GREMLIN Database
Q9HNH6 - Threonine dehydratase
UniProt: Q9HNH6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 495 (395)
Sequences: 2924 (1655)
Seq/√Len: 83.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
257_V274_L5.2151.00
215_H218_E5.0971.00
148_S151_Q4.3711.00
267_I333_V4.1731.00
121_D382_T3.8871.00
295_A299_D3.7641.00
305_A320_Q3.4201.00
143_R233_D3.2391.00
278_L281_V3.1881.00
271_A332_H3.1101.00
218_E222_A3.0971.00
146_T235_Y3.0521.00
247_I384_V3.0421.00
105_H250_D3.0121.00
289_E340_S2.9461.00
172_A179_S2.8281.00
178_D201_E2.6571.00
180_K201_E2.6281.00
105_H249_A2.5281.00
98_R142_N2.5111.00
292_S338_T2.5061.00
324_Q327_P2.4771.00
294_V321_V2.4601.00
110_Y121_D2.4251.00
232_D323_A2.4101.00
182_V219_L2.3931.00
149_A152_Q2.3301.00
259_V270_V2.2591.00
475_T479_D2.2221.00
293_T297_S2.2061.00
288_A316_I2.1991.00
320_Q323_A2.1811.00
173_S179_S2.1621.00
149_A153_D2.1281.00
275_K334_D2.0971.00
298_L336_V2.0761.00
316_I362_A2.0691.00
108_L251_C2.0591.00
267_I329_I2.0331.00
180_K225_R2.0011.00
123_R382_T1.9831.00
292_S296_R1.9761.00
296_R299_D1.9471.00
294_V336_V1.9411.00
343_E372_E1.9401.00
300_K304_Q1.9331.00
261_I294_V1.9061.00
244_G270_V1.8551.00
254_V384_V1.8501.00
282_R335_E1.8491.00
294_V329_I1.8471.00
258_V373_D1.8461.00
329_I333_V1.8071.00
261_I336_V1.7961.00
213_Q217_H1.7851.00
270_V386_A1.7851.00
122_V370_V1.7701.00
431_T480_E1.7631.00
90_S93_R1.7531.00
295_A338_T1.7281.00
245_L273_A1.7281.00
215_H219_L1.7211.00
152_Q177_V1.6971.00
260_P388_C1.6881.00
219_L223_E1.6741.00
234_E324_Q1.6711.00
151_Q226_T1.6691.00
110_Y123_R1.6591.00
316_I365_T1.6531.00
209_Y213_Q1.6431.00
366_A385_P1.6381.00
244_G274_L1.6381.00
217_H220_E1.6341.00
471_D475_T1.6271.00
178_D225_R1.6211.00
359_V387_L1.6111.00
159_A209_Y1.5981.00
301_G330_Q1.5831.00
253_T382_T1.5831.00
208_D211_D1.5831.00
313_A344_I1.5611.00
237_M328_V1.5541.00
102_T141_T1.5491.00
247_I254_V1.5481.00
107_P129_F1.5461.00
328_V332_H1.5441.00
296_R304_Q1.5070.99
284_I335_E1.5070.99
255_D381_E1.4970.99
340_S343_E1.4870.99
414_I474_L1.4730.99
119_G379_D1.4410.99
428_L458_V1.4320.99
439_I442_I1.4240.99
251_C254_V1.4210.99
348_L362_A1.3950.99
258_V370_V1.3920.99
148_S152_Q1.3770.99
244_G247_I1.3720.99
229_H233_D1.3620.99
292_S295_A1.3570.99
296_R300_K1.3470.99
348_L392_I1.3350.99
219_L225_R1.3260.99
438_N442_I1.3200.99
256_T381_E1.3120.98
201_E223_E1.3110.98
168_V181_V1.3100.98
120_A381_E1.2930.98
205_H215_H1.2890.98
285_G294_V1.2860.98
297_S303_P1.2850.98
157_V225_R1.2830.98
295_A336_V1.2790.98
254_V281_V1.2780.98
