GREMLIN Database
Q9HNH4 - Citrate synthase
UniProt: Q9HNH4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 376 (362)
Sequences: 4243 (2064)
Seq/√Len: 108.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_T212_S7.4591.00
38_D369_D4.1871.00
196_G213_A4.0381.00
56_D62_E3.4761.00
60_R64_D3.4501.00
158_A174_A3.2141.00
35_A38_D3.1731.00
43_A370_S3.0531.00
170_D285_A2.9181.00
41_R277_E2.8851.00
59_T62_E2.7931.00
199_T216_T2.7561.00
155_G158_A2.7121.00
250_A255_E2.6821.00
204_A218_S2.5781.00
244_L297_A2.5081.00
173_L323_M2.4741.00
241_K245_S2.4701.00
191_A202_T2.4341.00
280_E296_V2.4281.00
234_K321_Y2.4101.00
47_E63_L2.3751.00
102_A214_I2.3751.00
237_D241_K2.3591.00
198_V356_I2.3141.00
56_D368_R2.3081.00
277_E281_E2.1861.00
10_E354_R2.1701.00
159_N163_M2.1561.00
124_G343_V2.1151.00
301_Y305_E2.1071.00
195_S216_T2.1041.00
157_A178_D2.0901.00
202_T216_T2.0831.00
245_S249_D2.0231.00
44_S63_L1.9991.00
172_V285_A1.9141.00
200_A209_A1.8971.00
135_V336_M1.8951.00
154_L158_A1.8861.00
140_R145_D1.8711.00
82_A85_E1.8681.00
49_L340_G1.8451.00
50_Y56_D1.8141.00
234_K327_V1.8031.00
301_Y304_D1.7671.00
248_Q252_A1.7591.00
175_D178_D1.7511.00
131_L339_V1.7441.00
200_A346_V1.7201.00
227_A231_R1.7181.00
325_I333_I1.7091.00
20_S186_D1.7051.00
78_D82_A1.6981.00
37_E273_H1.6891.00
280_E284_A1.6791.00
180_A320_Y1.6721.00
155_G174_A1.6521.00
100_T103_S1.6501.00
34_Y368_R1.6321.00
99_R215_G1.6221.00
179_Q278_R1.6091.00
164_L325_I1.6081.00
295_S318_S1.5961.00
249_D253_N1.5921.00
101_A134_I1.5911.00
64_D68_A1.5871.00
116_D119_D1.5761.00
180_A275_L1.5421.00
99_R103_S1.5381.00
212_S216_T1.5171.00
289_T321_Y1.5151.00
170_D173_L1.5131.00
136_A160_F1.5091.00
61_S65_A1.4901.00
53_W128_T1.4901.00
151_R168_A1.4721.00
249_D254_G1.4591.00
73_H126_R1.4571.00
175_D179_Q1.4571.00
171_D175_D1.4561.00
46_E70_M1.4541.00
48_V182_V1.4531.00
97_A138_F1.4531.00
28_K35_A1.4461.00
68_A72_S1.4431.00
248_Q305_E1.4351.00
236_V250_A1.4321.00
50_Y62_E1.4271.00
69_D125_K1.4131.00
302_M305_E1.3941.00
277_E280_E1.3891.00
191_A216_T1.3881.00
295_S299_E1.3801.00
195_S212_S1.3711.00
151_R162_Y1.3661.00
244_L301_Y1.3611.00
249_D255_E1.3571.00
16_E361_R1.3481.00
148_V163_M1.3331.00
102_A131_L1.3290.99
82_A86_N1.3250.99
268_K273_H1.3240.99
217_L335_A1.3160.99
81_L137_A1.3080.99
185_A340_G1.3050.99
150_P159_N1.2890.99
74_R156_H1.2830.99
289_T293_E1.2820.99
10_E263_R1.2790.99
188_G359_R1.2720.99
151_R154_L1.2420.99
195_S199_T1.2410.99
208_A218_S1.2290.99
83_L104_A1.2280.99
123_S206_V1.2110.99
47_E370_S1.2090.99
34_Y57_L1.2030.99
279_S318_S1.2020.99
222_H225_A1.2020.99
196_G346_V1.1980.99
204_A208_A1.1960.99
32_C55_G1.1900.99
74_R152_D1.1850.99
278_R281_E1.1800.99
98_L135_V1.1790.99
85_E146_D1.1790.99
248_Q301_Y1.1770.99
206_V343_V1.1760.99
231_R327_V1.1760.99
52_L340_G1.1620.99
321_Y327_V1.1590.99
37_E274_I1.1500.99
275_L319_T1.1490.99
