Q9HNG3 - HALSA - GREMLIN Contacts

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Q9HNG3 - Uncharacterized protein

UniProt:	Q9HNG3	Sequences: MNRAEKATLQLQAVDVLRTLKETRTYDELSADTGLPAGDLNRYVNGHVLPSADRAREVVQNAGADLLQAELAARVHVDDDGYVDNSGIVFDQSFLELVAPVAAETFDFDAPDVVLTAATDGITLAAALAGYYGADCAYAKQSKETAVEEFVEARQRLESGIEFTYYLPASALDDGDTVLVVDDLIRSGETQELLLDIADAAGADVTGVFALIAAGETGVDRARERTDAPVGALTDLDDL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	239 (205)
Sequences:	624 (399)
Seq/√Len:	27.9

ECOLI - APT
BACSU - PURR XPT APT
HALSA - Q9HNG3 HPRL
SULSO - Q980Q2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_T	204_D	7.384	1.00
229_P	232_A	5.702	1.00
174_D	202_G	5.476	1.00
57_E	62_A	4.968	1.00
115_L	139_A	4.442	1.00
58_V	62_A	3.805	1.00
57_E	60_Q	3.502	1.00
115_L	194_L	3.419	1.00
221_R	224_E	2.778	1.00
181_V	209_F	2.717	1.00
112_D	176_D	2.669	1.00
102_A	209_F	2.541	0.99
180_V	194_L	2.489	0.99
106_F	209_F	2.484	0.99
177_T	206_T	2.215	0.98
126_A	136_C	2.203	0.98
63_G	94_F	2.099	0.97
198_A	203_A	2.093	0.97
232_A	235_D	2.053	0.97
176_D	203_A	1.940	0.96
230_V	234_T	1.906	0.95
115_L	198_A	1.868	0.95
110_A	177_T	1.856	0.94
117_A	141_Q	1.822	0.94
179_L	206_T	1.817	0.94
144_E	192_E	1.673	0.91
154_R	167_L	1.631	0.89
106_F	181_V	1.628	0.89
179_L	207_G	1.628	0.89
145_T	212_I	1.626	0.89
191_Q	210_A	1.606	0.89
139_A	194_L	1.592	0.88
229_P	234_T	1.516	0.86
96_E	130_G	1.495	0.85
39_D	43_Y	1.429	0.82
113_V	176_D	1.420	0.81
102_A	106_F	1.391	0.80
95_L	126_A	1.382	0.80
192_E	196_D	1.354	0.78
42_R	110_A	1.330	0.77
112_D	173_D	1.328	0.77
38_G	42_R	1.324	0.77
55_A	137_A	1.310	0.76
121_G	182_D	1.308	0.76
206_T	215_G	1.292	0.75
178_V	203_A	1.267	0.73
229_P	235_D	1.264	0.73
111_P	134_A	1.262	0.73
27_D	30_S	1.235	0.71
71_L	191_Q	1.219	0.70
35_L	171_A	1.215	0.70
47_H	179_L	1.214	0.70
214_A	217_T	1.204	0.69
121_G	188_G	1.201	0.69
166_Y	196_D	1.201	0.69
143_K	166_Y	1.195	0.69
120_D	140_K	1.185	0.68
128_L	150_F	1.185	0.68
66_L	97_L	1.184	0.68
91_D	174_D	1.173	0.67
33_T	48_V	1.167	0.67
198_A	205_V	1.165	0.67
179_L	198_A	1.160	0.66
37_A	41_N	1.152	0.66
118_A	171_A	1.147	0.66
103_A	132_Y	1.143	0.65
38_G	41_N	1.141	0.65
114_V	132_Y	1.130	0.64
213_A	217_T	1.112	0.63
117_A	156_R	1.105	0.63
49_L	113_V	1.099	0.62
80_D	200_A	1.066	0.60
146_A	186_R	1.061	0.59
186_R	208_V	1.060	0.59
139_A	198_A	1.056	0.59
144_E	166_Y	1.056	0.59
41_N	96_E	1.051	0.59
36_P	43_Y	1.042	0.58
90_F	136_C	1.041	0.58
113_V	172_L	1.037	0.58
175_G	203_A	1.036	0.58
89_V	190_T	1.031	0.57
57_E	61_N	1.028	0.57
150_F	211_L	1.027	0.57
44_V	48_V	1.023	0.57
85_N	138_Y	1.019	0.56
141_Q	163_F	1.019	0.56
86_S	137_A	1.016	0.56
155_Q	165_Y	1.015	0.56
173_D	176_D	1.004	0.55
91_D	94_F	0.999	0.55