91_D94_D1.2780.98
426_N430_A1.2620.98
151_Q154_A1.2580.98
114_F367_L1.2490.98
421_S427_D1.2460.98
150_D154_A1.2430.98
97_E100_S1.2430.98
352_L358_L1.2420.98
289_E338_T1.2400.98
290_G310_D1.2290.98
302_Q326_F1.2260.98
183_M204_L1.2260.98
261_I267_I1.2240.98
303_P320_Q1.2180.98
267_I283_V1.2090.97
326_F330_Q1.2030.97
173_S200_A1.1990.97
297_S321_V1.1970.97
432_A460_L1.1750.97
427_D480_E1.1740.97
450_D456_T1.1730.97
144_I175_S1.1720.97
144_I177_V1.1710.97
259_V283_V1.1660.97
303_P323_A1.1650.97
89_L93_R1.1630.97
144_I168_V1.1540.97
142_N146_T1.1530.97
313_A362_A1.1530.97
424_S427_D1.1510.97
187_A314_D1.1480.96
255_D380_G1.1470.96
123_R251_C1.1450.96
182_V205_H1.1430.96
98_R145_R1.1400.96
257_V270_V1.1350.96
439_I443_Q1.1340.96
440_Y445_D1.1320.96
288_A291_A1.1290.96
255_D382_T1.1280.96
92_I273_A1.1250.96
327_P331_E1.1200.96
207_A211_D1.1200.96
143_R228_V1.1200.96
327_P330_Q1.1190.96
335_E376_E1.1090.96
150_D153_D1.1080.96
474_L478_Q1.1040.96
185_E207_A1.1030.96
147_L151_Q1.1030.96
173_S198_Y1.1020.96
256_T282_R1.0990.95
178_D223_E1.0940.95
143_R229_H1.0930.95
478_Q484_V1.0910.95
108_L384_V1.0900.95
180_K203_V1.0860.95
255_D383_I1.0860.95
293_T321_V1.0850.95
417_V483_D1.0820.95
122_V374_K1.0740.95
272_T328_V1.0720.95
168_V177_V1.0710.95
439_I446_R1.0690.95
114_F124_P1.0680.95
442_I446_R1.0620.95
158_T181_V1.0610.94
344_I365_T1.0590.94
346_T404_G1.0580.94
154_A224_G1.0580.94
243_L266_L1.0540.94
243_L270_V1.0510.94
392_I400_V1.0500.94
468_E471_D1.0500.94
274_L281_V1.0480.94
323_A327_P1.0460.94
248_A278_L1.0460.94
99_V141_T1.0380.94
248_A274_L1.0340.94
437_A473_L1.0330.94
438_N441_A1.0330.94
441_A445_D1.0190.93
351_L359_V1.0170.93
287_Q321_V1.0160.93
216_A227_Y1.0140.93
370_V374_K1.0090.93
442_I445_D1.0090.93
124_P385_P1.0010.93
213_Q229_H0.9970.92
193_K196_K0.9930.92
237_M324_Q0.9900.92
284_I337_V0.9850.92
306_V309_V0.9850.92
348_L400_V0.9820.92
271_A283_V0.9810.92
290_G341_D0.9790.92
270_V274_L0.9780.92
437_A440_Y0.9770.92
430_A434_E0.9750.92
120_A383_I0.9740.92
256_T284_I0.9730.91
96_R249_A0.9660.91
247_I257_V0.9650.91
437_A441_A0.9630.91
467_P471_D0.9590.91
238_A241_G0.9530.91
287_Q295_A0.9520.91
180_K219_L0.9510.91
183_M195_T0.9510.91
259_V267_I0.9460.90
288_A344_I0.9430.90
313_A316_I0.9370.90
158_T227_Y0.9360.90
268_S328_V0.9300.90
290_G309_V0.9290.90
437_A442_I0.9270.89
367_L370_V0.9210.89
124_P387_L0.9200.89
93_R277_E0.9200.89
213_Q227_Y0.9170.89
260_P366_A0.9170.89
267_I285_G0.9150.89
154_A226_T0.9150.89
203_V215_H0.9130.89
432_A437_A0.9130.89
