GREMLIN Database
Q9HNH9 - Uncharacterized protein
UniProt: Q9HNH9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 401 (368)
Sequences: 2016 (1657)
Seq/√Len: 86.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_I382_L6.7491.00
109_I129_G5.4961.00
327_N370_S4.8641.00
334_V362_V3.8461.00
109_I126_V3.4931.00
31_I67_V3.1791.00
105_S132_A3.1751.00
107_W389_L3.1711.00
245_A249_R3.1561.00
138_A149_A3.1041.00
84_A233_F3.0651.00
379_Y384_W3.0381.00
143_T234_H3.0061.00
102_V133_L2.8981.00
337_A344_L2.8641.00
147_L231_A2.8111.00
119_L332_T2.8051.00
77_L232_L2.7171.00
350_V358_I2.7131.00
143_T231_A2.6711.00
138_A227_L2.6671.00
372_L376_Y2.5861.00
326_S330_L2.4951.00
194_G197_A2.4531.00
142_E145_D2.4411.00
141_W149_A2.4031.00
81_T233_F2.3961.00
141_W145_D2.3761.00
84_A230_M2.3351.00
320_V327_N2.3081.00
316_G319_A2.2861.00
144_R148_L2.2161.00
138_A141_W2.1511.00
143_T235_T2.1461.00
254_G299_G2.1361.00
83_V101_H2.1351.00
62_A66_L2.1331.00
251_V299_G2.1221.00
256_T260_A2.1201.00
320_V367_I2.1161.00
251_V300_A2.1021.00
251_V296_A2.0641.00
336_T342_H1.9921.00
111_F382_L1.9851.00
319_A371_V1.9541.00
231_A235_T1.8111.00
326_S369_L1.8111.00
19_A301_V1.8081.00
244_R248_R1.7871.00
150_G228_Y1.7841.00
250_L299_G1.7801.00
145_D148_L1.7621.00
29_L335_A1.7381.00
27_G71_F1.7341.00
70_K262_T1.7121.00
114_V119_L1.7031.00
115_H332_T1.6991.00
74_V298_L1.6961.00
384_W388_A1.6901.00
26_L363_W1.6881.00
73_T290_S1.5811.00
148_L152_A1.5791.00
354_A357_G1.5761.00
18_D21_R1.5701.00
323_T373_W1.5611.00
102_V106_L1.5281.00
322_R374_V1.5081.00
323_T374_V1.4950.99
150_G231_A1.4910.99
258_G296_A1.4890.99
20_L301_V1.4880.99
89_N92_R1.4780.99
102_V136_V1.4750.99
17_L81_T1.4510.99
330_L369_L1.4500.99
70_K293_L1.4450.99
378_Q384_W1.4400.99
327_N366_Q1.4340.99
19_A318_A1.4280.99
24_A27_G1.4250.99
83_V135_V1.4190.99
372_L375_R1.4040.99
357_G361_A1.4010.99
323_T369_L1.3870.99
370_S374_V1.3850.99
56_N351_S1.3780.99
54_G58_W1.3760.99
373_W377_F1.3760.99
105_S133_L1.3720.99
379_Y388_A1.3690.99
111_F325_F1.3490.99
105_S129_G1.3290.99
149_A227_L1.3280.99
101_H105_S1.3150.99
30_V359_V1.3120.99
300_A304_V1.3000.99
296_A299_G1.3000.99
73_T294_A1.2960.99
254_G296_A1.2820.98
83_V139_R1.2760.98
107_W386_W1.2750.98
114_V118_V1.2740.98
154_L224_G1.2560.98
237_V246_F1.2560.98
73_T225_L1.2490.98
365_G369_L1.2490.98
124_I128_Y1.2470.98
255_G296_A1.2370.98
84_A234_H1.2290.98
351_S354_A1.2230.98
23_V301_V1.2220.98
261_V289_G1.2200.98
260_A264_A1.2200.98
331_Q366_Q1.2150.98
85_M89_N1.2100.98
145_D149_A1.2090.98
140_N144_R1.2080.98
133_L137_A1.1990.98
87_V97_A1.1980.98
15_I318_A1.1980.98
25_L324_A1.1940.98
371_V375_R1.1920.97
135_V230_M1.1860.97
107_W111_F1.1780.97
240_N243_S1.1700.97
84_A88_R1.1670.97
231_A234_H1.1630.97
193_G197_A1.1600.97
236_G239_T1.1580.97
256_T296_A1.1550.97
337_A342_H1.1520.97
16_G302_M1.1450.97
368_A372_L1.1400.97
56_N353_V1.1380.97
201_H205_S1.1370.97
