G0.6360.91
61_G108_D0.6260.90
51_G201_G0.6240.90
26_V87_I0.6190.89
16_V46_L0.6190.89
140_R170_V0.6180.89
137_A149_D0.6150.89
18_Y63_G0.6070.88
183_V192_G0.6070.88
24_R179_F0.6060.88
140_R167_G0.6050.88
16_V74_L0.6050.88
28_R205_L0.5990.88
151_E206_R0.5940.87
15_V39_I0.5910.87
63_G66_N0.5900.87
96_S164_D0.5880.87
43_P69_P0.5880.87
170_V191_F0.5870.87
23_L127_K0.5860.87
143_P146_G0.5850.87
98_S122_F0.5820.86
67_A74_L0.5820.86
117_G161_A0.5800.86
33_A208_L0.5780.86
144_L207_I0.5770.86
26_V29_G0.5750.86
59_A62_D0.5740.86
20_L23_L0.5710.85
164_D167_G0.5700.85
85_F211_F0.5670.85
52_I80_E0.5660.85
152_Y203_T0.5660.85
115_I190_V0.5650.85
37_V89_L0.5640.85
54_L93_M0.5590.84
26_V89_L0.5590.84
191_F211_F0.5570.84
54_L57_V0.5500.83
121_R159_Y0.5480.83
20_L63_G0.5460.83
99_E123_T0.5450.83
19_G119_N0.5440.82
89_L93_M0.5420.82
145_V171_A0.5420.82
134_N175_Y0.5380.82
148_V153_A0.5380.82
52_I82_R0.5360.81
98_S109_A0.5360.81
75_T78_A0.5330.81
138_V151_E0.5310.81
25_S28_R0.5290.81
136_L179_F0.5270.80
16_V70_F0.5270.80
69_P73_A0.5270.80
115_I185_N0.5260.80
64_M99_E0.5240.80
70_F73_A0.5230.80
169_V172_E0.5220.80
71_R74_L0.5220.80
98_S128_V0.5210.80
51_G191_F0.5200.79
24_R31_E0.5180.79
119_N163_P0.5180.79
26_V53_V0.5170.79
163_P168_H0.5150.79
41_G66_N0.5140.79
98_S107_G0.5130.79
37_V212_V0.5130.79
140_R149_D0.5120.78
118_R164_D0.5120.78
153_A195_F0.5120.78
81_G190_V0.5100.78
161_A183_V0.5100.78
60_F98_S0.5090.78
74_L77_A0.5080.78
117_G163_P0.5060.78
131_M155_F0.5050.78
64_M112_L0.5050.78
74_L112_L0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jvnA 1 0.9266 100 0.464 Contact Map
4gudA 1 0.8945 100 0.514 Contact Map
1ka9H 1 0.8807 100 0.534 Contact Map
1gpwB 1 0.8761 100 0.547 Contact Map
3uowA 2 0.8853 100 0.554 Contact Map
2v4uA 1 0.8899 100 0.573 Contact Map
2w7tA 1 0.8899 100 0.593 Contact Map
2ywdA 1 0.8486 100 0.6 Contact Map
2issD 1 0.789 100 0.602 Contact Map
3d54D 1 0.867 100 0.606 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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