Q9HNH4 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HNH4 - Citrate synthase

UniProt:	Q9HNH4	Sequences: MSDELKKGLEDVLVAESDLSFIDGDAGKLVYCGYAIEDLARTASYEEVLYLLWHGDLPTRSELDAFRADMASHREIDDDVLALVENLAAADADPMAALRTAASALSAHDDTAGGSDPDDARESGKRITAKLPTIVAAFTRLRNGDDVVAPRDDLGHAANFLYMLNGEAPDDVLADVFDQALVLHADHGLNASTFSGMVTASTLADVHAAVTSAIGTLSGSLHGGANANVMRMLKEVDDSDKDPLSWVQDALANGERVMGFGHRVYNVKDPRAHILSERSEELGAAAGDTKWYEMSVAIEDYMADEKGLAPNVDFYSASTYYQMGIPVDIYTPIFAMSRVGGWVGHVLEQYDDNRLIRPRARYVGAEDRDSTPLDER	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	376 (362)
Sequences:	4243 (2064)
Seq/√Len:	108.5

ECOLI - CISY PRPC
BACSU - CISY2 CISY3 CISY
HALSA - Q9HNH4
SULSO - CISY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_T	212_S	7.459	1.00
38_D	369_D	4.187	1.00
196_G	213_A	4.038	1.00
56_D	62_E	3.476	1.00
60_R	64_D	3.450	1.00
158_A	174_A	3.214	1.00
35_A	38_D	3.173	1.00
43_A	370_S	3.053	1.00
170_D	285_A	2.918	1.00
41_R	277_E	2.885	1.00
59_T	62_E	2.793	1.00
199_T	216_T	2.756	1.00
155_G	158_A	2.712	1.00
250_A	255_E	2.682	1.00
204_A	218_S	2.578	1.00
244_L	297_A	2.508	1.00
173_L	323_M	2.474	1.00
241_K	245_S	2.470	1.00
191_A	202_T	2.434	1.00
280_E	296_V	2.428	1.00
234_K	321_Y	2.410	1.00
47_E	63_L	2.375	1.00
102_A	214_I	2.375	1.00
237_D	241_K	2.359	1.00
198_V	356_I	2.314	1.00
56_D	368_R	2.308	1.00
277_E	281_E	2.186	1.00
10_E	354_R	2.170	1.00
159_N	163_M	2.156	1.00
124_G	343_V	2.115	1.00
301_Y	305_E	2.107	1.00
195_S	216_T	2.104	1.00
157_A	178_D	2.090	1.00
202_T	216_T	2.083	1.00
245_S	249_D	2.023	1.00
44_S	63_L	1.999	1.00
172_V	285_A	1.914	1.00
200_A	209_A	1.897	1.00
135_V	336_M	1.895	1.00
154_L	158_A	1.886	1.00
140_R	145_D	1.871	1.00
82_A	85_E	1.868	1.00
49_L	340_G	1.845	1.00
50_Y	56_D	1.814	1.00
234_K	327_V	1.803	1.00
301_Y	304_D	1.767	1.00
248_Q	252_A	1.759	1.00
175_D	178_D	1.751	1.00
131_L	339_V	1.744	1.00
200_A	346_V	1.720	1.00
227_A	231_R	1.718	1.00
325_I	333_I	1.709	1.00
20_S	186_D	1.705	1.00
78_D	82_A	1.698	1.00
37_E	273_H	1.689	1.00
280_E	284_A	1.679	1.00
180_A	320_Y	1.672	1.00
155_G	174_A	1.652	1.00
100_T	103_S	1.650	1.00
34_Y	368_R	1.632	1.00
99_R	215_G	1.622	1.00
179_Q	278_R	1.609	1.00
164_L	325_I	1.608	1.00
295_S	318_S	1.596	1.00
249_D	253_N	1.592	1.00
101_A	134_I	1.591	1.00
64_D	68_A	1.587	1.00
