GREMLIN Database
PYRE - Orotate phosphoribosyltransferase
UniProt: Q9HNG2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 175 (167)
Sequences: 3459 (1843)
Seq/√Len: 142.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_L136_A3.6761.00
148_E169_S3.6531.00
23_E29_T3.5861.00
21_E29_T3.5251.00
110_E137_T3.4631.00
106_D109_E2.7521.00
143_I164_A2.5451.00
51_A80_E2.3381.00
65_G74_A2.3361.00
129_D133_D2.1771.00
57_I112_V2.0951.00
128_V160_V2.0321.00
152_R156_A2.0181.00
74_A85_Y1.9561.00
124_A141_A1.8871.00
18_Q22_F1.8681.00
91_Q94_E1.8331.00
9_S13_A1.8321.00
62_T109_E1.8241.00
54_A81_A1.7911.00
64_A86_V1.7661.00
61_T109_E1.7641.00
52_A55_D1.7501.00
39_F49_I1.7391.00
56_R163_A1.7101.00
129_D158_H1.7051.00
140_R163_A1.6721.00
129_D132_R1.6591.00
118_A162_M1.6371.00
110_E139_N1.6331.00
76_A79_T1.6311.00
105_L109_E1.5991.00
47_S82_G1.5921.00
153_E157_E1.5911.00
50_A76_A1.5441.00
6_D48_A1.5081.00
47_S80_E1.5051.00
132_R137_T1.4961.00
132_R160_V1.4761.00
10_A48_A1.4701.00
24_L30_S1.4571.00
57_I142_L1.4121.00
154_L157_E1.3861.00
105_L136_A1.3791.00
50_A77_T1.3771.00
14_A45_C1.3741.00
115_E118_A1.3711.00
167_T170_D1.3701.00
148_E167_T1.3481.00
10_A45_C1.3401.00
140_R161_E1.3341.00
61_T110_E1.3191.00
62_T86_V1.3181.00
84_P109_E1.3161.00
143_I162_M1.3131.00
67_A71_V1.2981.00
118_A143_I1.2961.00
38_L104_R1.2951.00
61_T108_G1.2811.00
118_A151_G1.2761.00
10_A13_A1.1951.00
125_V158_H1.1931.00
75_A85_Y1.1921.00
141_A160_V1.1861.00
60_D163_A1.1781.00
34_V145_V1.1761.00
100_R133_D1.1621.00
77_T114_V1.1360.99
100_R130_A1.1300.99
113_V124_A1.1280.99
88_A130_A1.1100.99
52_A165_L1.1000.99
146_D150_G1.0880.99
44_E82_G1.0740.99
138_V160_V1.0690.99
53_F142_L1.0630.99
113_V128_V1.0610.99
109_E136_A1.0580.99
19_F32_Y1.0480.99
68_L71_V1.0400.99
112_V140_R1.0360.99
6_D9_S1.0290.99
55_D59_E1.0260.99
36_K117_I1.0120.99
21_E31_E1.0080.99
55_D58_D0.9870.98
155_L162_M0.9860.98
78_A84_P0.9650.98
54_A58_D0.9620.98
78_A85_Y0.9580.98
18_Q97_T0.9570.98
164_A167_T0.9520.98
11_L39_F0.9500.98
128_V132_R0.9420.98
19_F31_E0.9250.98
149_E153_E0.9200.97
125_V154_L0.9180.97
8_V166_V0.9160.97
11_L34_V0.9120.97
113_V138_V0.9050.97
17_V34_V0.9010.97
26_H119_T0.9010.97
6_D10_A0.8980.97
12_R19_F0.8940.97
71_V87_I0.8850.97
132_R158_H0.8840.97
60_D161_E0.8830.97
105_L111_V0.8780.97
56_R60_D0.8720.96
92_A100_R0.8700.96
25_S94_E0.8590.96
54_A77_T0.8580.96
62_T105_L0.8540.96
41_T84_P0.8520.96
76_A80_E0.8460.96
50_A80_E0.8430.96
132_R138_V0.8430.96
53_F165_L0.8410.96
50_A73_L0.8380.96
156_A161_E0.8260.95
125_V157_E0.8220.95
115_E124_A0.8210.95
153_E156_A0.8150.95
69_G72_P0.8030.94
18_Q38_L0.8000.94
63_L74_A0.7950.94
125_V128_V0.7950.94
47_S51_A0.7900.94
28_G149_E0.7890.94
57_I77_T0.7830.94
145_V171_L0.7820.94
25_S122_Q0.7820.94
