GREMLIN Database
Q9HNH0 - Threonine synthase
UniProt: Q9HNH0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (288)
Sequences: 20115 (10612)
Seq/√Len: 625.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_A137_A3.8601.00
173_A176_S3.2861.00
205_I352_V2.7011.00
310_A338_A2.6761.00
216_A250_L2.6171.00
105_R109_L2.5201.00
143_A164_A2.4981.00
140_Y177_E2.4651.00
105_R193_S2.4211.00
255_A307_D2.4211.00
317_S320_E2.4111.00
147_A151_D2.3911.00
136_D159_T2.3641.00
70_W207_A2.3521.00
113_R138_E2.3171.00
248_R302_D2.2501.00
196_A199_A2.2091.00
138_E159_T2.2051.00
176_S180_G2.1691.00
238_A246_M2.1471.00
256_G308_E2.1421.00
261_A265_N2.1221.00
107_A135_I2.0921.00
70_W208_Q2.0651.00
346_G349_D2.0431.00
231_Y299_T2.0361.00
307_D310_A2.0311.00
332_A353_V2.0181.00
73_L352_V1.9921.00
231_Y249_L1.9501.00
138_E161_V1.9181.00
107_A110_G1.9171.00
104_T133_A1.9011.00
238_A247_P1.8541.00
203_Y233_G1.8221.00
177_E181_S1.7901.00
258_E262_A1.7851.00
318_L325_V1.7721.00
91_S128_Q1.7691.00
217_V234_F1.7651.00
190_W291_Q1.7511.00
198_T236_A1.7351.00
250_L302_D1.7181.00
214_P352_V1.7111.00
215_D349_D1.7101.00
221_V251_G1.6931.00
198_T232_R1.6921.00
252_V335_G1.6781.00
215_D350_D1.6781.00
318_L333_V1.6561.00
175_V179_V1.6421.00
314_A334_A1.6291.00
113_R136_D1.6231.00
187_S190_W1.6201.00
317_S337_A1.6181.00
294_A298_A1.5991.00
217_V230_A1.5771.00
281_I331_V1.5521.00
206_A237_L1.5401.00
202_A230_A1.5261.00
75_S80_D1.5251.00
262_A265_N1.5001.00
82_E317_S1.4991.00
150_L162_P1.4931.00
235_R301_G1.4761.00
83_F355_L1.4721.00
151_D154_E1.4531.00
216_A349_D1.4451.00
212_R350_D1.4291.00
102_L191_S1.4211.00
216_A248_R1.4011.00
202_A234_F1.4001.00
100_A104_T1.3981.00
314_A337_A1.3881.00
118_S123_G1.3841.00
103_M114_V1.3731.00
218_V339_Y1.3681.00
334_A338_A1.3441.00
218_V252_V1.3421.00
262_A266_G1.3401.00
171_T175_V1.3391.00
270_D285_S1.3381.00
261_A305_A1.3351.00
202_A233_G1.2941.00
227_L300_D1.2901.00
255_A305_A1.2791.00
166_G169_A1.2781.00
325_V355_L1.2741.00
150_L154_E1.2691.00
228_L292_V1.2611.00
107_A133_A1.2551.00
161_V173_A1.2441.00
78_E321_A1.2421.00
313_D317_S1.2401.00
258_E305_A1.2281.00
141_V153_M1.2261.00
310_A334_A1.2161.00
82_E320_E1.2161.00
293_A297_A1.2081.00
209_R214_P1.2071.00
314_A333_V1.1971.00
278_A311_T1.1911.00
216_A351_V1.1901.00
76_A83_F1.1861.00
277_A312_T1.1841.00
147_A150_L1.1821.00
306_C334_A1.1751.00
304_V335_G1.1671.00
73_L209_R1.1651.00
178_A185_Y1.1581.00
140_Y173_A1.1541.00
233_G237_L1.1541.00
310_A313_D1.1431.00
234_F247_P1.1401.00
209_R352_V1.1391.00
250_L304_V1.1391.00
74_V85_L1.1251.00
213_A350_D1.1231.00
153_M158_A1.1211.00
232_R294_A1.1181.00
104_T108_A1.1171.00
77_S81_A1.1131.00
72_P88_V1.1031.00
199_A203_Y1.0991.00
105_R108_A1.0941.00
203_Y207_A1.0941.00
258_E261_A1.0921.00
168_R172_E1.0911.00
206_A233_G1.0891.00
78_E81_A1.0841.00
230_A354_A1.0821.00
251_G303_V1.0811.00
73_L205_I1.0811.00
316_A319_H1.0781.00
143_A165_G1.0751.00
266_G269_S1.0741.00
123_G153_M1.0731.00
227_L249_L1.0721.00
173_A177_E1.0681.00
141_V162_P1.0661.00
150_L160_T1.0621.00
216_A345_V1.0591.00
172_E176_S1.0551.00
172_E175_V1.0531.00
209_R350_D1.0531.00