116_D	119_D	1.576	1.00
180_A	275_L	1.542	1.00
99_R	103_S	1.538	1.00
212_S	216_T	1.517	1.00
289_T	321_Y	1.515	1.00
170_D	173_L	1.513	1.00
136_A	160_F	1.509	1.00
61_S	65_A	1.490	1.00
53_W	128_T	1.490	1.00
151_R	168_A	1.472	1.00
249_D	254_G	1.459	1.00
73_H	126_R	1.457	1.00
175_D	179_Q	1.457	1.00
171_D	175_D	1.456	1.00
46_E	70_M	1.454	1.00
48_V	182_V	1.453	1.00
97_A	138_F	1.453	1.00
28_K	35_A	1.446	1.00
68_A	72_S	1.443	1.00
248_Q	305_E	1.435	1.00
236_V	250_A	1.432	1.00
50_Y	62_E	1.427	1.00
69_D	125_K	1.413	1.00
302_M	305_E	1.394	1.00
277_E	280_E	1.389	1.00
191_A	216_T	1.388	1.00
295_S	299_E	1.380	1.00
195_S	212_S	1.371	1.00
151_R	162_Y	1.366	1.00
244_L	301_Y	1.361	1.00
249_D	255_E	1.357	1.00
16_E	361_R	1.348	1.00
148_V	163_M	1.333	1.00
102_A	131_L	1.329	0.99
82_A	86_N	1.325	0.99
268_K	273_H	1.324	0.99
217_L	335_A	1.316	0.99
81_L	137_A	1.308	0.99
185_A	340_G	1.305	0.99
150_P	159_N	1.289	0.99
74_R	156_H	1.283	0.99
289_T	293_E	1.282	0.99
10_E	263_R	1.279	0.99
188_G	359_R	1.272	0.99
151_R	154_L	1.242	0.99
195_S	199_T	1.241	0.99
208_A	218_S	1.229	0.99
83_L	104_A	1.228	0.99
123_S	206_V	1.211	0.99
47_E	370_S	1.209	0.99
34_Y	57_L	1.203	0.99
279_S	318_S	1.202	0.99
222_H	225_A	1.202	0.99
196_G	346_V	1.198	0.99
204_A	208_A	1.196	0.99
32_C	55_G	1.190	0.99
74_R	152_D	1.185	0.99
278_R	281_E	1.180	0.99
98_L	135_V	1.179	0.99
85_E	146_D	1.179	0.99
248_Q	301_Y	1.177	0.99
206_V	343_V	1.176	0.99
231_R	327_V	1.176	0.99
52_L	340_G	1.162	0.99
321_Y	327_V	1.159	0.99
37_E	274_I	1.150	0.99
275_L	319_T	1.149	0.99
276_S	280_E	1.149	0.99
289_T	299_E	1.142	0.98
95_M	226_N	1.137	0.98
142_R	328_D	1.131	0.98
119_D	123_S	1.131	0.98
240_D	297_A	1.129	0.98
195_S	198_V	1.129	0.98
51_L	57_L	1.128	0.98
243_P	297_A	1.124	0.98
300_D	304_D	1.123	0.98
67_R	71_A	1.118	0.98
76_I	137_A	1.117	0.98
276_S	299_E	1.115	0.98
50_Y	54_H	1.109	0.98
117_P	351_D	1.108	0.98
34_Y	51_L	1.107	0.98
62_E	65_A	1.103	0.98
53_W	343_V	1.102	0.98
244_L	248_Q	1.102	0.98
221_L	256_R	1.101	0.98
73_H	125_K	1.099	0.98
206_V	346_V	1.097	0.98
31_Y	185_A	1.096	0.98
44_S	178_D	1.082	0.98
347_L	351_D	1.081	0.98
293_E	296_V	1.077	0.98
88_A	91_D	1.065	0.98
150_P	163_M	1.052	0.97
210_V	339_V	1.047	0.97
135_V	332_P	1.040	0.97
69_D	122_E	1.039	0.97
16_E	363_V	1.034	0.97
178_D	182_V	1.033	0.97
