GREMLIN Database
Y2112 - Putative HTH-type transcriptional regulatory protein VNG_2112C
UniProt: Q9HNG7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (305)
Sequences: 151 (119)
Seq/√Len: 6.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_L54_F4.4700.98
19_F48_L3.9810.95
7_I169_E2.8470.79
182_L307_L2.7810.77
32_F233_F2.7800.77
303_D307_L2.7730.77
97_P166_A2.5660.71
113_P179_G2.3820.65
75_V128_D2.3270.63
66_G259_K2.3200.63
76_V104_A2.2960.62
73_P171_A2.2840.61
104_A271_T2.2250.59
51_I129_G2.2130.59
45_M225_V2.1940.58
144_G154_R2.1260.56
74_L116_V2.1090.55
45_M309_D2.0750.54
100_N299_A2.0610.53
237_G292_I2.0540.53
88_G106_E2.0460.53
74_L169_E1.9610.49
132_L307_L1.9540.49
32_F77_G1.9490.49
120_P155_R1.9410.49
141_L260_R1.9360.49
182_L230_Q1.9340.48
97_P178_F1.9310.48
34_V214_V1.9220.48
183_T307_L1.9140.48
31_S81_R1.8950.47
146_L157_V1.8890.47
214_V298_L1.8770.46
51_I278_V1.8770.46
58_T264_M1.8080.44
32_F93_R1.8080.44
110_D116_V1.7930.43
73_P137_E1.7580.42
43_V108_F1.7470.41
129_G177_L1.7430.41
52_D77_G1.6960.40
296_E299_A1.6840.39
31_S58_T1.6460.38
157_V178_F1.6380.37
267_V285_E1.6200.37
44_L228_T1.6180.37
128_D184_A1.6110.37
73_P125_V1.5920.36
77_G122_G1.5850.36
128_D276_V1.5400.34
127_I182_L1.5370.34
90_V103_T1.5360.34
144_G155_R1.5350.34
62_M307_L1.5190.33
77_G118_A1.5180.33
76_V305_E1.5170.33
32_F50_N1.5140.33
267_V296_E1.5070.33
76_V223_F1.5050.33
182_L294_E1.4990.33
207_A288_D1.4970.33
172_M218_L1.4820.32
52_D122_G1.4780.32
260_R277_Y1.4650.32
65_L237_G1.4400.31
74_L167_S1.4400.31
29_P120_P1.4360.31
19_F198_T1.4260.30
54_F128_D1.4100.30
50_N77_G1.4090.30
61_E297_E1.4070.30
86_D121_G1.3920.29
77_G222_G1.3870.29
150_L178_F1.3800.29
182_L295_R1.3780.29
91_Y103_T1.3660.28
139_E178_F1.3650.28
116_V311_L1.3590.28
108_F123_L1.3570.28
76_V134_D1.3300.27
96_V236_V1.3270.27
107_L116_V1.3210.27
114_P232_P1.3150.27
101_P177_L1.3100.27
140_R278_V1.3100.27
246_L306_D1.3040.27
248_T261_A1.2890.26
99_F116_V1.2850.26
32_F175_E1.2800.26
105_M189_M1.2770.26
140_R285_E1.2710.26
25_C123_L1.2670.25
21_V69_L1.2630.25
98_V159_K1.2620.25
52_D233_F1.2550.25
306_D312_A1.2520.25
252_A305_E1.2490.25
77_G233_F1.2480.25
3_R214_V1.2320.25
52_D247_L1.2270.24
86_D122_G1.2230.24
167_S187_D1.2100.24
54_F230_Q1.2080.24
51_I182_L1.2040.24
47_V194_D1.2000.24
43_V280_D1.1970.24
147_A171_A1.1920.23
132_L170_V1.1900.23
48_L75_V1.1900.23
153_S258_V1.1860.23
220_R230_Q1.1760.23
