GREMLIN Database
Q9HNF8 - Branched-chain amino acid aminotransferase
UniProt: Q9HNF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (270)
Sequences: 8697 (5679)
Seq/√Len: 345.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
209_E240_H4.3791.00
143_D270_Q4.1731.00
209_E238_T3.1061.00
240_H243_V3.0991.00
62_Q79_P3.0211.00
210_L232_A2.9891.00
243_V249_E2.9731.00
65_Y79_P2.9211.00
38_G164_T2.8731.00
221_D226_D2.4991.00
18_F92_R2.4981.00
290_T294_D2.3521.00
211_F243_V2.3391.00
193_N244_S2.3221.00
235_R291_A2.2891.00
88_E92_R2.2331.00
78_T81_E2.1911.00
59_D226_D2.1911.00
72_D179_R2.0751.00
145_M182_F2.0581.00
84_D88_E2.0391.00
229_I239_V2.0251.00
146_V272_D1.9741.00
39_I67_S1.9331.00
206_R254_D1.9321.00
256_L268_I1.9211.00
145_M180_N1.9001.00
270_Q273_N1.8721.00
88_E91_Q1.8551.00
235_R287_E1.8521.00
201_N222_G1.8481.00
37_S106_Y1.7701.00
58_D83_T1.7491.00
64_F104_A1.7491.00
146_V247_R1.7351.00
197_G200_E1.7321.00
226_D230_T1.7201.00
286_E290_T1.6901.00
69_K76_E1.6761.00
144_V268_I1.6671.00
46_Y264_E1.6511.00
56_R227_T1.6391.00
21_W27_H1.6191.00
68_A104_A1.6061.00
176_E180_N1.6061.00
287_E291_A1.5951.00
251_H274_V1.5831.00
205_V284_V1.5791.00
204_L245_I1.5701.00
144_V197_G1.5371.00
20_D23_D1.5361.00
228_V259_T1.5351.00
256_L271_V1.5351.00
73_L104_A1.5331.00
144_V186_I1.5311.00
62_Q66_E1.5051.00
202_I256_L1.5001.00
142_V183_T1.4911.00
39_I68_A1.4891.00
291_A294_D1.4881.00
85_A122_V1.4691.00
57_W61_L1.4511.00
214_G244_S1.4491.00
197_G258_F1.4321.00
57_W83_T1.4251.00
203_F259_T1.4241.00
193_N246_S1.4121.00
143_D269_K1.4071.00
58_D62_Q1.3961.00
83_T87_V1.3931.00
189_N193_N1.3891.00
143_D183_T1.3841.00
230_T234_E1.3831.00
210_L237_Y1.3701.00
270_Q275_E1.3551.00
66_E69_K1.3491.00
204_L253_A1.3491.00
43_V54_I1.3471.00
225_R241_D1.3351.00
95_L98_C1.3281.00
45_V90_I1.3011.00
186_I202_I1.2941.00
203_F257_F1.2921.00
66_E221_D1.2911.00
217_E244_S1.2761.00
255_E282_G1.2751.00
84_D87_V1.2731.00
54_I57_W1.2701.00
204_L211_F1.2681.00
204_L256_L1.2671.00
32_A105_Y1.2621.00
59_D62_Q1.2591.00
59_D230_T1.2561.00
232_A237_Y1.2521.00
175_E179_R1.2501.00
205_V210_L1.2361.00
56_R59_D1.2341.00
287_E290_T1.2311.00
87_V91_Q1.2251.00
30_T105_Y1.2191.00
32_A38_G1.2111.00
212_T225_R1.2081.00
34_H101_R1.2031.00
89_L124_I1.1991.00
211_F240_H1.1971.00
206_R252_T1.1701.00
260_G263_A1.1651.00
237_Y284_V1.1481.00
45_V98_C1.1391.00
135_D140_N1.1301.00
86_T100_I1.1281.00
246_S249_E1.1231.00
13_W85_A1.1191.00
81_E84_D1.1081.00
86_T124_I1.1071.00
54_I86_T1.0981.00
67_S161_A1.0861.00
80_D84_D1.0781.00
13_W18_F1.0701.00
245_I249_E1.0661.00
144_V258_F1.0601.00
149_W176_E1.0591.00
39_I64_F1.0581.00
255_E285_T1.0571.00
173_A187_V1.0521.00
214_G243_V1.0511.00
232_A288_L1.0441.00
18_F89_L1.0371.00
85_A124_I1.0281.00
89_L126_A1.0241.00
33_L105_Y1.0231.00
141_G269_K1.0211.00
174_G178_R1.0181.00
225_R229_I1.0121.00
206_R249_E1.0101.00
70_P161_A1.0101.00
