GREMLIN Database
Q9HNG8 - tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS
UniProt: Q9HNG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (406)
Sequences: 222 (173)
Seq/√Len: 8.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_D409_R4.5260.99
22_A243_F4.4400.99
89_N137_T4.0250.98
302_E305_K3.9670.98
220_D409_R3.5550.96
359_E368_R3.3210.94
271_G289_I3.2220.93
48_V115_D3.0830.91
170_W209_T2.8930.88
118_P142_V2.8820.87
343_R383_L2.7690.85
303_P308_R2.6710.83
188_A192_A2.6620.83
302_E308_R2.6140.81
307_F396_P2.5770.80
303_P399_A2.5480.80
77_V92_V2.5240.79
302_E307_F2.4930.78
250_D335_K2.4820.78
125_A132_T2.4480.77
7_D10_D2.4310.76
73_A94_V2.3260.73
194_D395_V2.2710.71
394_E400_R2.1520.67
167_R170_W2.1320.66
112_L154_F2.1170.65
44_L146_A2.0780.64
130_Y149_G2.0780.64
171_G235_E2.0720.64
193_W204_V2.0590.63
394_E407_L2.0230.62
287_V298_C2.0040.61
279_T312_R1.9920.60
350_V357_T1.9870.60
311_V336_F1.9710.60
156_D220_D1.9700.59
47_A325_E1.9570.59
110_R114_A1.9450.58
300_A394_E1.9300.58
286_F299_V1.9020.57
107_F145_L1.9010.57
184_A195_T1.8980.56
173_T238_H1.8680.55
22_A58_L1.8540.55
49_A264_G1.8000.52
9_T20_Y1.7920.52
192_A228_V1.7910.52
204_V397_P1.7890.52
308_R335_K1.7610.51
23_H239_A1.7610.51
200_E398_C1.7550.50
271_G296_L1.7540.50
298_C322_A1.7520.50
253_L268_R1.7510.50
16_M20_Y1.7380.50
89_N136_G1.7300.49
70_F94_V1.7250.49
154_F251_A1.7190.49
114_A265_R1.7130.49
400_R404_A1.7030.48
305_K396_P1.6940.48
308_R396_P1.6850.47
177_D304_T1.6740.47
163_Q215_Y1.6550.46
307_F335_K1.6500.46
256_A259_A1.6440.46
58_L286_F1.6310.45
225_V242_L1.6030.44
321_T337_A1.6000.44
193_W205_C1.5880.43
8_D11_S1.5490.42
195_T205_C1.5340.41
300_A400_R1.5230.41
39_V241_E1.5190.41
165_R174_R1.5180.40
107_F121_A1.5130.40
214_L235_E1.5120.40
396_P400_R1.5050.40
50_Y88_T1.5010.40
313_N387_A1.4900.39
296_L331_L1.4890.39
201_D270_E1.4830.39
141_V195_T1.4780.39
303_P335_K1.4750.39
261_A326_V1.4720.39
184_A228_V1.4680.38
299_V330_T1.4660.38
369_C372_C1.4610.38
48_V264_G1.4440.37
138_G162_I1.4340.37
112_L254_A1.4330.37
291_D326_V1.4250.37
122_A134_G1.4250.37
110_R120_D1.4210.37
222_A359_E1.4120.36
115_D211_G1.4050.36
213_I398_C1.4030.36
88_T136_G1.4020.36
335_K400_R1.3800.35
280_R286_F1.3760.35
335_K396_P1.3680.34
80_H114_A1.3670.34
76_V80_H1.3600.34
208_H343_R1.3560.34
338_V341_L1.3510.34
303_P307_F1.3500.34
161_C225_V1.3420.34
4_V25_V1.3390.33
171_G407_L1.3390.33
304_T399_A1.3270.33
47_A232_I1.3270.33
320_I364_T1.3150.32
305_K308_R1.3100.32
291_D294_A1.3090.32
81_A190_P1.3070.32
88_T395_V1.3060.32
