GREMLIN Database
Q9HNG4 - Uncharacterized protein
UniProt: Q9HNG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 478 (370)
Sequences: 9090 (5611)
Seq/√Len: 291.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_F333_A3.6811.00
416_L437_S3.4531.00
85_A361_L3.3651.00
252_Q255_P3.3071.00
420_V433_A3.1771.00
354_G359_V3.0881.00
134_T323_M2.8961.00
82_L364_A2.8301.00
176_D182_A2.7771.00
170_M195_S2.7361.00
259_Y262_T2.7171.00
260_D264_L2.5101.00
83_V331_F2.4601.00
128_L132_V2.4571.00
76_A340_V2.4111.00
87_Y327_I2.3881.00
258_Q264_L2.3231.00
140_E319_D2.3191.00
78_G368_F2.2971.00
259_Y264_L2.2961.00
447_D450_E2.2431.00
417_T434_G2.1851.00
125_T284_V2.1751.00
218_I222_A2.1501.00
131_I330_T2.1411.00
132_V136_V2.1391.00
265_V268_F2.1361.00
260_D263_P2.1341.00
216_L222_A2.1261.00
261_I264_L2.1231.00
255_P258_Q2.1171.00
349_G359_V2.0221.00
332_G337_T2.0111.00
365_V369_L2.0081.00
93_A363_V1.9941.00
184_G187_A1.9931.00
82_L361_L1.9851.00
193_V197_L1.9731.00
212_G216_L1.9711.00
222_A225_G1.9671.00
216_L220_A1.9461.00
179_T182_A1.9381.00
128_L330_T1.9081.00
197_L201_F1.9041.00
80_A328_G1.8931.00
92_F342_T1.8591.00
222_A226_G1.8531.00
198_G221_T1.8421.00
98_L101_N1.8201.00
135_A323_M1.8011.00
199_L391_V1.7751.00
179_T184_G1.7741.00
78_G364_A1.7681.00
81_M364_A1.7401.00
420_V424_T1.7391.00
216_L219_I1.7211.00
221_T225_G1.7101.00
124_F330_T1.6951.00
362_V366_L1.6911.00
261_I265_V1.6801.00
259_Y263_P1.6741.00
195_S387_I1.6301.00
251_T255_P1.6181.00
306_G309_L1.6161.00
191_V195_S1.6041.00
199_L387_I1.6011.00
83_V324_A1.5681.00
223_A227_V1.5681.00
125_T280_F1.5651.00
358_M362_V1.5511.00
83_V87_Y1.5481.00
206_H395_L1.5201.00
127_G330_T1.5191.00
181_L184_G1.5151.00
401_T405_W1.5041.00
102_A338_S1.4841.00
258_Q262_T1.4701.00
408_I412_I1.4661.00
129_L288_F1.4621.00
108_V287_F1.4601.00
131_I323_M1.4521.00
202_T217_G1.4331.00
442_K450_E1.4191.00
271_G274_D1.4151.00
176_D179_T1.4111.00
217_G221_T1.4051.00
200_F204_A1.3991.00
426_S429_Y1.3961.00
224_T228_L1.3891.00
159_G393_A1.3741.00
217_G220_A1.3731.00
257_A262_T1.3721.00
96_P100_L1.3701.00
222_A229_T1.3461.00
270_A274_D1.3361.00
253_R258_Q1.3261.00
182_A187_A1.3191.00
168_E180_I1.3181.00
180_I184_G1.3111.00
202_T391_V1.2991.00
229_T232_G1.2961.00
182_A185_N1.2931.00
108_V283_I1.2861.00
213_S216_L1.2781.00
179_T187_A1.2621.00
206_H391_V1.2601.00
317_D320_E1.2501.00
85_A360_A1.2471.00
271_G275_I1.2371.00
202_T206_H1.2291.00
215_V218_I1.2291.00
222_A233_V1.2281.00
117_Q269_L1.2271.00
212_G215_V1.2241.00
419_I423_F1.2241.00
254_L257_A1.2241.00
170_M386_H1.2191.00
194_V221_T1.2141.00
227_V231_A1.2141.00
331_F335_I1.2121.00
312_D350_V1.2071.00
140_E144_T1.2031.00
214_I388_A1.1991.00
212_G218_I1.1951.00
440_V444_A1.1901.00
87_Y324_A1.1891.00
216_L226_G1.1861.00
80_A340_V1.1861.00
349_G354_G1.1831.00
254_L258_Q1.1771.00
302_V350_V1.1761.00
174_V178_G1.1711.00
152_L402_A1.1701.00
132_V135_A1.1691.00
131_I326_A1.1661.00
230_F234_V1.1611.00
229_T233_V1.1611.00
