Q9HNF9 - HALSA - GREMLIN Contacts

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Q9HNF9 - Uncharacterized protein

UniProt:	Q9HNF9	Sequences: MGSWKRDFASGLIVLVPIVVTLYVIYWLFGLLSNITLFTQLTDTQYQAVAATLAVFVLIVFSVGYLMRTAAGSILEALIDYVMNRLPVLRIVYNASKMAVETVLSDGTGEFQQPVRVEPWPGMRLTAFKTGKKAPDGREVVFMPTAPNITTGFVMEVEPEDLEETDEGVEDALTRVLSAGFGENDDSEVAIDELLPEDDDDENEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	205 (184)
Sequences:	1292 (857)
Seq/√Len:	63.2

HALSA - Q9HNF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
137_G	159_P	5.480	1.00
145_T	151_T	4.616	1.00
8_F	60_V	4.123	1.00
15_L	63_V	3.766	1.00
33_S	52_T	3.363	1.00
33_S	50_A	3.267	1.00
113_Q	164_E	3.227	1.00
127_A	141_V	2.946	1.00
115_V	127_A	2.615	1.00
118_E	121_P	2.560	1.00
118_E	122_G	2.553	1.00
114_P	172_A	2.386	1.00
168_G	171_D	2.346	1.00
139_E	162_L	2.339	1.00
120_W	161_D	2.181	1.00
61_F	65_Y	2.126	1.00
116_R	165_T	2.106	1.00
7_D	61_F	2.070	1.00
47_Q	50_A	2.068	1.00
37_L	44_T	2.044	1.00
20_V	96_S	2.012	1.00
136_D	167_E	1.944	1.00
23_Y	27_W	1.925	1.00
117_V	143_M	1.894	1.00
80_D	97_K	1.864	1.00
148_N	151_T	1.848	1.00
124_R	163_E	1.830	1.00
14_V	67_M	1.769	1.00
140_V	154_V	1.750	0.99
121_P	161_D	1.750	0.99
27_W	31_L	1.724	0.99
156_E	175_R	1.719	0.99
145_T	148_N	1.691	0.99
81_Y	85_R	1.650	0.99
37_L	43_D	1.642	0.99
115_V	129_K	1.640	0.99
118_E	124_R	1.604	0.99
97_K	101_E	1.575	0.99
40_Q	43_D	1.556	0.99
36_T	130_T	1.542	0.99
8_F	61_F	1.528	0.99
23_Y	26_Y	1.496	0.98
33_S	49_V	1.485	0.98
21_T	89_L	1.458	0.98
69_T	72_G	1.455	0.98
145_T	178_S	1.448	0.98
11_G	17_P	1.440	0.98
59_I	63_V	1.388	0.97
145_T	149_I	1.387	0.97
143_M	155_M	1.380	0.97
7_D	68_R	1.380	0.97
139_E	159_P	1.375	0.97
41_L	44_T	1.358	0.97
37_L	40_Q	1.357	0.97
39_T	42_T	1.357	0.97
113_Q	159_P	1.331	0.97
117_V	123_M	1.325	0.96
126_T	167_E	1.321	0.96
40_Q	44_T	1.292	0.96
147_P	150_T	1.252	0.95
113_Q	132_K	1.243	0.95
115_V	164_E	1.237	0.95
171_D	174_T	1.202	0.94
146_A	154_V	1.167	0.93
22_L	85_R	1.165	0.93
118_E	161_D	1.141	0.92
37_L	41_L	1.141	0.92
77_A	81_Y	1.105	0.91
24_V	96_S	1.101	0.91
123_M	155_M	1.091	0.90
32_L	86_L	1.090	0.90
96_S	175_R	1.053	0.89
170_E	179_A	1.047	0.88
114_P	142_F	1.046	0.88
174_T	178_S	1.030	0.88
129_K	139_E	1.030	0.88
138_R	158_E	1.015	0.87
56_F	60_V	1.014	0.87
12_L	16_V	1.010	0.87
104_L	111_F	0.982	0.85
113_Q	129_K	0.981	0.85
72_G	147_P	0.975	0.85
153_F	170_E	0.972	0.84