478_Q483_D0.9110.89
121_D380_G0.9060.88
350_L371_L0.9020.88
464_T470_V0.9020.88
157_V220_E0.9000.88
147_L226_T0.8980.88
438_N443_Q0.8960.88
440_Y443_Q0.8960.88
424_S428_L0.8940.88
258_V337_V0.8940.88
441_A446_R0.8870.87
261_I285_G0.8860.87
118_T122_V0.8830.87
429_L458_V0.8790.87
104_R130_Q0.8760.87
439_I445_D0.8750.86
351_L387_L0.8670.86
189_I193_K0.8630.86
335_E373_D0.8600.86
475_T478_Q0.8590.85
397_L414_I0.8590.85
143_R151_Q0.8430.84
291_A306_V0.8410.84
305_A319_R0.8370.84
209_Y229_H0.8330.84
214_A218_E0.8320.84
476_R479_D0.8300.83
210_D291_A0.8260.83
143_R235_Y0.8260.83
170_L174_R0.8200.83
472_R476_R0.8190.83
98_R146_T0.8120.82
124_P359_V0.8110.82
285_G333_V0.8080.82
409_G470_V0.8070.82
349_V394_L0.8050.82
260_P316_I0.8040.81
211_D319_R0.8030.81
234_E238_A0.7950.81
158_T229_H0.7950.81
435_E476_R0.7950.81
153_D479_D0.7930.81
116_D197_S0.7930.81
237_M272_T0.7920.81
93_R96_R0.7910.80
187_A190_S0.7910.80
182_V215_H0.7910.80
440_Y446_R0.7880.80
297_S359_V0.7880.80
443_Q446_R0.7880.80
143_R146_T0.7870.80
210_D231_F0.7860.80
298_L329_I0.7840.80
297_S326_F0.7810.80
471_D478_Q0.7810.80
220_E227_Y0.7810.80
112_H116_D0.7810.80
345_A403_R0.7790.79
464_T469_H0.7730.79
431_T476_R0.7720.79
298_L330_Q0.7690.79
244_G273_A0.7680.78
438_N446_R0.7670.78
107_P126_L0.7670.78
468_E472_R0.7660.78
474_L484_V0.7660.78
231_F320_Q0.7660.78
418_L424_S0.7640.78
261_I298_L0.7600.78
99_V134_S0.7600.78
141_T174_R0.7590.78
152_Q155_G0.7580.78
275_K283_V0.7570.77
187_A230_A0.7560.77
426_N429_L0.7540.77
157_V219_L0.7520.77
147_L152_Q0.7470.76
258_V369_A0.7400.76
148_S226_T0.7380.76
353_E410_R0.7360.75
217_H221_A0.7340.75
416_T428_L0.7330.75
194_A354_R0.7310.75
293_T296_R0.7310.75
147_L155_G0.7310.75
108_L247_I0.7300.75
245_L249_A0.7250.74
196_K202_V0.7240.74
209_Y230_A0.7220.74
438_N445_D0.7210.74
203_V219_L0.7150.73
157_V182_V0.7140.73
186_S207_A0.7140.73
135_F260_P0.7130.73
312_I461_D0.7120.73
321_V329_I0.7110.73
437_A443_Q0.7100.73
182_V212_A0.7100.73
89_L276_G0.7100.73
414_I462_L0.7100.73
465_R469_H0.7080.73
237_M325_T0.7080.73
370_V385_P0.7050.72
185_E205_H0.7050.72
171_A175_S0.7040.72
99_V103_A0.7010.72
96_R245_L0.7000.72
111_S355_G0.7000.72
422_P444_H0.6990.72
196_K201_E0.6970.71
90_S94_D0.6960.71
251_C382_T0.6960.71
156_V177_V0.6930.71
99_V145_R0.6920.71
312_I341_D0.6900.71
233_D236_I0.6900.71
182_V203_V0.6890.71
116_D119_G0.6890.71
161_A164_H0.6890.71
243_L247_I0.6830.70
424_S458_V0.6830.70
210_D287_Q0.6820.70
248_A252_P0.6820.70
365_T388_C0.6790.69
179_S200_A0.6790.69
218_E221_A0.6780.69
