GREMLIN Database
Q9HNG6 - Uncharacterized protein
UniProt: Q9HNG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (246)
Sequences: 11469 (8344)
Seq/√Len: 532.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_K252_D3.7381.00
124_A129_E3.4031.00
186_E249_T3.3511.00
133_T143_R3.1181.00
193_E197_T3.0231.00
189_E245_R2.9221.00
214_A221_V2.8151.00
250_A253_D2.8081.00
187_T254_A2.6701.00
250_A254_A2.6681.00
199_V242_A2.6271.00
122_W129_E2.4851.00
184_D187_T2.4381.00
213_T223_E2.4311.00
156_N160_A2.3841.00
190_D194_D2.3381.00
99_R103_G2.3351.00
216_G221_V2.3351.00
178_G219_A2.2801.00
27_A68_A2.2781.00
194_D250_A2.2221.00
194_D198_D2.0941.00
176_A223_E2.0921.00
134_D141_R2.0511.00
246_A249_T1.9921.00
176_A221_V1.9751.00
191_V250_A1.9721.00
122_W131_T1.9701.00
240_T244_V1.9671.00
192_I247_V1.9191.00
187_T190_D1.9041.00
124_A165_R1.8521.00
189_E193_E1.8521.00
191_V254_A1.8481.00
187_T191_V1.8401.00
180_D257_D1.8281.00
198_D246_A1.7361.00
195_A246_A1.7021.00
242_A246_A1.7001.00
195_A250_A1.6801.00
179_V188_A1.6671.00
133_T149_E1.6651.00
124_A163_T1.6641.00
183_A257_D1.6491.00
144_N150_V1.6381.00
174_S223_E1.6111.00
114_A138_V1.6081.00
249_T253_D1.5961.00
212_P220_I1.5701.00
196_I224_C1.5631.00
29_V33_V1.5191.00
100_T103_G1.5081.00
122_W145_P1.4961.00
124_A127_D1.4751.00
25_G29_V1.4671.00
178_G221_V1.4661.00
186_E245_R1.4581.00
126_A160_A1.4471.00
198_D250_A1.4381.00
140_T154_N1.4371.00
251_L256_I1.4361.00
117_F140_T1.4301.00
128_A161_T1.4041.00
226_F243_V1.3991.00
141_R149_E1.3981.00
24_A28_L1.3941.00
245_R249_T1.3811.00
150_V163_T1.3721.00
92_I95_G1.3701.00
64_V68_A1.3641.00
238_M242_A1.3581.00
123_I132_V1.3481.00
148_E163_T1.3301.00
199_V246_A1.3301.00
177_V247_V1.3291.00
217_D263_R1.3261.00
188_A222_L1.3061.00
24_A27_A1.2871.00
246_A250_A1.2541.00
130_G142_V1.2531.00
235_K238_M1.2501.00
236_R240_T1.2461.00
190_D193_E1.2341.00
191_V194_D1.2271.00
173_L226_F1.2221.00
126_A161_T1.2091.00
228_I239_A1.2081.00
156_N159_N1.2041.00
230_H235_K1.1851.00
194_D197_T1.1791.00
86_G89_F1.1761.00
144_N148_E1.1741.00
176_A214_A1.1671.00
186_E190_D1.1641.00
73_L78_V1.1621.00
203_L206_P1.1561.00
201_R235_K1.1561.00
61_Q65_L1.1501.00
180_D183_A1.1451.00
192_I224_C1.1361.00
118_E167_S1.1301.00
182_D260_Y1.1231.00
179_V183_A1.1191.00
25_G28_L1.1161.00
39_T57_Y1.1121.00
183_A188_A1.1021.00
173_L240_T1.1011.00
201_R242_A1.0991.00
27_A31_L1.0931.00
125_L157_V1.0921.00
121_D167_S1.0891.00
72_A76_W1.0891.00
178_G216_G1.0841.00
28_L32_D1.0731.00
20_T24_A1.0721.00
171_L236_R1.0561.00
182_D248_K1.0541.00
28_L65_L1.0481.00
182_D257_D1.0471.00
156_N161_T1.0301.00
197_T204_D1.0291.00
149_E167_S1.0291.00
82_G85_V1.0181.00
