GREMLIN Database
GLNA - Glutamine synthetase
UniProt: Q9HNI2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 454 (426)
Sequences: 6393 (3327)
Seq/√Len: 161.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
410_E432_R5.2091.00
286_G372_A4.7481.00
180_E234_H4.0161.00
257_I284_F3.8711.00
366_D370_T3.7991.00
284_F364_G3.7621.00
128_R369_D3.5571.00
132_M369_D3.4781.00
105_D123_K3.4541.00
283_Q371_D3.3751.00
108_D112_N3.0821.00
290_E370_T2.9591.00
127_A131_D2.8441.00
421_E425_E2.8051.00
145_F200_A2.7791.00
177_I181_I2.7701.00
125_V362_A2.7571.00
416_Q421_E2.7301.00
294_A412_D2.6731.00
121_V423_V2.6301.00
444_E448_D2.5901.00
227_V238_A2.5731.00
127_A130_D2.5641.00
138_I357_L2.4861.00
267_V280_T2.4551.00
20_D24_A2.4551.00
180_E233_Q2.4311.00
211_D219_N2.4021.00
279_E371_D2.3991.00
211_D215_T2.3971.00
257_I360_V2.3641.00
291_H366_D2.2821.00
291_H412_D2.2771.00
298_V359_A2.2581.00
401_H404_D2.2331.00
282_Y373_D2.1851.00
407_T432_R2.1801.00
403_G439_K2.1721.00
130_D135_S2.1661.00
126_L214_L2.1581.00
215_T219_N2.1561.00
283_Q286_G2.1431.00
299_T356_A2.0791.00
297_A409_L2.0621.00
21_D25_Q2.0161.00
185_L226_V1.9981.00
212_D215_T1.9891.00
49_H186_E1.9711.00
126_L213_A1.9671.00
188_M226_V1.9331.00
146_L177_I1.9321.00
181_I227_V1.9221.00
293_P396_D1.9161.00
400_G404_D1.9021.00
32_L104_C1.8731.00
147_F245_I1.8631.00
409_L424_C1.8551.00
115_A422_H1.8521.00
408_A411_S1.8431.00
28_D183_F1.8271.00
129_A136_V1.8221.00
16_R20_D1.8171.00
191_E209_K1.8171.00
280_T368_I1.7771.00
279_E283_Q1.7681.00
437_E449_R1.7651.00
126_L212_D1.7641.00
294_A414_V1.7621.00
277_L281_A1.7541.00
286_G374_P1.7241.00
283_Q372_A1.7191.00
295_F299_T1.6911.00
217_A357_L1.6901.00
27_I88_V1.6851.00
145_F251_S1.6741.00
298_V409_L1.6371.00
184_T230_V1.6351.00
403_G407_T1.6331.00
291_H363_A1.6321.00
406_V428_A1.6241.00
351_C356_A1.6231.00
223_F227_V1.6191.00
80_D107_V1.5961.00
55_F83_P1.5871.00
121_V358_A1.5791.00
293_P408_A1.5761.00
142_P220_I1.5741.00
184_T187_A1.5621.00
290_E372_A1.5611.00
414_V418_A1.5561.00
362_A418_A1.5531.00
404_D407_T1.5521.00
22_I48_A1.5451.00
85_T103_I1.5181.00
129_A365_L1.5091.00
123_K214_L1.5071.00
273_D282_Y1.5011.00
381_D384_E1.4701.00
410_E428_A1.4571.00
33_Q101_R1.4421.00
125_V358_A1.4391.00
136_V361_I1.4231.00
300_N305_S1.4021.00
134_Y267_V1.3881.00
185_L190_F1.3781.00
146_L231_A1.3651.00
283_Q373_D1.3631.00
101_R222_T1.3581.00
407_T410_E1.3431.00
297_A406_V1.3391.00
125_V128_R1.3311.00
413_P417_D1.3281.00
282_Y374_P1.3221.00
216_T219_N1.3211.00
296_T300_N1.3211.00
208_F216_T1.3131.00
20_D23_E1.3041.00
148_E158_T1.3021.00
279_E373_D1.3011.00
407_T411_S1.2981.00
344_I360_V1.2961.00
35_T221_A1.2911.00
279_E282_Y1.2881.00
