GREMLIN Database
Y2119 - UPF0290 protein VNG_2119C
UniProt: Q9HNG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (159)
Sequences: 293 (245)
Seq/√Len: 19.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_L103_I7.1601.00
114_R118_A4.4751.00
120_F123_V4.3841.00
48_G116_R3.8061.00
127_D131_V3.7391.00
100_V135_L3.6321.00
18_Y160_T3.4511.00
43_R47_D3.0440.99
58_T96_F2.7010.98
33_I51_W2.6110.98
65_A91_M2.3620.96
25_V49_K2.2260.94
17_A97_G2.2200.94
49_K103_I2.1520.93
164_H168_N2.1310.93
108_L159_L2.1180.93
105_A120_F1.9970.90
57_G99_M1.8900.87
18_Y94_L1.8340.86
91_M95_A1.7300.82
119_A173_A1.7050.81
37_R44_L1.6430.79
19_V37_R1.6420.79
105_A128_F1.6310.78
40_G111_R1.5940.76
57_G61_G1.5920.76
117_G176_V1.5800.76
21_N102_D1.5610.75
49_K180_P1.5580.75
129_V156_V1.5390.74
33_I54_T1.5230.73
114_R120_F1.4930.71
48_G117_G1.4850.71
56_V67_A1.4850.71
45_L49_K1.4840.71
61_G95_A1.4370.68
47_D116_R1.4280.68
52_R106_S1.4200.68
35_G51_W1.3670.64
31_R35_G1.3440.63
59_A154_V1.3330.62
74_A85_A1.3140.61
40_G50_T1.2640.58
105_A108_L1.2630.58
93_T139_A1.2630.58
105_A123_V1.2450.57
25_V171_A1.2210.56
25_V103_I1.2200.56
94_L160_T1.1520.51
41_G108_L1.1480.51
102_D105_A1.1450.51
26_L67_A1.1400.50
38_S44_L1.1350.50
104_A131_V1.1330.50
93_T136_T1.1220.49
54_T58_T1.1120.49
59_A95_A1.1110.49
38_S154_V1.0920.47
60_A166_L1.0900.47
21_N24_A1.0800.47
128_F132_A1.0780.46
16_P168_N1.0710.46
34_D41_G1.0560.45
21_N101_G1.0530.45
93_T159_L1.0350.44
14_M129_V1.0300.43
11_V163_L1.0190.43
97_G135_L1.0080.42
36_G51_W0.9980.41
154_V169_G0.9970.41
57_G102_D0.9840.41
52_R68_L0.9780.40
62_V92_G0.9730.40
25_V176_V0.9680.40
45_L180_P0.9580.39
21_N98_A0.9540.39
104_A108_L0.9430.38
32_P41_G0.9290.37
16_P164_H0.9220.37
159_L178_D0.9060.36
24_A102_D0.8820.34
128_F171_A0.8720.34
54_T103_I0.8660.34
89_A92_G0.8640.33
19_V88_P0.8620.33
92_G96_F0.8570.33
115_Q118_A0.8540.33
69_N91_M0.8540.33
102_D128_F0.8530.33
57_G101_G0.8520.33
128_F160_T0.8420.32
168_N171_A0.8410.32
61_G164_H0.8250.31
71_L157_A0.8240.31
7_V11_V0.8220.31
171_A177_K0.8220.31
34_D40_G0.8160.31
130_V157_A0.8100.30
36_G67_A0.8060.30
38_S150_L0.8060.30
37_R175_G0.8050.30
14_M18_Y0.8020.30
127_D138_L0.7990.30
20_P24_A0.7920.29
85_A89_A0.7900.29
15_L97_G0.7860.29
60_A133_L0.7750.29
23_A92_G0.7750.29
69_N87_P0.7730.28
63_A67_A0.7680.28
67_A112_T0.7670.28
168_N172_Y0.7640.28
64_L68_L0.7630.28
161_P181_W0.7620.28
29_G52_R0.7620.28
25_V181_W0.7590.28
156_V159_L0.7570.28
27_A133_L0.7570.28
102_D132_A0.7470.27
119_A165_L0.7460.27
25_V98_A0.7450.27
66_V88_P0.7440.27
113_G134_A0.7440.27
23_A44_L0.7430.27
127_D167_T0.7380.27
112_T130_V0.7370.27
21_N57_G0.7370.27