150_D331_E0.6760.69
275_K333_V0.6730.69
272_T332_H0.6710.69
287_Q298_L0.6690.68
443_Q459_E0.6650.68
229_H325_T0.6650.68
180_K223_E0.6630.68
258_V286_V0.6620.67
259_V333_V0.6610.67
292_S306_V0.6600.67
273_A277_E0.6600.67
446_R450_D0.6570.67
261_I287_Q0.6570.67
137_I171_A0.6560.67
274_L334_D0.6550.67
152_Q175_S0.6550.67
411_Y440_Y0.6540.67
170_L173_S0.6530.66
335_E338_T0.6510.66
367_L387_L0.6490.66
412_V470_V0.6490.66
395_N401_I0.6490.66
166_Q240_Q0.6480.66
113_T354_R0.6470.66
135_F243_L0.6460.66
153_D299_D0.6420.65
131_R170_L0.6420.65
272_T276_G0.6420.65
94_D97_E0.6410.65
282_R381_E0.6410.65
374_K377_Y0.6400.65
89_L245_L0.6390.65
260_P268_S0.6350.64
299_D335_E0.6340.64
446_R456_T0.6320.64
306_V310_D0.6310.64
297_S304_Q0.6300.64
450_D457_E0.6280.63
442_I458_V0.6260.63
199_G388_C0.6260.63
343_E371_L0.6250.63
426_N433_A0.6240.63
300_K303_P0.6240.63
329_I336_V0.6230.63
294_V326_F0.6220.63
157_V215_H0.6200.62
124_P367_L0.6190.62
442_I451_I0.6190.62
247_I274_L0.6170.62
285_G336_V0.6170.62
275_K279_D0.6150.62
148_S155_G0.6130.62
118_T374_K0.6100.61
358_L397_L0.6090.61
114_F118_T0.6090.61
451_I456_T0.6070.61
429_L439_I0.6060.61
99_V102_T0.6060.61
244_G283_V0.6040.60
207_A288_A0.6020.60
437_A462_L0.6020.60
243_L386_A0.6010.60
135_F355_G0.5990.60
397_L486_V0.5990.60
128_C357_T0.5980.60
208_D309_V0.5980.60
312_I396_L0.5970.60
287_Q316_I0.5950.59
437_A469_H0.5940.59
251_C384_V0.5940.59
167_G240_Q0.5940.59
117_L350_L0.5930.59
178_D282_R0.5930.59
208_D319_R0.5920.59
192_I204_L0.5910.59
155_G225_R0.5910.59
159_A231_F0.5900.59
287_Q291_A0.5890.59
148_S178_D0.5890.59
470_V486_V0.5880.58
126_L357_T0.5880.58
347_A367_L0.5860.58
287_Q297_S0.5850.58
232_D303_P0.5850.58
466_G469_H0.5840.58
152_Q226_T0.5840.58
428_L462_L0.5820.58
200_A464_T0.5810.57
194_A197_S0.5810.57
103_A130_Q0.5810.57
353_E404_G0.5800.57
314_D367_L0.5790.57
414_I477_I0.5790.57
346_T408_Q0.5780.57
435_E472_R0.5780.57
337_V373_D0.5770.57
428_L460_L0.5770.57
442_I447_T0.5770.57
168_V227_Y0.5770.57
442_I450_D0.5760.57
113_T350_L0.5760.57
409_G467_P0.5740.57
332_H335_E0.5730.56
340_S372_E0.5720.56
291_A309_V0.5710.56
95_A98_R0.5700.56
253_T278_L0.5680.56
248_A273_A0.5670.56
274_L278_L0.5650.55
288_A313_A0.5650.55
345_A361_G0.5630.55
416_T484_V0.5630.55
91_D235_Y0.5630.55
164_H240_Q0.5630.55
299_D472_R0.5620.55
103_A137_I0.5610.55
151_Q155_G0.5600.55
367_L385_P0.5600.55
346_T350_L0.5590.55
119_G224_G0.5590.55
347_A368_A0.5570.54
97_E101_E0.5570.54
271_A333_V0.5570.54
361_G395_N0.5550.54
277_E281_V0.5550.54
209_Y231_F0.5550.54
