Q9HNG0 - HALSA - GREMLIN Contacts

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Q9HNG0 - Proline dehydrogenase

UniProt:	Q9HNG0	Sequences: MIPPIANRFVAGETPAEAIEYAADLNDRGVTAILNLLGEHYHERPPADEDAAAYRRLVADVGDSDVDACVSVKPSQIGLDVGPEVFAENLETIAAAAADHDVFAWVDMEDHETTDATMDTFESLARTHAGNMGLCVQANLKRTEQDLDRLADVPGKVRLVKGAYDEPDDVAYQDKPDVNEAYRTHLEFMFREFDDGVAVGSHDPAMISYAAELHEEYGTDYEVQMLMGIREDAQTELAATGVPTYQYVPYGGKWFSYFYRRAMERKENLVFALRAVLGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	279 (270)
Sequences:	2783 (1723)
Seq/√Len:	104.9

ECOLI - PUTA
BACSU - PROD1 PROD2
HALSA - Q9HNG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
91_E	127_T	6.174	1.00
59_A	96_A	5.199	1.00
175_K	179_N	3.963	1.00
87_A	123_S	3.532	1.00
183_R	209_Y	3.331	1.00
51_A	92_T	3.262	1.00
186_L	199_V	3.241	1.00
199_V	210_A	3.189	1.00
136_V	143_T	3.084	1.00
146_D	150_L	2.800	1.00
52_A	56_R	2.766	1.00
14_T	17_E	2.718	1.00
96_A	99_D	2.668	1.00
148_D	188_F	2.649	1.00
55_R	96_A	2.593	1.00
187_E	213_L	2.589	1.00
122_E	149_R	2.588	1.00
106_V	121_F	2.582	1.00
48_D	89_N	2.486	1.00
95_A	99_D	2.481	1.00
13_E	17_E	2.479	1.00
115_D	119_D	2.305	1.00
28_R	235_T	2.259	1.00
138_A	185_H	2.226	1.00
186_L	210_A	2.218	1.00
94_A	104_A	2.217	1.00
172_Y	181_A	2.188	1.00
105_W	135_C	2.138	1.00
53_A	250_Y	2.116	1.00
147_L	185_H	2.061	1.00
62_G	100_H	2.044	1.00
77_I	93_I	2.034	1.00
48_D	52_A	2.031	1.00
183_R	205_A	2.013	1.00
95_A	129_A	1.977	1.00
59_A	100_H	1.971	1.00
176_P	180_E	1.971	1.00
91_E	95_A	1.959	1.00
144_E	184_T	1.941	1.00
44_R	89_N	1.836	1.00
53_A	56_R	1.827	1.00
84_E	88_E	1.815	1.00
191_R	217_Y	1.808	1.00
96_A	100_H	1.741	1.00
44_R	48_D	1.727	1.00
221_Y	242_V	1.697	1.00
83_P	119_D	1.677	1.00
55_R	92_T	1.669	1.00
214_H	221_Y	1.655	1.00
87_A	120_T	1.647	1.00
247_Y	257_Y	1.618	1.00
44_R	85_V	1.555	1.00
58_V	102_V	1.517	1.00
16_A	56_R	1.504	1.00
91_E	129_A	1.500	1.00
237_L	244_T	1.492	1.00
187_E	209_Y	1.459	1.00
187_E	191_R	1.444	1.00
121_F	134_L	1.429	1.00
87_A	124_L	1.428	1.00
108_M	117_T	1.405	1.00
93_I	104_A	1.389	1.00
55_R	59_A	1.383	1.00
144_E	148_D	1.377	1.00
30_V	235_T	1.355	1.00
204_P	233_A	1.350	0.99
174_D	177_D	1.347	0.99
144_E	188_F	1.333	0.99
173_Q	177_D	1.323	0.99
145_Q	149_R	1.313	0.99
144_E	181_A	1.310	0.99
177_D	180_E	1.299	0.99
69_C	105_W	1.295	0.99
43_E	46_P	1.279	0.99
52_A	55_R	1.264	0.99
201_S	206_M	1.254	0.99
151_A	188_F	1.237	0.99
87_A	127_T	1.236	0.99
23_A	64_S	1.220	0.99
172_Y	177_D	1.216	0.99
223_V	242_V	1.216	0.99
136_V	150_L	1.213	0.99
160_V	163_A	1.213	0.99
31_T	243_P	1.211	0.99
51_A	55_R	1.203	0.99
75_S	113_T	1.201	0.99