149_K232_E1.2841.00
257_I364_G1.2841.00
285_M342_F1.2831.00
19_L52_E1.2761.00
436_A439_K1.2651.00
123_K127_A1.2601.00
330_I342_F1.2531.00
17_A20_D1.2521.00
293_P296_T1.2511.00
117_G120_Q1.2421.00
416_Q425_E1.2421.00
148_E236_V1.2391.00
198_E205_E1.2261.00
108_D115_A1.2241.00
284_F365_L1.2191.00
180_E184_T1.2191.00
286_G375_G1.2181.00
62_D65_S1.2161.00
416_Q424_C1.2161.00
294_A415_M1.2101.00
137_S260_F1.1981.00
200_A249_N1.1981.00
28_D186_E1.1881.00
86_F100_A1.1881.00
431_K434_E1.1851.00
294_A408_A1.1821.00
295_F359_A1.1811.00
128_R362_A1.1791.00
410_E425_E1.1741.00
280_T283_Q1.1641.00
22_I51_A1.1641.00
174_A204_H1.1631.00
438_Y445_W1.1621.00
436_A440_A1.1561.00
409_L415_M1.1471.00
285_M330_I1.1371.00
226_V230_V1.1351.00
62_D66_I1.1341.00
41_V103_I1.1311.00
62_D70_V1.1291.00
230_V234_H1.1281.00
79_L106_V1.1271.00
291_H370_T1.1271.00
295_F363_A1.1211.00
296_T346_S1.1211.00
27_I100_A1.1151.00
137_S210_Y1.1081.00
292_A329_L1.1051.00
201_R248_I1.1031.00
241_M304_N1.0931.00
82_D105_D1.0921.00
211_D216_T1.0881.00
306_Y402_L1.0860.99
194_A207_N1.0860.99
129_A132_M1.0830.99
255_S360_V1.0780.99
63_G66_I1.0700.99
289_L330_I1.0640.99
284_F360_V1.0610.99
113_A120_Q1.0600.99
433_H437_E1.0580.99
293_P404_D1.0510.99
297_A300_N1.0500.99
262_E265_E1.0490.99
305_S348_D1.0450.99
122_L213_A1.0450.99
146_L238_A1.0440.99
134_Y280_T1.0440.99
79_L104_C1.0430.99
153_G156_T1.0410.99
323_G377_A1.0360.99
145_F249_N1.0290.99
442_V446_E1.0270.99
52_E56_T1.0260.99
297_A427_F1.0240.99
18_V86_F1.0190.99
147_F239_T1.0180.99
246_G442_V1.0170.99
205_E254_H1.0160.99
131_D369_D1.0160.99
184_T233_Q1.0120.99
199_V249_N1.0120.99
30_L51_A0.9990.99
193_E209_K0.9980.99
198_E254_H0.9930.99
428_A432_R0.9930.99
154_N157_T0.9910.99
409_L428_A0.9890.99
435_Y439_K0.9880.99
184_T226_V0.9800.99
269_A276_N0.9790.99
307_K446_E0.9780.99
231_A238_A0.9720.99
87_A101_R0.9680.99
41_V221_A0.9620.99
286_G373_D0.9620.99
425_E429_E0.9540.99
303_V402_L0.9500.99
329_L346_S0.9490.99
68_G71_R0.9490.99
293_P319_I0.9480.99
412_D416_Q0.9470.99
36_D42_K0.9430.99
295_F415_M0.9360.98
412_D415_M0.9350.98
283_Q368_I0.9330.98
65_S70_V0.9330.98
255_S356_A0.9310.98
177_I236_V0.9300.98
206_I223_F0.9250.98
288_V330_I0.9240.98
296_T299_T0.9240.98
208_F223_F0.9220.98
121_V125_V0.9180.98
28_D94_N0.9170.98
188_M222_T0.9170.98
438_Y443_S0.9160.98
62_D67_E0.9140.98
17_A21_D0.9100.98
406_V435_Y0.9060.98
320_A395_I0.9030.98
66_I69_F0.9020.98
432_R436_A0.9000.98
73_Q381_D0.8980.98
18_V102_L0.8970.98
15_E19_L0.8970.98
182_I195_S0.8960.98
443_S446_E0.8900.98
366_D417_D0.8890.98
406_V431_K0.8890.98
138_I216_T0.8880.98
62_D69_F0.8870.98
19_L23_E0.8870.98
441_S445_W0.8850.98
410_E421_E0.8840.98
242_P348_D0.8830.98