105_A171_A0.7370.27
141_P178_D0.7330.26
63_A88_P0.7270.26
50_T125_Q0.7260.26
51_W54_T0.7250.26
67_A74_A0.7250.26
65_A105_A0.7240.26
56_V126_L0.7220.26
57_G119_A0.7210.26
98_A102_D0.7030.25
130_V166_L0.7000.25
44_L150_L0.6990.25
135_L154_V0.6920.24
122_V178_D0.6910.24
24_A43_R0.6870.24
29_G135_L0.6850.24
93_T135_L0.6830.24
172_Y180_P0.6810.24
95_A181_W0.6790.24
67_A88_P0.6770.24
37_R61_G0.6740.24
49_K54_T0.6710.23
22_N174_L0.6690.23
26_L99_M0.6670.23
128_F177_K0.6590.23
24_A127_D0.6560.23
107_F111_R0.6560.23
14_M133_L0.6560.23
135_L156_V0.6550.23
45_L122_V0.6510.23
132_A170_I0.6490.22
45_L64_L0.6490.22
65_A113_G0.6420.22
105_A179_E0.6380.22
14_M90_A0.6350.22
164_H172_Y0.6310.22
21_N128_F0.6310.22
8_V150_L0.6300.22
134_A175_G0.6290.22
7_V160_T0.6270.22
22_N54_T0.6270.22
8_V170_I0.6270.22
20_P23_A0.6210.21
41_G44_L0.6140.21
90_A93_T0.6110.21
26_L52_R0.6090.21
59_A155_T0.6080.21
7_V54_T0.6060.21
46_G110_R0.6000.20
46_G124_D0.6000.20
46_G53_G0.6000.20
46_G109_K0.6000.20
53_G110_R0.6000.20
110_R124_D0.6000.20
109_K124_D0.6000.20
53_G124_D0.6000.20
53_G109_K0.6000.20
166_L170_I0.5980.20
64_L99_M0.5970.20
88_P178_D0.5970.20
134_A170_I0.5880.20
170_I174_L0.5880.20
8_V138_L0.5870.20
95_A100_V0.5870.20
33_I99_M0.5840.20
17_A132_A0.5840.20
89_A174_L0.5830.20
140_V181_W0.5810.20
26_L60_A0.5810.20
90_A162_A0.5750.19
31_R108_L0.5740.19
63_A162_A0.5710.19
164_H175_G0.5700.19
45_L121_P0.5700.19
114_R121_P0.5690.19
134_A159_L0.5660.19
28_G102_D0.5660.19
61_G167_T0.5620.19
33_I149_G0.5600.19
95_A132_A0.5590.19
59_A73_P0.5590.19
122_V153_L0.5580.19
23_A51_W0.5530.18
63_A154_V0.5470.18
11_V108_L0.5470.18
105_A127_D0.5420.18
60_A100_V0.5400.18
134_A166_L0.5370.18
61_G179_E0.5330.18
108_L120_F0.5330.18
98_A171_A0.5280.18
128_F168_N0.5250.17
65_A120_F0.5240.17
34_D107_F0.5240.17
62_V95_A0.5240.17
12_W68_L0.5220.17
42_R162_A0.5210.17
25_V102_D0.5170.17
91_M123_V0.5160.17
37_R163_L0.5140.17
103_I116_R0.5140.17
24_A101_G0.5060.17
130_V152_V0.5060.17
42_R54_T0.5040.17
62_V89_A0.5030.17
100_V152_V0.5030.17
85_A134_A0.5020.17
121_P165_L0.5020.17
165_L169_G0.5020.17
37_R92_G0.5010.17
71_L169_G0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q2eA 2 0.8122 99.6 0.713 Contact Map
4lg3A 1 0.6243 15.2 0.953 Contact Map
3k3fA 3 0.7238 5.5 0.961 Contact Map
4od4A 1 0.8508 3.5 0.965 Contact Map
3j1zP 8 0.9503 3.5 0.965 Contact Map
3h90A 3 0.9503 3.2 0.965 Contact Map
1m56D 1 0.232 2.9 0.966 Contact Map
4m64A 1 0.7293 2.9 0.966 Contact Map
2gfpA 2 0.9392 2.4 0.968 Contact Map
3wdoA 1 0.7127 2.1 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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