236_V	246_W	1.032	0.97
65_A	69_D	1.026	0.97
75_E	149_A	1.021	0.97
165_N	173_L	1.020	0.97
284_A	289_T	1.015	0.97
24_G	27_G	1.010	0.97
31_Y	48_V	1.008	0.97
158_A	171_D	1.003	0.96
64_D	67_R	1.002	0.96
232_M	250_A	1.002	0.96
45_Y	340_G	1.001	0.96
204_A	209_A	1.000	0.96
246_W	250_A	1.000	0.96
36_I	274_I	0.996	0.96
38_D	41_R	0.994	0.96
197_M	349_Q	0.993	0.96
23_D	26_A	0.987	0.96
239_S	294_M	0.982	0.96
210_V	343_V	0.981	0.96
43_A	47_E	0.973	0.96
61_S	64_D	0.973	0.96
93_D	227_A	0.971	0.96
237_D	290_K	0.969	0.96
148_V	162_Y	0.963	0.96
236_V	243_P	0.963	0.96
300_D	303_A	0.962	0.96
139_T	143_N	0.959	0.95
56_D	59_T	0.958	0.95
122_E	126_R	0.958	0.95
30_V	367_D	0.956	0.95
225_A	311_N	0.953	0.95
291_W	295_S	0.952	0.95
146_D	149_A	0.951	0.95
99_R	211_T	0.950	0.95
244_L	304_D	0.947	0.95
52_L	185_A	0.942	0.95
296_V	299_E	0.941	0.95
120_A	123_S	0.940	0.95
20_S	188_G	0.936	0.95
337_S	340_G	0.935	0.95
141_L	146_D	0.935	0.95
143_N	146_D	0.934	0.95
172_V	281_E	0.934	0.95
81_L	85_E	0.932	0.95
54_H	121_R	0.926	0.94
175_D	281_E	0.926	0.94
38_D	42_T	0.918	0.94
187_H	265_Y	0.916	0.94
292_Y	296_V	0.912	0.94
84_V	101_A	0.910	0.94
159_N	162_Y	0.907	0.94
175_D	278_R	0.907	0.94
34_Y	39_L	0.906	0.94
87_L	104_A	0.903	0.94
237_D	240_D	0.902	0.94
223_G	334_F	0.893	0.93
15_A	189_L	0.891	0.93
184_H	312_V	0.888	0.93
203_L	221_L	0.886	0.93
260_F	310_P	0.884	0.93
279_S	295_S	0.882	0.93
228_N	231_R	0.880	0.93
192_S	222_H	0.879	0.93
154_L	159_N	0.879	0.93
133_T	150_P	0.878	0.93
76_I	134_I	0.877	0.93
235_E	255_E	0.874	0.93
69_D	73_H	0.871	0.92
214_I	335_A	0.865	0.92
46_E	157_A	0.864	0.92
7_K	352_D	0.859	0.92
50_Y	66_F	0.856	0.92
80_V	83_L	0.856	0.92
133_T	163_M	0.856	0.92
121_R	347_L	0.855	0.92
114_G	119_D	0.848	0.91
276_S	296_V	0.845	0.91
217_L	223_G	0.843	0.91
80_V	104_A	0.843	0.91
248_Q	304_D	0.843	0.91
229_V	233_L	0.839	0.91
181_L	336_M	0.839	0.91
238_D	290_K	0.839	0.91
84_V	138_F	0.839	0.91
235_E	238_D	0.839	0.91
39_L	48_V	0.837	0.91
155_G	178_D	0.836	0.91
127_I	210_V	0.835	0.91
294_M	299_E	0.833	0.91
157_A	174_A	0.829	0.91
189_L	359_R	0.827	0.90
234_K	291_W	0.827	0.90
26_A	267_V	0.825	0.90
128_T	156_H	0.824	0.90
194_F	356_I	0.822	0.90
268_K	276_S	0.820	0.90
83_L	86_N	0.817	0.90
293_E	297_A	0.817	0.90
289_T	295_S	0.816	0.90
