GREMLIN Database
Q9HNH1 - Succinate dehydrogenase subunit
UniProt: Q9HNH1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (283)
Sequences: 3033 (2066)
Seq/√Len: 122.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_L223_L5.7621.00
266_D290_N4.2151.00
270_A284_T3.4931.00
259_V269_D3.4401.00
122_H126_T3.4091.00
165_E225_H3.1631.00
48_M63_V3.1001.00
255_V272_F3.0831.00
270_A286_T2.9541.00
41_R76_A2.8881.00
63_V81_I2.7781.00
45_T78_E2.6981.00
39_G43_G2.6421.00
266_D269_D2.5981.00
67_V81_I2.5821.00
46_L228_F2.5581.00
147_N150_R2.5251.00
138_H200_E2.4871.00
65_R216_V2.4711.00
260_E263_D2.4561.00
36_V78_E2.4241.00
164_L168_K2.4091.00
85_A124_T2.3771.00
147_N152_R2.3321.00
224_R231_G2.2551.00
115_S118_E1.9711.00
258_A273_D1.9551.00
117_S124_T1.9201.00
184_Q188_A1.9151.00
259_V293_F1.8971.00
58_N139_Q1.8771.00
95_H106_R1.8651.00
117_S121_A1.8231.00
273_D284_T1.8201.00
95_H105_N1.8161.00
47_Y131_A1.8091.00
117_S120_I1.7801.00
135_V222_V1.7141.00
35_A67_V1.7131.00
148_E152_R1.6751.00
249_S253_G1.6331.00
79_I228_F1.6231.00
125_F188_A1.6221.00
184_Q187_R1.6201.00
105_N138_H1.6091.00
51_A60_V1.6081.00
38_N78_E1.5821.00
45_T80_L1.5791.00
53_D138_H1.5691.00
46_L226_Y1.5661.00
49_Q52_S1.5651.00
55_D95_H1.5611.00
60_V90_F1.5541.00
221_N224_R1.5461.00
259_V263_D1.5141.00
217_T221_N1.5001.00
162_Q165_E1.4971.00
106_R138_H1.4721.00
75_I228_F1.4711.00
111_T118_E1.4621.00
247_Y288_D1.4621.00
223_L226_Y1.4541.00
47_Y134_V1.4491.00
149_V152_R1.4461.00
110_G114_G1.4281.00
270_A273_D1.4231.00
253_G262_G1.4101.00
208_D211_S1.4061.00
66_V219_V1.4031.00
71_D74_E1.3971.00
56_E138_H1.3921.00
293_F309_C1.3901.00
255_V258_A1.3651.00
209_A213_E1.3601.00
105_N198_D1.3581.00
39_G74_E1.3521.00
287_A290_N1.3471.00
149_V153_C1.3401.00
169_V225_H1.3341.00
69_Q220_F1.3321.00
105_N200_E1.3311.00
45_T130_S1.3221.00
52_S136_D1.3021.00
120_I125_F1.2951.00
263_D269_D1.2851.00
39_G75_I1.2801.00
133_L226_Y1.2771.00
50_A63_V1.2701.00
53_D56_E1.2651.00
62_V215_G1.2601.00
184_Q189_G1.2551.00
224_R230_D1.2521.00
276_D280_M1.2490.99
95_H138_H1.2470.99
216_V220_F1.2470.99
70_L75_I1.2430.99
146_I149_V1.2400.99
217_T224_R1.2310.99
19_L80_L1.2250.99
53_D200_E1.2220.99
201_L215_G1.2220.99
219_V223_L1.2130.99
48_M79_I1.2080.99
186_A189_G1.1960.99
211_S214_Y1.1890.99
259_V262_G1.1860.99
65_R209_A1.1800.99
56_E105_N1.1770.99
37_V67_V1.1690.99
53_D136_D1.1540.99
176_L244_F1.1310.99
163_C197_I1.1290.99
118_E124_T1.1210.99
249_S274_V1.1120.99
285_V308_V1.1050.99
56_E200_E1.1030.99
95_H103_K1.1000.99
49_Q124_T1.0980.99
234_D237_E1.0940.99
43_G77_G1.0940.99
106_R200_E1.0920.99
178_Q181_P1.0920.99
258_A270_A1.0800.99
250_P283_A1.0740.98
165_E169_V1.0710.98
109_P114_G1.0710.98
105_N136_D1.0620.98
95_H200_E1.0550.98
147_N153_C1.0450.98
66_V220_F1.0440.98
62_V201_L1.0310.98
185_L188_A1.0270.98
54_G89_A1.0270.98
66_V81_I1.0230.98
253_G256_D1.0220.98
118_E125_F1.0220.98
178_Q182_D1.0210.98
82_V124_T1.0190.98
56_E106_R1.0180.98
147_N155_R1.0120.98
207_W212_I1.0070.98
129_E192_T1.0040.98
136_D200_E1.0010.98