73_P223_F1.1760.23
178_F262_R1.1700.23
66_G96_V1.1690.23
66_G260_R1.1660.23
51_I77_G1.1650.23
80_T231_A1.1630.23
299_A307_L1.1620.23
137_E171_A1.1600.23
90_V134_D1.1570.22
67_T285_E1.1480.22
31_S290_T1.1450.22
81_R159_K1.1440.22
58_T155_R1.1430.22
121_G124_Y1.1420.22
98_V273_T1.1390.22
248_T276_V1.1370.22
62_M82_D1.1350.22
166_A286_S1.1350.22
127_I148_S1.1330.22
174_L182_L1.1330.22
120_P158_S1.1250.22
43_V153_S1.1220.22
29_P158_S1.1220.22
44_L181_E1.1130.21
8_E311_L1.1130.21
173_R256_A1.1090.21
102_D274_R1.1080.21
104_A107_L1.1020.21
256_A311_L1.1000.21
175_E233_F1.1000.21
93_R175_E1.0970.21
100_N211_D1.0950.21
122_G248_T1.0920.21
71_A175_E1.0910.21
93_R233_F1.0830.21
147_A225_V1.0810.21
22_S232_P1.0790.20
37_R97_P1.0770.20
3_R169_E1.0770.20
131_V292_I1.0740.20
98_V186_V1.0690.20
32_F51_I1.0650.20
251_S290_T1.0640.20
173_R251_S1.0570.20
54_F78_L1.0500.20
19_F38_R1.0410.20
61_E193_E1.0400.20
163_G174_L1.0360.19
187_D285_E1.0340.19
81_R98_V1.0330.19
34_V204_D1.0330.19
164_M266_S1.0230.19
16_D74_L1.0190.19
105_M260_R1.0180.19
48_L77_G1.0170.19
148_S269_E1.0150.19
95_G270_V1.0100.19
10_V244_D1.0090.19
86_D116_V1.0040.19
26_A83_E1.0030.19
7_I258_V1.0010.19
116_V280_D0.9960.19
103_T125_V0.9940.18
77_G93_R0.9910.18
75_V277_Y0.9890.18
37_R166_A0.9820.18
67_T134_D0.9760.18
32_F114_P0.9760.18
100_N126_N0.9760.18
31_S82_D0.9740.18
12_A268_G0.9710.18
79_R268_G0.9700.18
153_S233_F0.9690.18
110_D147_A0.9690.18
136_R142_S0.9640.18
25_C158_S0.9630.18
35_A264_M0.9580.18
123_L164_M0.9550.18
32_F52_D0.9520.18
38_R53_A0.9520.18
96_V192_A0.9510.18
81_R156_T0.9510.18
44_L234_K0.9510.18
279_V307_L0.9410.17
305_E313_D0.9370.17
175_E235_A0.9350.17
52_D222_G0.9300.17
106_E151_G0.9280.17
169_E287_V0.9250.17
50_N233_F0.9250.17
97_P297_E0.9250.17
48_L297_E0.9240.17
95_G124_Y0.9240.17
21_V274_R0.9230.17
21_V144_G0.9070.17
181_E185_P0.9070.17
116_V146_L0.9030.16
81_R290_T0.8990.16
154_R222_G0.8970.16
197_D267_V0.8960.16
56_A96_V0.8870.16
89_V313_D0.8850.16
78_L268_G0.8840.16
115_L263_I0.8810.16
17_A29_P0.8760.16
182_L279_V0.8720.16
51_I99_F0.8720.16
267_V293_V0.8700.16
120_P162_D0.8700.16
155_R158_S0.8660.16
88_G231_A0.8650.16
168_I239_A0.8630.16
132_L248_T0.8590.16
72_T277_Y0.8540.15
62_M173_R0.8510.15
51_I233_F0.8490.15
81_R118_A0.8480.15
54_F75_V0.8480.15
144_G204_D0.8470.15
35_A65_L0.8450.15
194_D214_V0.8390.15
143_L185_P0.8370.15
53_A159_K0.8320.15
245_R283_G0.8320.15
14_L236_V0.8300.15
