GREMLIN Database
Q9HNG3 - Uncharacterized protein
UniProt: Q9HNG3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (205)
Sequences: 624 (399)
Seq/√Len: 27.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_T204_D7.3841.00
229_P232_A5.7021.00
174_D202_G5.4761.00
57_E62_A4.9681.00
115_L139_A4.4421.00
58_V62_A3.8051.00
57_E60_Q3.5021.00
115_L194_L3.4191.00
221_R224_E2.7781.00
181_V209_F2.7171.00
112_D176_D2.6691.00
102_A209_F2.5410.99
180_V194_L2.4890.99
106_F209_F2.4840.99
177_T206_T2.2150.98
126_A136_C2.2030.98
63_G94_F2.0990.97
198_A203_A2.0930.97
232_A235_D2.0530.97
176_D203_A1.9400.96
230_V234_T1.9060.95
115_L198_A1.8680.95
110_A177_T1.8560.94
117_A141_Q1.8220.94
179_L206_T1.8170.94
144_E192_E1.6730.91
154_R167_L1.6310.89
106_F181_V1.6280.89
179_L207_G1.6280.89
145_T212_I1.6260.89
191_Q210_A1.6060.89
139_A194_L1.5920.88
229_P234_T1.5160.86
96_E130_G1.4950.85
39_D43_Y1.4290.82
113_V176_D1.4200.81
102_A106_F1.3910.80
95_L126_A1.3820.80
192_E196_D1.3540.78
42_R110_A1.3300.77
112_D173_D1.3280.77
38_G42_R1.3240.77
55_A137_A1.3100.76
121_G182_D1.3080.76
206_T215_G1.2920.75
178_V203_A1.2670.73
229_P235_D1.2640.73
111_P134_A1.2620.73
27_D30_S1.2350.71
71_L191_Q1.2190.70
35_L171_A1.2150.70
47_H179_L1.2140.70
214_A217_T1.2040.69
121_G188_G1.2010.69
166_Y196_D1.2010.69
143_K166_Y1.1950.69
120_D140_K1.1850.68
128_L150_F1.1850.68
66_L97_L1.1840.68
91_D174_D1.1730.67
33_T48_V1.1670.67
198_A205_V1.1650.67
179_L198_A1.1600.66
37_A41_N1.1520.66
118_A171_A1.1470.66
103_A132_Y1.1430.65
38_G41_N1.1410.65
114_V132_Y1.1300.64
213_A217_T1.1120.63
117_A156_R1.1050.63
49_L113_V1.0990.62
80_D200_A1.0660.60
146_A186_R1.0610.59
186_R208_V1.0600.59
139_A198_A1.0560.59
144_E166_Y1.0560.59
41_N96_E1.0510.59
36_P43_Y1.0420.58
90_F136_C1.0410.58
113_V172_L1.0370.58
175_G203_A1.0360.58
89_V190_T1.0310.57
57_E61_N1.0280.57
150_F211_L1.0270.57
44_V48_V1.0230.57
85_N138_Y1.0190.56
141_Q163_F1.0190.56
86_S137_A1.0160.56
155_Q165_Y1.0150.56
173_D176_D1.0040.55
91_D94_F0.9990.55
181_V203_A0.9950.54
199_D204_D0.9940.54
172_L198_A0.9910.54
43_Y168_P0.9880.54
29_L33_T0.9830.54
114_V176_D0.9810.53
160_G187_S0.9810.53
153_A163_F0.9780.53
70_E91_D0.9690.53
143_K161_I0.9690.53
218_G221_R0.9660.52
85_N163_F0.9630.52
122_I203_A0.9540.51
50_P54_R0.9500.51
129_A143_K0.9490.51
102_A128_L0.9370.50
29_L186_R0.9370.50
32_D56_R0.9370.50
123_T138_Y0.9270.49
115_L172_L0.9210.49
27_D31_A0.9200.49
53_D56_R0.9180.49
112_D175_G0.9150.48
153_A196_D0.9130.48
33_T107_D0.9080.48
30_S56_R0.8960.47
40_L124_L0.8830.46
64_A233_L0.8760.45
117_A198_A0.8710.45
60_Q114_V0.8700.45
126_A198_A0.8690.45
151_V201_A0.8660.45
47_H70_E0.8630.44
139_A180_V0.8600.44
154_R170_S0.8560.44
102_A181_V0.8530.44
78_D135_D0.8520.44
33_T37_A0.8520.44
185_I214_A0.8490.43
169_A196_D0.8450.43
26_Y32_D0.8440.43
171_A189_E0.8430.43
28_E136_C0.8340.42
91_D108_F0.8290.42
66_L91_D0.8270.42
119_T167_L0.8230.41
95_L211_L0.8200.41
183_D188_G0.8190.41
69_A72_A0.8180.41
137_A144_E0.8170.41
59_V97_L0.8160.41
76_H122_I0.8100.40
28_E35_L0.7980.40
230_V235_D0.7970.39
51_S193_L0.7930.39
65_D91_D0.7910.39
57_E107_D0.7900.39
118_A196_D0.7880.39
43_Y52_A0.7880.39
85_N141_Q0.7840.39
46_G167_L0.7820.38
195_L205_V0.7820.38
181_V230_V0.7800.38
69_A204_D0.7750.38
83_V102_A0.7640.37
114_V169_A0.7570.37
41_N44_V0.7550.36
216_E230_V0.7540.36
129_A136_C0.7530.36
114_V124_L0.7500.36