64_R68_P1.0000.98
52_S85_A0.9980.98
121_A125_F0.9920.97
227_G230_D0.9870.97
135_V219_V0.9850.97
96_R100_D0.9820.97
152_R155_R0.9770.97
100_D117_S0.9660.97
71_D75_I0.9640.97
56_E95_H0.9580.97
167_A197_I0.9570.97
37_V74_E0.9550.97
35_A83_G0.9480.97
255_V308_V0.9430.97
48_M81_I0.9410.96
48_M137_L0.9320.96
57_L90_F0.9250.96
76_A227_G0.9120.96
268_G286_T0.9100.96
298_R308_V0.9050.96
222_V226_Y0.9000.95
267_A287_A0.8940.95
117_S125_F0.8920.95
121_A128_A0.8910.95
22_G27_G0.8890.95
182_D188_A0.8870.95
220_F224_R0.8830.95
261_L264_R0.8810.95
137_L292_I0.8810.95
271_L309_C0.8800.95
33_P39_G0.8780.95
210_D214_Y0.8750.95
146_I150_R0.8730.95
296_S309_C0.8720.95
161_S165_E0.8690.95
203_G206_G0.8630.94
49_Q85_A0.8570.94
198_D201_L0.8520.94
133_L166_L0.8490.94
253_G261_L0.8480.94
112_A122_H0.8420.94
106_R198_D0.8420.94
124_T128_A0.8390.93
60_V84_I0.8390.93
20_T31_G0.8370.93
40_A43_G0.8360.93
50_A60_V0.8360.93
247_Y251_A0.8350.93
150_R154_G0.8340.93
137_L199_P0.8330.93
148_E153_C0.8310.93
61_G64_R0.8290.93
201_L211_S0.8270.93
124_T185_L0.8260.93
44_K77_G0.8240.93
84_I90_F0.8230.93
174_H177_D0.8230.93
223_L228_F0.8210.93
48_M219_V0.8150.92
165_E168_K0.8140.92
48_M223_L0.8130.92
119_R123_A0.8120.92
120_I123_A0.8100.92
249_S254_L0.8070.92
135_V197_I0.8050.92
33_P36_V0.8040.92
185_L189_G0.8030.92
233_V236_T0.8020.92
76_A230_D0.8020.92
107_A118_E0.8000.92
69_Q217_T0.7980.92
170_F218_G0.7980.92
54_G103_K0.7980.92
36_V80_L0.7960.91
168_K237_E0.7920.91
251_A254_L0.7860.91
224_R234_D0.7860.91
302_V308_V0.7810.91
107_A121_A0.7710.90
248_G307_Y0.7670.90
21_V25_R0.7650.90
179_K182_D0.7630.90
278_F281_L0.7620.90
118_E121_A0.7600.90
151_V155_R0.7580.89
274_V285_V0.7550.89
141_S144_R0.7520.89
134_V185_L0.7510.89
133_L195_P0.7490.89
70_L79_I0.7490.89
52_S82_V0.7490.89
225_H230_D0.7460.89
224_R229_L0.7440.89
243_E253_G0.7430.88
248_G253_G0.7420.88
148_E151_V0.7420.88
53_D95_H0.7420.88
207_W211_S0.7410.88
221_N225_H0.7380.88
75_I81_I0.7360.88
106_R136_D0.7350.88
166_L197_I0.7350.88
230_D233_V0.7320.88
265_V269_D0.7320.88
253_G257_Y0.7320.88
139_Q206_G0.7320.88
82_V131_A0.7310.88
267_A270_A0.7260.87
127_A130_S0.7230.87
186_A198_D0.7120.86
150_R155_R0.7080.86
274_V286_T0.7020.85
216_V222_V0.7000.85
107_A117_S0.7000.85
45_T132_D0.7000.85
221_N234_D0.6980.85
231_G234_D0.6910.85
36_V39_G0.6900.84
170_F199_P0.6900.84
23_E26_D0.6890.84
260_E270_A0.6870.84
172_T175_V0.6870.84
187_R197_I0.6870.84
53_D105_N0.6850.84
232_D235_T0.6790.84
86_N89_A0.6790.84
246_R249_S0.6780.83
120_I124_T0.6770.83
271_L287_A0.6770.83
261_L308_V0.6730.83
250_P253_G0.6730.83
272_F308_V0.6710.83
61_G209_A0.6710.83
64_R84_I0.6700.83
276_D281_L0.6680.83
238_Q241_A0.6620.82
257_Y272_F0.6590.82
114_G118_E0.6580.82
66_V70_L0.6560.81
267_A290_N0.6540.81
296_S308_V0.6540.81
72_P231_G0.6530.81
117_S128_A0.6520.81
33_P38_N0.6510.81
169_V172_T0.6500.81
59_G83_G0.6490.81
146_I152_R0.6490.81
140_G295_R0.6480.81
144_R295_R0.6420.80
48_M66_V0.6400.80
135_V163_C0.6370.79
265_V287_A0.6360.79
49_Q82_V0.6360.79
245_D288_D0.6350.79