264_V303_V1.0521.00
101_V199_A1.0471.00
239_A246_M1.0471.00
304_V338_A1.0441.00
227_L251_G1.0351.00
109_L193_S1.0351.00
263_A266_G1.0351.00
63_A66_L1.0321.00
144_D165_G1.0291.00
103_M133_A1.0291.00
338_A341_A1.0271.00
345_V349_D1.0201.00
315_L330_A1.0201.00
329_S355_L1.0191.00
63_A101_V1.0061.00
336_L353_V1.0061.00
309_S313_D1.0041.00
205_I214_P1.0041.00
126_V137_A1.0001.00
174_C178_A0.9931.00
169_A172_E0.9901.00
218_V336_L0.9801.00
99_A125_A0.9791.00
261_A303_V0.9791.00
131_A137_A0.9771.00
128_Q156_A0.9731.00
154_E159_T0.9721.00
206_A238_A0.9681.00
175_V178_A0.9641.00
291_Q294_A0.9561.00
167_R170_V0.9501.00
103_M129_Y0.9391.00
113_R183_A0.9391.00
101_V196_A0.9381.00
102_L186_A0.9311.00
116_E139_I0.9291.00
329_S356_T0.9221.00
78_E320_E0.9221.00
114_V130_A0.9191.00
62_D66_L0.9141.00
302_D344_V0.9061.00
101_V104_T0.9061.00
260_V286_P0.9031.00
203_Y237_L0.8981.00
115_V177_E0.8971.00
233_G236_A0.8941.00
218_V250_L0.8911.00
276_E282_Q0.8901.00
248_R301_G0.8901.00
177_E180_G0.8901.00
190_W290_D0.8861.00
127_A158_A0.8841.00
227_L296_V0.8831.00
210_G213_A0.8791.00
151_D155_A0.8751.00
101_V105_R0.8751.00
325_V329_S0.8741.00
221_V227_L0.8731.00
85_L355_L0.8701.00
138_E177_E0.8701.00
115_V174_C0.8691.00
339_Y344_V0.8621.00
71_T89_C0.8581.00
112_D182_D0.8561.00
138_E181_S0.8561.00
67_G100_A0.8541.00
106_A184_W0.8531.00
219_V230_A0.8481.00
277_A308_E0.8401.00
128_Q132_R0.8401.00
232_R236_A0.8391.00
115_V183_A0.8371.00
314_A317_S0.8361.00
216_A339_Y0.8361.00
214_P350_D0.8351.00
125_A129_Y0.8341.00
294_A297_A0.8331.00
248_R349_D0.8301.00
218_V335_G0.8251.00
267_S297_A0.8251.00
260_V296_V0.8211.00
117_D167_R0.8211.00
176_S179_V0.8181.00
325_V330_A0.8161.00
209_R212_R0.8091.00
332_A356_T0.8061.00
324_Y359_G0.8061.00
201_V354_A0.7991.00
197_G201_V0.7971.00
62_D75_S0.7971.00
190_W228_L0.7941.00
201_V226_L0.7881.00
265_N302_D0.7861.00
333_V353_V0.7841.00
105_R196_A0.7841.00
198_T233_G0.7831.00
138_E183_A0.7821.00
296_V300_D0.7771.00
76_A321_A0.7751.00
260_V303_V0.7731.00
337_A341_A0.7721.00
201_V230_A0.7671.00
259_P284_R0.7671.00
77_S80_D0.7671.00
131_A156_A0.7661.00
195_Y292_V0.7651.00
124_A153_M0.7641.00
311_T331_V0.7621.00
113_R177_E0.7621.00
217_V354_A0.7621.00
102_L193_S0.7551.00
165_G169_A0.7551.00
206_A234_F0.7551.00
62_D65_S0.7521.00
281_I328_T0.7511.00
139_I153_M0.7471.00
115_V178_A0.7441.00
285_S290_D0.7391.00
221_V303_V0.7371.00
221_V260_V0.7361.00
220_P356_T0.7351.00
99_A129_Y0.7351.00
114_V135_I0.7261.00
178_A183_A0.7251.00
333_V355_L0.7241.00
191_S194_F0.7231.00
112_D136_D0.7231.00
101_V193_S0.7211.00
102_L194_F0.7191.00
85_L88_V0.7161.00
195_Y232_R0.7121.00
192_P291_Q0.7111.00
216_A346_G0.7101.00
174_C185_Y0.7021.00
79_W337_A0.7021.00
154_E162_P0.7011.00
254_A281_I0.6991.00
76_A333_V0.6971.00
297_A300_D0.6951.00
214_P247_P0.6941.00
92_G358_S0.6921.00
206_A210_G0.6901.00
312_T327_P0.6891.00
196_A232_R0.6891.00
205_I230_A0.6881.00
167_R171_T0.6871.00
84_K204_E0.6851.00
114_V137_A0.6831.00
149_K279_D0.6831.00
143_A162_P0.6821.00
79_W321_A0.6791.00
106_A110_G0.6791.00
113_R181_S0.6771.00
193_S196_A0.6761.00
187_S191_S0.6751.00
69_G90_P0.6721.00