80_D	114_P	0.969	0.84
102_T	111_F	0.963	0.84
25_I	56_F	0.963	0.84
62_S	66_L	0.959	0.84
140_V	156_E	0.953	0.83
114_P	169_V	0.949	0.83
3_S	55_V	0.943	0.83
58_L	141_V	0.934	0.82
132_K	159_P	0.930	0.82
146_A	150_T	0.914	0.81
95_A	176_V	0.912	0.80
142_F	148_N	0.902	0.80
19_V	106_D	0.899	0.79
37_L	177_L	0.898	0.79
29_F	53_L	0.884	0.78
148_N	176_V	0.873	0.77
142_F	154_V	0.868	0.77
130_T	179_A	0.863	0.77
58_L	62_S	0.858	0.76
166_D	177_L	0.857	0.76
16_V	20_V	0.855	0.76
120_W	123_M	0.854	0.76
34_N	57_V	0.853	0.76
55_V	58_L	0.851	0.76
117_V	157_V	0.848	0.75
68_R	97_K	0.840	0.75
98_M	182_G	0.838	0.74
135_P	155_M	0.830	0.74
25_I	92_V	0.828	0.74
56_F	75_L	0.827	0.73
46_Y	83_M	0.826	0.73
49_V	52_T	0.825	0.73
28_L	45_Q	0.825	0.73
80_D	168_G	0.822	0.73
43_D	46_Y	0.818	0.73
15_L	68_R	0.814	0.72
126_T	165_T	0.809	0.72
33_S	47_Q	0.804	0.71
146_A	178_S	0.798	0.71
7_D	65_Y	0.794	0.70
124_R	138_R	0.792	0.70
64_G	87_P	0.791	0.70
10_S	147_P	0.790	0.70
99_A	102_T	0.789	0.70
5_K	112_Q	0.787	0.70
44_T	47_Q	0.786	0.70
30_G	85_R	0.775	0.69
136_D	166_D	0.764	0.67
39_T	43_D	0.764	0.67
39_T	58_L	0.763	0.67
28_L	162_L	0.759	0.67
102_T	151_T	0.757	0.67
143_M	157_V	0.756	0.67
74_I	86_L	0.752	0.66
26_Y	30_G	0.749	0.66
3_S	9_A	0.747	0.66
10_S	76_E	0.743	0.65
22_L	186_D	0.743	0.65
68_R	171_D	0.741	0.65
158_E	161_D	0.735	0.64
10_S	149_I	0.727	0.64
133_K	181_F	0.726	0.63
162_L	186_D	0.725	0.63
14_V	72_G	0.722	0.63
76_E	97_K	0.716	0.62
116_R	122_G	0.715	0.62
127_A	143_M	0.715	0.62
16_V	36_T	0.711	0.62
41_L	45_Q	0.707	0.61
36_T	76_E	0.707	0.61
111_F	128_F	0.707	0.61
10_S	119_P	0.707	0.61
18_I	153_F	0.705	0.61
53_L	185_D	0.702	0.61
75_L	78_L	0.700	0.61
142_F	147_P	0.699	0.61
68_R	102_T	0.699	0.61
84_N	90_R	0.694	0.60
110_E	131_G	0.690	0.60
36_T	56_F	0.687	0.59
82_V	103_V	0.686	0.59
18_I	83_M	0.686	0.59
145_T	176_V	0.685	0.59
183_E	186_D	0.684	0.59
7_D	13_I	0.683	0.59
89_L	97_K	0.681	0.59
13_I	181_F	0.675	0.58
66_L	186_D	0.674	0.58
32_L	36_T	0.673	0.58
69_T	111_F	0.673	0.58
24_V	162_L	0.667	0.57
22_L	37_L	0.664	0.57
30_G	82_V	0.663	0.56
49_V	68_R	0.657	0.56
35_I	80_D	0.657	0.56
33_S	51_A	0.654	0.55
177_L	181_F	0.654	0.55
39_T	66_L	0.653	0.55
22_L	58_L	0.648	0.55
158_E	162_L	0.648	0.55
3_S	6_R	0.645	0.54
25_I	85_R	0.644	0.54
22_L	106_D	0.643	0.54
36_T	51_A	0.642	0.54
129_K	164_E	0.639	0.54
22_L	83_M	0.631	0.53
29_F	56_F	0.630	0.53
94_N	109_G	0.623	0.52