276_S280_E1.1490.99
289_T299_E1.1420.98
95_M226_N1.1370.98
142_R328_D1.1310.98
119_D123_S1.1310.98
240_D297_A1.1290.98
195_S198_V1.1290.98
51_L57_L1.1280.98
243_P297_A1.1240.98
300_D304_D1.1230.98
67_R71_A1.1180.98
76_I137_A1.1170.98
276_S299_E1.1150.98
50_Y54_H1.1090.98
117_P351_D1.1080.98
34_Y51_L1.1070.98
62_E65_A1.1030.98
53_W343_V1.1020.98
244_L248_Q1.1020.98
221_L256_R1.1010.98
73_H125_K1.0990.98
206_V346_V1.0970.98
31_Y185_A1.0960.98
44_S178_D1.0820.98
347_L351_D1.0810.98
293_E296_V1.0770.98
88_A91_D1.0650.98
150_P163_M1.0520.97
210_V339_V1.0470.97
135_V332_P1.0400.97
69_D122_E1.0390.97
16_E363_V1.0340.97
178_D182_V1.0330.97
236_V246_W1.0320.97
65_A69_D1.0260.97
75_E149_A1.0210.97
165_N173_L1.0200.97
284_A289_T1.0150.97
24_G27_G1.0100.97
31_Y48_V1.0080.97
158_A171_D1.0030.96
64_D67_R1.0020.96
232_M250_A1.0020.96
45_Y340_G1.0010.96
204_A209_A1.0000.96
246_W250_A1.0000.96
36_I274_I0.9960.96
38_D41_R0.9940.96
197_M349_Q0.9930.96
23_D26_A0.9870.96
239_S294_M0.9820.96
210_V343_V0.9810.96
43_A47_E0.9730.96
61_S64_D0.9730.96
93_D227_A0.9710.96
237_D290_K0.9690.96
148_V162_Y0.9630.96
236_V243_P0.9630.96
300_D303_A0.9620.96
139_T143_N0.9590.95
56_D59_T0.9580.95
122_E126_R0.9580.95
30_V367_D0.9560.95
225_A311_N0.9530.95
291_W295_S0.9520.95
146_D149_A0.9510.95
99_R211_T0.9500.95
244_L304_D0.9470.95
52_L185_A0.9420.95
296_V299_E0.9410.95
120_A123_S0.9400.95
20_S188_G0.9360.95
337_S340_G0.9350.95
141_L146_D0.9350.95
143_N146_D0.9340.95
172_V281_E0.9340.95
81_L85_E0.9320.95
54_H121_R0.9260.94
175_D281_E0.9260.94
38_D42_T0.9180.94
187_H265_Y0.9160.94
292_Y296_V0.9120.94
84_V101_A0.9100.94
159_N162_Y0.9070.94
175_D278_R0.9070.94
34_Y39_L0.9060.94
87_L104_A0.9030.94
237_D240_D0.9020.94
223_G334_F0.8930.93
15_A189_L0.8910.93
184_H312_V0.8880.93
203_L221_L0.8860.93
260_F310_P0.8840.93
279_S295_S0.8820.93
228_N231_R0.8800.93
192_S222_H0.8790.93
154_L159_N0.8790.93
133_T150_P0.8780.93
76_I134_I0.8770.93
235_E255_E0.8740.93
69_D73_H0.8710.92
214_I335_A0.8650.92
46_E157_A0.8640.92
7_K352_D0.8590.92
50_Y66_F0.8560.92
80_V83_L0.8560.92
133_T163_M0.8560.92
121_R347_L0.8550.92
114_G119_D0.8480.91
276_S296_V0.8450.91
217_L223_G0.8430.91
80_V104_A0.8430.91
248_Q304_D0.8430.91
229_V233_L0.8390.91
181_L336_M0.8390.91
238_D290_K0.8390.91
84_V138_F0.8390.91
235_E238_D0.8390.91
39_L48_V0.8370.91
155_G178_D0.8360.91
127_I210_V0.8350.91
294_M299_E0.8330.91
157_A174_A0.8290.91
189_L359_R0.8270.90
234_K291_W0.8270.90
26_A267_V0.8250.90
128_T156_H0.8240.90
194_F356_I0.8220.90
268_K276_S0.8200.90
83_L86_N0.8170.90
293_E297_A0.8170.90
289_T295_S0.8160.90
238_D241_K0.8140.90
9_L12_V0.8130.90
18_D363_V0.8110.90
53_W340_G0.8110.90
217_L334_F0.8040.89
141_L145_D0.8010.89
222_H313_D0.8000.89
111_T122_E0.7990.89
39_L57_L0.7960.89
295_S317_A0.7950.89
140_R148_V0.7940.89
103_S215_G0.7930.88
63_L67_R0.7930.88
173_L282_L0.7910.88