238_D	241_K	0.814	0.90
9_L	12_V	0.813	0.90
18_D	363_V	0.811	0.90
53_W	340_G	0.811	0.90
217_L	334_F	0.804	0.89
141_L	145_D	0.801	0.89
222_H	313_D	0.800	0.89
111_T	122_E	0.799	0.89
39_L	57_L	0.796	0.89
295_S	317_A	0.795	0.89
140_R	148_V	0.794	0.89
103_S	215_G	0.793	0.88
63_L	67_R	0.793	0.88
173_L	282_L	0.791	0.88
194_F	198_V	0.788	0.88
119_D	122_E	0.787	0.88
222_H	334_F	0.785	0.88
70_M	125_K	0.784	0.88
44_S	47_E	0.783	0.88
226_N	313_D	0.778	0.88
157_A	177_F	0.776	0.87
21_F	26_A	0.775	0.87
126_R	130_K	0.775	0.87
257_V	302_M	0.775	0.87
123_S	207_H	0.770	0.87
144_G	147_V	0.770	0.87
209_A	346_V	0.768	0.87
31_Y	51_L	0.767	0.87
295_S	298_I	0.765	0.87
233_L	295_S	0.762	0.86
154_L	174_A	0.762	0.86
202_T	355_L	0.760	0.86
252_A	305_E	0.758	0.86
184_H	226_N	0.757	0.86
79_D	108_H	0.757	0.86
245_S	248_Q	0.751	0.86
75_E	152_D	0.748	0.85
230_M	327_V	0.747	0.85
76_I	81_L	0.747	0.85
49_L	128_T	0.745	0.85
290_K	293_E	0.742	0.85
203_L	220_S	0.737	0.85
232_M	246_W	0.734	0.84
20_S	30_V	0.732	0.84
47_E	57_L	0.730	0.84
14_V	194_F	0.729	0.84
157_A	181_L	0.727	0.84
250_A	253_N	0.726	0.84
111_T	114_G	0.724	0.84
87_L	107_A	0.721	0.83
103_S	211_T	0.718	0.83
230_M	330_Y	0.718	0.83
240_D	244_L	0.717	0.83
30_V	35_A	0.717	0.83
187_H	223_G	0.715	0.83
228_N	258_M	0.714	0.83
226_N	331_T	0.713	0.83
172_V	176_V	0.712	0.82
192_S	223_G	0.712	0.82
129_A	132_P	0.711	0.82
79_D	90_A	0.710	0.82
167_E	173_L	0.709	0.82
114_G	117_P	0.706	0.82
124_G	347_L	0.706	0.82
21_F	24_G	0.706	0.82
229_V	312_V	0.705	0.82
365_A	368_R	0.705	0.82
109_D	126_R	0.702	0.82
179_Q	182_V	0.700	0.81
48_V	185_A	0.699	0.81
157_A	161_L	0.699	0.81
240_D	243_P	0.698	0.81
295_S	314_F	0.693	0.81
84_V	147_V	0.692	0.81
109_D	123_S	0.691	0.81
43_A	182_V	0.691	0.81
17_S	20_S	0.691	0.81
188_G	360_A	0.690	0.80
34_Y	56_D	0.689	0.80
225_A	261_G	0.689	0.80
292_Y	295_S	0.688	0.80
205_D	208_A	0.687	0.80
36_I	183_L	0.686	0.80
45_Y	49_L	0.684	0.80
292_Y	299_E	0.684	0.80
154_L	162_Y	0.683	0.80
278_R	319_T	0.678	0.79
85_E	137_A	0.677	0.79
9_L	13_L	0.676	0.79
234_K	238_D	0.676	0.79
78_D	149_A	0.675	0.79
235_E	250_A	0.674	0.79
29_L	36_I	0.674	0.79
239_S	243_P	0.672	0.79
279_S	319_T	0.672	0.79
111_T	126_R	0.669	0.78
217_L	226_N	0.668	0.78
291_W	321_Y	0.668	0.78
229_V	294_M	0.667	0.78
49_L	66_F	0.665	0.78
