GREMLIN Database
Q9HNG5 - Uncharacterized protein
UniProt: Q9HNG5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 81 (77)
Sequences: 412 (222)
Seq/√Len: 25.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_L55_L3.9501.00
20_K76_E3.8481.00
4_E31_H2.8681.00
47_S66_P2.5330.99
7_K34_P2.4200.99
16_K69_D2.4180.99
43_V54_V2.2690.98
74_H78_H2.2040.97
7_K30_E2.1260.97
62_I65_M1.9030.94
21_L28_Y1.8190.92
4_E58_P1.7120.89
13_Y67_E1.6550.88
70_D73_A1.5200.83
46_V64_G1.4930.82
7_K14_C1.4160.78
54_V64_G1.4080.77
14_C32_E1.4050.77
40_R67_E1.3650.75
4_E56_V1.3110.72
13_Y40_R1.2290.67
27_D37_H1.1920.65
41_D52_V1.1730.63
69_D77_Q1.1620.63
9_P32_E1.1490.62
41_D45_S1.1450.62
40_R68_S1.1350.61
4_E42_A1.1280.60
41_D72_V1.1170.60
13_Y68_S1.1130.59
30_E34_P1.1080.59
36_S39_D1.0940.58
12_P33_V1.0710.56
50_T66_P1.0490.55
6_Y14_C1.0370.54
11_C66_P1.0370.54
57_D79_Y1.0360.54
15_A19_T1.0250.53
61_D73_A0.9950.51
8_L11_C0.9880.50
42_A46_V0.9870.50
20_K72_V0.9810.50
25_G32_E0.9670.49
6_Y34_P0.9590.48
21_L30_E0.9530.48
10_G31_H0.9280.46
6_Y50_T0.9000.44
34_P37_H0.8930.43
3_L29_V0.8900.43
16_K23_E0.8820.43
62_I77_Q0.8770.42
56_V61_D0.8760.42
10_G49_Q0.8680.42
5_L55_L0.8490.40
15_A35_S0.8460.40
17_V65_M0.8210.38
11_C14_C0.8190.38
46_V56_V0.8180.38
43_V47_S0.8100.38
35_S40_R0.8000.37
42_A45_S0.7760.35
7_K32_E0.7700.35
20_K45_S0.7690.35
35_S59_D0.7600.34
8_L35_S0.7560.34
39_D50_T0.7550.34
49_Q66_P0.7510.34
8_L37_H0.7500.34
4_E29_V0.7470.33
68_S80_A0.7450.33
73_A78_H0.7390.33
22_D25_G0.7350.33
14_C30_E0.7320.32
24_L27_D0.7210.32
15_A32_E0.7130.31
13_Y33_V0.7000.30
41_D46_V0.6890.30
6_Y80_A0.6770.29
10_G16_K0.6760.29
15_A18_E0.6730.29
18_E22_D0.6730.29
58_P61_D0.6680.28
51_G66_P0.6310.26
11_C27_D0.6150.25
7_K15_A0.6130.25
5_L30_E0.6130.25
33_V43_V0.6020.25
4_E46_V0.5980.24
7_K28_Y0.5920.24
19_T32_E0.5890.24
56_V73_A0.5770.23
6_Y56_V0.5640.23
12_P68_S0.5630.23
64_G70_D0.5630.23
9_P19_T0.5620.23
11_C16_K0.5510.22
25_G77_Q0.5480.22
51_G54_V0.5440.22
40_R65_M0.5400.21
33_V52_V0.5360.21
9_P15_A0.5330.21
5_L21_L0.5290.21
29_V43_V0.5280.21
13_Y35_S0.5250.21
31_H42_A0.5230.21
8_L12_P0.5220.21
62_I78_H0.5210.21
29_V77_Q0.5190.20
6_Y31_H0.5160.20
12_P67_E0.5120.20
43_V52_V0.5120.20
36_S50_T0.5100.20
40_R43_V0.5090.20
25_G73_A0.5080.20
54_V66_P0.5060.20
26_L55_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kh7A 2 0.9877 99.4 0.57 Contact Map
3wywA 2 0.963 99.4 0.576 Contact Map
3nivA 2 0.7654 99.4 0.582 Contact Map
4mpgA 2 0.963 99.4 0.582 Contact Map
4igjA 2 0.9136 99.4 0.582 Contact Map
4ielA 2 0.963 99.3 0.583 Contact Map
3m0fA 2 0.9383 99.3 0.585 Contact Map
3touA 2 0.9506 99.3 0.586 Contact Map
1gnwA 2 0.9506 99.3 0.587 Contact Map
3vk9A 2 0.963 99.3 0.588 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0053 seconds.