335_A362_V1.1300.97
33_V355_A1.1280.96
82_G85_M1.1260.96
367_I371_V1.1170.96
272_A275_A1.1070.96
163_L167_V1.1050.96
334_V338_I1.1030.96
370_S373_W1.0950.96
258_G293_L1.0930.96
106_L133_L1.0920.96
103_R107_W1.0910.96
316_G371_V1.0890.96
81_T236_G1.0880.96
387_R391_Y1.0870.96
151_T155_A1.0850.96
374_V377_F1.0710.95
28_I332_T1.0690.95
31_I68_K1.0670.95
338_I346_L1.0670.95
131_T223_A1.0630.95
120_W332_T1.0610.95
249_R253_V1.0530.95
19_A305_A1.0510.95
64_H68_K1.0490.95
87_V139_R1.0420.95
74_V294_A1.0390.94
82_G391_Y1.0350.94
244_R306_K1.0340.94
253_V256_T1.0330.94
155_A159_L1.0290.94
81_T232_L1.0210.94
379_Y387_R1.0180.94
13_R18_D1.0140.94
147_L151_T1.0120.94
26_L320_V1.0080.93
83_V226_M1.0070.93
134_F137_A1.0030.93
325_F382_L0.9920.93
195_W199_L0.9910.93
86_F100_L0.9900.93
111_F386_W0.9860.93
17_L322_R0.9780.92
19_A317_L0.9780.92
119_L123_D0.9760.92
111_F125_L0.9710.92
14_I239_T0.9700.92
70_K128_Y0.9640.92
72_I290_S0.9630.92
181_D184_L0.9620.92
149_A152_A0.9590.92
247_Y299_G0.9570.92
77_L225_L0.9570.92
262_T289_G0.9530.91
106_L110_A0.9520.91
324_A327_N0.9500.91
142_E148_L0.9440.91
81_T238_T0.9430.91
299_G303_L0.9410.91
202_R342_H0.9410.91
125_L325_F0.9410.91
247_Y303_L0.9400.91
179_P182_G0.9400.91
341_G345_G0.9390.91
59_A353_V0.9380.91
97_A101_H0.9370.91
252_A256_T0.9340.91
250_L254_G0.9290.90
122_G332_T0.9280.90
33_V335_A0.9280.90
29_L324_A0.9230.90
59_A356_L0.9200.90
195_W342_H0.9180.90
198_Q340_Y0.9140.90
236_G240_N0.9130.90
131_T226_M0.9130.90
221_R224_G0.9120.90
131_T219_G0.9120.90
111_F389_L0.9090.89
98_V139_R0.9070.89
147_L150_G0.9050.89
148_L151_T0.9010.89
84_A87_V0.9010.89
72_I76_T0.9000.89
28_I72_I0.9000.89
198_Q342_H0.8980.89
33_V358_I0.8960.89
199_L203_V0.8920.88
150_G224_G0.8920.88
247_Y251_V0.8900.88
29_L362_V0.8890.88
146_L234_H0.8880.88
338_I344_L0.8880.88
372_L377_F0.8830.88
63_G67_V0.8800.88
20_L293_L0.8770.88
103_R387_R0.8640.87
102_V137_A0.8630.87
296_A300_A0.8590.87
183_A186_A0.8580.86
32_N82_G0.8570.86
368_A371_V0.8530.86
243_S246_F0.8500.86
377_F384_W0.8460.86
197_A201_H0.8430.85
86_F97_A0.8410.85
149_A153_L0.8390.85
18_D22_G0.8390.85
117_Y203_V0.8380.85
115_H120_W0.8330.85
363_W367_I0.8310.85
158_T288_W0.8280.84
115_H119_L0.8250.84
83_V87_V0.8230.84
36_F39_P0.8220.84
292_P296_A0.8200.84
32_N37_S0.8180.84
346_L350_V0.8160.84
54_G57_Y0.8120.83
336_T343_G0.8120.83
47_T50_G0.8110.83
32_N120_W0.8100.83
294_A298_L0.8090.83
115_H123_D0.8090.83
97_A129_G0.8080.83
70_K289_G0.8080.83
334_V366_Q0.8070.83
105_S109_I0.8050.83
89_N93_D0.8050.83
310_T314_T0.8040.83
258_G262_T0.7990.82
13_R21_R0.7970.82
12_D391_Y0.7960.82
82_G286_N0.7930.82
312_V316_G0.7890.82
330_L366_Q0.7830.81
198_Q202_R0.7820.81
324_A374_V0.7820.81
246_F254_G0.7810.81
230_M233_F0.7810.81
75_F78_L0.7790.81
27_G32_N0.7790.81
197_A200_A0.7760.80
22_G26_L0.7740.80
257_V292_P0.7730.80
33_V37_S0.7710.80
70_K101_H0.7700.80
209_R212_T0.7690.80
150_G333_V0.7660.80
