Q9HNH0 - HALSA - GREMLIN Contacts

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Q9HNH0 - Threonine synthase

UniProt:	Q9HNH0	Sequences: MLVCRSCGATYETGPEEPWRCRACEHAVDFAERPRATGDPTAVDPTAGLWAFSEFLPVAADDAVSLGEGWTPLVSASEWDAEFKLDYVCPSGSYKDRGAAVLMTRAAALGVDRVVEDSSGNAGAAVAQYAARAGIDAEIYVPADAPAAKLDAMEAAGATTVPVAGGRRAVTEACVSEAVGSDAWYASHAWSPSFYAGTATVAYEIAAQRGWRAPDAVVVPVGHGTLLLGAYRGFRALAAGGWIESMPRLLGVQAAGVEPVAAAVNGSASDEDAVNEAADGIQIRSPARLDQVAAAVAATDGDVVACDESATTDALASLHEAGLYVEPTSAVAVAGLAAYRARGVVGDSDDVVVALTGSGLKKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	363 (288)
Sequences:	20115 (10612)
Seq/√Len:	625.3

ECOLI - SDHD ILVA CYSK DPAL TRPB TDCB CYSM DCYD THRC
BACSU - SDHD ILVA TRPB THRC CYSM CYSK MCCA
HALSA - Q9HNH0 Q9HMQ7 Q9HRU4 Q9HNH6 TRPB Q9HQ70 Q9HRP3
SULSO - Q97ZL6 Q97ZT5 Q980P1 TRPB1 TRPB2 Q980F2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
130_A	137_A	3.860	1.00
173_A	176_S	3.286	1.00
205_I	352_V	2.701	1.00
310_A	338_A	2.676	1.00
216_A	250_L	2.617	1.00
105_R	109_L	2.520	1.00
143_A	164_A	2.498	1.00
140_Y	177_E	2.465	1.00
105_R	193_S	2.421	1.00
255_A	307_D	2.421	1.00
317_S	320_E	2.411	1.00
147_A	151_D	2.391	1.00
136_D	159_T	2.364	1.00
70_W	207_A	2.352	1.00
113_R	138_E	2.317	1.00
248_R	302_D	2.250	1.00
196_A	199_A	2.209	1.00
138_E	159_T	2.205	1.00
176_S	180_G	2.169	1.00
238_A	246_M	2.147	1.00
256_G	308_E	2.142	1.00
261_A	265_N	2.122	1.00
107_A	135_I	2.092	1.00
70_W	208_Q	2.065	1.00
346_G	349_D	2.043	1.00
231_Y	299_T	2.036	1.00
307_D	310_A	2.031	1.00
332_A	353_V	2.018	1.00
73_L	352_V	1.992	1.00
231_Y	249_L	1.950	1.00
138_E	161_V	1.918	1.00
107_A	110_G	1.917	1.00
104_T	133_A	1.901	1.00
238_A	247_P	1.854	1.00
203_Y	233_G	1.822	1.00
177_E	181_S	1.790	1.00
258_E	262_A	1.785	1.00
318_L	325_V	1.772	1.00
91_S	128_Q	1.769	1.00
217_V	234_F	1.765	1.00
190_W	291_Q	1.751	1.00
198_T	236_A	1.735	1.00
250_L	302_D	1.718	1.00
214_P	352_V	1.711	1.00
215_D	349_D	1.710	1.00
221_V	251_G	1.693	1.00
198_T	232_R	1.692	1.00
252_V	335_G	1.678	1.00
215_D	350_D	1.678	1.00
318_L	333_V	1.656	1.00
175_V	179_V	1.642	1.00
314_A	334_A	1.629	1.00
113_R	136_D	1.623	1.00
187_S	190_W	1.620	1.00
317_S	337_A	1.618	1.00
294_A	298_A	1.599	1.00
217_V	230_A	1.577	1.00
281_I	331_V	1.552	1.00
206_A	237_L	1.540	1.00
202_A	230_A	1.526	1.00