115_P118_T1.1561.00
230_F233_V1.1471.00
198_G387_I1.1461.00
279_S282_L1.1451.00
183_L187_A1.1441.00
251_T254_L1.1441.00
225_G229_T1.1441.00
358_M361_L1.1431.00
190_P193_V1.1431.00
78_G82_L1.1351.00
189_N193_V1.1341.00
327_I331_F1.1331.00
370_S373_V1.1271.00
362_V365_V1.1271.00
258_Q261_I1.1241.00
195_S198_G1.1241.00
86_F361_L1.1161.00
199_L203_I1.1121.00
264_L268_F1.1111.00
291_D339_T1.1081.00
156_T418_I1.1041.00
231_A234_V1.1031.00
149_P410_H1.0991.00
258_Q263_P1.0921.00
255_P259_Y1.0901.00
257_A264_L1.0891.00
175_G178_G1.0831.00
443_V448_A1.0801.00
226_G230_F1.0781.00
178_G182_A1.0741.00
227_V230_F1.0721.00
225_G230_F1.0711.00
97_G101_N1.0691.00
83_V327_I1.0661.00
222_A230_F1.0651.00
299_L321_P1.0581.00
416_L420_V1.0571.00
260_D265_V1.0561.00
400_V418_I1.0551.00
234_V238_V1.0491.00
133_L288_F1.0461.00
177_A180_I1.0441.00
229_T234_V1.0361.00
153_A417_T1.0351.00
204_A208_R1.0331.00
415_G419_I1.0311.00
364_A368_F1.0291.00
330_T333_A1.0271.00
97_G105_A1.0251.00
228_L231_A1.0251.00
409_T445_T1.0241.00
359_V363_V1.0241.00
106_F110_G1.0231.00
226_G231_A1.0211.00
192_A196_I1.0181.00
96_P101_N1.0171.00
122_A280_F1.0141.00
441_V445_T1.0121.00
219_I222_A1.0091.00
166_G390_V1.0051.00
129_L284_V1.0021.00
327_I330_T1.0021.00
133_L138_A0.9991.00
191_V383_Y0.9971.00
96_P111_T0.9971.00
68_M338_S0.9941.00
216_L229_T0.9931.00
203_I391_V0.9901.00
192_A195_S0.9851.00
232_G236_P0.9771.00
160_L422_P0.9761.00
131_I135_A0.9741.00
164_I168_E0.9731.00
191_V194_V0.9711.00
96_P345_E0.9701.00
328_G340_V0.9681.00
218_I226_G0.9671.00
102_A105_A0.9671.00
164_I423_F0.9661.00
252_Q259_Y0.9651.00
323_M327_I0.9611.00
189_N192_A0.9611.00
193_V196_I0.9601.00
121_A272_F0.9601.00
196_I200_F0.9571.00
208_R211_T0.9541.00
222_A232_G0.9491.00
218_I221_T0.9491.00
71_V371_L0.9491.00
225_G231_A0.9481.00
176_D187_A0.9471.00
272_F275_I0.9461.00
397_L400_V0.9451.00
361_L365_V0.9421.00
175_G179_T0.9421.00
262_T265_V0.9391.00
231_A235_D0.9391.00
170_M390_V0.9371.00
259_Y265_V0.9371.00
399_N402_A0.9321.00
221_T226_G0.9321.00
311_T314_N0.9281.00
414_A418_I0.9271.00
163_A390_V0.9251.00
269_L274_D0.9211.00
181_L187_A0.9151.00
84_M95_A0.9141.00
126_E288_F0.9101.00
129_L281_A0.9081.00
448_A451_V0.9081.00
212_G222_A0.9071.00
220_A223_A0.9051.00
234_V237_G0.9041.00
96_P105_A0.9011.00
213_S217_G0.9001.00
222_A234_V0.8951.00
424_T429_Y0.8951.00
174_V177_A0.8911.00
137_G319_D0.8881.00
129_L285_F0.8871.00
197_L200_F0.8851.00
269_L275_I0.8821.00
402_A406_D0.8821.00
347_A351_E0.8701.00
270_A275_I0.8701.00
90_R321_P0.8701.00
198_G384_A0.8691.00
175_G180_I0.8681.00
72_V116_W0.8671.00
432_A436_V0.8671.00
381_P384_A0.8651.00
216_L225_G0.8641.00
437_S441_V0.8631.00
233_V236_P0.8631.00
213_S218_I0.8611.00
222_A231_A0.8601.00
255_P260_D0.8521.00
122_A126_E0.8481.00
205_L216_L0.8451.00
226_G235_D0.8381.00
232_G235_D0.8361.00
230_F235_D0.8351.00
220_A224_T0.8341.00
291_D329_T0.8321.00
176_D181_L0.8231.00
330_T334_I0.8231.00
270_A334_I0.8221.00