356_T409_R1.3050.32
21_A48_V1.2980.32
272_V373_S1.2910.32
42_V142_V1.2830.31
61_H327_A1.2820.31
192_A242_L1.2800.31
190_P312_R1.2790.31
112_L251_A1.2790.31
56_A122_A1.2740.31
352_P374_T1.2730.31
200_E215_Y1.2700.31
244_V320_I1.2680.31
326_V352_P1.2650.31
50_Y327_A1.2430.30
128_H289_I1.2410.30
30_R238_H1.2370.30
184_A193_W1.2370.30
45_N51_K1.2360.30
42_V145_L1.2340.30
91_G138_G1.2330.30
251_A292_G1.2290.29
310_H336_F1.2280.29
5_A8_D1.2160.29
34_C239_A1.2160.29
16_M107_F1.2120.29
174_R318_D1.2110.29
190_P397_P1.2100.29
89_N122_A1.2070.29
27_E117_D1.1990.28
166_P236_P1.1980.28
9_T401_R1.1890.28
263_D301_F1.1860.28
196_V397_P1.1840.28
39_V49_A1.1830.28
20_Y88_T1.1810.28
117_D142_V1.1770.28
259_A269_V1.1760.28
209_T264_G1.1760.28
4_V370_R1.1660.27
245_T250_D1.1640.27
92_V133_A1.1620.27
303_P396_P1.1590.27
176_V234_S1.1590.27
89_N305_K1.1560.27
45_N164_Y1.1560.27
139_R142_V1.1530.27
108_A125_A1.1490.27
125_A130_Y1.1490.27
315_R342_T1.1470.27
15_G358_M1.1460.27
92_V376_A1.1420.26
252_H334_E1.1380.26
51_K164_Y1.1330.26
323_C392_W1.1320.26
305_K335_K1.1310.26
88_T400_R1.1310.26
174_R235_E1.1310.26
122_A364_T1.1300.26
88_T300_A1.1250.26
42_V108_A1.1230.26
248_G401_R1.1180.26
7_D19_T1.1180.26
10_D17_C1.1180.26
7_D17_C1.1180.26
10_D19_T1.1180.26
9_T400_R1.1150.26
222_A370_R1.1100.25
274_A316_P1.1040.25
302_E396_P1.1000.25
70_F131_R1.0950.25
202_D211_G1.0930.25
3_V368_R1.0910.25
3_V58_L1.0860.25
9_T88_T1.0800.24
195_T215_Y1.0800.24
232_I320_I1.0790.24
338_V383_L1.0780.24
8_D140_G1.0780.24
395_V400_R1.0740.24
49_A112_L1.0700.24
270_E321_T1.0650.24
192_A195_T1.0580.24
271_G287_V1.0570.24
194_D394_E1.0510.23
335_K394_E1.0490.23
349_P358_M1.0470.23
250_D396_P1.0450.23
6_L258_L1.0430.23
3_V59_A1.0410.23
110_R116_I1.0360.23
211_G398_C1.0300.23
301_F327_A1.0290.23
301_F332_K1.0280.23
88_T394_E1.0250.23
180_S298_C1.0190.23
56_A134_G1.0120.22
58_L94_V1.0080.22
208_H242_L1.0070.22
228_V332_K1.0060.22
262_R274_A1.0020.22
49_A58_L0.9990.22
10_D18_T0.9990.22
7_D18_T0.9990.22
386_R393_Y0.9980.22
4_V110_R0.9970.22
194_D400_R0.9960.22
108_A251_A0.9940.22
189_Y397_P0.9900.22
290_T295_T0.9890.22
37_H40_L0.9830.21
332_K399_A0.9820.21
23_H243_F0.9820.21
279_T365_Q0.9810.21
275_D288_P0.9800.21
207_P284_H0.9780.21
116_I181_V0.9760.21
35_T62_A0.9750.21
37_H102_A0.9690.21
31_A238_H0.9560.21
365_Q374_T0.9500.21
6_L260_D0.9460.20
179_D340_G0.9440.20
367_Y391_G0.9430.20
308_R394_E0.9390.20
214_L245_T0.9350.20
169_R243_F0.9310.20
342_T345_T0.9290.20
87_R213_I0.9240.20
258_L291_D0.9190.20
77_V258_L0.9180.20
110_R142_V0.9160.20