75_S	80_D	1.525	1.00
262_A	265_N	1.500	1.00
82_E	317_S	1.499	1.00
150_L	162_P	1.493	1.00
235_R	301_G	1.476	1.00
83_F	355_L	1.472	1.00
151_D	154_E	1.453	1.00
216_A	349_D	1.445	1.00
212_R	350_D	1.429	1.00
102_L	191_S	1.421	1.00
216_A	248_R	1.401	1.00
202_A	234_F	1.400	1.00
100_A	104_T	1.398	1.00
314_A	337_A	1.388	1.00
118_S	123_G	1.384	1.00
103_M	114_V	1.373	1.00
218_V	339_Y	1.368	1.00
334_A	338_A	1.344	1.00
218_V	252_V	1.342	1.00
262_A	266_G	1.340	1.00
171_T	175_V	1.339	1.00
270_D	285_S	1.338	1.00
261_A	305_A	1.335	1.00
202_A	233_G	1.294	1.00
227_L	300_D	1.290	1.00
255_A	305_A	1.279	1.00
166_G	169_A	1.278	1.00
325_V	355_L	1.274	1.00
150_L	154_E	1.269	1.00
228_L	292_V	1.261	1.00
107_A	133_A	1.255	1.00
161_V	173_A	1.244	1.00
78_E	321_A	1.242	1.00
313_D	317_S	1.240	1.00
258_E	305_A	1.228	1.00
141_V	153_M	1.226	1.00
310_A	334_A	1.216	1.00
82_E	320_E	1.216	1.00
293_A	297_A	1.208	1.00
209_R	214_P	1.207	1.00
314_A	333_V	1.197	1.00
278_A	311_T	1.191	1.00
216_A	351_V	1.190	1.00
76_A	83_F	1.186	1.00
277_A	312_T	1.184	1.00
147_A	150_L	1.182	1.00
306_C	334_A	1.175	1.00
304_V	335_G	1.167	1.00
73_L	209_R	1.165	1.00
178_A	185_Y	1.158	1.00
140_Y	173_A	1.154	1.00
233_G	237_L	1.154	1.00
310_A	313_D	1.143	1.00
234_F	247_P	1.140	1.00
209_R	352_V	1.139	1.00
250_L	304_V	1.139	1.00
74_V	85_L	1.125	1.00
213_A	350_D	1.123	1.00
153_M	158_A	1.121	1.00
232_R	294_A	1.118	1.00
104_T	108_A	1.117	1.00
77_S	81_A	1.113	1.00
72_P	88_V	1.103	1.00
199_A	203_Y	1.099	1.00
105_R	108_A	1.094	1.00
203_Y	207_A	1.094	1.00
258_E	261_A	1.092	1.00
168_R	172_E	1.091	1.00
206_A	233_G	1.089	1.00
78_E	81_A	1.084	1.00
230_A	354_A	1.082	1.00
251_G	303_V	1.081	1.00
73_L	205_I	1.081	1.00
316_A	319_H	1.078	1.00
143_A	165_G	1.075	1.00
266_G	269_S	1.074	1.00
123_G	153_M	1.073	1.00
227_L	249_L	1.072	1.00
173_A	177_E	1.068	1.00
141_V	162_P	1.066	1.00
150_L	160_T	1.062	1.00
216_A	345_V	1.059	1.00
172_E	176_S	1.055	1.00
172_E	175_V	1.053	1.00
209_R	350_D	1.053	1.00
264_V	303_V	1.052	1.00
101_V	199_A	1.047	1.00
239_A	246_M	1.047	1.00
304_V	338_A	1.044	1.00
227_L	251_G	1.035	1.00
109_L	193_S	1.035	1.00
263_A	266_G	1.035	1.00
63_A	66_L	1.032	1.00
144_D	165_G	1.029	1.00
103_M	133_A	1.029	1.00
338_A	341_A	1.027	1.00
345_V	349_D	1.020	1.00
315_L	330_A	1.020	1.00