120_W123_D0.7650.79
100_L390_T0.7630.79
153_L223_A0.7630.79
111_F126_V0.7600.79
66_L297_Y0.7600.79
32_N128_Y0.7600.79
58_W62_A0.7600.79
37_S339_F0.7590.79
253_V257_V0.7590.79
82_G100_L0.7590.79
32_N35_A0.7580.79
36_F339_F0.7550.79
326_S382_L0.7510.78
82_G230_M0.7500.78
136_V139_R0.7490.78
55_M353_V0.7440.78
10_P263_A0.7400.77
244_R303_L0.7400.77
61_L266_V0.7400.77
206_A210_Q0.7400.77
23_V317_L0.7390.77
14_I302_M0.7390.77
232_L237_V0.7350.77
14_I17_L0.7350.77
115_H329_I0.7340.77
220_W224_G0.7310.76
78_L81_T0.7300.76
72_I221_R0.7290.76
111_F329_I0.7280.76
196_S200_A0.7270.76
378_Q388_A0.7260.76
120_W324_A0.7250.76
29_L33_V0.7230.76
389_L392_R0.7200.75
86_F139_R0.7190.75
30_V67_V0.7190.75
258_G289_G0.7180.75
17_L82_G0.7170.75
79_F132_A0.7150.75
16_G20_L0.7150.75
255_G297_Y0.7110.74
323_T326_S0.7100.74
146_L231_A0.7090.74
248_R252_A0.7090.74
225_L261_V0.7070.74
33_V362_V0.7050.74
78_L128_Y0.7040.74
265_G285_F0.7040.74
85_M373_W0.7020.73
25_L320_V0.7010.73
125_L329_I0.7010.73
103_R391_Y0.7010.73
13_R17_L0.7000.73
323_T366_Q0.6990.73
311_G314_T0.6990.73
203_V207_L0.6980.73
135_V226_M0.6970.73
36_F120_W0.6970.73
245_A248_R0.6970.73
32_N36_F0.6950.73
55_M59_A0.6930.72
90_R100_L0.6930.72
180_A183_A0.6930.72
324_A370_S0.6910.72
108_L125_L0.6870.72
54_G298_L0.6850.72
188_I191_Y0.6850.72
22_G366_Q0.6840.71
380_G383_E0.6830.71
82_G262_T0.6830.71
108_L377_F0.6810.71
303_L306_K0.6790.71
336_T340_Y0.6790.71
19_A310_T0.6780.71
362_V366_Q0.6750.70
81_T363_W0.6740.70
262_T266_V0.6740.70
88_R92_R0.6730.70
350_V355_A0.6730.70
117_Y206_A0.6720.70
369_L373_W0.6710.70
82_G86_F0.6700.70
105_S136_V0.6690.70
182_G241_D0.6680.70
323_T370_S0.6660.69
135_V223_A0.6620.69
166_L170_P0.6610.69
129_G230_M0.6590.69
202_R206_A0.6580.69
253_V361_A0.6560.68
24_A108_L0.6560.68
91_E94_G0.6530.68
355_A359_V0.6520.68
187_Q190_A0.6510.68
100_L391_Y0.6510.68
56_N322_R0.6480.67
72_I222_T0.6480.67
25_L75_F0.6470.67
202_R336_T0.6460.67
105_S366_Q0.6440.67
119_L336_T0.6420.67
192_R195_W0.6410.66
293_L296_A0.6410.66
47_T51_D0.6400.66
333_V382_L0.6390.66
130_V134_F0.6380.66
75_F104_R0.6370.66
387_R390_T0.6370.66
160_L345_G0.6370.66
155_A300_A0.6360.66
324_A386_W0.6360.66
71_F297_Y0.6350.66
28_I75_F0.6350.66
79_F331_Q0.6350.66
297_Y301_V0.6340.66
29_L359_V0.6330.66
89_N120_W0.6320.65
21_R104_R0.6260.65
116_A206_A0.6250.65
20_L23_V0.6250.65
69_Q73_T0.6250.65
311_G315_R0.6210.64
72_I121_Y0.6190.64
162_L166_L0.6190.64
135_V139_R0.6170.64
105_S386_W0.6160.63
26_L291_V0.6160.63
38_M42_V0.6140.63
167_V171_G0.6140.63
204_D211_T0.6110.63
189_E193_G0.6110.63
20_L86_F0.6110.63
252_A255_G0.6090.63
18_D24_A0.6080.62
166_L169_D0.6060.62
32_N359_V0.6040.62
246_F250_L0.6040.62
386_W389_L0.6030.62
20_L298_L0.6030.62
180_A185_Q0.6020.62
131_T222_T0.6010.62
27_G323_T0.6010.62
103_R392_R0.6000.61
32_N103_R0.5990.61
154_L158_T0.5980.61
325_F386_W0.5970.61
187_Q191_Y0.5960.61