5_A10_D0.9150.20
50_Y118_P0.9120.20
5_A148_V0.9120.20
111_A116_I0.9110.19
275_D281_E0.9100.19
60_V285_V0.9060.19
16_M358_M0.9050.19
303_P332_K0.9050.19
299_V342_T0.9050.19
265_R359_E0.9040.19
137_T208_H0.9030.19
180_S399_A0.9030.19
315_R344_T0.9030.19
394_E404_A0.9030.19
361_A365_Q0.9030.19
220_D356_T0.8950.19
180_S214_L0.8950.19
57_A107_F0.8930.19
157_W244_V0.8900.19
162_I333_L0.8900.19
304_T395_V0.8890.19
191_A224_A0.8870.19
145_L397_P0.8850.19
121_A145_L0.8850.19
296_L326_V0.8850.19
6_L77_V0.8830.19
201_D384_I0.8800.19
50_Y395_V0.8750.19
4_V29_L0.8710.18
182_F196_V0.8650.18
25_V76_V0.8650.18
209_T400_R0.8640.18
104_V145_L0.8630.18
69_G363_A0.8630.18
7_D11_S0.8570.18
22_A25_V0.8560.18
320_I338_V0.8540.18
307_F311_V0.8520.18
114_A119_A0.8500.18
29_L34_C0.8480.18
221_D230_A0.8450.18
47_A211_G0.8430.18
194_D204_V0.8420.18
16_M108_A0.8420.18
215_Y229_A0.8420.18
245_T308_R0.8400.18
210_P309_D0.8390.18
302_E400_R0.8390.18
314_L318_D0.8390.18
209_T325_E0.8320.17
72_T147_A0.8310.17
89_N170_W0.8300.17
25_V29_L0.8290.17
149_G211_G0.8280.17
307_F394_E0.8280.17
112_L358_M0.8230.17
108_A286_F0.8230.17
36_V166_P0.8230.17
88_T245_T0.8210.17
48_V368_R0.8200.17
254_A325_E0.8200.17
184_A225_V0.8180.17
75_R297_A0.8170.17
345_T382_R0.8150.17
184_A205_C0.8140.17
142_V405_Q0.8130.17
250_D323_C0.8090.17
27_E159_Y0.8080.17
245_T335_K0.8080.17
44_L57_A0.8080.17
89_N118_P0.8070.17
322_A391_G0.8030.17
288_P295_T0.8020.17
42_V110_R0.7990.17
210_P284_H0.7950.17
3_V56_A0.7950.17
192_A403_I0.7950.17
75_R179_D0.7930.17
300_A396_P0.7920.17
56_A94_V0.7920.17
195_T206_V0.7910.16
289_I384_I0.7890.16
250_D307_F0.7880.16
139_R250_D0.7860.16
308_R311_V0.7840.16
250_D267_Y0.7840.16
267_Y409_R0.7830.16
150_A368_R0.7830.16
70_F73_A0.7820.16
35_T65_D0.7810.16
286_F330_T0.7800.16
9_T300_A0.7800.16
184_A307_F0.7770.16
33_G331_L0.7770.16
193_W333_L0.7760.16
254_A266_G0.7720.16
124_L145_L0.7720.16
209_T394_E0.7700.16
170_W320_I0.7690.16
20_Y194_D0.7680.16
40_L162_I0.7670.16
193_W401_R0.7660.16
291_D368_R0.7650.16
44_L349_P0.7640.16
109_H112_L0.7630.16
67_Q142_V0.7630.16
93_V308_R0.7620.16
311_V361_A0.7620.16
27_E385_E0.7590.16
283_G348_T0.7560.16
159_Y291_D0.7560.16
56_A126_A0.7550.16
347_T380_A0.7540.16
361_A366_G0.7540.16
208_H244_V0.7450.15
396_P399_A0.7420.15
273_V318_D0.7400.15
226_Q405_Q0.7400.15
174_R366_G0.7390.15
178_A181_V0.7380.15
173_T233_D0.7380.15
90_P140_G0.7330.15
108_A150_A0.7330.15
210_P361_A0.7280.15
270_E319_R0.7260.15
300_A307_F0.7240.15
81_A352_P0.7220.15
6_L200_E0.7200.15
194_D404_A0.7200.15