227_G233_V0.6340.79
102_T107_A0.6340.79
89_A150_R0.6280.79
283_A288_D0.6250.78
245_D250_P0.6250.78
238_Q243_E0.6240.78
121_A124_T0.6220.78
184_Q196_T0.6210.78
116_S120_I0.6210.78
267_A289_R0.6200.78
178_Q186_A0.6160.77
40_A71_D0.6150.77
247_Y253_G0.6150.77
109_P125_F0.6130.77
65_R165_E0.6110.77
51_A90_F0.6100.76
125_F192_T0.6100.76
140_G144_R0.6100.76
111_T114_G0.6090.76
123_A127_A0.6090.76
53_D106_R0.6090.76
70_L81_I0.6060.76
23_E31_G0.6040.76
213_E250_P0.6020.76
198_D205_V0.6020.76
46_L133_L0.6010.75
134_V196_T0.6000.75
22_G30_L0.5970.75
138_H198_D0.5960.75
141_S204_C0.5960.75
24_T30_L0.5940.75
221_N231_G0.5900.74
226_Y229_L0.5890.74
48_M135_V0.5890.74
128_A131_A0.5880.74
100_D118_E0.5870.74
49_Q134_V0.5860.74
168_K217_T0.5840.73
57_L297_R0.5840.73
150_R153_C0.5840.73
97_N102_T0.5810.73
256_D275_T0.5790.73
96_R115_S0.5780.73
76_A224_R0.5780.73
103_K186_A0.5770.72
137_L219_V0.5770.72
188_A192_T0.5760.72
217_T220_F0.5750.72
149_V155_R0.5750.72
110_G125_F0.5720.72
233_V237_E0.5720.72
38_N41_R0.5710.72
71_D80_L0.5710.72
147_N151_V0.5710.72
39_G72_P0.5710.72
252_G304_T0.5660.71
139_Q204_C0.5640.71
22_G88_P0.5630.71
32_L120_I0.5620.71
264_R267_A0.5610.70
289_R292_I0.5600.70
230_D234_D0.5590.70
297_R308_V0.5550.70
102_T118_E0.5550.70
239_V242_R0.5540.69
267_A281_L0.5540.69
243_E254_L0.5540.69
26_D30_L0.5530.69
97_N117_S0.5530.69
269_D291_G0.5530.69
167_A175_V0.5510.69
171_G217_T0.5510.69
256_D273_D0.5510.69
54_G59_G0.5500.69
77_G305_G0.5480.69
274_V283_A0.5480.69
166_L226_Y0.5480.69
303_A306_E0.5460.68
165_E233_V0.5460.68
271_L308_V0.5430.68
266_D286_T0.5420.68
216_V219_V0.5420.68
126_T129_E0.5400.67
152_R180_G0.5380.67
128_A192_T0.5370.67
169_V221_N0.5370.67
278_F282_K0.5370.67
110_G121_A0.5340.67
49_Q185_L0.5340.67
202_G215_G0.5330.66
93_A205_V0.5310.66
219_V222_V0.5310.66
227_G231_G0.5300.66
103_K137_L0.5290.66
245_D249_S0.5290.66
243_E252_G0.5290.66
62_V207_W0.5270.66
236_T251_A0.5270.66
250_P256_D0.5260.65
209_A256_D0.5260.65
239_V243_E0.5250.65
267_A308_V0.5250.65
20_T23_E0.5230.65
142_T211_S0.5230.65
44_K268_G0.5210.65
166_L222_V0.5200.65
75_I230_D0.5190.64
168_K171_G0.5180.64
133_L222_V0.5170.64
178_Q198_D0.5170.64
43_G76_A0.5170.64
19_L26_D0.5140.64
146_I296_S0.5140.64
162_Q166_L0.5130.64
215_G223_L0.5110.63
243_E289_R0.5100.63
282_K308_V0.5100.63
68_P191_N0.5090.63
141_S297_R0.5080.63
58_N204_C0.5080.63
23_E27_G0.5040.62
168_K175_V0.5030.62
283_A286_T0.5030.62
246_R253_G0.5020.62
178_Q184_Q0.5010.62
217_T233_V0.5000.62
66_V216_V0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qj8A 2 0.978 100 0.26 Contact Map
3cdxA 4 0.9811 100 0.263 Contact Map
3na6A 4 0.9874 100 0.274 Contact Map
3fmcA 4 0.9277 100 0.296 Contact Map
2bcoA 1 0.9497 100 0.406 Contact Map
1yw4A 1 0.8931 100 0.454 Contact Map
3nh4A 2 0.8239 100 0.468 Contact Map
1yw6A 4 0.9214 100 0.472 Contact Map
2gu2A 3 0.8365 100 0.518 Contact Map
4wckA 1 0.8868 100 0.547 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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