403_G435_Y0.8830.98
220_I253_M0.8760.98
117_G121_V0.8750.98
242_P350_S0.8730.98
295_F300_N0.8670.98
176_D234_H0.8640.97
141_E205_E0.8630.97
410_E413_P0.8620.97
30_L48_A0.8580.97
382_I385_F0.8560.97
268_F281_A0.8560.97
424_C428_A0.8560.97
141_E198_E0.8540.97
177_I234_H0.8530.97
385_F395_I0.8510.97
140_P220_I0.8460.97
336_A339_S0.8430.97
129_A259_L0.8420.97
177_I230_V0.8420.97
427_F431_K0.8400.97
175_S179_R0.8380.97
92_R99_S0.8370.97
320_A328_A0.8370.97
84_E215_T0.8360.97
298_V424_C0.8350.97
442_V445_W0.8350.97
335_A339_S0.8320.97
25_Q88_V0.8320.97
282_Y286_G0.8310.97
116_G422_H0.8300.97
162_Q165_Y0.8300.97
154_N158_T0.8260.97
134_Y259_L0.8250.97
71_R74_E0.8230.97
89_L101_R0.8210.97
316_P345_R0.8200.97
257_I344_I0.8190.96
366_D414_V0.8190.96
54_A59_I0.8180.96
359_A419_L0.8170.96
138_I284_F0.8170.96
260_F267_V0.8160.96
406_V432_R0.8160.96
107_V113_A0.8120.96
113_A123_K0.8040.96
49_H191_E0.8010.96
62_D71_R0.8000.96
288_V342_F0.7960.96
46_I54_A0.7950.96
296_T398_L0.7920.96
298_V419_L0.7910.96
381_D385_F0.7890.96
302_T350_S0.7880.96
62_D68_G0.7860.96
180_E230_V0.7850.96
125_V129_A0.7850.96
433_H436_A0.7830.95
333_P341_R0.7820.95
403_G432_R0.7820.95
18_V83_P0.7800.95
420_G423_V0.7780.95
183_F186_E0.7780.95
292_A330_I0.7740.95
44_V166_F0.7710.95
246_G441_S0.7690.95
437_E440_A0.7690.95
413_P421_E0.7690.95
129_A134_Y0.7680.95
63_G71_R0.7660.95
107_V120_Q0.7610.95
65_S68_G0.7590.95
310_V317_V0.7560.95
144_F181_I0.7560.95
173_L232_E0.7550.94
132_M365_L0.7550.94
143_E198_E0.7540.94
183_F187_A0.7530.94
115_A420_G0.7510.94
63_G69_F0.7500.94
65_S71_R0.7490.94
259_L267_V0.7480.94
50_Q53_K0.7480.94
408_A412_D0.7470.94
301_P305_S0.7450.94
125_V418_A0.7440.94
132_M267_V0.7440.94
159_A165_Y0.7410.94
63_G70_V0.7380.94
320_A382_I0.7370.94
376_D379_R0.7360.94
153_G157_T0.7330.94
120_Q124_N0.7330.94
378_V382_I0.7320.94
115_A120_Q0.7310.93
138_I217_A0.7280.93
415_M424_C0.7260.93
67_E71_R0.7250.93
93_S176_D0.7230.93
29_F182_I0.7220.93
153_G158_T0.7220.93
135_S262_E0.7220.93
426_K429_E0.7220.93
366_D372_A0.7210.93
42_K167_D0.7210.93
237_H451_L0.7210.93
275_F323_G0.7200.93
380_E385_F0.7200.93
284_F288_V0.7150.93
291_H294_A0.7140.93
25_Q86_F0.7120.93
15_E56_T0.7080.92
105_D117_G0.7080.92
358_A419_L0.7070.92
299_T412_D0.7070.92
288_V344_I0.7060.92
259_L361_I0.7060.92
136_V257_I0.7050.92
327_S382_I0.7050.92
190_F208_F0.7030.92
270_D273_D0.7000.92
258_S341_R0.6970.92
121_V124_N0.6960.92
38_L430_A0.6930.92
182_I192_I0.6900.91
128_R131_D0.6890.91
321_W332_V0.6890.91
191_E219_N0.6890.91
447_T451_L0.6890.91
82_D85_T0.6880.91
241_M307_K0.6880.91
245_I248_I0.6880.91
199_V314_E0.6870.91
165_Y196_H0.6860.91
22_I30_L0.6860.91
326_R345_R0.6860.91