147_A163_Q0.7170.15
134_G141_V0.7130.15
302_E335_K0.7120.15
185_A280_R0.7110.15
304_T393_Y0.7100.15
223_D227_A0.7070.15
302_E399_A0.7070.15
88_T194_D0.7030.15
4_V263_D0.7010.14
159_Y181_V0.7000.14
118_P227_A0.6990.14
165_R211_G0.6970.14
345_T363_A0.6960.14
228_V403_I0.6950.14
302_E329_G0.6920.14
125_A347_T0.6920.14
300_A333_L0.6910.14
21_A76_V0.6900.14
138_G141_V0.6870.14
193_W409_R0.6830.14
112_L266_G0.6810.14
260_D276_H0.6800.14
102_A127_A0.6800.14
111_A146_A0.6790.14
75_R243_F0.6780.14
43_R46_P0.6780.14
52_T55_N0.6780.14
46_P55_N0.6780.14
43_R52_T0.6780.14
46_P54_G0.6780.14
43_R54_G0.6780.14
46_P52_T0.6780.14
43_R55_N0.6780.14
87_R201_D0.6760.14
8_D90_P0.6750.14
74_R133_A0.6740.14
250_D394_E0.6730.14
134_G162_I0.6710.14
141_V359_E0.6700.14
126_A173_T0.6700.14
122_A167_R0.6700.14
147_A197_D0.6680.14
12_R368_R0.6680.14
233_D331_L0.6680.14
3_V159_Y0.6670.14
188_A213_I0.6670.14
39_V161_C0.6650.14
317_G334_E0.6600.14
169_R374_T0.6590.14
91_G303_P0.6590.14
29_L70_F0.6590.14
40_L138_G0.6520.13
67_Q213_I0.6490.13
118_P281_E0.6490.13
405_Q411_D0.6470.13
56_A404_A0.6450.13
5_A217_I0.6440.13
264_G392_W0.6440.13
202_D241_E0.6430.13
221_D301_F0.6420.13
258_L382_R0.6410.13
323_C395_V0.6390.13
204_V267_Y0.6380.13
109_H113_R0.6370.13
204_V211_G0.6370.13
11_S15_G0.6360.13
250_D300_A0.6350.13
15_G210_P0.6340.13
57_A329_G0.6330.13
234_S340_G0.6310.13
37_H244_V0.6310.13
307_F400_R0.6310.13
89_N141_V0.6310.13
25_V343_R0.6290.13
142_V267_Y0.6280.13
139_R267_Y0.6280.13
147_A162_I0.6280.13
88_T267_Y0.6230.13
227_A230_A0.6220.13
113_R355_G0.6210.13
311_V395_V0.6200.13
247_Q360_S0.6200.13
242_L390_P0.6190.13
74_R231_D0.6190.13
202_D205_C0.6170.13
67_Q281_E0.6160.13
76_V346_P0.6150.13
108_A411_D0.6140.13
20_Y395_V0.6080.13
156_D356_T0.6070.13
71_D382_R0.6050.13
221_D344_T0.6050.13
117_D272_V0.6050.13
93_V173_T0.6050.13
314_L386_R0.6040.13
108_A149_G0.6040.13
33_G145_L0.6030.13
308_R400_R0.6020.13
12_R85_D0.6010.12
102_A105_A0.6000.12
159_Y222_A0.6000.12
301_F368_R0.6000.12
397_P408_V0.5980.12
145_L196_V0.5970.12
44_L111_A0.5970.12
379_T389_D0.5950.12
87_R301_F0.5940.12
95_A101_P0.5940.12
220_D371_D0.5930.12
249_T283_G0.5930.12
230_A388_L0.5910.12
173_T375_T0.5910.12
64_V162_I0.5890.12
20_Y307_F0.5890.12
374_T398_C0.5880.12
257_P276_H0.5860.12
308_R399_A0.5840.12
49_A209_T0.5830.12
273_V355_G0.5830.12
89_N167_R0.5820.12
274_A384_I0.5810.12
77_V91_G0.5810.12
29_L72_T0.5800.12
112_L148_V0.5800.12
50_Y301_F0.5800.12
163_Q242_L0.5800.12
365_Q368_R0.5790.12
131_R232_I0.5750.12
232_I316_P0.5750.12
