GREMLIN Database
Q9HNI3 - Uncharacterized protein
UniProt: Q9HNI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (194)
Sequences: 963 (784)
Seq/√Len: 56.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_A173_A7.9701.00
9_I41_I4.3271.00
18_A34_G3.9581.00
48_G99_V3.8401.00
169_A172_A3.8001.00
35_F87_D3.3021.00
168_G172_A3.2431.00
74_S92_A3.1701.00
35_F90_A3.0031.00
40_A74_S2.8191.00
180_S184_G2.7331.00
168_G173_A2.7211.00
16_F35_F2.5131.00
5_G45_V2.2171.00
5_G41_I2.1441.00
40_A92_A2.1411.00
26_A29_T2.0951.00
165_A168_G2.0471.00
19_P34_G2.0001.00
111_G114_F1.9821.00
151_V155_G1.9791.00
126_A130_P1.8711.00
34_G85_L1.8560.99
17_A33_T1.7260.99
12_L16_F1.7190.99
9_I38_G1.7180.99
18_A86_V1.7150.99
113_G116_L1.7080.99
6_L10_V1.7070.99
32_G82_V1.6930.99
44_A99_V1.6860.99
43_S95_G1.6810.99
18_A35_F1.6620.99
166_G169_A1.6580.99
18_A87_D1.6550.99
162_R169_A1.6170.99
18_A84_Y1.5180.98
44_A92_A1.5120.98
9_I94_V1.5010.98
115_G119_I1.4740.97
22_P26_A1.4390.97
175_G183_V1.4160.97
32_G84_Y1.4010.96
178_A182_G1.3710.96
22_P84_Y1.3670.96
189_P193_A1.3580.96
47_Y69_M1.3490.96
172_A180_S1.3370.95
177_A181_V1.2660.94
119_I127_V1.2640.94
163_P167_V1.2590.94
165_A169_A1.2500.93
47_Y70_V1.2460.93
7_A32_G1.2440.93
14_G33_T1.2430.93
14_G82_V1.2370.93
189_P192_G1.2030.92
162_R165_A1.1960.92
34_G87_D1.1830.91
32_G38_G1.1790.91
151_V157_V1.1660.91
93_G96_V1.1630.90
76_T80_L1.1600.90
116_L126_A1.1560.90
184_G192_G1.1550.90
13_K20_R1.1550.90
6_L137_A1.1450.90
162_R166_G1.1430.90
40_A43_S1.1340.89
34_G151_V1.1340.89
35_F86_V1.1040.88
70_V92_A1.1000.88
101_G171_V1.0870.87
118_V122_A1.0820.87
179_A184_G1.0790.87
87_D90_A1.0760.87
13_K21_P1.0740.87
14_G32_G1.0690.86
133_D140_G1.0660.86
127_V130_P1.0600.86
47_Y82_V1.0590.86
145_L148_W1.0260.84
116_L130_P1.0200.84
160_A167_V1.0190.84
25_V29_T1.0160.83
161_V164_V1.0050.83
3_G140_G1.0010.82
38_G47_Y1.0000.82
14_G25_V0.9860.82
4_V101_G0.9820.81
193_A196_A0.9810.81
180_S185_A0.9800.81
70_V139_G0.9770.81
90_A104_A0.9760.81
197_A200_V0.9740.81
132_T135_V0.9690.80
192_G196_A0.9640.80
179_A195_A0.9450.79
59_R171_V0.9370.78
22_P34_G0.9350.78
48_G70_V0.9330.78
54_L62_R0.9300.78
16_F94_V0.9240.77
40_A130_P0.9240.77
178_A183_V0.9200.77
190_V193_A0.9140.76
76_T136_A0.9030.75
73_V128_A0.9010.75
112_Y116_L0.8960.75
182_G190_V0.8870.74
166_G174_G0.8840.74
34_G91_G0.8770.73
41_I94_V0.8720.73
77_R83_H0.8720.73
160_A169_A0.8720.73
176_V180_S0.8660.72
113_G117_A0.8640.72
45_V99_V0.8640.72
55_D59_R0.8580.72
73_V76_T0.8580.72
22_P28_V0.8540.71
139_G143_G0.8520.71
22_P30_A0.8510.71
176_V182_G0.8490.71
137_A144_G0.8480.71
52_A103_L0.8430.70
42_G49_G0.8380.70
3_G38_G0.8370.70
143_G147_G0.8340.69
40_A91_G0.8320.69
24_S27_H0.8310.69
187_A191_F0.8250.69
101_G164_V0.8220.68
12_L40_A0.8220.68
181_V185_A0.8120.67
136_A144_G0.8100.67
68_A108_R0.8050.67
110_V116_L0.8020.66
64_A68_A0.8020.66
6_L47_Y0.8010.66
114_F128_A0.7990.66
125_V167_V0.7970.66
31_H38_G0.7950.66
51_A63_Y0.7940.66
181_V184_G0.7930.66
191_F196_A0.7930.66
22_P87_D0.7890.65
194_H198_G0.7880.65
107_R191_F0.7760.64
147_G150_I0.7740.64
29_T32_G0.7670.63
68_A125_V0.7670.63
91_G95_G0.7650.63