12_G	17_E	1.185	0.99
60_D	64_S	1.164	0.98
181_A	185_H	1.150	0.98
183_R	206_M	1.149	0.98
22_A	34_L	1.147	0.98
146_D	149_R	1.135	0.98
212_E	216_E	1.125	0.98
201_S	207_I	1.121	0.98
58_V	100_H	1.113	0.98
234_Q	244_T	1.110	0.98
69_C	156_K	1.108	0.98
16_A	60_D	1.102	0.98
95_A	128_H	1.102	0.98
235_T	239_A	1.095	0.98
21_Y	24_D	1.086	0.98
213_L	217_Y	1.085	0.98
268_N	271_F	1.081	0.98
69_C	103_F	1.077	0.97
83_P	116_A	1.072	0.97
141_K	173_Q	1.071	0.97
71_S	247_Y	1.068	0.97
157_V	189_M	1.065	0.97
19_I	66_V	1.059	0.97
44_R	79_L	1.057	0.97
24_D	27_D	1.045	0.97
79_L	82_G	1.039	0.97
22_A	32_A	1.037	0.97
51_A	89_N	1.037	0.97
191_R	213_L	1.037	0.97
73_K	164_Y	1.034	0.97
15_P	60_D	1.031	0.97
213_L	216_E	1.028	0.97
59_A	99_D	1.027	0.97
209_Y	213_L	1.021	0.96
35_N	247_Y	1.020	0.96
90_L	106_V	1.018	0.96
30_V	238_A	1.016	0.96
165_D	173_Q	1.013	0.96
134_L	157_V	1.011	0.96
45_P	49_E	1.009	0.96
142_R	146_D	0.999	0.96
188_F	192_E	0.992	0.96
90_L	124_L	0.988	0.96
236_E	240_T	0.988	0.96
178_V	267_E	0.976	0.95
44_R	82_G	0.968	0.95
110_D	113_T	0.964	0.95
58_V	70_V	0.958	0.95
55_R	93_I	0.957	0.95
94_A	132_M	0.948	0.95
187_E	216_E	0.944	0.95
54_Y	70_V	0.943	0.95
125_A	155_G	0.943	0.95
35_N	73_K	0.941	0.94
198_A	224_Q	0.937	0.94
255_F	266_K	0.935	0.94
23_A	27_D	0.924	0.94
233_A	236_E	0.923	0.94
35_N	107_D	0.921	0.94
56_R	59_A	0.920	0.94
114_T	142_R	0.916	0.94
87_A	91_E	0.914	0.94
190_F	217_Y	0.913	0.94
192_E	195_D	0.911	0.93
111_H	170_V	0.910	0.93
114_T	160_V	0.901	0.93
143_T	185_H	0.900	0.93
215_E	218_G	0.896	0.93
82_G	85_V	0.893	0.93
26_N	32_A	0.888	0.93
26_N	68_A	0.886	0.92
211_A	240_T	0.872	0.92
78_G	85_V	0.872	0.92
84_E	123_S	0.869	0.92
122_E	126_R	0.868	0.92
9_F	163_A	0.867	0.92
203_D	206_M	0.850	0.91
15_P	56_R	0.846	0.91
190_F	214_H	0.845	0.91
147_L	151_A	0.845	0.91
211_A	223_V	0.844	0.91
105_W	156_K	0.843	0.90
158_R	161_K	0.832	0.90
139_N	181_A	0.826	0.90
123_S	126_R	0.825	0.90
235_T	238_A	0.822	0.89
211_A	242_V	0.821	0.89
178_V	265_R	0.816	0.89
39_E	73_K	0.814	0.89
126_R	151_A	0.814	0.89
105_W	198_A	0.811	0.89
145_Q	148_D	0.811	0.89
165_D	171_A	0.804	0.88
144_E	185_H	0.804	0.88
148_D	151_A	0.803	0.88
59_A	62_G	0.797	0.88
73_K	107_D	0.796	0.88
107_D	260_R	0.795	0.88
196_G	221_Y	0.791	0.87
91_E	124_L	0.788	0.87
186_L	213_L	0.785	0.87
136_V	157_V	0.783	0.87
49_E	53_A	0.781	0.87
136_V	147_L	0.777	0.87
180_E	183_R	0.776	0.86
111_H	140_L	0.776	0.86
19_I	60_D	0.775	0.86
49_E	52_A	0.772	0.86
102_V	132_M	0.771	0.86
159_L	185_H	0.771	0.86
15_P	53_A	0.770	0.86
159_L	186_L	0.768	0.86
52_A	92_T	0.767	0.86