161_D165_Y0.6860.91
296_T399_P0.6860.91
438_Y441_S0.6850.91
255_S357_L0.6850.91
419_L424_C0.6840.91
325_N383_Y0.6830.91
328_A382_I0.6780.91
303_V438_Y0.6780.91
312_G315_A0.6770.91
31_R43_N0.6760.91
356_A359_A0.6720.90
257_I288_V0.6710.90
82_D123_K0.6710.90
291_H372_A0.6710.90
423_V426_K0.6680.90
192_I206_I0.6680.90
311_P317_V0.6670.90
291_H295_F0.6670.90
423_V427_F0.6660.90
438_Y449_R0.6660.90
307_K438_Y0.6630.90
178_R195_S0.6630.90
242_P305_S0.6630.90
185_L223_F0.6600.89
67_E70_V0.6580.89
143_E254_H0.6580.89
243_K250_G0.6550.89
21_D88_V0.6520.89
283_Q374_P0.6520.89
63_G67_E0.6520.89
290_E396_D0.6500.89
217_A353_P0.6420.88
51_A102_L0.6410.88
120_Q123_K0.6410.88
417_D421_E0.6400.88
298_V427_F0.6400.88
325_N381_D0.6380.88
242_P302_T0.6370.88
45_S92_R0.6360.88
64_S67_E0.6360.88
141_E256_H0.6340.88
138_I257_I0.6320.87
37_I423_V0.6320.87
143_E205_E0.6310.87
60_Y335_A0.6310.87
126_L130_D0.6300.87
55_F58_G0.6290.87
124_N128_R0.6270.87
268_F361_I0.6260.87
190_F222_T0.6250.87
327_S383_Y0.6250.87
319_I329_L0.6250.87
46_I59_I0.6240.87
142_P208_F0.6230.87
303_V443_S0.6230.87
58_G61_F0.6230.87
29_F183_F0.6220.87
124_N127_A0.6210.86
16_R19_L0.6210.86
341_R345_R0.6190.86
322_S328_A0.6180.86
377_A380_E0.6180.86
60_Y78_R0.6170.86
34_F66_I0.6170.86
112_N115_A0.6170.86
108_D114_F0.6150.86
146_L181_I0.6140.86
172_D229_A0.6140.86
149_K237_H0.6140.86
417_D420_G0.6130.86
160_H163_G0.6130.86
139_G207_N0.6120.86
294_A413_P0.6110.86
181_I226_V0.6110.86
141_E254_H0.6100.85
92_R176_D0.6090.85
369_D372_A0.6090.85
89_L188_M0.6090.85
155_A158_T0.6090.85
93_S99_S0.6080.85
292_A295_F0.6070.85
33_Q41_V0.6070.85
421_E424_C0.6030.85
65_S69_F0.6030.85
224_R228_R0.6020.85
259_L280_T0.6010.85
220_I357_L0.6000.85
430_A433_H0.6000.85
418_A423_V0.6000.85
138_I213_A0.6000.85
399_P402_L0.5990.84
181_I206_I0.5990.84
210_Y258_S0.5990.84
278_S281_A0.5960.84
32_L54_A0.5940.84
265_E338_V0.5940.84
87_A222_T0.5930.84
316_P327_S0.5930.84
29_F45_S0.5920.84
135_S212_D0.5910.84
34_F79_L0.5910.84
437_E445_W0.5900.84
135_S260_F0.5900.84
145_F248_I0.5900.84
91_W226_V0.5870.83
380_E383_Y0.5870.83
101_R188_M0.5860.83
87_A215_T0.5860.83
51_A83_P0.5860.83
420_G424_C0.5850.83
40_T228_R0.5850.83
132_M371_D0.5840.83
382_I397_T0.5840.83
273_D276_N0.5830.83
88_V100_A0.5820.83
294_A409_L0.5810.83
122_L358_A0.5810.83
129_A361_I0.5810.83
347_P351_C0.5800.83
256_H341_R0.5790.82
142_P223_F0.5780.82
287_G368_I0.5760.82
359_A415_M0.5760.82
445_W449_R0.5760.82
229_A232_E0.5740.82
210_Y213_A0.5730.82
364_G367_G0.5730.82
225_A229_A0.5730.82
300_N304_N0.5720.82
174_A236_V0.5700.81
288_V360_V0.5690.81
347_P356_A0.5690.81
153_G448_D0.5690.81
303_V446_E0.5680.81
150_D154_N0.5670.81
139_G196_H0.5660.81