281_R286_E1.0041.00
203_F225_R1.0021.00
103_L123_A1.0011.00
79_P83_T0.9951.00
147_S185_A0.9901.00
184_E198_P0.9891.00
73_L119_P0.9881.00
61_L83_T0.9841.00
258_F268_I0.9821.00
211_F245_I0.9791.00
189_N218_S0.9731.00
66_E160_N0.9701.00
203_F229_I0.9641.00
192_G248_G0.9631.00
233_E241_D0.9631.00
148_T176_E0.9581.00
70_P160_N0.9561.00
89_L93_Q0.9521.00
13_W77_F0.9501.00
40_F167_Y0.9451.00
58_D79_P0.9441.00
232_A239_V0.9381.00
282_G285_T0.9371.00
214_G241_D0.9361.00
186_I250_L0.9361.00
39_I104_A0.9331.00
90_I98_C0.9281.00
194_V202_I0.9281.00
47_D96_G0.9281.00
65_Y69_K0.9281.00
213_P245_I0.9261.00
104_A122_V0.9211.00
289_Q293_F0.9201.00
62_Q65_Y0.9171.00
215_L225_R0.9151.00
176_E179_R0.9131.00
14_M24_A0.9011.00
12_I21_W0.8951.00
286_E289_Q0.8931.00
65_Y76_E0.8921.00
30_T107_G0.8911.00
215_L221_D0.8851.00
142_V266_T0.8721.00
222_G259_T0.8711.00
248_G252_T0.8701.00
233_E238_T0.8621.00
61_L86_T0.8551.00
91_Q94_D0.8541.00
201_N259_T0.8521.00
61_L79_P0.8501.00
153_A190_K0.8441.00
72_D175_E0.8411.00
59_D227_T0.8411.00
26_V33_L0.8401.00
208_G238_T0.8381.00
103_L164_T0.8381.00
65_Y82_L0.8351.00
34_H103_L0.8341.00
44_R97_S0.8341.00
77_F81_E0.8341.00
23_D27_H0.8331.00
283_P287_E0.8321.00
188_L247_R0.8291.00
230_T233_E0.8291.00
61_L65_Y0.8291.00
234_E291_A0.8221.00
66_E70_P0.8131.00
283_P286_E0.8101.00
144_V184_E0.8101.00
98_C126_A0.8091.00
114_S117_D0.8011.00
34_H125_A0.8001.00
68_A73_L0.7951.00
17_E25_Q0.7931.00
211_F249_E0.7931.00
45_V54_I0.7911.00
43_V86_T0.7901.00
59_D223_I0.7901.00
81_E85_A0.7871.00
173_A198_P0.7811.00
205_V255_E0.7801.00
30_T109_E0.7761.00
194_V204_L0.7711.00
77_F85_A0.7671.00
57_W86_T0.7651.00
191_E244_S0.7651.00
206_R211_F0.7611.00
32_A164_T0.7611.00
28_V123_A0.7601.00
173_A185_A0.7601.00
207_D254_D0.7581.00
278_S281_R0.7571.00
253_A256_L0.7571.00
232_A235_R0.7551.00
14_M123_A0.7531.00
147_S176_E0.7531.00
25_Q28_V0.7511.00
45_V100_I0.7461.00
150_R155_S0.7461.00
120_T123_A0.7451.00
44_R264_E0.7431.00
229_I241_D0.7431.00
284_V287_E0.7391.00
185_A198_P0.7370.99
31_H37_S0.7360.99
18_F85_A0.7350.99
145_M272_D0.7350.99
80_D83_T0.7330.99
71_Y163_T0.7330.99
44_R261_S0.7300.99
105_Y123_A0.7290.99
37_S171_M0.7280.99
61_L82_L0.7280.99
55_F227_T0.7270.99
24_A123_A0.7270.99
42_G262_A0.7210.99
184_E197_G0.7200.99
146_V188_L0.7180.99
231_L235_R0.7180.99
227_T230_T0.7140.99
82_L122_V0.7140.99
71_Y168_V0.7130.99
99_Y262_A0.7130.99
205_V257_F0.7120.99
229_I233_E0.7090.99
21_W29_L0.7090.99
282_G286_E0.7070.99
43_V102_P0.7070.99
200_E258_F0.7040.99
149_W152_H0.6990.99
203_F212_T0.6940.99
196_E220_L0.6920.99
46_Y97_S0.6850.99
143_D182_F0.6820.99
46_Y55_F0.6810.99
114_S178_R0.6800.99
99_Y127_W0.6800.99
115_P175_E0.6770.99
163_T168_V0.6760.99
250_L271_V0.6720.99
202_I213_P0.6700.99
251_H272_D0.6660.99
184_E200_E0.6650.99
192_G247_R0.6640.99
18_F88_E0.6630.99
248_G251_H0.6630.99
208_G254_D0.6600.99
31_H106_Y0.6590.99