17_A193_A0.7600.62
66_G99_V0.7570.62
24_S84_Y0.7540.62
112_Y126_A0.7490.61
4_V98_V0.7460.61
46_L80_L0.7410.60
180_S183_V0.7410.60
164_V167_V0.7400.60
93_G97_A0.7280.59
4_V60_R0.7200.58
151_V154_R0.7190.58
6_L41_I0.7190.58
117_A126_A0.7100.57
177_A184_G0.7080.57
61_Q174_G0.6980.56
177_A180_S0.6970.56
15_M75_A0.6940.55
4_V45_V0.6910.55
159_R176_V0.6900.55
122_A128_A0.6880.55
29_T33_T0.6880.55
123_G126_A0.6810.54
26_A133_D0.6800.54
10_V18_A0.6790.54
97_A125_V0.6790.54
175_G182_G0.6780.54
152_A155_G0.6710.53
169_A184_G0.6700.53
187_A198_G0.6660.52
95_G146_V0.6590.52
34_G43_S0.6580.51
7_A88_V0.6580.51
71_V122_A0.6530.51
161_V165_A0.6520.51
75_A78_L0.6500.51
63_Y66_G0.6470.50
54_L132_T0.6460.50
78_L84_Y0.6420.50
20_R37_S0.6410.50
3_G78_L0.6400.49
174_G181_V0.6350.49
115_G130_P0.6340.49
114_F118_V0.6340.49
19_P26_A0.6320.49
112_Y115_G0.6280.48
74_S95_G0.6260.48
25_V28_V0.6240.48
12_L150_I0.6230.48
35_F82_V0.6200.47
154_R157_V0.6190.47
22_P25_V0.6180.47
161_V168_G0.6170.47
123_G129_G0.6170.47
110_V114_F0.6140.47
82_V133_D0.6130.47
22_P27_H0.6110.46
10_V14_G0.6080.46
174_G191_F0.6020.45
78_L86_V0.5970.45
167_V173_A0.5960.45
153_A157_V0.5960.45
44_A49_G0.5940.44
30_A85_L0.5940.44
96_V185_A0.5910.44
111_G118_V0.5900.44
186_G191_F0.5900.44
112_Y117_A0.5890.44
46_L200_V0.5880.44
75_A79_A0.5850.44
21_P37_S0.5800.43
64_A75_A0.5800.43
159_R163_P0.5790.43
67_A70_V0.5780.43
162_R170_V0.5770.43
184_G193_A0.5770.43
65_A140_G0.5750.42
68_A72_V0.5750.42
167_V170_V0.5740.42
151_V156_A0.5720.42
71_V120_L0.5710.42
6_L38_G0.5690.42
73_V85_L0.5690.42
42_G69_M0.5680.42
119_I123_G0.5670.42
196_A200_V0.5670.42
66_G70_V0.5660.41
61_Q152_A0.5660.41
68_A163_P0.5660.41
132_T136_A0.5650.41
37_S83_H0.5650.41
159_R169_A0.5640.41
62_R66_G0.5610.41
4_V78_L0.5590.41
35_F66_G0.5580.41
24_S82_V0.5560.40
7_A124_A0.5550.40
157_V167_V0.5550.40
34_G82_V0.5520.40
149_R153_A0.5500.40
37_S77_R0.5500.40
46_L69_M0.5480.40
34_G135_V0.5470.40
51_A66_G0.5460.39
10_V134_A0.5430.39
20_R83_H0.5410.39
47_Y99_V0.5390.39
133_D137_A0.5380.39
38_G76_T0.5350.38
105_V148_W0.5350.38
125_V129_G0.5340.38
80_L145_L0.5340.38
31_H42_G0.5340.38
89_V154_R0.5310.38
179_A196_A0.5300.38
110_V120_L0.5300.38
68_A101_G0.5300.38
76_T85_L0.5280.38
20_R77_R0.5270.37
17_A102_V0.5260.37
84_Y95_G0.5260.37
141_A145_L0.5220.37
25_V82_V0.5220.37
165_A174_G0.5210.37
24_S33_T0.5210.37
166_G175_G0.5200.37
150_I157_V0.5170.36
14_G29_T0.5150.36
83_H91_G0.5120.36
165_A170_V0.5110.36
170_V174_G0.5100.36
13_K36_P0.5100.36
44_A73_V0.5100.36
69_M120_L0.5100.36
14_G17_A0.5080.36
93_G153_A0.5080.36
32_G80_L0.5060.35
116_L134_A0.5050.35
50_L53_L0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4px7A 1 0.6226 99.9 0.538 Contact Map
4citA 1 0.5377 99.9 0.555 Contact Map
1qi9A 2 0.6981 99.8 0.561 Contact Map
3w36A 2 0.5377 99.8 0.582 Contact Map
1d2tA 5 0.5613 99.8 0.584 Contact Map
2ipbA 2 0.5755 99.8 0.592 Contact Map
1up8A 9 0.6038 99.8 0.595 Contact Map
3bb0A 1 0.7028 99.7 0.62 Contact Map
2couA 1 0.1745 2.6 0.959 Contact Map
4b19A 1 0.1415 2.5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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