255_F	263_M	0.764	0.86
89_N	92_T	0.764	0.86
37_L	71_S	0.763	0.86
222_E	245_Y	0.756	0.85
205_A	208_S	0.750	0.85
260_R	264_E	0.748	0.84
8_R	229_I	0.746	0.84
57_L	250_Y	0.745	0.84
40_H	110_D	0.745	0.84
257_Y	261_R	0.743	0.84
182_Y	206_M	0.742	0.84
110_D	167_P	0.739	0.84
121_F	132_M	0.735	0.83
4_P	13_E	0.733	0.83
27_D	45_P	0.733	0.83
20_E	23_A	0.732	0.83
258_F	265_R	0.732	0.83
70_V	94_A	0.731	0.83
30_V	244_T	0.729	0.83
189_M	195_D	0.729	0.83
141_K	172_Y	0.725	0.83
249_P	260_R	0.724	0.82
122_E	153_V	0.723	0.82
19_I	23_A	0.721	0.82
36_L	250_Y	0.719	0.82
159_L	189_M	0.718	0.82
14_T	252_G	0.714	0.82
74_P	120_T	0.714	0.82
29_G	34_L	0.713	0.81
209_Y	212_E	0.713	0.81
122_E	150_L	0.712	0.81
74_P	90_L	0.710	0.81
260_R	265_R	0.710	0.81
147_L	160_V	0.704	0.81
34_L	68_A	0.703	0.81
85_V	88_E	0.702	0.80
72_V	104_A	0.702	0.80
150_L	155_G	0.702	0.80
47_A	54_Y	0.701	0.80
91_E	128_H	0.700	0.80
151_A	195_D	0.699	0.80
201_S	210_A	0.697	0.80
17_E	20_E	0.693	0.80
267_E	271_F	0.693	0.80
181_A	184_T	0.693	0.80
61_V	70_V	0.690	0.79
174_D	180_E	0.688	0.79
73_K	135_C	0.685	0.79
20_E	64_S	0.682	0.79
121_F	155_G	0.682	0.79
210_A	214_H	0.682	0.79
205_A	209_Y	0.680	0.78
41_Y	46_P	0.679	0.78
207_I	237_L	0.678	0.78
98_A	130_G	0.677	0.78
119_D	123_S	0.675	0.78
50_D	54_Y	0.674	0.78
32_A	248_V	0.673	0.78
114_T	117_T	0.673	0.78
111_H	167_P	0.672	0.78
111_H	256_S	0.671	0.77
107_D	137_Q	0.670	0.77
156_K	198_A	0.668	0.77
175_K	206_M	0.666	0.77
57_L	70_V	0.663	0.77
65_D	102_V	0.663	0.77
73_K	224_Q	0.663	0.77
26_N	66_V	0.657	0.76
60_D	63_D	0.657	0.76
83_P	123_S	0.655	0.76
39_E	163_A	0.654	0.76
9_F	258_F	0.654	0.76
36_L	53_A	0.652	0.75
55_R	123_S	0.647	0.75
190_F	210_A	0.645	0.75
189_M	197_V	0.645	0.75
7_N	216_E	0.643	0.74
99_D	130_G	0.642	0.74
154_P	220_D	0.639	0.74
6_A	254_W	0.638	0.74
80_D	113_T	0.637	0.74
51_A	93_I	0.636	0.74
160_V	253_K	0.634	0.73
92_T	96_A	0.632	0.73
39_E	264_E	0.632	0.73
249_P	257_Y	0.630	0.73
180_E	184_T	0.628	0.73
185_H	189_M	0.628	0.73
190_F	213_L	0.628	0.73
178_V	203_D	0.627	0.73
243_P	274_R	0.627	0.73
95_A	127_T	0.623	0.72
18_A	34_L	0.623	0.72
52_A	84_E	0.623	0.72
84_E	87_A	0.623	0.72
207_I	223_V	0.622	0.72
42_H	98_A	0.621	0.72
59_A	63_D	0.620	0.72
48_D	92_T	0.619	0.72
52_A	59_A	0.617	0.71
238_A	244_T	0.617	0.71
26_N	64_S	0.616	0.71
124_L	132_M	0.616	0.71
22_A	26_N	0.615	0.71
48_D	85_V	0.614	0.71
111_H	142_R	0.614	0.71
108_M	225_M	0.613	0.71
35_N	39_E	0.613	0.71
41_Y	47_A	0.612	0.71
140_L	171_A	0.611	0.71
24_D	45_P	0.610	0.70
79_L	116_A	0.609	0.70
48_D	56_R	0.607	0.70
114_T	253_K	0.605	0.70
39_E	226_L	0.604	0.70