29_V32_D1.0171.00
186_E189_E1.0141.00
199_V243_V1.0071.00
243_V247_V1.0011.00
181_Y215_L1.0001.00
213_T221_V0.9961.00
217_D221_V0.9931.00
172_R227_W0.9861.00
193_E208_P0.9671.00
35_D57_Y0.9671.00
31_L35_D0.9541.00
199_V202_I0.9481.00
193_E210_V0.9471.00
229_T235_K0.9471.00
143_R149_E0.9441.00
98_A106_I0.9351.00
136_T141_R0.9321.00
84_L88_G0.9321.00
178_G218_S0.9251.00
33_V36_A0.9101.00
54_G58_R0.9101.00
35_D39_T0.9071.00
214_A244_V0.9061.00
16_R19_V0.9051.00
174_S225_R0.9031.00
218_S260_Y0.9011.00
178_G217_D0.8991.00
237_S241_A0.8981.00
185_I222_L0.8941.00
126_A156_N0.8921.00
139_N151_V0.8891.00
24_A68_A0.8891.00
90_L94_I0.8881.00
57_Y61_Q0.8811.00
37_R41_Y0.8801.00
211_V241_A0.8731.00
89_F98_A0.8731.00
179_V251_L0.8661.00
196_I226_F0.8651.00
210_V224_C0.8641.00
176_A213_T0.8611.00
86_G90_L0.8591.00
241_A245_R0.8571.00
115_R118_E0.8551.00
68_A72_A0.8551.00
147_G227_W0.8531.00
215_L220_I0.8501.00
183_A187_T0.8471.00
20_T76_W0.8461.00
132_V142_V0.8431.00
179_V256_I0.8341.00
97_A102_I0.8311.00
251_L258_I0.8281.00
103_G155_E0.8211.00
123_I142_V0.8181.00
110_V158_L0.8121.00
131_T143_R0.8111.00
177_V192_I0.8101.00
179_V222_L0.8081.00
74_T79_D0.8071.00
35_D61_Q0.8061.00
101_T107_A0.8061.00
212_P244_V0.8051.00
15_V19_V0.8021.00
192_I251_L0.7991.00
195_A243_V0.7851.00
201_R239_A0.7831.00
128_A150_V0.7741.00
216_G219_A0.7741.00
185_I220_I0.7741.00
189_E241_A0.7711.00
90_L93_V0.7601.00
181_Y220_I0.7601.00
242_A245_R0.7551.00
178_G181_Y0.7551.00
181_Y258_I0.7501.00
217_D261_P0.7501.00
213_T240_T0.7451.00
33_V37_R0.7431.00
180_D258_I0.7421.00
175_V244_V0.7411.00
257_D262_H0.7371.00
201_R238_M0.7331.00
114_A139_N0.7311.00
113_V116_P0.7281.00
195_A199_V0.7271.00
199_V203_L0.7251.00
94_I102_I0.7241.00
180_D259_P0.7231.00
20_T28_L0.7221.00
71_A75_I0.7201.00
103_G159_N0.7171.00
196_I243_V0.7161.00
218_S263_R0.7151.00
191_V256_I0.7141.00
191_V195_A0.7121.00
143_R147_G0.7081.00
203_L229_T0.7081.00
125_L152_I0.7071.00
65_L69_G0.7061.00
173_L228_I0.6981.00
237_S240_T0.6981.00
181_Y260_Y0.6971.00
79_D82_G0.6971.00
26_A29_V0.6941.00
14_A18_A0.6941.00
215_L244_V0.6931.00
66_V70_I0.6921.00
170_R206_P0.6881.00
185_I248_K0.6861.00
196_I202_I0.6841.00
197_T207_A0.6821.00
202_I226_F0.6811.00
87_A91_G0.6781.00
107_A158_L0.6741.00
117_F157_V0.6721.00
125_L128_A0.6691.00
68_A71_A0.6681.00
172_R225_R0.6681.00
200_S203_L0.6681.00
218_S261_P0.6681.00
128_A163_T0.6671.00
15_V29_V0.6651.00
184_D249_T0.6651.00
20_T72_A0.6631.00
18_A22_G0.6631.00
104_S155_E0.6571.00
15_V18_A0.6561.00
136_T139_N0.6551.00
94_I106_I0.6521.00
211_V223_E0.6501.00
50_Q53_Q0.6481.00
260_Y263_R0.6461.00
124_A128_A0.6461.00
22_G25_G0.6411.00