329_S	355_L	1.019	1.00
63_A	101_V	1.006	1.00
336_L	353_V	1.006	1.00
309_S	313_D	1.004	1.00
205_I	214_P	1.004	1.00
126_V	137_A	1.000	1.00
174_C	178_A	0.993	1.00
169_A	172_E	0.990	1.00
218_V	336_L	0.980	1.00
99_A	125_A	0.979	1.00
261_A	303_V	0.979	1.00
131_A	137_A	0.977	1.00
128_Q	156_A	0.973	1.00
154_E	159_T	0.972	1.00
206_A	238_A	0.968	1.00
175_V	178_A	0.964	1.00
291_Q	294_A	0.956	1.00
167_R	170_V	0.950	1.00
103_M	129_Y	0.939	1.00
113_R	183_A	0.939	1.00
101_V	196_A	0.938	1.00
102_L	186_A	0.931	1.00
116_E	139_I	0.929	1.00
329_S	356_T	0.922	1.00
78_E	320_E	0.922	1.00
114_V	130_A	0.919	1.00
62_D	66_L	0.914	1.00
302_D	344_V	0.906	1.00
101_V	104_T	0.906	1.00
260_V	286_P	0.903	1.00
203_Y	237_L	0.898	1.00
115_V	177_E	0.897	1.00
233_G	236_A	0.894	1.00
218_V	250_L	0.891	1.00
276_E	282_Q	0.890	1.00
248_R	301_G	0.890	1.00
177_E	180_G	0.890	1.00
190_W	290_D	0.886	1.00
127_A	158_A	0.884	1.00
227_L	296_V	0.883	1.00
210_G	213_A	0.879	1.00
151_D	155_A	0.875	1.00
101_V	105_R	0.875	1.00
325_V	329_S	0.874	1.00
221_V	227_L	0.873	1.00
85_L	355_L	0.870	1.00
138_E	177_E	0.870	1.00
115_V	174_C	0.869	1.00
339_Y	344_V	0.862	1.00
71_T	89_C	0.858	1.00
112_D	182_D	0.856	1.00
138_E	181_S	0.856	1.00
67_G	100_A	0.854	1.00
106_A	184_W	0.853	1.00
219_V	230_A	0.848	1.00
277_A	308_E	0.840	1.00
128_Q	132_R	0.840	1.00
232_R	236_A	0.839	1.00
115_V	183_A	0.837	1.00
314_A	317_S	0.836	1.00
216_A	339_Y	0.836	1.00
214_P	350_D	0.835	1.00
125_A	129_Y	0.834	1.00
294_A	297_A	0.833	1.00
248_R	349_D	0.830	1.00
218_V	335_G	0.825	1.00
267_S	297_A	0.825	1.00
260_V	296_V	0.821	1.00
117_D	167_R	0.821	1.00
176_S	179_V	0.818	1.00
325_V	330_A	0.816	1.00
209_R	212_R	0.809	1.00
332_A	356_T	0.806	1.00
324_Y	359_G	0.806	1.00
201_V	354_A	0.799	1.00
197_G	201_V	0.797	1.00
62_D	75_S	0.797	1.00
190_W	228_L	0.794	1.00
201_V	226_L	0.788	1.00
265_N	302_D	0.786	1.00
333_V	353_V	0.784	1.00
105_R	196_A	0.784	1.00
198_T	233_G	0.783	1.00
138_E	183_A	0.782	1.00
296_V	300_D	0.777	1.00
76_A	321_A	0.775	1.00
260_V	303_V	0.773	1.00
337_A	341_A	0.772	1.00
201_V	230_A	0.767	1.00
259_P	284_R	0.767	1.00
77_S	80_D	0.767	1.00
131_A	156_A	0.766	1.00
195_Y	292_V	0.765	1.00
124_A	153_M	0.764	1.00
311_T	331_V	0.762	1.00
113_R	177_E	0.762	1.00
217_V	354_A	0.762	1.00
102_L	193_S	0.755	1.00
165_G	169_A	0.755	1.00