181_V	203_A	0.995	0.54
199_D	204_D	0.994	0.54
172_L	198_A	0.991	0.54
43_Y	168_P	0.988	0.54
29_L	33_T	0.983	0.54
114_V	176_D	0.981	0.53
160_G	187_S	0.981	0.53
153_A	163_F	0.978	0.53
70_E	91_D	0.969	0.53
143_K	161_I	0.969	0.53
218_G	221_R	0.966	0.52
85_N	163_F	0.963	0.52
122_I	203_A	0.954	0.51
50_P	54_R	0.950	0.51
129_A	143_K	0.949	0.51
102_A	128_L	0.937	0.50
29_L	186_R	0.937	0.50
32_D	56_R	0.937	0.50
123_T	138_Y	0.927	0.49
115_L	172_L	0.921	0.49
27_D	31_A	0.920	0.49
53_D	56_R	0.918	0.49
112_D	175_G	0.915	0.48
153_A	196_D	0.913	0.48
33_T	107_D	0.908	0.48
30_S	56_R	0.896	0.47
40_L	124_L	0.883	0.46
64_A	233_L	0.876	0.45
117_A	198_A	0.871	0.45
60_Q	114_V	0.870	0.45
126_A	198_A	0.869	0.45
151_V	201_A	0.866	0.45
47_H	70_E	0.863	0.44
139_A	180_V	0.860	0.44
154_R	170_S	0.856	0.44
102_A	181_V	0.853	0.44
78_D	135_D	0.852	0.44
33_T	37_A	0.852	0.44
185_I	214_A	0.849	0.43
169_A	196_D	0.845	0.43
26_Y	32_D	0.844	0.43
171_A	189_E	0.843	0.43
28_E	136_C	0.834	0.42
91_D	108_F	0.829	0.42
66_L	91_D	0.827	0.42
119_T	167_L	0.823	0.41
95_L	211_L	0.820	0.41
183_D	188_G	0.819	0.41
69_A	72_A	0.818	0.41
137_A	144_E	0.817	0.41
59_V	97_L	0.816	0.41
76_H	122_I	0.810	0.40
28_E	35_L	0.798	0.40
230_V	235_D	0.797	0.39
51_S	193_L	0.793	0.39
65_D	91_D	0.791	0.39
57_E	107_D	0.790	0.39
118_A	196_D	0.788	0.39
43_Y	52_A	0.788	0.39
85_N	141_Q	0.784	0.39
46_G	167_L	0.782	0.38
195_L	205_V	0.782	0.38
181_V	230_V	0.780	0.38
69_A	204_D	0.775	0.38
83_V	102_A	0.764	0.37
114_V	169_A	0.757	0.37
41_N	44_V	0.755	0.36
216_E	230_V	0.754	0.36
129_A	136_C	0.753	0.36
114_V	124_L	0.750	0.36
32_D	53_D	0.748	0.36
153_A	211_L	0.747	0.36
133_G	164_T	0.746	0.36
153_A	200_A	0.746	0.36
59_V	62_A	0.743	0.36
28_E	90_F	0.743	0.36
55_A	180_V	0.738	0.35
44_V	175_G	0.731	0.35
94_F	211_L	0.730	0.35
160_G	164_T	0.726	0.34
70_E	73_A	0.724	0.34
119_T	122_I	0.721	0.34
84_D	120_D	0.721	0.34
89_V	132_Y	0.720	0.34
36_P	97_L	0.719	0.34
145_T	170_S	0.716	0.34
96_E	109_D	0.714	0.34
157_L	189_E	0.712	0.33
124_L	128_L	0.711	0.33
114_V	206_T	0.711	0.33
175_G	211_L	0.709	0.33
90_F	185_I	0.709	0.33
136_C	166_Y	0.708	0.33
69_A	181_V	0.708	0.33
98_V	133_G	0.707	0.33
86_S	216_E	0.707	0.33
177_T	213_A	0.707	0.33
139_A	161_I	0.706	0.33
71_L	85_N	0.700	0.33
191_Q	208_V	0.698	0.33
55_A	58_V	0.695	0.32
120_D	148_E	0.694	0.32
98_V	178_V	0.690	0.32
178_V	194_L	0.689	0.32
117_A	142_S	0.686	0.32
86_S	95_L	0.682	0.31
148_E	189_E	0.678	0.31
27_D	32_D	0.678	0.31
116_T	122_I	0.674	0.31
118_A	142_S	0.670	0.31
66_L	114_V	0.670	0.31
83_V	212_I	0.670	0.31
85_N	166_Y	0.669	0.31
30_S	53_D	0.668	0.31
145_T	187_S	0.668	0.31
223_R	235_D	0.666	0.30
105_T	139_A	0.665	0.30
57_E	110_A	0.661	0.30
135_D	170_S	0.660	0.30
199_D	224_E	0.660	0.30