194_F198_V0.7880.88
119_D122_E0.7870.88
222_H334_F0.7850.88
70_M125_K0.7840.88
44_S47_E0.7830.88
226_N313_D0.7780.88
157_A177_F0.7760.87
21_F26_A0.7750.87
126_R130_K0.7750.87
257_V302_M0.7750.87
123_S207_H0.7700.87
144_G147_V0.7700.87
209_A346_V0.7680.87
31_Y51_L0.7670.87
295_S298_I0.7650.87
233_L295_S0.7620.86
154_L174_A0.7620.86
202_T355_L0.7600.86
252_A305_E0.7580.86
184_H226_N0.7570.86
79_D108_H0.7570.86
245_S248_Q0.7510.86
75_E152_D0.7480.85
230_M327_V0.7470.85
76_I81_L0.7470.85
49_L128_T0.7450.85
290_K293_E0.7420.85
203_L220_S0.7370.85
232_M246_W0.7340.84
20_S30_V0.7320.84
47_E57_L0.7300.84
14_V194_F0.7290.84
157_A181_L0.7270.84
250_A253_N0.7260.84
111_T114_G0.7240.84
87_L107_A0.7210.83
103_S211_T0.7180.83
230_M330_Y0.7180.83
240_D244_L0.7170.83
30_V35_A0.7170.83
187_H223_G0.7150.83
228_N258_M0.7140.83
226_N331_T0.7130.83
172_V176_V0.7120.82
192_S223_G0.7120.82
129_A132_P0.7110.82
79_D90_A0.7100.82
167_E173_L0.7090.82
114_G117_P0.7060.82
124_G347_L0.7060.82
21_F24_G0.7060.82
229_V312_V0.7050.82
365_A368_R0.7050.82
109_D126_R0.7020.82
179_Q182_V0.7000.81
48_V185_A0.6990.81
157_A161_L0.6990.81
240_D243_P0.6980.81
295_S314_F0.6930.81
84_V147_V0.6920.81
109_D123_S0.6910.81
43_A182_V0.6910.81
17_S20_S0.6910.81
188_G360_A0.6900.80
34_Y56_D0.6890.80
225_A261_G0.6890.80
292_Y295_S0.6880.80
205_D208_A0.6870.80
36_I183_L0.6860.80
45_Y49_L0.6840.80
292_Y299_E0.6840.80
154_L162_Y0.6830.80
278_R319_T0.6780.79
85_E137_A0.6770.79
9_L13_L0.6760.79
234_K238_D0.6760.79
78_D149_A0.6750.79
235_E250_A0.6740.79
29_L36_I0.6740.79
239_S243_P0.6720.79
279_S319_T0.6720.79
111_T126_R0.6690.78
217_L226_N0.6680.78
291_W321_Y0.6680.78
229_V294_M0.6670.78
49_L66_F0.6650.78
40_A182_V0.6650.78
203_L350_Y0.6630.78
9_L14_V0.6620.78
241_K249_D0.6620.78
118_D122_E0.6610.78
35_A369_D0.6610.78
184_H316_S0.6590.77
24_G267_V0.6570.77
250_A254_G0.6570.77
256_R355_L0.6530.77
199_T209_A0.6530.77
173_L286_A0.6520.77
142_R145_D0.6520.77
120_A350_Y0.6500.76
302_M306_K0.6480.76
162_Y168_A0.6470.76
80_V101_A0.6460.76
9_L194_F0.6450.76
193_T331_T0.6410.75
266_N307_G0.6390.75
261_G311_N0.6390.75
275_L316_S0.6390.75
136_A163_M0.6380.75
141_L147_V0.6360.75
280_E292_Y0.6350.75
303_A309_A0.6330.75
231_R235_E0.6330.75
45_Y178_D0.6330.75
181_L337_S0.6320.74
187_H190_N0.6280.74
137_A163_M0.6280.74
133_T136_A0.6270.74
98_L214_I0.6270.74
339_V343_V0.6260.74
193_T345_H0.6260.74
87_L92_A0.6250.74
72_S152_D0.6240.73
187_H334_F0.6230.73
282_L319_T0.6230.73
205_D218_S0.6230.73
83_L87_L0.6220.73
70_M129_A0.6180.73
79_D82_A0.6180.73
236_V247_V0.6170.73
166_G169_P0.6160.73
335_A342_W0.6150.72
245_S252_A0.6150.72
136_A140_R0.6140.72
180_A333_I0.6140.72
19_L32_C0.6130.72
75_E122_E0.6120.72
230_M321_Y0.6120.72
193_T197_M0.6090.72
257_V306_K0.6050.71
73_H130_K0.6030.71
244_L280_E0.6000.71
175_D182_V0.6000.71
244_L247_V0.5990.70