126_E291_D0.8211.00
92_F350_V0.8191.00
421_M430_G0.8151.00
404_D411_S0.8141.00
320_E323_M0.8101.00
226_G229_T0.8101.00
137_G141_Y0.8061.00
76_A80_A0.8040.99
229_T235_D0.8020.99
252_Q257_A0.8010.99
214_I219_I0.8010.99
180_I185_N0.7960.99
87_Y323_M0.7950.99
74_L78_G0.7950.99
276_D279_S0.7950.99
185_N189_N0.7950.99
218_I232_G0.7940.99
97_G341_T0.7890.99
211_T352_E0.7880.99
212_G217_G0.7860.99
252_Q258_Q0.7850.99
79_V335_I0.7840.99
203_I394_L0.7830.99
156_T159_G0.7780.99
258_Q265_V0.7780.99
194_V197_L0.7730.99
126_E287_F0.7720.99
122_A287_F0.7710.99
215_V219_I0.7700.99
278_F282_L0.7690.99
163_A393_A0.7690.99
122_A283_I0.7690.99
179_T183_L0.7670.99
228_L232_G0.7670.99
284_V288_F0.7660.99
195_S383_Y0.7630.99
216_L235_D0.7620.99
77_S81_M0.7600.99
409_T442_K0.7600.99
87_Y320_E0.7590.99
369_L372_L0.7580.99
201_F205_L0.7580.99
107_T111_T0.7570.99
68_M72_V0.7560.99
401_T406_D0.7560.99
121_A277_A0.7550.99
305_A309_L0.7530.99
216_L232_G0.7530.99
148_E152_L0.7530.99
220_A225_G0.7520.99
163_A415_G0.7500.99
175_G182_A0.7500.99
204_A444_A0.7440.99
168_E175_G0.7420.99
401_T404_D0.7420.99
177_A181_L0.7420.99
106_F109_V0.7380.99
97_G102_A0.7370.99
270_A273_Q0.7360.99
181_L185_N0.7340.99
233_V237_G0.7340.99
90_R317_D0.7310.99
229_T236_P0.7290.99
273_Q276_D0.7270.99
411_S415_G0.7260.99
220_A236_P0.7250.99
79_V331_F0.7250.99
212_G231_A0.7250.99
259_Y268_F0.7230.99
269_L273_Q0.7220.99
100_L105_A0.7200.99
149_P153_A0.7190.99
219_I223_A0.7190.99
111_T283_I0.7190.99
217_G222_A0.7170.99
177_A182_A0.7160.99
328_G331_F0.7130.99
95_A325_D0.7120.99
220_A226_G0.7110.99
257_A260_D0.7050.99
121_A125_T0.7040.99
203_I207_A0.7040.99
222_A235_D0.7020.99
376_L379_A0.7000.99
82_L86_F0.6990.99
203_I206_H0.6960.99
370_S377_A0.6950.99
144_T314_N0.6950.99
97_G100_L0.6930.99
133_L322_L0.6920.98
179_T185_N0.6910.98
203_I412_I0.6850.98
410_H413_P0.6840.98
195_S390_V0.6820.98
94_L360_A0.6800.98
90_R315_L0.6800.98
217_G226_G0.6790.98
261_I268_F0.6750.98
371_L374_V0.6740.98
178_G181_L0.6740.98
442_K447_D0.6740.98
363_V370_S0.6730.98
160_L418_I0.6720.98
134_T326_A0.6720.98
306_G346_S0.6710.98
152_L399_N0.6670.98
118_T274_D0.6640.98
416_L433_A0.6640.98
120_L123_V0.6610.98
232_G237_G0.6600.98
197_L224_T0.6590.98
84_M94_L0.6580.98
99_G102_A0.6570.98
224_T227_V0.6570.98
235_D238_V0.6560.98
157_G422_P0.6510.98
181_L186_L0.6470.98
194_V198_G0.6450.98
213_S221_T0.6440.98
348_T352_E0.6430.98
157_G421_M0.6430.98
105_A339_T0.6430.98
164_I181_L0.6430.98
157_G418_I0.6410.98
121_A270_A0.6400.98
180_I183_L0.6400.98
257_A263_P0.6380.97
130_F291_D0.6380.97
177_A187_A0.6380.97
331_F334_I0.6370.97
105_A109_V0.6350.97
263_P268_F0.6340.97
429_Y432_A0.6330.97
176_D180_I0.6330.97
94_L340_V0.6320.97
134_T140_E0.6300.97
101_N105_A0.6300.97
212_G220_A0.6290.97
180_I187_A0.6290.97
194_V206_H0.6250.97
207_A211_T0.6240.97
216_L221_T0.6230.97
369_L373_V0.6210.97
155_G301_G0.6200.97
283_I286_T0.6190.97
119_A123_V0.6180.97
407_D410_H0.6170.97