168_I308_R0.8300.15
44_L227_P0.8280.15
124_Y143_L0.8280.15
105_M267_V0.8250.15
92_F120_P0.8160.15
237_G249_G0.8150.15
18_G180_G0.8130.15
26_A76_V0.8090.15
47_V219_A0.8080.15
138_D162_D0.8070.15
115_L178_F0.8060.15
100_N296_E0.8050.15
14_L48_L0.8050.15
196_R278_V0.8050.15
231_A247_L0.8050.15
63_R306_D0.8000.14
99_F312_A0.7990.14
71_A79_R0.7980.14
69_L268_G0.7970.14
144_G151_G0.7970.14
223_F297_E0.7900.14
123_L290_T0.7900.14
101_P178_F0.7880.14
55_D275_A0.7860.14
130_D230_Q0.7840.14
42_V135_R0.7840.14
122_G175_E0.7830.14
109_V260_R0.7830.14
144_G260_R0.7820.14
150_L157_V0.7800.14
128_D159_K0.7770.14
156_T169_E0.7740.14
45_M224_E0.7730.14
94_H104_A0.7720.14
85_L163_G0.7720.14
19_F37_R0.7710.14
90_V172_M0.7690.14
285_E311_L0.7670.14
18_G85_L0.7640.14
178_F205_P0.7640.14
118_A146_L0.7570.14
30_K291_A0.7570.14
286_S314_R0.7560.14
77_G175_E0.7560.14
109_V135_R0.7540.14
74_L101_P0.7510.14
127_I132_L0.7490.14
33_D160_Y0.7480.13
87_P116_V0.7470.13
32_F36_A0.7460.13
19_F54_F0.7440.13
187_D208_A0.7420.13
138_D176_D0.7390.13
182_L304_S0.7370.13
88_G168_I0.7330.13
91_Y114_P0.7290.13
135_R139_E0.7280.13
43_V177_L0.7250.13
158_S266_S0.7230.13
258_V296_E0.7180.13
69_L103_T0.7160.13
61_E97_P0.7160.13
55_D62_M0.7150.13
107_L307_L0.7150.13
90_V293_V0.7140.13
158_S173_R0.7140.13
168_I223_F0.7140.13
174_L257_A0.7120.13
104_A108_F0.7100.13
131_V156_T0.7100.13
164_M290_T0.7080.13
48_L128_D0.7070.13
147_A189_M0.7070.13
101_P169_E0.7060.13
50_N297_E0.7060.13
32_F122_G0.7040.13
70_H194_D0.7030.13
118_A122_G0.7010.13
169_E182_L0.7010.13
103_T118_A0.6970.13
293_V299_A0.6940.13
6_L123_L0.6910.13
50_N97_P0.6880.12
99_F130_D0.6850.12
8_E186_V0.6850.12
194_D220_R0.6830.12
38_R48_L0.6820.12
93_R153_S0.6810.12
96_V313_D0.6790.12
47_V267_V0.6770.12
44_L169_E0.6760.12
77_G91_Y0.6760.12
304_S314_R0.6750.12
278_V284_R0.6750.12
279_V294_E0.6740.12
289_D292_I0.6730.12
79_R111_G0.6730.12
53_A96_V0.6720.12
128_D176_D0.6710.12
40_S280_D0.6710.12
31_S266_S0.6710.12
48_L97_P0.6690.12
142_S160_Y0.6670.12
69_L277_Y0.6670.12
114_P118_A0.6660.12
47_V154_R0.6650.12
96_V212_V0.6640.12
58_T120_P0.6630.12
116_V206_E0.6620.12
182_L221_V0.6620.12
169_E218_L0.6620.12
150_L266_S0.6610.12
14_L222_G0.6600.12
47_V236_V0.6600.12
156_T164_M0.6600.12
76_V153_S0.6570.12
114_P175_E0.6560.12
94_H159_K0.6520.12
50_N228_T0.6520.12
54_F184_A0.6460.12
18_G141_L0.6460.12
56_A98_V0.6450.12
86_D307_L0.6420.12
140_R156_T0.6410.12