40_A	182_V	0.665	0.78
203_L	350_Y	0.663	0.78
9_L	14_V	0.662	0.78
241_K	249_D	0.662	0.78
118_D	122_E	0.661	0.78
35_A	369_D	0.661	0.78
184_H	316_S	0.659	0.77
24_G	267_V	0.657	0.77
250_A	254_G	0.657	0.77
256_R	355_L	0.653	0.77
199_T	209_A	0.653	0.77
173_L	286_A	0.652	0.77
142_R	145_D	0.652	0.77
120_A	350_Y	0.650	0.76
302_M	306_K	0.648	0.76
162_Y	168_A	0.647	0.76
80_V	101_A	0.646	0.76
9_L	194_F	0.645	0.76
193_T	331_T	0.641	0.75
266_N	307_G	0.639	0.75
261_G	311_N	0.639	0.75
275_L	316_S	0.639	0.75
136_A	163_M	0.638	0.75
141_L	147_V	0.636	0.75
280_E	292_Y	0.635	0.75
303_A	309_A	0.633	0.75
231_R	235_E	0.633	0.75
45_Y	178_D	0.633	0.75
181_L	337_S	0.632	0.74
187_H	190_N	0.628	0.74
137_A	163_M	0.628	0.74
133_T	136_A	0.627	0.74
98_L	214_I	0.627	0.74
339_V	343_V	0.626	0.74
193_T	345_H	0.626	0.74
87_L	92_A	0.625	0.74
72_S	152_D	0.624	0.73
187_H	334_F	0.623	0.73
282_L	319_T	0.623	0.73
205_D	218_S	0.623	0.73
83_L	87_L	0.622	0.73
70_M	129_A	0.618	0.73
79_D	82_A	0.618	0.73
236_V	247_V	0.617	0.73
166_G	169_P	0.616	0.73
335_A	342_W	0.615	0.72
245_S	252_A	0.615	0.72
136_A	140_R	0.614	0.72
180_A	333_I	0.614	0.72
19_L	32_C	0.613	0.72
75_E	122_E	0.612	0.72
230_M	321_Y	0.612	0.72
193_T	197_M	0.609	0.72
257_V	306_K	0.605	0.71
73_H	130_K	0.603	0.71
244_L	280_E	0.600	0.71
175_D	182_V	0.600	0.71
244_L	247_V	0.599	0.70
151_R	159_N	0.598	0.70
169_P	174_A	0.598	0.70
73_H	122_E	0.597	0.70
21_F	362_Y	0.596	0.70
124_G	206_V	0.596	0.70
268_K	309_A	0.594	0.70
286_A	322_Q	0.593	0.70
44_S	67_R	0.593	0.70
9_L	356_I	0.591	0.69
77_D	80_V	0.589	0.69
84_V	141_L	0.584	0.68
180_A	184_H	0.581	0.68
189_L	197_M	0.581	0.68
137_A	147_V	0.581	0.68
325_I	329_I	0.579	0.68
186_D	343_V	0.577	0.68
32_C	49_L	0.577	0.68
133_T	159_N	0.576	0.67
120_A	347_L	0.574	0.67
113_G	117_P	0.573	0.67
17_S	345_H	0.573	0.67
178_D	354_R	0.573	0.67
276_S	315_Y	0.572	0.67
109_D	350_Y	0.572	0.67
106_S	205_D	0.572	0.67
190_N	312_V	0.571	0.67
327_V	330_Y	0.571	0.67
188_G	308_L	0.570	0.67
43_A	178_D	0.569	0.67
161_L	174_A	0.568	0.66
243_P	294_M	0.568	0.66
308_L	314_F	0.566	0.66
222_H	261_G	0.566	0.66
233_L	291_W	0.565	0.66
80_V	84_V	0.565	0.66
197_M	233_L	0.565	0.66
294_M	297_A	0.565	0.66
69_D	72_S	0.564	0.66
263_R	355_L	0.564	0.66
190_N	222_H	0.564	0.66
288_D	291_W	0.563	0.66
