GREMLIN Database
Q9HNG0 - Proline dehydrogenase
UniProt: Q9HNG0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 279 (270)
Sequences: 2783 (1723)
Seq/√Len: 104.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_E127_T6.1741.00
59_A96_A5.1991.00
175_K179_N3.9631.00
87_A123_S3.5321.00
183_R209_Y3.3311.00
51_A92_T3.2621.00
186_L199_V3.2411.00
199_V210_A3.1891.00
136_V143_T3.0841.00
146_D150_L2.8001.00
52_A56_R2.7661.00
14_T17_E2.7181.00
96_A99_D2.6681.00
148_D188_F2.6491.00
55_R96_A2.5931.00
187_E213_L2.5891.00
122_E149_R2.5881.00
106_V121_F2.5821.00
48_D89_N2.4861.00
95_A99_D2.4811.00
13_E17_E2.4791.00
115_D119_D2.3051.00
28_R235_T2.2591.00
138_A185_H2.2261.00
186_L210_A2.2181.00
94_A104_A2.2171.00
172_Y181_A2.1881.00
105_W135_C2.1381.00
53_A250_Y2.1161.00
147_L185_H2.0611.00
62_G100_H2.0441.00
77_I93_I2.0341.00
48_D52_A2.0311.00
183_R205_A2.0131.00
95_A129_A1.9771.00
59_A100_H1.9711.00
176_P180_E1.9711.00
91_E95_A1.9591.00
144_E184_T1.9411.00
44_R89_N1.8361.00
53_A56_R1.8271.00
84_E88_E1.8151.00
191_R217_Y1.8081.00
96_A100_H1.7411.00
44_R48_D1.7271.00
221_Y242_V1.6971.00
83_P119_D1.6771.00
55_R92_T1.6691.00
214_H221_Y1.6551.00
87_A120_T1.6471.00
247_Y257_Y1.6181.00
44_R85_V1.5551.00
58_V102_V1.5171.00
16_A56_R1.5041.00
91_E129_A1.5001.00
237_L244_T1.4921.00
187_E209_Y1.4591.00
187_E191_R1.4441.00
121_F134_L1.4291.00
87_A124_L1.4281.00
108_M117_T1.4051.00
93_I104_A1.3891.00
55_R59_A1.3831.00
144_E148_D1.3771.00
30_V235_T1.3551.00
204_P233_A1.3500.99
174_D177_D1.3470.99
144_E188_F1.3330.99
173_Q177_D1.3230.99
145_Q149_R1.3130.99
144_E181_A1.3100.99
177_D180_E1.2990.99
69_C105_W1.2950.99
43_E46_P1.2790.99
52_A55_R1.2640.99
201_S206_M1.2540.99
151_A188_F1.2370.99
87_A127_T1.2360.99
23_A64_S1.2200.99
172_Y177_D1.2160.99
223_V242_V1.2160.99
136_V150_L1.2130.99
160_V163_A1.2130.99
31_T243_P1.2110.99
51_A55_R1.2030.99
75_S113_T1.2010.99
12_G17_E1.1850.99
60_D64_S1.1640.98
181_A185_H1.1500.98
183_R206_M1.1490.98
22_A34_L1.1470.98
146_D149_R1.1350.98
212_E216_E1.1250.98
201_S207_I1.1210.98
58_V100_H1.1130.98
234_Q244_T1.1100.98
69_C156_K1.1080.98
16_A60_D1.1020.98
95_A128_H1.1020.98
235_T239_A1.0950.98
21_Y24_D1.0860.98
213_L217_Y1.0850.98
268_N271_F1.0810.98
69_C103_F1.0770.97
83_P116_A1.0720.97
141_K173_Q1.0710.97
71_S247_Y1.0680.97
157_V189_M1.0650.97
19_I66_V1.0590.97
44_R79_L1.0570.97
24_D27_D1.0450.97
79_L82_G1.0390.97
22_A32_A1.0370.97
51_A89_N1.0370.97
191_R213_L1.0370.97
73_K164_Y1.0340.97
15_P60_D1.0310.97
213_L216_E1.0280.97
59_A99_D1.0270.97
209_Y213_L1.0210.96
35_N247_Y1.0200.96
90_L106_V1.0180.96
30_V238_A1.0160.96
165_D173_Q1.0130.96
134_L157_V1.0110.96
45_P49_E1.0090.96
142_R146_D0.9990.96
188_F192_E0.9920.96
90_L124_L0.9880.96
236_E240_T0.9880.96
178_V267_E0.9760.95
44_R82_G0.9680.95
110_D113_T0.9640.95
58_V70_V0.9580.95
55_R93_I0.9570.95
94_A132_M0.9480.95
187_E216_E0.9440.95