7_D	49_V	0.620	0.52
81_Y	89_L	0.619	0.51
123_M	157_V	0.618	0.51
173_L	181_F	0.618	0.51
4_W	103_V	0.615	0.51
132_K	177_L	0.614	0.51
4_W	61_F	0.614	0.51
47_Q	51_A	0.613	0.51
121_P	169_V	0.610	0.50
32_L	89_L	0.609	0.50
126_T	172_A	0.609	0.50
151_T	178_S	0.606	0.50
37_L	42_T	0.603	0.50
76_E	114_P	0.603	0.50
128_F	161_D	0.602	0.49
13_I	74_I	0.599	0.49
23_Y	40_Q	0.593	0.48
18_I	86_L	0.592	0.48
131_G	181_F	0.591	0.48
3_S	23_Y	0.590	0.48
112_Q	117_V	0.590	0.48
46_Y	56_F	0.590	0.48
57_V	164_E	0.588	0.48
127_A	162_L	0.581	0.47
36_T	47_Q	0.577	0.47
37_L	60_V	0.577	0.47
65_Y	69_T	0.577	0.47
145_T	153_F	0.576	0.46
99_A	112_Q	0.576	0.46
99_A	173_L	0.575	0.46
12_L	66_L	0.573	0.46
84_N	138_R	0.572	0.46
61_F	67_M	0.572	0.46
16_V	96_S	0.571	0.46
148_N	154_V	0.571	0.46
98_M	147_P	0.570	0.46
5_K	12_L	0.569	0.46
22_L	68_R	0.565	0.45
98_M	174_T	0.565	0.45
15_L	172_A	0.565	0.45
122_G	161_D	0.564	0.45
104_L	173_L	0.562	0.45
6_R	92_V	0.560	0.45
147_P	170_E	0.558	0.44
123_M	186_D	0.557	0.44
32_L	63_V	0.556	0.44
70_A	73_S	0.555	0.44
97_K	102_T	0.555	0.44
26_Y	36_T	0.555	0.44
52_T	69_T	0.551	0.44
72_G	98_M	0.551	0.44
92_V	104_L	0.550	0.44
125_L	143_M	0.544	0.43
111_F	174_T	0.544	0.43
131_G	140_V	0.540	0.42
62_S	65_Y	0.535	0.42
175_R	179_A	0.534	0.42
146_A	175_R	0.534	0.42
59_I	89_L	0.534	0.42
101_E	175_R	0.533	0.42
10_S	67_M	0.533	0.42
144_P	147_P	0.533	0.42
127_A	153_F	0.531	0.41
77_A	85_R	0.528	0.41
125_L	151_T	0.524	0.41
6_R	55_V	0.521	0.40
65_Y	162_L	0.521	0.40
57_V	61_F	0.519	0.40
71_A	109_G	0.518	0.40
140_V	161_D	0.516	0.40
71_A	187_S	0.515	0.40
116_R	146_A	0.515	0.40
22_L	74_I	0.514	0.39
10_S	68_R	0.514	0.39
25_I	53_L	0.512	0.39
29_F	43_D	0.507	0.39
145_T	150_T	0.507	0.39
87_P	152_G	0.507	0.39
35_I	115_V	0.506	0.39
31_L	34_N	0.506	0.39
71_A	81_Y	0.505	0.39
162_L	166_D	0.504	0.38
65_Y	108_T	0.503	0.38
46_Y	68_R	0.503	0.38
119_P	125_L	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2fyuK	1	0.2439	8.3	0.958	Contact Map
3orgA	2	0.878	7	0.96	Contact Map
1je5A	2	0.3707	6.8	0.96	Contact Map
2zy9A	2	0.4683	5.4	0.962	Contact Map
4aw6A	2	0.5951	5.2	0.962	Contact Map
4k0mC	1	0.4098	5.2	0.962	Contact Map
2bz1A	2	0.522	5	0.962	Contact Map
1v64A	1	0.3659	4.7	0.963	Contact Map
4i0uA	4	0.3073	4.3	0.964	Contact Map
2lefA	1	0.3024	3.9	0.964	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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