214_I217_G0.6170.97
77_S367_F0.6160.97
206_H213_S0.6150.97
96_P109_V0.6150.97
288_F292_F0.6150.97
92_F308_F0.6140.97
199_L390_V0.6130.97
105_A110_G0.6130.97
74_L367_F0.6120.97
124_F270_A0.6120.97
187_A190_P0.6110.97
100_L290_V0.6100.97
89_N356_T0.6090.97
95_A328_G0.6070.97
326_A330_T0.6070.97
226_G234_V0.6060.97
442_K446_G0.6060.97
280_F283_I0.6050.97
193_V198_G0.6040.96
329_T339_T0.6030.96
433_A437_S0.6020.96
174_V179_T0.6020.96
409_T413_P0.6010.96
212_G235_D0.5990.96
303_G307_G0.5990.96
129_L133_L0.5950.96
282_L286_T0.5950.96
196_I199_L0.5920.96
120_L333_A0.5920.96
97_G111_T0.5900.96
269_L272_F0.5870.96
295_T342_T0.5860.96
198_G201_F0.5860.96
218_I229_T0.5850.96
291_D341_T0.5840.96
257_A261_I0.5840.96
68_M116_W0.5830.96
123_V287_F0.5810.96
77_S94_L0.5810.96
223_A226_G0.5810.96
200_F203_I0.5810.96
222_A380_I0.5800.96
153_A414_A0.5800.96
215_V222_A0.5780.95
220_A230_F0.5770.95
127_G329_T0.5770.95
111_T114_V0.5770.95
99_G341_T0.5720.95
97_G109_V0.5700.95
400_V414_A0.5700.95
304_Q402_A0.5700.95
411_S414_A0.5690.95
121_A275_I0.5660.95
104_F287_F0.5660.95
220_A229_T0.5660.95
233_V238_V0.5650.95
195_S199_L0.5640.95
253_R260_D0.5630.95
84_M325_D0.5630.95
400_V405_W0.5620.95
420_V429_Y0.5620.95
231_A236_P0.5610.95
183_L186_L0.5600.95
304_Q309_L0.5590.95
102_A106_F0.5570.95
96_P102_A0.5550.94
98_L343_Y0.5530.94
97_G345_E0.5520.94
175_G186_L0.5460.94
123_V339_T0.5450.94
397_L418_I0.5450.94
308_F311_T0.5420.94
274_D277_A0.5410.94
292_F322_L0.5410.94
197_L228_L0.5390.94
89_N324_A0.5390.94
326_A329_T0.5380.93
439_P443_V0.5370.93
251_T258_Q0.5370.93
214_I218_I0.5350.93
305_A308_F0.5340.93
182_A186_L0.5340.93
272_F276_D0.5310.93
96_P108_V0.5300.93
386_H390_V0.5280.93
255_P373_V0.5280.93
380_I384_A0.5270.93
212_G221_T0.5270.93
225_G233_V0.5270.93
92_F312_D0.5260.93
295_T341_T0.5260.93
212_G219_I0.5240.93
383_Y387_I0.5240.93
214_I230_F0.5240.93
217_G225_G0.5230.92
220_A227_V0.5230.92
66_V70_A0.5230.92
175_G185_N0.5210.92
74_L371_L0.5210.92
211_T214_I0.5210.92
159_G397_L0.5190.92
92_F314_N0.5180.92
220_A233_V0.5180.92
103_F106_F0.5170.92
130_F288_F0.5170.92
141_Y144_T0.5170.92
84_M88_A0.5150.92
84_M324_A0.5140.92
81_M360_A0.5140.92
291_D295_T0.5130.92
207_A210_V0.5090.91
400_V403_I0.5090.91
123_V333_A0.5080.91
403_I411_S0.5080.91
125_T129_L0.5070.91
201_F204_A0.5060.91
124_F334_I0.5060.91
72_V337_T0.5050.91
92_F354_G0.5050.91
309_L315_L0.5050.91
402_A405_W0.5050.91
207_A408_I0.5040.91
189_N207_A0.5030.91
201_F221_T0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.7971 100 0.562 Contact Map
1jjgA 1 0.0711 17 0.973 Contact Map
4a82A 2 0.1715 7 0.977 Contact Map
4huqS 1 0.3117 5.2 0.979 Contact Map
2zy9A 2 0.2238 4.5 0.979 Contact Map
3zdqA 2 0.1715 3.9 0.98 Contact Map
3lt7A 3 0.0649 3.8 0.98 Contact Map
4ujpg 1 0.0795 3.8 0.98 Contact Map
3o7qA 1 0.3954 3.7 0.98 Contact Map
4qtnA 3 0.1695 3.5 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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