54_Y70_V0.9430.95
125_A155_G0.9430.95
35_N73_K0.9410.94
198_A224_Q0.9370.94
255_F266_K0.9350.94
23_A27_D0.9240.94
233_A236_E0.9230.94
35_N107_D0.9210.94
56_R59_A0.9200.94
114_T142_R0.9160.94
87_A91_E0.9140.94
190_F217_Y0.9130.94
192_E195_D0.9110.93
111_H170_V0.9100.93
114_T160_V0.9010.93
143_T185_H0.9000.93
215_E218_G0.8960.93
82_G85_V0.8930.93
26_N32_A0.8880.93
26_N68_A0.8860.92
211_A240_T0.8720.92
78_G85_V0.8720.92
84_E123_S0.8690.92
122_E126_R0.8680.92
9_F163_A0.8670.92
203_D206_M0.8500.91
15_P56_R0.8460.91
190_F214_H0.8450.91
147_L151_A0.8450.91
211_A223_V0.8440.91
105_W156_K0.8430.90
158_R161_K0.8320.90
139_N181_A0.8260.90
123_S126_R0.8250.90
235_T238_A0.8220.89
211_A242_V0.8210.89
178_V265_R0.8160.89
39_E73_K0.8140.89
126_R151_A0.8140.89
105_W198_A0.8110.89
145_Q148_D0.8110.89
165_D171_A0.8040.88
144_E185_H0.8040.88
148_D151_A0.8030.88
59_A62_G0.7970.88
73_K107_D0.7960.88
107_D260_R0.7950.88
196_G221_Y0.7910.87
91_E124_L0.7880.87
186_L213_L0.7850.87
136_V157_V0.7830.87
49_E53_A0.7810.87
136_V147_L0.7770.87
180_E183_R0.7760.86
111_H140_L0.7760.86
19_I60_D0.7750.86
49_E52_A0.7720.86
102_V132_M0.7710.86
159_L185_H0.7710.86
15_P53_A0.7700.86
159_L186_L0.7680.86
52_A92_T0.7670.86
255_F263_M0.7640.86
89_N92_T0.7640.86
37_L71_S0.7630.86
222_E245_Y0.7560.85
205_A208_S0.7500.85
260_R264_E0.7480.84
8_R229_I0.7460.84
57_L250_Y0.7450.84
40_H110_D0.7450.84
257_Y261_R0.7430.84
182_Y206_M0.7420.84
110_D167_P0.7390.84
121_F132_M0.7350.83
4_P13_E0.7330.83
27_D45_P0.7330.83
20_E23_A0.7320.83
258_F265_R0.7320.83
70_V94_A0.7310.83
30_V244_T0.7290.83
189_M195_D0.7290.83
141_K172_Y0.7250.83
249_P260_R0.7240.82
122_E153_V0.7230.82
19_I23_A0.7210.82
36_L250_Y0.7190.82
159_L189_M0.7180.82
14_T252_G0.7140.82
74_P120_T0.7140.82
29_G34_L0.7130.81
209_Y212_E0.7130.81
122_E150_L0.7120.81
74_P90_L0.7100.81
260_R265_R0.7100.81
147_L160_V0.7040.81
34_L68_A0.7030.81
85_V88_E0.7020.80
72_V104_A0.7020.80
150_L155_G0.7020.80
47_A54_Y0.7010.80
91_E128_H0.7000.80
151_A195_D0.6990.80
201_S210_A0.6970.80
17_E20_E0.6930.80
267_E271_F0.6930.80
181_A184_T0.6930.80
61_V70_V0.6900.79
174_D180_E0.6880.79
73_K135_C0.6850.79
20_E64_S0.6820.79
121_F155_G0.6820.79
210_A214_H0.6820.79
205_A209_Y0.6800.78
41_Y46_P0.6790.78
207_I237_L0.6780.78
98_A130_G0.6770.78
119_D123_S0.6750.78
50_D54_Y0.6740.78
32_A248_V0.6730.78
114_T117_T0.6730.78
111_H167_P0.6720.78
111_H256_S0.6710.77
107_D137_Q0.6700.77
156_K198_A0.6680.77
175_K206_M0.6660.77
57_L70_V0.6630.77
65_D102_V0.6630.77
73_K224_Q0.6630.77
26_N66_V0.6570.76
60_D63_D0.6570.76
83_P123_S0.6550.76
39_E163_A0.6540.76
9_F258_F0.6540.76
36_L53_A0.6520.75
55_R123_S0.6470.75
190_F210_A0.6450.75
189_M197_V0.6450.75
7_N216_E0.6430.74
99_D130_G0.6420.74
154_P220_D0.6390.74
6_A254_W0.6380.74
80_D113_T0.6370.74
51_A93_I0.6360.74
160_V253_K0.6340.73
92_T96_A0.6320.73
39_E264_E0.6320.73