177_A181_G0.6560.99
116_G119_P0.6540.99
42_G260_G0.6530.99
206_R253_A0.6520.99
69_K74_D0.6520.99
263_A266_T0.6510.99
188_L194_V0.6500.99
42_G99_Y0.6490.99
269_K281_R0.6480.99
250_L256_L0.6470.99
142_V258_F0.6470.99
86_T102_P0.6430.99
234_E295_L0.6430.99
36_G166_L0.6410.99
41_E67_S0.6400.99
272_D275_E0.6390.99
249_E252_T0.6390.99
85_A88_E0.6390.99
256_L276_I0.6380.99
24_A28_V0.6370.99
228_V288_L0.6350.99
147_S173_A0.6340.98
277_G282_G0.6330.98
62_Q226_D0.6320.98
152_H156_Q0.6310.98
114_S118_C0.6300.98
39_I71_Y0.6290.98
135_D183_T0.6260.98
14_M19_V0.6250.98
89_L92_R0.6240.98
194_V245_I0.6240.98
26_V30_T0.6240.98
174_G199_G0.6220.98
175_E178_R0.6210.98
277_G281_R0.6200.98
186_I256_L0.6180.98
113_V170_S0.6180.98
264_E293_F0.6170.98
212_T241_D0.6150.98
247_R251_H0.6140.98
65_Y78_T0.6130.98
141_G266_T0.6130.98
231_L291_A0.6130.98
227_T231_L0.6070.98
210_L257_F0.6070.98
204_L250_L0.6050.98
145_M176_E0.6040.98
174_G184_E0.6020.98
162_K220_L0.5940.98
167_Y170_S0.5920.98
111_L114_S0.5890.98
55_F261_S0.5850.97
54_I87_V0.5830.97
215_L241_D0.5820.97
223_I226_D0.5820.97
64_F102_P0.5800.97
153_A156_Q0.5790.97
54_I100_I0.5790.97
162_K196_E0.5780.97
265_V288_L0.5780.97
210_L284_V0.5770.97
93_Q126_A0.5770.97
203_F210_L0.5760.97
180_N273_N0.5760.97
140_N280_T0.5740.97
267_P282_G0.5730.97
43_V57_W0.5720.97
144_V271_V0.5690.97
33_L123_A0.5690.97
33_L103_L0.5660.97
167_Y220_L0.5640.97
216_S244_S0.5610.97
19_V22_E0.5600.97
56_R223_I0.5580.97
115_P119_P0.5570.97
105_Y164_T0.5570.97
208_G237_Y0.5540.96
12_I24_A0.5520.96
57_W87_V0.5520.96
227_T292_F0.5520.96
264_E292_F0.5510.96
122_V125_A0.5500.96
29_L108_Y0.5470.96
233_E239_V0.5470.96
107_G120_T0.5470.96
140_N183_T0.5440.96
173_A176_E0.5420.96
45_V126_A0.5410.96
269_K276_I0.5400.96
47_D97_S0.5390.96
188_L195_A0.5390.96
155_S191_E0.5390.96
27_H108_Y0.5360.96
291_A295_L0.5350.96
224_T292_F0.5350.96
35_Y166_L0.5350.96
211_F254_D0.5340.96
29_L34_H0.5320.96
84_D91_Q0.5320.96
39_I163_T0.5290.95
214_G217_E0.5280.95
201_N221_D0.5280.95
19_V24_A0.5270.95
41_E64_F0.5250.95
43_V61_L0.5220.95
278_S282_G0.5190.95
195_A219_I0.5160.95
205_V208_G0.5140.95
202_I250_L0.5140.95
39_I161_A0.5140.95
160_N217_E0.5140.95
37_S73_L0.5110.95
73_L106_Y0.5100.94
231_L234_E0.5070.94
101_R167_Y0.5070.94
186_I271_V0.5060.94
152_H169_N0.5050.94
21_W93_Q0.5040.94
223_I227_T0.5040.94
170_S187_V0.5040.94
251_H254_D0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iyeA 5 0.974 100 0.143 Contact Map
2eiyA 5 0.9773 100 0.147 Contact Map
3u0gA 5 0.9805 100 0.148 Contact Map
4chiA 2 0.9643 100 0.148 Contact Map
3dtgA 2 0.9805 100 0.175 Contact Map
2coiA 2 0.9708 100 0.181 Contact Map
4dqnA 2 0.9708 100 0.188 Contact Map
3uzoA 2 0.9675 100 0.188 Contact Map
5bwxA 2 0.9838 100 0.19 Contact Map
4cmfA 4 0.974 100 0.191 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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