70_G87_I0.7820.94
24_L119_T0.7790.94
127_A130_A0.7610.93
122_Q126_D0.7570.93
11_L36_K0.7540.92
16_A39_F0.7540.92
133_D137_T0.7540.92
49_I165_L0.7460.92
17_V32_Y0.7450.92
50_A79_T0.7390.92
50_A54_A0.7380.92
7_L44_E0.7340.91
66_V69_G0.7300.91
51_A54_A0.7270.91
18_Q66_V0.7220.91
113_V131_L0.7160.90
39_F144_V0.7140.90
61_T83_V0.7130.90
62_T136_A0.7130.90
65_G85_Y0.7080.90
99_N102_E0.7040.90
53_F77_T0.6960.89
115_E143_I0.6950.89
107_D135_G0.6910.89
47_S79_T0.6890.89
70_G86_V0.6840.88
73_L114_V0.6830.88
11_L16_A0.6780.88
142_L163_A0.6770.88
124_A155_L0.6760.88
144_V165_L0.6750.88
24_L147_R0.6750.88
51_A55_D0.6720.87
56_R59_E0.6690.87
107_D134_A0.6690.87
10_A14_A0.6660.87
66_V127_A0.6640.87
155_L161_E0.6630.87
15_D18_Q0.6620.86
126_D129_D0.6570.86
105_L131_L0.6560.86
54_A80_E0.6550.86
45_C48_A0.6550.86
88_A131_L0.6550.86
108_G135_G0.6510.86
40_E76_A0.6490.85
112_V139_N0.6400.85
151_G162_M0.6400.85
132_R159_G0.6360.84
56_R165_L0.6340.84
86_V136_A0.6270.83
117_I145_V0.6230.83
62_T111_V0.6230.83
70_G74_A0.6230.83
128_V141_A0.6160.82
146_D167_T0.6140.82
13_A45_C0.6100.82
146_D152_R0.6100.82
7_L166_V0.6070.81
123_S128_V0.6050.81
37_Y68_L0.6040.81
52_A56_R0.6020.81
68_L87_I0.5990.81
139_N161_E0.5990.81
58_D81_A0.5980.80
67_A90_K0.5960.80
94_E133_D0.5940.80
128_V138_V0.5920.80
107_D137_T0.5910.80
77_T142_L0.5880.79
89_R102_E0.5870.79
72_P89_R0.5870.79
47_S76_A0.5850.79
53_F73_L0.5840.79
7_L49_I0.5820.79
112_V142_L0.5800.78
25_S123_S0.5730.78
111_V131_L0.5700.77
99_N103_G0.5690.77
48_A51_A0.5690.77
49_I144_V0.5670.77
156_A159_G0.5650.77
149_E152_R0.5620.76
25_S66_V0.5600.76
41_T86_V0.5560.75
26_H30_S0.5530.75
34_V117_I0.5520.75
91_Q126_D0.5510.75
72_P75_A0.5490.75
141_A155_L0.5480.74
25_S95_Y0.5480.74
92_A98_A0.5480.74
67_A70_G0.5460.74
69_G88_A0.5440.74
5_D9_S0.5420.74
115_E127_A0.5410.73
32_Y168_A0.5400.73
86_V105_L0.5390.73
43_P84_P0.5360.73
25_S124_A0.5310.72
63_L112_V0.5290.72
37_Y102_E0.5290.72
9_S166_V0.5230.71
166_V170_D0.5220.71
64_A131_L0.5220.71
88_A127_A0.5210.71
20_G147_R0.5180.70
28_G122_Q0.5170.70
64_A88_A0.5150.70
120_T123_S0.5150.70
35_D66_V0.5140.70
104_R109_E0.5140.70
8_V12_R0.5120.69
65_G68_L0.5120.69
115_E165_L0.5060.68
36_K144_V0.5020.68
74_A114_V0.5010.68
150_G153_E0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qw4B 4 0.9714 100 0.301 Contact Map
3mjdA 2 0.9543 100 0.316 Contact Map
3n2lA 4 0.9429 100 0.322 Contact Map
2wnsA 2 0.9886 100 0.333 Contact Map
4fymA 4 0.9486 100 0.335 Contact Map
3m3hA 2 0.9314 100 0.343 Contact Map
2ps1A 2 0.9943 100 0.346 Contact Map
1lh0A 2 0.9886 100 0.347 Contact Map
3dezA 2 0.9543 100 0.357 Contact Map
4ohcA 5 1 100 0.363 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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