GREMLIN Database
Q9HNF9 - Uncharacterized protein
UniProt: Q9HNF9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (184)
Sequences: 1292 (857)
Seq/√Len: 63.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_G159_P5.4801.00
145_T151_T4.6161.00
8_F60_V4.1231.00
15_L63_V3.7661.00
33_S52_T3.3631.00
33_S50_A3.2671.00
113_Q164_E3.2271.00
127_A141_V2.9461.00
115_V127_A2.6151.00
118_E121_P2.5601.00
118_E122_G2.5531.00
114_P172_A2.3861.00
168_G171_D2.3461.00
139_E162_L2.3391.00
120_W161_D2.1811.00
61_F65_Y2.1261.00
116_R165_T2.1061.00
7_D61_F2.0701.00
47_Q50_A2.0681.00
37_L44_T2.0441.00
20_V96_S2.0121.00
136_D167_E1.9441.00
23_Y27_W1.9251.00
117_V143_M1.8941.00
80_D97_K1.8641.00
148_N151_T1.8481.00
124_R163_E1.8301.00
14_V67_M1.7691.00
140_V154_V1.7500.99
121_P161_D1.7500.99
27_W31_L1.7240.99
156_E175_R1.7190.99
145_T148_N1.6910.99
81_Y85_R1.6500.99
37_L43_D1.6420.99
115_V129_K1.6400.99
118_E124_R1.6040.99
97_K101_E1.5750.99
40_Q43_D1.5560.99
36_T130_T1.5420.99
8_F61_F1.5280.99
23_Y26_Y1.4960.98
33_S49_V1.4850.98
21_T89_L1.4580.98
69_T72_G1.4550.98
145_T178_S1.4480.98
11_G17_P1.4400.98
59_I63_V1.3880.97
145_T149_I1.3870.97
143_M155_M1.3800.97
7_D68_R1.3800.97
139_E159_P1.3750.97
41_L44_T1.3580.97
37_L40_Q1.3570.97
39_T42_T1.3570.97
113_Q159_P1.3310.97
117_V123_M1.3250.96
126_T167_E1.3210.96
40_Q44_T1.2920.96
147_P150_T1.2520.95
113_Q132_K1.2430.95
115_V164_E1.2370.95
171_D174_T1.2020.94
146_A154_V1.1670.93
22_L85_R1.1650.93
118_E161_D1.1410.92
37_L41_L1.1410.92
77_A81_Y1.1050.91
24_V96_S1.1010.91
123_M155_M1.0910.90
32_L86_L1.0900.90
96_S175_R1.0530.89
170_E179_A1.0470.88
114_P142_F1.0460.88
174_T178_S1.0300.88
129_K139_E1.0300.88
138_R158_E1.0150.87
56_F60_V1.0140.87
12_L16_V1.0100.87
104_L111_F0.9820.85
113_Q129_K0.9810.85
72_G147_P0.9750.85
153_F170_E0.9720.84
80_D114_P0.9690.84
102_T111_F0.9630.84
25_I56_F0.9630.84
62_S66_L0.9590.84
140_V156_E0.9530.83
114_P169_V0.9490.83
3_S55_V0.9430.83
58_L141_V0.9340.82
132_K159_P0.9300.82
146_A150_T0.9140.81
95_A176_V0.9120.80
142_F148_N0.9020.80
19_V106_D0.8990.79
37_L177_L0.8980.79
29_F53_L0.8840.78
148_N176_V0.8730.77
142_F154_V0.8680.77
130_T179_A0.8630.77
58_L62_S0.8580.76
166_D177_L0.8570.76
16_V20_V0.8550.76
120_W123_M0.8540.76
34_N57_V0.8530.76
55_V58_L0.8510.76
117_V157_V0.8480.75
68_R97_K0.8400.75
98_M182_G0.8380.74
135_P155_M0.8300.74
25_I92_V0.8280.74
56_F75_L0.8270.73
46_Y83_M0.8260.73
49_V52_T0.8250.73
28_L45_Q0.8250.73
80_D168_G0.8220.73
43_D46_Y0.8180.73
15_L68_R0.8140.72
126_T165_T0.8090.72
33_S47_Q0.8040.71
146_A178_S0.7980.71
7_D65_Y0.7940.70
124_R138_R0.7920.70
64_G87_P0.7910.70
10_S147_P0.7900.70
99_A102_T0.7890.70
5_K112_Q0.7870.70
44_T47_Q0.7860.70
30_G85_R0.7750.69
136_D166_D0.7640.67
39_T43_D0.7640.67
39_T58_L0.7630.67
28_L162_L0.7590.67
102_T151_T0.7570.67
143_M157_V0.7560.67
74_I86_L0.7520.66
26_Y30_G0.7490.66
3_S9_A0.7470.66
10_S76_E0.7430.65
22_L186_D0.7430.65
68_R171_D0.7410.65
158_E161_D0.7350.64
10_S149_I0.7270.64
133_K181_F0.7260.63