246_L288_D0.6410.12
136_R160_Y0.6390.12
176_D179_G0.6390.12
129_G298_L0.6370.12
10_V231_A0.6370.12
278_V306_D0.6370.12
127_I278_V0.6360.12
198_T278_V0.6360.12
47_V186_V0.6320.12
172_M238_E0.6300.12
21_V72_T0.6270.11
74_L138_D0.6250.11
62_M97_P0.6230.11
174_L245_R0.6220.11
13_M66_G0.6170.11
137_E181_E0.6160.11
227_P291_A0.6150.11
57_E105_M0.6140.11
36_A233_F0.6130.11
7_I281_E0.6120.11
3_R50_N0.6110.11
70_H281_E0.6090.11
30_K34_V0.6090.11
116_V157_V0.6090.11
74_L190_D0.6060.11
50_N54_F0.6040.11
246_L312_A0.6020.11
29_P82_D0.6010.11
161_E232_P0.6000.11
115_L266_S0.6000.11
10_V166_A0.5990.11
95_G211_D0.5990.11
76_V189_M0.5970.11
32_F118_A0.5960.11
102_D230_Q0.5930.11
59_G272_H0.5920.11
128_D223_F0.5880.11
68_Y126_N0.5870.11
96_V176_D0.5850.11
65_L185_P0.5850.11
71_A147_A0.5840.11
56_A176_D0.5830.11
85_L260_R0.5810.11
158_S234_K0.5790.11
73_P122_G0.5760.11
173_R311_L0.5740.11
34_V41_D0.5730.11
207_A228_T0.5730.11
156_T227_P0.5680.11
69_L164_M0.5640.11
236_V262_R0.5640.11
53_A166_A0.5640.11
143_L256_A0.5600.11
67_T138_D0.5590.10
5_A23_D0.5590.10
75_V312_A0.5560.10
45_M129_G0.5560.10
152_V261_A0.5560.10
47_V245_R0.5550.10
60_A279_V0.5550.10
103_T143_L0.5520.10
27_T123_L0.5520.10
57_E100_N0.5510.10
86_D234_K0.5510.10
112_I305_E0.5490.10
153_S161_E0.5480.10
37_R314_R0.5470.10
221_V280_D0.5460.10
155_R290_T0.5450.10
19_F22_S0.5420.10
3_R22_S0.5410.10
134_D138_D0.5410.10
98_V105_M0.5350.10
35_A213_P0.5340.10
107_L271_T0.5340.10
152_V248_T0.5330.10
39_G157_V0.5300.10
13_M45_M0.5300.10
35_A294_E0.5300.10
174_L274_R0.5280.10
214_V294_E0.5280.10
182_L299_A0.5270.10
46_K93_R0.5250.10
109_V275_A0.5240.10
46_K160_Y0.5240.10
95_G171_A0.5210.10
85_L174_L0.5210.10
43_V189_M0.5200.10
297_E314_R0.5190.10
132_L156_T0.5130.10
46_K91_Y0.5100.10
133_A308_R0.5090.10
85_L91_Y0.5070.10
27_T275_A0.5060.10
69_L155_R0.5050.10
44_L62_M0.5010.10
125_V178_F0.5000.10
123_L185_P0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a6cA 2 0.2313 98.7 0.898 Contact Map
3tysA 2 0.2344 98.5 0.906 Contact Map
2ppxA 4 0.1906 98.5 0.906 Contact Map
3qq6A 2 0.2156 98.5 0.906 Contact Map
2l49A 2 0.2969 98.4 0.907 Contact Map
2xi8A 2 0.2031 98.4 0.908 Contact Map
4jcyA 2 0.2719 98.4 0.908 Contact Map
3fmyA 2 0.1844 98.3 0.909 Contact Map
1b0nA 2 0.3156 98.3 0.91 Contact Map
1r69A 1 0.1969 98.3 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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