206_A	234_F	0.755	1.00
62_D	65_S	0.752	1.00
281_I	328_T	0.751	1.00
139_I	153_M	0.747	1.00
115_V	178_A	0.744	1.00
285_S	290_D	0.739	1.00
221_V	303_V	0.737	1.00
221_V	260_V	0.736	1.00
220_P	356_T	0.735	1.00
99_A	129_Y	0.735	1.00
114_V	135_I	0.726	1.00
178_A	183_A	0.725	1.00
333_V	355_L	0.724	1.00
191_S	194_F	0.723	1.00
112_D	136_D	0.723	1.00
101_V	193_S	0.721	1.00
102_L	194_F	0.719	1.00
85_L	88_V	0.716	1.00
195_Y	232_R	0.712	1.00
192_P	291_Q	0.711	1.00
216_A	346_G	0.710	1.00
174_C	185_Y	0.702	1.00
79_W	337_A	0.702	1.00
154_E	162_P	0.701	1.00
254_A	281_I	0.699	1.00
76_A	333_V	0.697	1.00
297_A	300_D	0.695	1.00
214_P	247_P	0.694	1.00
92_G	358_S	0.692	1.00
206_A	210_G	0.690	1.00
312_T	327_P	0.689	1.00
196_A	232_R	0.689	1.00
205_I	230_A	0.688	1.00
167_R	171_T	0.687	1.00
84_K	204_E	0.685	1.00
114_V	137_A	0.683	1.00
149_K	279_D	0.683	1.00
143_A	162_P	0.682	1.00
79_W	321_A	0.679	1.00
106_A	110_G	0.679	1.00
113_R	181_S	0.677	1.00
193_S	196_A	0.676	1.00
187_S	191_S	0.675	1.00
69_G	90_P	0.672	1.00
63_A	104_T	0.670	1.00
201_V	205_I	0.668	1.00
137_A	158_A	0.668	1.00
136_D	183_A	0.665	1.00
259_P	263_A	0.663	1.00
217_V	247_P	0.660	1.00
252_V	304_V	0.658	1.00
68_E	96_D	0.656	1.00
259_P	262_A	0.653	1.00
124_A	152_A	0.652	1.00
163_V	173_A	0.652	1.00
145_A	279_D	0.647	1.00
295_A	299_T	0.642	1.00
79_W	333_V	0.642	1.00
262_A	269_S	0.641	1.00
280_G	328_T	0.641	1.00
94_Y	226_L	0.641	1.00
195_Y	291_Q	0.638	1.00
85_L	323_L	0.637	1.00
230_A	234_F	0.635	1.00
302_D	339_Y	0.635	1.00
290_D	294_A	0.634	1.00
178_A	181_S	0.633	1.00
207_A	237_L	0.631	1.00
96_D	128_Q	0.629	1.00
248_R	344_V	0.628	1.00
64_V	67_G	0.625	1.00
171_T	174_C	0.615	1.00
76_A	79_W	0.615	1.00
120_G	123_G	0.613	1.00
75_S	350_D	0.613	1.00
83_F	318_L	0.612	1.00
195_Y	295_A	0.611	1.00
235_R	298_A	0.611	1.00
152_A	155_A	0.611	1.00
213_A	238_A	0.609	1.00
339_Y	345_V	0.603	1.00
271_E	274_V	0.603	1.00
341_A	344_V	0.601	1.00
220_P	332_A	0.600	1.00
140_Y	161_V	0.600	1.00
126_V	139_I	0.597	1.00
206_A	209_R	0.597	1.00
159_T	181_S	0.596	1.00
209_R	213_A	0.596	1.00
318_L	355_L	0.595	1.00
335_G	339_Y	0.595	1.00
76_A	80_D	0.595	1.00
140_Y	163_V	0.595	1.00
235_R	299_T	0.594	1.00
307_D	338_A	0.593	1.00
336_L	340_R	0.592	1.00
73_L	208_Q	0.589	1.00
308_E	312_T	0.588	1.00