70_K73_T0.5960.61
71_F290_S0.5950.61
53_T56_N0.5920.60
83_V230_M0.5920.60
206_A209_R0.5910.60
221_R225_L0.5910.60
243_S254_G0.5900.60
359_V363_W0.5870.60
37_S355_A0.5870.60
120_W336_T0.5870.60
222_T225_L0.5850.59
343_G346_L0.5840.59
361_A368_A0.5820.59
108_L386_W0.5800.59
82_G387_R0.5790.59
251_V303_L0.5780.59
179_P183_A0.5780.59
122_G387_R0.5770.58
32_N122_G0.5770.58
326_S352_R0.5750.58
340_Y343_G0.5720.58
164_S281_L0.5720.58
79_F128_Y0.5710.58
75_F332_T0.5710.58
161_T367_I0.5700.58
119_L196_S0.5700.58
143_T146_L0.5690.57
214_Y220_W0.5680.57
37_S350_V0.5660.57
386_W390_T0.5650.57
293_L297_Y0.5620.56
323_T330_L0.5600.56
72_I291_V0.5590.56
72_I79_F0.5570.56
388_A392_R0.5570.56
155_A252_A0.5570.56
204_D207_L0.5570.56
155_A372_L0.5560.56
69_Q72_I0.5550.56
16_G294_A0.5550.56
79_F115_H0.5540.55
195_W198_Q0.5540.55
81_T298_L0.5540.55
26_L366_Q0.5530.55
83_V136_V0.5530.55
28_I115_H0.5530.55
24_A373_W0.5520.55
139_R230_M0.5500.55
72_I115_H0.5480.55
115_H387_R0.5470.54
72_I331_Q0.5470.54
115_H122_G0.5460.54
182_G185_Q0.5430.54
168_A255_G0.5430.54
96_P130_V0.5430.54
127_A213_G0.5430.54
34_R68_K0.5420.54
312_V315_R0.5400.54
110_A304_V0.5390.53
331_Q383_E0.5390.53
159_L183_A0.5390.53
252_A364_V0.5390.53
72_I297_Y0.5390.53
67_V293_L0.5380.53
101_H139_R0.5380.53
72_I233_F0.5380.53
82_G120_W0.5370.53
144_R346_L0.5370.53
385_L392_R0.5360.53
102_V105_S0.5360.53
219_G287_Y0.5360.53
28_I359_V0.5360.53
366_Q374_V0.5330.53
109_I133_L0.5330.53
12_D89_N0.5320.52
110_A142_E0.5300.52
90_R97_A0.5300.52
91_E365_G0.5290.52
83_V105_S0.5290.52
138_A384_W0.5280.52
196_S312_V0.5280.52
25_L29_L0.5250.51
258_G341_G0.5250.51
119_L122_G0.5240.51
258_G291_V0.5230.51
74_V136_V0.5230.51
130_V137_A0.5220.51
331_Q340_Y0.5220.51
31_I290_S0.5200.51
291_V304_V0.5200.51
300_A308_W0.5190.51
350_V354_A0.5180.51
23_V185_Q0.5140.50
248_R303_L0.5130.50
191_Y340_Y0.5130.50
225_L294_A0.5120.50
268_Y333_V0.5120.50
254_G260_A0.5100.49
149_A260_A0.5100.49
53_T182_G0.5090.49
86_F90_R0.5080.49
60_W352_R0.5080.49
59_A351_S0.5080.49
114_V142_E0.5080.49
295_G298_L0.5060.49
108_L329_I0.5060.49
86_F390_T0.5060.49
186_A189_E0.5060.49
24_A324_A0.5050.49
47_T52_F0.5050.49
114_V192_R0.5050.49
49_Y52_F0.5040.49
221_R324_A0.5040.49
214_Y326_S0.5030.49
127_A237_V0.5020.48
215_I292_P0.5020.48
28_I290_S0.5010.48
296_A303_L0.5010.48
155_A158_T0.5010.48
187_Q201_H0.5010.48
77_L82_G0.5000.48
219_G225_L0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q16C 2 0.4414 3.2 0.978 Contact Map
3rkoA 1 0.2219 2.9 0.978 Contact Map
2o5gB 1 0.0474 2.8 0.979 Contact Map
2k1aA 1 0.1047 2.4 0.979 Contact Map
4qndA 2 0.2319 2.1 0.98 Contact Map
4cadC 1 0.3416 2 0.98 Contact Map
2lomA 1 0.2269 1.8 0.981 Contact Map
4p02A 1 0.3242 1.7 0.981 Contact Map
2l2tA 2 0.1097 1.6 0.981 Contact Map
3rlbA 1 0.4339 1.6 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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