195_A198_D0.6401.00
19_V29_V0.6381.00
218_S262_H0.6371.00
192_I196_I0.6361.00
114_A141_R0.6361.00
196_I210_V0.6361.00
100_T159_N0.6351.00
85_V88_G0.6321.00
67_A71_A0.6321.00
54_G134_D0.6311.00
31_L68_A0.6311.00
188_A191_V0.6271.00
149_E168_L0.6271.00
117_F123_I0.6261.00
209_Q225_R0.6251.00
179_V185_I0.6211.00
32_D36_A0.6211.00
129_E165_R0.6201.00
123_I157_V0.6191.00
84_L93_V0.6161.00
31_L61_Q0.6141.00
24_A31_L0.6131.00
40_A43_E0.6121.00
194_D254_A0.6111.00
89_F93_V0.6081.00
101_T158_L0.6041.00
50_Q54_G0.6031.00
175_V226_F0.6001.00
191_V251_L0.5961.00
86_G91_G0.5961.00
99_R155_E0.5951.00
187_T194_D0.5931.00
215_L248_K0.5931.00
244_V247_V0.5931.00
133_T168_L0.5900.99
173_L236_R0.5890.99
100_T155_E0.5840.99
178_G260_Y0.5820.99
188_A192_I0.5820.99
141_R151_V0.5810.99
34_V37_R0.5810.99
189_E210_V0.5800.99
16_R75_I0.5800.99
195_A254_A0.5800.99
188_A256_I0.5790.99
185_I189_E0.5760.99
107_A155_E0.5760.99
190_D197_T0.5750.99
22_G26_A0.5750.99
202_I239_A0.5730.99
28_L31_L0.5700.99
39_T43_E0.5700.99
51_H112_M0.5680.99
39_T42_A0.5680.99
96_T99_R0.5650.99
143_R168_L0.5640.99
16_R20_T0.5590.99
193_E207_A0.5540.99
152_I161_T0.5530.99
214_A240_T0.5520.99
37_R40_A0.5510.99
15_V24_A0.5500.99
17_L21_L0.5470.99
180_D260_Y0.5460.99
19_V23_I0.5400.99
185_I249_T0.5400.99
193_E196_I0.5390.99
190_D254_A0.5380.99
87_A90_L0.5370.99
71_A74_T0.5360.99
215_L247_V0.5360.99
38_I41_Y0.5350.99
24_A35_D0.5330.99
220_I248_K0.5300.99
89_F92_I0.5300.99
192_I210_V0.5280.99
23_I75_I0.5280.99
146_S172_R0.5280.99
211_V237_S0.5270.99
26_A30_T0.5270.99
239_A242_A0.5270.99
58_R134_D0.5270.99
81_S85_V0.5260.99
258_I262_H0.5260.99
88_G91_G0.5250.99
49_T53_Q0.5240.99
212_P215_L0.5240.99
191_V253_D0.5230.99
249_T252_D0.5230.99
144_N163_T0.5230.99
188_A251_L0.5200.99
146_S174_S0.5190.99
111_L117_F0.5180.99
224_C247_V0.5160.99
117_F162_I0.5150.99
58_R62_I0.5130.99
14_A17_L0.5130.99
49_T115_R0.5130.99
128_A142_V0.5130.99
70_I74_T0.5120.99
31_L57_Y0.5090.99
102_I106_I0.5080.98
180_D262_H0.5080.98
28_L38_I0.5080.98
183_A220_I0.5070.98
125_L161_T0.5060.98
23_I27_A0.5040.98
19_V22_G0.5020.98
145_P225_R0.5020.98
33_V41_Y0.5010.98
27_A64_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ajiA 3 0.9599 100 0.124 Contact Map
4hw9A 3 0.9234 100 0.126 Contact Map
3udcA 3 0.9307 100 0.179 Contact Map
1nz9A 1 0.1752 20.5 0.946 Contact Map
3a8gA 1 0.3029 17.6 0.948 Contact Map
2dirA 1 0.3139 17 0.948 Contact Map
2mi6A 1 0.1898 13.7 0.95 Contact Map
2mq8A 1 0.3686 12.8 0.951 Contact Map
2e6zA 1 0.1861 12.3 0.952 Contact Map
2lt1A 1 0.2299 12.1 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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