32_D53_D0.7480.36
153_A211_L0.7470.36
133_G164_T0.7460.36
153_A200_A0.7460.36
59_V62_A0.7430.36
28_E90_F0.7430.36
55_A180_V0.7380.35
44_V175_G0.7310.35
94_F211_L0.7300.35
160_G164_T0.7260.34
70_E73_A0.7240.34
119_T122_I0.7210.34
84_D120_D0.7210.34
89_V132_Y0.7200.34
36_P97_L0.7190.34
145_T170_S0.7160.34
96_E109_D0.7140.34
157_L189_E0.7120.33
124_L128_L0.7110.33
114_V206_T0.7110.33
175_G211_L0.7090.33
90_F185_I0.7090.33
136_C166_Y0.7080.33
69_A181_V0.7080.33
98_V133_G0.7070.33
86_S216_E0.7070.33
177_T213_A0.7070.33
139_A161_I0.7060.33
71_L85_N0.7000.33
191_Q208_V0.6980.33
55_A58_V0.6950.32
120_D148_E0.6940.32
98_V178_V0.6900.32
178_V194_L0.6890.32
117_A142_S0.6860.32
86_S95_L0.6820.31
148_E189_E0.6780.31
27_D32_D0.6780.31
116_T122_I0.6740.31
118_A142_S0.6700.31
66_L114_V0.6700.31
83_V212_I0.6700.31
85_N166_Y0.6690.31
30_S53_D0.6680.31
145_T187_S0.6680.31
223_R235_D0.6660.30
105_T139_A0.6650.30
57_E110_A0.6610.30
135_D170_S0.6600.30
199_D224_E0.6600.30
113_V137_A0.6590.30
36_P203_A0.6580.30
112_D160_G0.6560.30
31_A56_R0.6550.30
82_Y118_A0.6540.30
138_Y171_A0.6530.30
101_V152_E0.6530.30
174_D192_E0.6490.29
81_G178_V0.6420.29
96_E202_G0.6410.29
38_G104_E0.6370.29
40_L45_N0.6330.28
89_V99_A0.6330.28
132_Y201_A0.6310.28
175_G178_V0.6300.28
42_R199_D0.6290.28
80_D184_L0.6230.28
81_G189_E0.6220.28
72_A199_D0.6210.28
134_A180_V0.6170.27
29_L35_L0.6070.27
120_D189_E0.6070.27
182_D188_G0.6010.26
84_D147_V0.5980.26
130_G191_Q0.5980.26
116_T207_G0.5970.26
111_P198_A0.5970.26
72_A204_D0.5970.26
83_V166_Y0.5960.26
114_V134_A0.5950.26
88_I164_T0.5940.26
101_V176_D0.5940.26
28_E32_D0.5920.26
74_R203_A0.5920.26
49_L180_V0.5880.26
41_N212_I0.5860.25
45_N118_A0.5860.25
111_P195_L0.5820.25
151_V165_Y0.5810.25
174_D203_A0.5730.25
124_L215_G0.5730.25
78_D146_A0.5730.25
27_D56_R0.5720.25
126_A131_Y0.5720.25
66_L69_A0.5720.25
25_T39_D0.5710.25
198_A216_E0.5680.24
154_R161_I0.5670.24
128_L199_D0.5660.24
26_Y36_P0.5650.24
48_V54_R0.5600.24
70_E105_T0.5590.24
124_L163_F0.5570.24
157_L187_S0.5560.24
46_G50_P0.5560.24
65_D177_T0.5560.24
33_T186_R0.5560.24
37_A50_P0.5550.24
85_N162_E0.5550.24
102_A139_A0.5540.24
126_A213_A0.5530.24
83_V94_F0.5520.24
103_A201_A0.5510.24
84_D87_G0.5400.23
181_V202_G0.5400.23
45_N77_V0.5400.23
196_D204_D0.5400.23
111_P128_L0.5370.23
101_V181_V0.5370.23
70_E94_F0.5360.23
120_D155_Q0.5350.23
128_L215_G0.5340.23
72_A107_D0.5330.23
173_D199_D0.5320.22
99_A116_T0.5290.22
148_E155_Q0.5280.22
29_L132_Y0.5240.22
140_K189_E0.5210.22
78_D145_T0.5210.22
43_Y115_L0.5210.22
72_A149_E0.5200.22
82_Y115_L0.5200.22
71_L117_A0.5180.22
69_A124_L0.5170.22
135_D184_L0.5130.21
231_G235_D0.5110.21
83_V224_E0.5110.21
74_R122_I0.5100.21
71_L206_T0.5080.21
120_D146_A0.5050.21
27_D189_E0.5040.21
80_D193_L0.5040.21
180_V191_Q0.5040.21
69_A175_G0.5030.21
84_D116_T0.5010.21
128_L181_V0.5000.21
34_G58_V0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m0kA 2 0.7155 100 0.516 Contact Map
4lzaA 2 0.7113 100 0.518 Contact Map
1o57A 2 0.9582 100 0.529 Contact Map
1qb7A 2 0.8033 100 0.582 Contact Map
2dy0A 2 0.7531 100 0.594 Contact Map
1y0bA 2 0.749 100 0.616 Contact Map
1l1qA 2 0.7322 100 0.619 Contact Map
1zn8A 2 0.728 100 0.62 Contact Map
1g2qA 2 0.7197 99.9 0.627 Contact Map
3qw4B 4 0.8703 99.9 0.652 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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