113_V	137_A	0.659	0.30
36_P	203_A	0.658	0.30
112_D	160_G	0.656	0.30
31_A	56_R	0.655	0.30
82_Y	118_A	0.654	0.30
138_Y	171_A	0.653	0.30
101_V	152_E	0.653	0.30
174_D	192_E	0.649	0.29
81_G	178_V	0.642	0.29
96_E	202_G	0.641	0.29
38_G	104_E	0.637	0.29
40_L	45_N	0.633	0.28
89_V	99_A	0.633	0.28
132_Y	201_A	0.631	0.28
175_G	178_V	0.630	0.28
42_R	199_D	0.629	0.28
80_D	184_L	0.623	0.28
81_G	189_E	0.622	0.28
72_A	199_D	0.621	0.28
134_A	180_V	0.617	0.27
29_L	35_L	0.607	0.27
120_D	189_E	0.607	0.27
182_D	188_G	0.601	0.26
84_D	147_V	0.598	0.26
130_G	191_Q	0.598	0.26
116_T	207_G	0.597	0.26
111_P	198_A	0.597	0.26
72_A	204_D	0.597	0.26
83_V	166_Y	0.596	0.26
114_V	134_A	0.595	0.26
88_I	164_T	0.594	0.26
101_V	176_D	0.594	0.26
28_E	32_D	0.592	0.26
74_R	203_A	0.592	0.26
49_L	180_V	0.588	0.26
41_N	212_I	0.586	0.25
45_N	118_A	0.586	0.25
111_P	195_L	0.582	0.25
151_V	165_Y	0.581	0.25
174_D	203_A	0.573	0.25
124_L	215_G	0.573	0.25
78_D	146_A	0.573	0.25
27_D	56_R	0.572	0.25
126_A	131_Y	0.572	0.25
66_L	69_A	0.572	0.25
25_T	39_D	0.571	0.25
198_A	216_E	0.568	0.24
154_R	161_I	0.567	0.24
128_L	199_D	0.566	0.24
26_Y	36_P	0.565	0.24
48_V	54_R	0.560	0.24
70_E	105_T	0.559	0.24
124_L	163_F	0.557	0.24
157_L	187_S	0.556	0.24
46_G	50_P	0.556	0.24
65_D	177_T	0.556	0.24
33_T	186_R	0.556	0.24
37_A	50_P	0.555	0.24
85_N	162_E	0.555	0.24
102_A	139_A	0.554	0.24
126_A	213_A	0.553	0.24
83_V	94_F	0.552	0.24
103_A	201_A	0.551	0.24
84_D	87_G	0.540	0.23
181_V	202_G	0.540	0.23
45_N	77_V	0.540	0.23
196_D	204_D	0.540	0.23
111_P	128_L	0.537	0.23
101_V	181_V	0.537	0.23
70_E	94_F	0.536	0.23
120_D	155_Q	0.535	0.23
128_L	215_G	0.534	0.23
72_A	107_D	0.533	0.23
173_D	199_D	0.532	0.22
99_A	116_T	0.529	0.22
148_E	155_Q	0.528	0.22
29_L	132_Y	0.524	0.22
140_K	189_E	0.521	0.22
78_D	145_T	0.521	0.22
43_Y	115_L	0.521	0.22
72_A	149_E	0.520	0.22
82_Y	115_L	0.520	0.22
71_L	117_A	0.518	0.22
69_A	124_L	0.517	0.22
135_D	184_L	0.513	0.21
231_G	235_D	0.511	0.21
83_V	224_E	0.511	0.21
74_R	122_I	0.510	0.21
71_L	206_T	0.508	0.21
120_D	146_A	0.505	0.21
27_D	189_E	0.504	0.21
80_D	193_L	0.504	0.21
180_V	191_Q	0.504	0.21
69_A	175_G	0.503	0.21
84_D	116_T	0.501	0.21
128_L	181_V	0.500	0.21
34_G	58_V	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m0kA	2	0.7155	100	0.516	Contact Map
4lzaA	2	0.7113	100	0.518	Contact Map
1o57A	2	0.9582	100	0.529	Contact Map
1qb7A	2	0.8033	100	0.582	Contact Map
2dy0A	2	0.7531	100	0.594	Contact Map
1y0bA	2	0.749	100	0.616	Contact Map
1l1qA	2	0.7322	100	0.619	Contact Map
1zn8A	2	0.728	100	0.62	Contact Map
1g2qA	2	0.7197	99.9	0.627	Contact Map
3qw4B	4	0.8703	99.9	0.652	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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