162_L186_D0.7250.63
14_V72_G0.7220.63
76_E97_K0.7160.62
116_R122_G0.7150.62
127_A143_M0.7150.62
16_V36_T0.7110.62
41_L45_Q0.7070.61
36_T76_E0.7070.61
111_F128_F0.7070.61
10_S119_P0.7070.61
18_I153_F0.7050.61
53_L185_D0.7020.61
75_L78_L0.7000.61
142_F147_P0.6990.61
68_R102_T0.6990.61
84_N90_R0.6940.60
110_E131_G0.6900.60
36_T56_F0.6870.59
82_V103_V0.6860.59
18_I83_M0.6860.59
145_T176_V0.6850.59
183_E186_D0.6840.59
7_D13_I0.6830.59
89_L97_K0.6810.59
13_I181_F0.6750.58
66_L186_D0.6740.58
32_L36_T0.6730.58
69_T111_F0.6730.58
24_V162_L0.6670.57
22_L37_L0.6640.57
30_G82_V0.6630.56
49_V68_R0.6570.56
35_I80_D0.6570.56
33_S51_A0.6540.55
177_L181_F0.6540.55
39_T66_L0.6530.55
22_L58_L0.6480.55
158_E162_L0.6480.55
3_S6_R0.6450.54
25_I85_R0.6440.54
22_L106_D0.6430.54
36_T51_A0.6420.54
129_K164_E0.6390.54
22_L83_M0.6310.53
29_F56_F0.6300.53
94_N109_G0.6230.52
7_D49_V0.6200.52
81_Y89_L0.6190.51
123_M157_V0.6180.51
173_L181_F0.6180.51
4_W103_V0.6150.51
132_K177_L0.6140.51
4_W61_F0.6140.51
47_Q51_A0.6130.51
121_P169_V0.6100.50
32_L89_L0.6090.50
126_T172_A0.6090.50
151_T178_S0.6060.50
37_L42_T0.6030.50
76_E114_P0.6030.50
128_F161_D0.6020.49
13_I74_I0.5990.49
23_Y40_Q0.5930.48
18_I86_L0.5920.48
131_G181_F0.5910.48
3_S23_Y0.5900.48
112_Q117_V0.5900.48
46_Y56_F0.5900.48
57_V164_E0.5880.48
127_A162_L0.5810.47
36_T47_Q0.5770.47
37_L60_V0.5770.47
65_Y69_T0.5770.47
145_T153_F0.5760.46
99_A112_Q0.5760.46
99_A173_L0.5750.46
12_L66_L0.5730.46
84_N138_R0.5720.46
61_F67_M0.5720.46
16_V96_S0.5710.46
148_N154_V0.5710.46
98_M147_P0.5700.46
5_K12_L0.5690.46
22_L68_R0.5650.45
98_M174_T0.5650.45
15_L172_A0.5650.45
122_G161_D0.5640.45
104_L173_L0.5620.45
6_R92_V0.5600.45
147_P170_E0.5580.44
123_M186_D0.5570.44
32_L63_V0.5560.44
70_A73_S0.5550.44
97_K102_T0.5550.44
26_Y36_T0.5550.44
52_T69_T0.5510.44
72_G98_M0.5510.44
92_V104_L0.5500.44
125_L143_M0.5440.43
111_F174_T0.5440.43
131_G140_V0.5400.42
62_S65_Y0.5350.42
175_R179_A0.5340.42
146_A175_R0.5340.42
59_I89_L0.5340.42
101_E175_R0.5330.42
10_S67_M0.5330.42
144_P147_P0.5330.42
127_A153_F0.5310.41
77_A85_R0.5280.41
125_L151_T0.5240.41
6_R55_V0.5210.40
65_Y162_L0.5210.40
57_V61_F0.5190.40
71_A109_G0.5180.40
140_V161_D0.5160.40
71_A187_S0.5150.40
116_R146_A0.5150.40
22_L74_I0.5140.39
10_S68_R0.5140.39
25_I53_L0.5120.39
29_F43_D0.5070.39
145_T150_T0.5070.39
87_P152_G0.5070.39
35_I115_V0.5060.39
31_L34_N0.5060.39
71_A81_Y0.5050.39
162_L166_D0.5040.38
65_Y108_T0.5030.38
46_Y68_R0.5030.38
119_P125_L0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fyuK 1 0.2439 8.3 0.958 Contact Map
3orgA 2 0.878 7 0.96 Contact Map
1je5A 2 0.3707 6.8 0.96 Contact Map
2zy9A 2 0.4683 5.4 0.962 Contact Map
4aw6A 2 0.5951 5.2 0.962 Contact Map
4k0mC 1 0.4098 5.2 0.962 Contact Map
2bz1A 2 0.522 5 0.962 Contact Map
1v64A 1 0.3659 4.7 0.963 Contact Map
4i0uA 4 0.3073 4.3 0.964 Contact Map
2lefA 1 0.3024 3.9 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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