315_L	327_P	0.587	1.00
79_W	82_E	0.586	1.00
341_A	345_V	0.586	1.00
251_G	300_D	0.586	1.00
345_V	351_V	0.585	1.00
260_V	292_V	0.585	1.00
71_T	84_K	0.583	1.00
79_W	317_S	0.582	1.00
252_V	331_V	0.582	1.00
127_A	137_A	0.582	1.00
123_G	139_I	0.581	1.00
83_F	333_V	0.579	1.00
141_V	150_L	0.579	1.00
117_D	171_T	0.574	1.00
110_G	184_W	0.574	1.00
318_L	323_L	0.573	1.00
87_Y	323_L	0.572	1.00
161_V	177_E	0.572	1.00
83_F	353_V	0.572	1.00
69_G	89_C	0.572	1.00
250_L	339_Y	0.569	1.00
312_T	316_A	0.569	1.00
340_R	345_V	0.568	1.00
230_A	249_L	0.567	1.00
170_V	174_C	0.566	1.00
219_V	227_L	0.564	1.00
218_V	351_V	0.564	1.00
145_A	150_L	0.559	1.00
83_F	87_Y	0.557	1.00
117_D	185_Y	0.557	1.00
217_V	249_L	0.557	1.00
289_L	292_V	0.555	1.00
144_D	162_P	0.554	1.00
79_W	314_A	0.554	1.00
90_P	96_D	0.549	1.00
256_G	274_V	0.549	1.00
78_E	82_E	0.548	1.00
228_L	232_R	0.547	1.00
91_S	156_A	0.547	1.00
83_F	325_V	0.544	0.99
318_L	321_A	0.543	0.99
162_P	165_G	0.543	0.99
167_R	188_H	0.542	0.99
263_A	293_A	0.542	0.99
87_Y	358_S	0.541	0.99
91_S	96_D	0.541	0.99
116_E	126_V	0.536	0.99
313_D	316_A	0.536	0.99
239_A	247_P	0.535	0.99
98_G	102_L	0.533	0.99
308_E	311_T	0.531	0.99
117_D	174_C	0.530	0.99
166_G	170_V	0.530	0.99
68_E	100_A	0.529	0.99
177_E	183_A	0.529	0.99
113_R	159_T	0.527	0.99
203_Y	236_A	0.526	0.99
250_L	301_G	0.524	0.99
169_A	173_A	0.524	0.99
205_I	354_A	0.524	0.99
306_C	335_G	0.523	0.99
230_A	233_G	0.521	0.99
269_S	272_D	0.521	0.99
306_C	331_V	0.520	0.99
126_V	186_A	0.519	0.99
119_S	280_G	0.519	0.99
256_G	275_N	0.514	0.99
98_G	122_A	0.514	0.99
147_A	154_E	0.508	0.99
293_A	300_D	0.506	0.99
111_V	182_D	0.506	0.99
278_A	281_I	0.506	0.99
99_A	126_V	0.506	0.99
329_S	332_A	0.503	0.99
152_A	324_Y	0.502	0.99
192_P	196_A	0.501	0.99
253_Q	259_P	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1e5xA	2	0.9339	100	0.182	Contact Map
2zsjA	2	0.8623	100	0.286	Contact Map
2d1fA	2	0.865	100	0.288	Contact Map
3aeyA	2	0.8595	100	0.289	Contact Map
1tdjA	2	0.8512	100	0.294	Contact Map
3ss7X	1	0.9725	100	0.3	Contact Map
4cooA	2	0.843	100	0.326	Contact Map
2rkbA	2	0.8017	100	0.335	Contact Map
2gn0A	2	0.8595	100	0.335	Contact Map
1v71A	2	0.8264	100	0.336	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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