151_R159_N0.5980.70
169_P174_A0.5980.70
73_H122_E0.5970.70
21_F362_Y0.5960.70
124_G206_V0.5960.70
268_K309_A0.5940.70
286_A322_Q0.5930.70
44_S67_R0.5930.70
9_L356_I0.5910.69
77_D80_V0.5890.69
84_V141_L0.5840.68
180_A184_H0.5810.68
189_L197_M0.5810.68
137_A147_V0.5810.68
325_I329_I0.5790.68
186_D343_V0.5770.68
32_C49_L0.5770.68
133_T159_N0.5760.67
120_A347_L0.5740.67
113_G117_P0.5730.67
17_S345_H0.5730.67
178_D354_R0.5730.67
276_S315_Y0.5720.67
109_D350_Y0.5720.67
106_S205_D0.5720.67
190_N312_V0.5710.67
327_V330_Y0.5710.67
188_G308_L0.5700.67
43_A178_D0.5690.67
161_L174_A0.5680.66
243_P294_M0.5680.66
308_L314_F0.5660.66
222_H261_G0.5660.66
233_L291_W0.5650.66
80_V84_V0.5650.66
197_M233_L0.5650.66
294_M297_A0.5650.66
69_D72_S0.5640.66
263_R355_L0.5640.66
190_N222_H0.5640.66
288_D291_W0.5630.66
289_T292_Y0.5610.65
231_R234_K0.5600.65
46_E156_H0.5600.65
312_V316_S0.5580.65
80_V88_A0.5560.65
307_G310_P0.5540.64
143_N326_P0.5520.64
239_S297_A0.5510.64
311_N317_A0.5510.64
297_A300_D0.5510.64
262_H334_F0.5510.64
113_G116_D0.5500.64
288_D295_S0.5500.64
192_S217_L0.5490.64
192_S334_F0.5470.63
236_V298_I0.5470.63
102_A127_I0.5460.63
32_C363_V0.5450.63
275_L312_V0.5430.63
190_N334_F0.5430.63
106_S204_A0.5430.63
220_S225_A0.5430.63
363_V366_E0.5420.63
286_A289_T0.5410.63
249_D252_A0.5410.63
232_M236_V0.5410.63
192_S313_D0.5390.62
66_F70_M0.5360.62
275_L279_S0.5350.62
65_A68_A0.5340.62
49_L53_W0.5330.61
303_A307_G0.5330.61
120_A124_G0.5320.61
128_T343_V0.5320.61
131_L134_I0.5300.61
141_L144_G0.5300.61
234_K330_Y0.5290.61
195_S306_K0.5280.61
44_S49_L0.5260.60
73_H213_A0.5250.60
71_A152_D0.5240.60
71_A74_R0.5230.60
46_E67_R0.5230.60
203_L353_N0.5230.60
179_Q281_E0.5230.60
34_Y38_D0.5230.60
261_G313_D0.5220.60
42_T370_S0.5210.60
73_H129_A0.5200.60
29_L33_G0.5190.59
127_I206_V0.5180.59
248_Q251_L0.5170.59
145_D148_V0.5170.59
130_K133_T0.5150.59
150_P154_L0.5150.59
27_G270_P0.5150.59
312_V319_T0.5150.59
77_D105_L0.5150.59
28_K367_D0.5140.59
190_N262_H0.5130.59
297_A301_Y0.5130.59
184_H313_D0.5120.58
232_M258_M0.5120.58
135_V214_I0.5120.58
187_H192_S0.5110.58
11_D14_V0.5110.58
81_L174_A0.5100.58
60_R167_E0.5090.58
125_K132_P0.5060.58
176_V282_L0.5050.57
51_L185_A0.5040.57
128_T340_G0.5040.57
303_A308_L0.5040.57
282_L326_P0.5030.57
110_D126_R0.5020.57
346_V360_A0.5010.57
87_L100_T0.5010.57
260_F302_M0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h12A 4 0.9947 100 0.039 Contact Map
4xghA 5 0.9122 100 0.041 Contact Map
1o7xA 2 0.9681 100 0.045 Contact Map
2ibpA 2 0.992 100 0.045 Contact Map
1iomA 2 0.984 100 0.046 Contact Map
1vgmA 2 0.9814 100 0.048 Contact Map
3o8jA 3 0.9628 100 0.048 Contact Map
1vgpA 2 0.9787 100 0.053 Contact Map
2ifcA 2 0.984 100 0.053 Contact Map
1aj8A 2 0.9734 100 0.056 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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