249_P257_Y0.6300.73
180_E184_T0.6280.73
185_H189_M0.6280.73
190_F213_L0.6280.73
178_V203_D0.6270.73
243_P274_R0.6270.73
95_A127_T0.6230.72
18_A34_L0.6230.72
52_A84_E0.6230.72
84_E87_A0.6230.72
207_I223_V0.6220.72
42_H98_A0.6210.72
59_A63_D0.6200.72
48_D92_T0.6190.72
52_A59_A0.6170.71
238_A244_T0.6170.71
26_N64_S0.6160.71
124_L132_M0.6160.71
22_A26_N0.6150.71
48_D85_V0.6140.71
111_H142_R0.6140.71
108_M225_M0.6130.71
35_N39_E0.6130.71
41_Y47_A0.6120.71
140_L171_A0.6110.71
24_D45_P0.6100.70
79_L116_A0.6090.70
48_D56_R0.6070.70
114_T253_K0.6050.70
39_E226_L0.6040.70
126_R153_V0.6030.70
126_R176_P0.6030.70
29_G67_D0.6030.70
164_Y224_Q0.6010.69
10_V253_K0.6000.69
107_D139_N0.5980.69
135_C140_L0.5980.69
135_C160_V0.5970.69
263_M266_K0.5970.69
226_L247_Y0.5960.69
95_A98_A0.5930.68
48_D88_E0.5930.68
48_D51_A0.5870.68
35_N71_S0.5830.67
103_F156_K0.5830.67
261_R264_E0.5820.67
160_V178_V0.5800.67
172_Y184_T0.5790.66
214_H232_D0.5770.66
166_E263_M0.5740.66
160_V179_N0.5730.66
30_V246_Q0.5720.66
223_V237_L0.5720.66
19_I34_L0.5710.65
114_T178_V0.5690.65
229_I258_F0.5640.64
5_I15_P0.5630.64
133_G158_R0.5620.64
215_E240_T0.5620.64
203_D229_I0.5600.64
160_V229_I0.5600.64
103_F133_G0.5590.64
35_N249_P0.5590.64
26_N29_G0.5580.64
125_A132_M0.5570.64
237_L242_V0.5560.63
212_E215_E0.5550.63
71_S224_Q0.5540.63
203_D254_W0.5510.63
116_A120_T0.5500.63
227_M263_M0.5480.62
105_W256_S0.5480.62
83_P168_D0.5470.62
186_L209_Y0.5460.62
107_D164_Y0.5460.62
73_K139_N0.5460.62
229_I265_R0.5460.62
249_P256_S0.5450.62
88_E91_E0.5440.62
33_I245_Y0.5440.62
78_G86_F0.5430.62
182_Y210_A0.5430.62
45_P184_T0.5410.61
73_K175_K0.5400.61
211_A221_Y0.5390.61
175_K178_V0.5390.61
145_Q157_V0.5380.61
139_N260_R0.5380.61
265_R268_N0.5380.61
179_N229_I0.5360.61
50_D229_I0.5340.60
69_C102_V0.5300.60
219_T243_P0.5290.60
103_F135_C0.5290.60
51_A104_A0.5290.60
229_I267_E0.5280.59
208_S211_A0.5280.59
54_Y72_V0.5270.59
70_V102_V0.5260.59
225_M231_E0.5250.59
159_L199_V0.5220.59
132_M135_C0.5210.58
73_K260_R0.5190.58
16_A24_D0.5190.58
166_E170_V0.5180.58
118_M146_D0.5150.58
25_L227_M0.5150.58
39_E247_Y0.5130.57
54_Y76_Q0.5130.57
137_Q226_L0.5110.57
7_N63_D0.5100.57
144_E252_G0.5090.57
91_E123_S0.5090.57
113_T117_T0.5080.57
138_A143_T0.5070.56
18_A37_L0.5040.56
26_N61_V0.5010.56
139_N178_V0.5010.56
172_Y178_V0.5010.56
35_N164_Y0.5000.55
161_K268_N0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ekgA 2 0.9391 100 0.082 Contact Map
4h6qA 1 0.9498 100 0.1 Contact Map
3hazA 3 0.9964 100 0.12 Contact Map
4nm9A 2 1 100 0.133 Contact Map
3e2qA 2 0.9964 100 0.147 Contact Map
4o8aA 2 0.9964 100 0.148 Contact Map
1i60A 1 0.7885 69.9 0.952 Contact Map
4ovxA 1 0.7527 65 0.954 Contact Map
3cqjA 2 0.7778 57.4 0.956 Contact Map
3dx5A 2 0.7599 52.3 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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