63_A104_T0.6701.00
201_V205_I0.6681.00
137_A158_A0.6681.00
136_D183_A0.6651.00
259_P263_A0.6631.00
217_V247_P0.6601.00
252_V304_V0.6581.00
68_E96_D0.6561.00
259_P262_A0.6531.00
124_A152_A0.6521.00
163_V173_A0.6521.00
145_A279_D0.6471.00
295_A299_T0.6421.00
79_W333_V0.6421.00
262_A269_S0.6411.00
280_G328_T0.6411.00
94_Y226_L0.6411.00
195_Y291_Q0.6381.00
85_L323_L0.6371.00
230_A234_F0.6351.00
302_D339_Y0.6351.00
290_D294_A0.6341.00
178_A181_S0.6331.00
207_A237_L0.6311.00
96_D128_Q0.6291.00
248_R344_V0.6281.00
64_V67_G0.6251.00
171_T174_C0.6151.00
76_A79_W0.6151.00
120_G123_G0.6131.00
75_S350_D0.6131.00
83_F318_L0.6121.00
195_Y295_A0.6111.00
235_R298_A0.6111.00
152_A155_A0.6111.00
213_A238_A0.6091.00
339_Y345_V0.6031.00
271_E274_V0.6031.00
341_A344_V0.6011.00
220_P332_A0.6001.00
140_Y161_V0.6001.00
126_V139_I0.5971.00
206_A209_R0.5971.00
159_T181_S0.5961.00
209_R213_A0.5961.00
318_L355_L0.5951.00
335_G339_Y0.5951.00
76_A80_D0.5951.00
140_Y163_V0.5951.00
235_R299_T0.5941.00
307_D338_A0.5931.00
336_L340_R0.5921.00
73_L208_Q0.5891.00
308_E312_T0.5881.00
315_L327_P0.5871.00
79_W82_E0.5861.00
341_A345_V0.5861.00
251_G300_D0.5861.00
345_V351_V0.5851.00
260_V292_V0.5851.00
71_T84_K0.5831.00
79_W317_S0.5821.00
252_V331_V0.5821.00
127_A137_A0.5821.00
123_G139_I0.5811.00
83_F333_V0.5791.00
141_V150_L0.5791.00
117_D171_T0.5741.00
110_G184_W0.5741.00
318_L323_L0.5731.00
87_Y323_L0.5721.00
161_V177_E0.5721.00
83_F353_V0.5721.00
69_G89_C0.5721.00
250_L339_Y0.5691.00
312_T316_A0.5691.00
340_R345_V0.5681.00
230_A249_L0.5671.00
170_V174_C0.5661.00
219_V227_L0.5641.00
218_V351_V0.5641.00
145_A150_L0.5591.00
83_F87_Y0.5571.00
117_D185_Y0.5571.00
217_V249_L0.5571.00
289_L292_V0.5551.00
144_D162_P0.5541.00
79_W314_A0.5541.00
90_P96_D0.5491.00
256_G274_V0.5491.00
78_E82_E0.5481.00
228_L232_R0.5471.00
91_S156_A0.5471.00
83_F325_V0.5440.99
318_L321_A0.5430.99
162_P165_G0.5430.99
167_R188_H0.5420.99
263_A293_A0.5420.99
87_Y358_S0.5410.99
91_S96_D0.5410.99
116_E126_V0.5360.99
313_D316_A0.5360.99
239_A247_P0.5350.99
98_G102_L0.5330.99
308_E311_T0.5310.99
117_D174_C0.5300.99
166_G170_V0.5300.99
68_E100_A0.5290.99
177_E183_A0.5290.99
113_R159_T0.5270.99
203_Y236_A0.5260.99
250_L301_G0.5240.99
169_A173_A0.5240.99
205_I354_A0.5240.99
306_C335_G0.5230.99
230_A233_G0.5210.99
269_S272_D0.5210.99
306_C331_V0.5200.99
126_V186_A0.5190.99
119_S280_G0.5190.99
256_G275_N0.5140.99
98_G122_A0.5140.99
147_A154_E0.5080.99
293_A300_D0.5060.99
111_V182_D0.5060.99
278_A281_I0.5060.99
99_A126_V0.5060.99
329_S332_A0.5030.99
152_A324_Y0.5020.99
192_P196_A0.5010.99
253_Q259_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e5xA 2 0.9339 100 0.182 Contact Map
2zsjA 2 0.8623 100 0.286 Contact Map
2d1fA 2 0.865 100 0.288 Contact Map
3aeyA 2 0.8595 100 0.289 Contact Map
1tdjA 2 0.8512 100 0.294 Contact Map
3ss7X 1 0.9725 100 0.3 Contact Map
4cooA 2 0.843 100 0.326 Contact Map
2rkbA 2 0.8017 100 0.335 Contact Map
2gn0A 2 0.8595 100 0.335 Contact Map
1v71A 2 0.8264 100 0.336 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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