295_F298_V0.5660.81
50_Q191_E0.5650.81
325_N378_V0.5640.81
304_N446_E0.5640.81
413_P416_Q0.5630.81
205_E343_E0.5620.81
193_E210_Y0.5620.81
270_D274_E0.5610.80
196_H199_V0.5600.80
361_I365_L0.5590.80
365_L369_D0.5590.80
146_L174_A0.5590.80
425_E428_A0.5580.80
64_S69_F0.5560.80
22_I27_I0.5560.80
34_F106_V0.5560.80
310_V313_Y0.5560.80
159_A162_Q0.5560.80
83_P102_L0.5550.80
90_P188_M0.5550.80
442_V447_T0.5520.79
99_S179_R0.5500.79
409_L412_D0.5500.79
290_E294_A0.5480.79
385_F393_Y0.5480.79
403_G410_E0.5470.79
254_H343_E0.5460.79
298_V355_L0.5450.78
379_R385_F0.5450.78
147_F244_P0.5440.78
437_E441_S0.5430.78
250_G308_R0.5430.78
159_A163_G0.5430.78
275_F282_Y0.5430.78
140_P253_M0.5430.78
185_L192_I0.5420.78
193_E207_N0.5420.78
190_F220_I0.5420.78
15_E83_P0.5420.78
323_G379_R0.5410.78
31_R225_A0.5390.78
198_E256_H0.5370.77
292_A346_S0.5370.77
31_R45_S0.5360.77
103_I222_T0.5360.77
139_G210_Y0.5360.77
54_A57_E0.5350.77
412_D424_C0.5350.77
415_M419_L0.5340.77
128_R132_M0.5340.77
146_L236_V0.5340.77
72_I75_S0.5340.77
297_A305_S0.5330.77
292_A319_I0.5330.77
299_T344_I0.5330.77
378_V385_F0.5330.77
29_F92_R0.5330.77
165_Y199_V0.5330.77
402_L406_V0.5320.77
251_S349_P0.5320.77
307_K443_S0.5320.77
190_F223_F0.5310.77
221_A351_C0.5300.77
413_P425_E0.5300.77
270_D282_Y0.5290.76
33_Q222_T0.5270.76
438_Y442_V0.5270.76
43_N168_L0.5270.76
270_D279_E0.5260.76
65_S199_V0.5260.76
296_T405_A0.5260.76
365_L368_I0.5250.76
72_I314_E0.5240.76
270_D276_N0.5230.76
422_H425_E0.5220.75
275_F377_A0.5220.75
141_E326_R0.5220.75
122_L214_L0.5210.75
318_Y394_G0.5210.75
139_G258_S0.5210.75
203_Q251_S0.5210.75
326_R343_E0.5200.75
303_V435_Y0.5180.75
260_F263_D0.5180.75
315_A383_Y0.5170.75
179_R183_F0.5170.75
148_E160_H0.5170.75
145_F243_K0.5140.74
199_V313_Y0.5140.74
66_I70_V0.5140.74
21_D86_F0.5130.74
406_V410_E0.5120.74
139_G244_P0.5110.74
136_V284_F0.5110.74
362_A415_M0.5110.74
296_T319_I0.5110.74
50_Q193_E0.5080.74
94_N183_F0.5080.74
401_H435_Y0.5080.74
287_G367_G0.5070.73
409_L419_L0.5070.73
28_D187_A0.5060.73
193_E258_S0.5050.73
319_I396_D0.5040.73
81_P102_L0.5020.73
138_I255_S0.5020.73
291_H414_V0.5010.73
160_H165_Y0.5010.73
370_T373_D0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lniA 5 0.9736 100 0.094 Contact Map
4acfA 5 0.9581 100 0.116 Contact Map
4s17A 5 0.9163 100 0.117 Contact Map
1f52A 5 0.9537 100 0.125 Contact Map
3ng0A 5 0.9427 100 0.129 Contact Map
4hppA 3 0.9009 100 0.138 Contact Map
2j9iA 5 0.9053 100 0.18 Contact Map
3o6xA 3 0.8414 100 0.336 Contact Map
3fkyA 8 0.7115 100 0.35 Contact Map
2ojwA 5 0.7599 100 0.361 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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