167_G209_Y0.5540.54
124_P314_D0.5540.54
105_H130_Q0.5540.54
287_Q293_T0.5530.54
258_V375_F0.5520.54
476_R480_E0.5510.54
194_A356_K0.5490.53
304_Q326_F0.5480.53
394_L404_G0.5470.53
174_R462_L0.5470.53
347_A371_L0.5470.53
337_V369_A0.5450.53
405_L410_R0.5450.53
99_V135_F0.5450.53
438_N444_H0.5440.53
443_Q450_D0.5440.53
425_L460_L0.5440.53
183_M206_G0.5440.53
329_I332_H0.5440.53
314_D385_P0.5430.53
178_D222_A0.5420.52
353_E466_G0.5420.52
435_E439_I0.5410.52
380_G383_I0.5410.52
166_Q210_D0.5400.52
141_T145_R0.5400.52
415_R459_E0.5390.52
429_L442_I0.5380.52
435_E473_L0.5380.52
240_Q263_G0.5380.52
341_D463_E0.5380.52
472_R479_D0.5370.52
173_S176_G0.5370.52
462_L473_L0.5350.51
271_A275_K0.5350.51
294_V298_L0.5350.51
254_V382_T0.5340.51
185_E211_D0.5340.51
260_P362_A0.5340.51
210_D319_R0.5330.51
373_D377_Y0.5320.51
349_V404_G0.5310.51
221_A472_R0.5310.51
335_E479_D0.5300.51
427_D430_A0.5300.51
348_L364_A0.5290.51
96_R100_S0.5280.51
232_D322_G0.5280.51
299_D302_Q0.5280.51
137_I170_L0.5270.50
230_A318_V0.5270.50
231_F409_G0.5270.50
293_T338_T0.5270.50
177_V392_I0.5260.50
108_L250_D0.5260.50
422_P477_I0.5250.50
321_V336_V0.5250.50
374_K383_I0.5240.50
232_D332_H0.5230.50
345_A365_T0.5220.50
209_Y319_R0.5210.50
256_T278_L0.5200.49
427_D434_E0.5200.49
415_R457_E0.5190.49
313_A345_A0.5190.49
442_I456_T0.5190.49
120_A380_G0.5160.49
399_T404_G0.5150.49
421_S473_L0.5150.49
427_D431_T0.5140.49
143_R156_V0.5130.49
135_F271_A0.5130.49
359_V392_I0.5130.49
118_T370_V0.5130.49
134_S366_A0.5130.49
418_L456_T0.5120.48
432_A447_T0.5120.48
267_I270_V0.5120.48
153_D214_A0.5120.48
470_V474_L0.5110.48
429_L473_L0.5110.48
131_R354_R0.5110.48
436_R469_H0.5110.48
153_D226_T0.5100.48
445_D448_N0.5090.48
350_L355_G0.5090.48
205_H218_E0.5080.48
302_Q323_A0.5080.48
194_A198_Y0.5080.48
186_S288_A0.5070.48
116_D214_A0.5060.48
250_D348_L0.5060.48
164_H263_G0.5060.48
234_E237_M0.5050.47
284_I376_E0.5030.47
232_D325_T0.5030.47
261_I329_I0.5020.47
210_D214_A0.5020.47
328_V331_E0.5010.47
257_V384_V0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tdjA 2 0.8303 100 0.366 Contact Map
2gn0A 2 0.6626 100 0.537 Contact Map
3ss7X 1 0.7212 100 0.538 Contact Map
1v71A 2 0.6424 100 0.546 Contact Map
3iauA 1 0.7152 100 0.553 Contact Map
1ve5A 3 0.6121 100 0.561 Contact Map
3l6bA 2 0.6424 100 0.563 Contact Map
2rkbA 2 0.6202 100 0.575 Contact Map
4d9iA 2 0.6869 100 0.576 Contact Map
4h27A 1 0.6182 100 0.578 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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