16_M194_D0.5750.12
39_V116_I0.5740.12
141_V205_C0.5730.12
254_A357_T0.5720.12
319_R350_V0.5720.12
80_H112_L0.5720.12
16_M395_V0.5710.12
189_Y267_Y0.5700.12
29_L210_P0.5700.12
250_D308_R0.5700.12
351_C372_C0.5700.12
351_C369_C0.5700.12
20_Y400_R0.5690.12
89_N209_T0.5670.12
304_T386_R0.5660.12
405_Q410_G0.5650.12
91_G142_V0.5630.12
102_A385_E0.5630.12
196_V267_Y0.5610.12
193_W240_R0.5600.12
301_F366_G0.5600.12
347_T382_R0.5600.12
171_G210_P0.5580.12
4_V291_D0.5580.12
9_T21_A0.5580.12
97_D100_A0.5570.12
41_L55_N0.5570.12
41_L54_G0.5570.12
41_L52_T0.5570.12
41_L46_P0.5570.12
122_A383_L0.5570.12
141_V358_M0.5550.12
298_C333_L0.5550.12
335_K404_A0.5550.12
112_L322_A0.5540.12
169_R363_A0.5530.12
204_V263_D0.5530.12
77_V215_Y0.5510.12
307_F404_A0.5510.12
21_A209_T0.5510.12
157_W185_A0.5500.12
20_Y89_N0.5490.12
185_A332_K0.5490.12
101_P128_H0.5480.12
112_L265_R0.5470.12
133_A326_V0.5460.12
15_G139_R0.5460.12
71_D389_D0.5450.11
113_R116_I0.5450.11
308_R332_K0.5430.11
300_A303_P0.5420.11
25_V112_L0.5420.11
131_R173_T0.5410.11
167_R311_V0.5390.11
180_S304_T0.5380.11
257_P260_D0.5380.11
22_A60_V0.5370.11
366_G391_G0.5350.11
172_T235_E0.5350.11
149_G209_T0.5340.11
136_G305_K0.5340.11
111_A398_C0.5330.11
366_G405_Q0.5330.11
211_G327_A0.5330.11
259_A262_R0.5320.11
20_Y50_Y0.5320.11
66_P269_V0.5310.11
19_T41_L0.5280.11
17_C41_L0.5280.11
248_G367_Y0.5280.11
56_A133_A0.5270.11
49_A83_T0.5270.11
58_L85_D0.5270.11
311_V408_V0.5250.11
81_A154_F0.5240.11
4_V68_V0.5240.11
221_D276_H0.5230.11
180_S235_E0.5220.11
320_I340_G0.5210.11
136_G395_V0.5210.11
23_H213_I0.5210.11
286_F297_A0.5190.11
214_L335_K0.5180.11
60_V124_L0.5180.11
210_P319_R0.5180.11
173_T231_D0.5170.11
141_V266_G0.5170.11
197_D304_T0.5150.11
217_I245_T0.5150.11
119_A127_A0.5120.11
24_L33_G0.5120.11
117_D328_D0.5110.11
46_P53_R0.5070.11
43_R53_R0.5070.11
82_E112_L0.5060.11
95_A104_V0.5050.11
351_C354_C0.5040.11
196_V408_V0.5030.11
248_G266_G0.5030.11
307_F395_V0.5030.11
323_C335_K0.5010.11
361_A368_R0.5010.11
318_D386_R0.5010.11
109_H231_D0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3au7A 1 0.8333 100 0.213 Contact Map
3u02A 3 0.5833 100 0.481 Contact Map
4gnxB 1 0.2762 97.3 0.957 Contact Map
3e0eA 1 0.1976 97.1 0.958 Contact Map
3kdfD 2 0.269 95.5 0.964 Contact Map
4gn4B 1 0.2214 95.3 0.965 Contact Map
4joiA 1 0.3119 94.8 0.966 Contact Map
2k50A 1 0.2286 94.7 0.966 Contact Map
1vd4A 1 0.131 94 0.967 Contact Map
3dm3A 4 0.2024 93.9 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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