GREMLIN Database
Q9HNI1 - Transcription regulator
UniProt: Q9HNI1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (140)
Sequences: 13641 (8898)
Seq/√Len: 752.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_E52_Y2.9131.00
13_E28_D2.8941.00
72_K130_E2.5841.00
100_D132_S2.5101.00
93_S106_I2.4841.00
22_L40_L2.2641.00
110_T114_D2.2461.00
59_E113_D2.1101.00
50_N57_D2.0431.00
7_D39_H2.0251.00
13_E20_A2.0081.00
42_T46_E1.9731.00
88_H121_E1.9321.00
74_D129_N1.8491.00
66_T106_I1.7901.00
68_I95_Y1.7881.00
6_L31_V1.7701.00
50_N55_V1.7551.00
92_V108_K1.7441.00
88_H118_L1.6761.00
31_V35_T1.6651.00
13_E16_G1.6621.00
41_Q45_D1.6261.00
70_Q134_S1.6251.00
23_R27_D1.6171.00
111_D114_D1.5671.00
20_A28_D1.5281.00
84_T125_D1.5251.00
114_D117_T1.5021.00
24_S27_D1.4781.00
23_R33_V1.4611.00
139_A142_E1.4591.00
84_T87_G1.4431.00
31_V36_V1.4411.00
90_Q114_D1.4371.00
32_S35_T1.4201.00
81_I85_L1.4151.00
10_L25_L1.4141.00
22_L37_S1.3981.00
71_L105_A1.3811.00
82_T86_R1.3621.00
72_K100_D1.3501.00
29_L36_V1.3281.00
19_R52_Y1.3271.00
70_Q101_Y1.3121.00
77_A80_E1.3081.00
69_L107_G1.3071.00
20_A25_L1.2891.00
65_V112_T1.2761.00
79_P83_G1.2681.00
5_N9_K1.2681.00
117_T120_K1.2491.00
63_Y110_T1.2471.00
14_L40_L1.2381.00
24_S28_D1.2381.00
73_V81_I1.2261.00
72_K129_N1.2091.00
82_T138_N1.2031.00
90_Q121_E1.2011.00
116_N138_N1.1881.00
6_L9_K1.1831.00
41_Q44_E1.1651.00
21_S24_S1.1491.00
16_G28_D1.1401.00
4_E39_H1.1231.00
17_D28_D1.1211.00
13_E25_L1.1061.00
66_T108_K1.0981.00
70_Q132_S1.0851.00
6_L29_L1.0581.00
51_G55_V1.0551.00
9_K12_N1.0541.00
22_L26_A1.0451.00
9_K13_E1.0431.00
91_M107_G1.0301.00
109_F114_D1.0011.00
80_E84_T0.9891.00
20_A24_S0.9791.00
12_N16_G0.9771.00
82_T103_V0.9761.00
94_V105_A0.9761.00
33_V37_S0.9751.00
26_A36_V0.9681.00
57_D60_R0.9561.00
97_I104_L0.9561.00
83_G86_R0.9531.00
68_I104_L0.9501.00
18_G52_Y0.9431.00
37_S41_Q0.9431.00
109_F115_M0.9311.00
19_R44_E0.9291.00
107_G118_L0.9221.00
9_K29_L0.9221.00
68_I106_I0.9171.00
109_F118_L0.9141.00
58_Y108_K0.9141.00
83_G87_G0.9121.00
22_L33_V0.9041.00
95_Y106_I0.9031.00
3_Y8_V0.8931.00
100_D130_E0.8681.00
23_R37_S0.8571.00
95_Y139_A0.8561.00
64_D111_D0.8551.00
43_L48_A0.8461.00
26_A31_V0.8411.00
68_I136_V0.8391.00
95_Y136_V0.8361.00
91_M94_V0.8221.00
18_G24_S0.8151.00
74_D77_A0.7961.00
91_M105_A0.7941.00
7_D42_T0.7921.00
84_T88_H0.7871.00
117_T121_E0.7841.00
4_E7_D0.7831.00
85_L94_V0.7731.00
34_T38_N0.7601.00
119_I133_T0.7601.00
25_L36_V0.7571.00
70_Q104_L0.7531.00
25_L40_L0.7521.00
8_V12_N0.7511.00
79_P82_T0.7491.00
18_G54_P0.7491.00
10_L36_V0.7471.00
98_T135_V0.7431.00
101_Y132_S0.7341.00
78_L103_V0.7311.00
80_E83_G0.7311.00
71_L81_I0.7301.00
3_Y48_A0.7231.00
72_K101_Y0.7121.00
10_L39_H0.7111.00
123_L131_S0.7091.00
10_L20_A0.7091.00
112_T135_V0.7071.00
63_Y90_Q0.6931.00
17_D20_A0.6921.00
69_L105_A0.6921.00
67_A115_M0.6881.00
82_T140_A0.6851.00
48_A60_R0.6851.00
74_D127_D0.6831.00
113_D116_N0.6791.00
63_Y108_K0.6741.00
11_V43_L0.6741.00
70_Q100_D0.6691.00
38_N42_T0.6681.00
90_Q118_L0.6651.00
5_N8_V0.6581.00
10_L13_E0.6521.00
13_E17_D0.6441.00
66_T136_V0.6431.00
69_L131_S0.6411.00
85_L105_A0.6371.00
90_Q110_T0.6361.00
96_E103_V0.6321.00
119_I131_S0.6301.00
80_E127_D0.6271.00
88_H125_D0.6261.00
81_I103_V0.6241.00
97_I101_Y0.6231.00
38_N41_Q0.6211.00
113_D117_T0.6201.00
26_A33_V0.6181.00
93_S142_E0.6171.00
7_D43_L0.6111.00
10_L40_L0.6081.00
39_H43_L0.6061.00
34_T37_S0.6021.00
67_A135_V0.5951.00
18_G51_G0.5941.00
22_L36_V0.5941.00
47_G50_N0.5921.00
10_L43_L0.5871.00
49_V52_Y0.5861.00
77_A126_A0.5831.00
66_T139_A0.5801.00
71_L128_I0.5791.00
79_P124_A0.5781.00
57_D61_L0.5761.00
114_D118_L0.5731.00
66_T95_Y0.5731.00
80_E126_A0.5711.00
56_V61_L0.5681.00
84_T126_A0.5631.00
67_A133_T0.5561.00
71_L131_S0.5541.00
112_T137_L0.5521.00
78_L123_L0.5521.00
97_I136_V0.5491.00
121_E125_D0.5461.00
23_R26_A0.5461.00
15_L53_T0.5451.00
72_K132_S0.5421.00
6_L35_T0.5361.00
55_V58_Y0.5311.00
96_E137_L0.5221.00
42_T45_D0.5171.00
17_D24_S0.5171.00
70_Q97_I0.5161.00
119_I137_L0.5141.00
96_E123_L0.5131.00
118_L122_L0.5091.00
97_I134_S0.5081.00
94_V140_A0.5071.00
100_D134_S0.5071.00
98_T137_L0.5071.00
7_D46_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9545 100 0.123 Contact Map
4un1A 1 0.9221 100 0.17 Contact Map
4un1B 1 0.9675 100 0.173 Contact Map
2e1cA 1 0.9545 100 0.186 Contact Map
2p5vA 5 0.987 100 0.202 Contact Map
4pcqA 2 0.9416 100 0.208 Contact Map
2ia0A 2 0.961 100 0.225 Contact Map
3i4pA 5 0.9675 100 0.235 Contact Map
2cg4A 6 0.9545 100 0.238 Contact Map
2pn6A 5 0.9545 100 0.239 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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