289_T	292_Y	0.561	0.65
231_R	234_K	0.560	0.65
46_E	156_H	0.560	0.65
312_V	316_S	0.558	0.65
80_V	88_A	0.556	0.65
307_G	310_P	0.554	0.64
143_N	326_P	0.552	0.64
239_S	297_A	0.551	0.64
311_N	317_A	0.551	0.64
297_A	300_D	0.551	0.64
262_H	334_F	0.551	0.64
113_G	116_D	0.550	0.64
288_D	295_S	0.550	0.64
192_S	217_L	0.549	0.64
192_S	334_F	0.547	0.63
236_V	298_I	0.547	0.63
102_A	127_I	0.546	0.63
32_C	363_V	0.545	0.63
275_L	312_V	0.543	0.63
190_N	334_F	0.543	0.63
106_S	204_A	0.543	0.63
220_S	225_A	0.543	0.63
363_V	366_E	0.542	0.63
286_A	289_T	0.541	0.63
249_D	252_A	0.541	0.63
232_M	236_V	0.541	0.63
192_S	313_D	0.539	0.62
66_F	70_M	0.536	0.62
275_L	279_S	0.535	0.62
65_A	68_A	0.534	0.62
49_L	53_W	0.533	0.61
303_A	307_G	0.533	0.61
120_A	124_G	0.532	0.61
128_T	343_V	0.532	0.61
131_L	134_I	0.530	0.61
141_L	144_G	0.530	0.61
234_K	330_Y	0.529	0.61
195_S	306_K	0.528	0.61
44_S	49_L	0.526	0.60
73_H	213_A	0.525	0.60
71_A	152_D	0.524	0.60
71_A	74_R	0.523	0.60
46_E	67_R	0.523	0.60
203_L	353_N	0.523	0.60
179_Q	281_E	0.523	0.60
34_Y	38_D	0.523	0.60
261_G	313_D	0.522	0.60
42_T	370_S	0.521	0.60
73_H	129_A	0.520	0.60
29_L	33_G	0.519	0.59
127_I	206_V	0.518	0.59
248_Q	251_L	0.517	0.59
145_D	148_V	0.517	0.59
130_K	133_T	0.515	0.59
150_P	154_L	0.515	0.59
27_G	270_P	0.515	0.59
312_V	319_T	0.515	0.59
77_D	105_L	0.515	0.59
28_K	367_D	0.514	0.59
190_N	262_H	0.513	0.59
297_A	301_Y	0.513	0.59
184_H	313_D	0.512	0.58
232_M	258_M	0.512	0.58
135_V	214_I	0.512	0.58
187_H	192_S	0.511	0.58
11_D	14_V	0.511	0.58
81_L	174_A	0.510	0.58
60_R	167_E	0.509	0.58
125_K	132_P	0.506	0.58
176_V	282_L	0.505	0.57
51_L	185_A	0.504	0.57
128_T	340_G	0.504	0.57
303_A	308_L	0.504	0.57
282_L	326_P	0.503	0.57
110_D	126_R	0.502	0.57
346_V	360_A	0.501	0.57
87_L	100_T	0.501	0.57
260_F	302_M	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2h12A	4	0.9947	100	0.039	Contact Map
4xghA	5	0.9122	100	0.041	Contact Map
1o7xA	2	0.9681	100	0.045	Contact Map
2ibpA	2	0.992	100	0.045	Contact Map
1iomA	2	0.984	100	0.046	Contact Map
1vgmA	2	0.9814	100	0.048	Contact Map
3o8jA	3	0.9628	100	0.048	Contact Map
1vgpA	2	0.9787	100	0.053	Contact Map
2ifcA	2	0.984	100	0.053	Contact Map
1aj8A	2	0.9734	100	0.056	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0114 seconds.