126_R	153_V	0.603	0.70
126_R	176_P	0.603	0.70
29_G	67_D	0.603	0.70
164_Y	224_Q	0.601	0.69
10_V	253_K	0.600	0.69
107_D	139_N	0.598	0.69
135_C	140_L	0.598	0.69
135_C	160_V	0.597	0.69
263_M	266_K	0.597	0.69
226_L	247_Y	0.596	0.69
95_A	98_A	0.593	0.68
48_D	88_E	0.593	0.68
48_D	51_A	0.587	0.68
35_N	71_S	0.583	0.67
103_F	156_K	0.583	0.67
261_R	264_E	0.582	0.67
160_V	178_V	0.580	0.67
172_Y	184_T	0.579	0.66
214_H	232_D	0.577	0.66
166_E	263_M	0.574	0.66
160_V	179_N	0.573	0.66
30_V	246_Q	0.572	0.66
223_V	237_L	0.572	0.66
19_I	34_L	0.571	0.65
114_T	178_V	0.569	0.65
229_I	258_F	0.564	0.64
5_I	15_P	0.563	0.64
133_G	158_R	0.562	0.64
215_E	240_T	0.562	0.64
203_D	229_I	0.560	0.64
160_V	229_I	0.560	0.64
103_F	133_G	0.559	0.64
35_N	249_P	0.559	0.64
26_N	29_G	0.558	0.64
125_A	132_M	0.557	0.64
237_L	242_V	0.556	0.63
212_E	215_E	0.555	0.63
71_S	224_Q	0.554	0.63
203_D	254_W	0.551	0.63
116_A	120_T	0.550	0.63
227_M	263_M	0.548	0.62
105_W	256_S	0.548	0.62
83_P	168_D	0.547	0.62
186_L	209_Y	0.546	0.62
107_D	164_Y	0.546	0.62
73_K	139_N	0.546	0.62
229_I	265_R	0.546	0.62
249_P	256_S	0.545	0.62
88_E	91_E	0.544	0.62
33_I	245_Y	0.544	0.62
78_G	86_F	0.543	0.62
182_Y	210_A	0.543	0.62
45_P	184_T	0.541	0.61
73_K	175_K	0.540	0.61
211_A	221_Y	0.539	0.61
175_K	178_V	0.539	0.61
145_Q	157_V	0.538	0.61
139_N	260_R	0.538	0.61
265_R	268_N	0.538	0.61
179_N	229_I	0.536	0.61
50_D	229_I	0.534	0.60
69_C	102_V	0.530	0.60
219_T	243_P	0.529	0.60
103_F	135_C	0.529	0.60
51_A	104_A	0.529	0.60
229_I	267_E	0.528	0.59
208_S	211_A	0.528	0.59
54_Y	72_V	0.527	0.59
70_V	102_V	0.526	0.59
225_M	231_E	0.525	0.59
159_L	199_V	0.522	0.59
132_M	135_C	0.521	0.58
73_K	260_R	0.519	0.58
16_A	24_D	0.519	0.58
166_E	170_V	0.518	0.58
118_M	146_D	0.515	0.58
25_L	227_M	0.515	0.58
39_E	247_Y	0.513	0.57
54_Y	76_Q	0.513	0.57
137_Q	226_L	0.511	0.57
7_N	63_D	0.510	0.57
144_E	252_G	0.509	0.57
91_E	123_S	0.509	0.57
113_T	117_T	0.508	0.57
138_A	143_T	0.507	0.56
18_A	37_L	0.504	0.56
26_N	61_V	0.501	0.56
139_N	178_V	0.501	0.56
172_Y	178_V	0.501	0.56
35_N	164_Y	0.500	0.55
161_K	268_N	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ekgA	2	0.9391	100	0.082	Contact Map
4h6qA	1	0.9498	100	0.1	Contact Map
3hazA	3	0.9964	100	0.12	Contact Map
4nm9A	2	1	100	0.133	Contact Map
3e2qA	2	0.9964	100	0.147	Contact Map
4o8aA	2	0.9964	100	0.148	Contact Map
1i60A	1	0.7885	69.9	0.952	Contact Map
4ovxA	1	0.7527	65	0.954	Contact Map
3cqjA	2	0.7778	57.4	0.956	Contact Map
3dx5A	2	0.7599	52.3	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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