Q9HNF8 - HALSA - GREMLIN Contacts

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Q9HNF8 - Branched-chain amino acid aminotransferase

UniProt:	Q9HNF8	Sequences: MPSFSEMDVDTIWMDGEFVDWEDAQVHVLTHALHYGSGIFEGVRVYDTDNGPAIFRWDDHLQRFYESAKPYDLDIEFTPDELTDATVELIQRQDLGSCYIRPLAYYGYESLGVSPGDCPTDVAIAAWPWGAYLGDDALENGVDVMVSTWRKHASSQIPTNAKTTGLYVNSMLAGEEARRNGFTEAIVLNKEGNVAEGPGENIFLVRDGELFTPGLSESILDGITRDTVITLAEERGYTVHDDVSISRGELHTADELFFTGSAAEVTPIKQVDNVEIGSGTRGPVTEELQTAFFDLVEAGDREEWFHYV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	308 (270)
Sequences:	8697 (5679)
Seq/√Len:	345.6

ECOLI - ILVE PABC
BACSU - ILVE1 ILVE2 PABC DAAA
HALSA - Q9HNF8 Q9HS64

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
209_E	240_H	4.379	1.00
143_D	270_Q	4.173	1.00
209_E	238_T	3.106	1.00
240_H	243_V	3.099	1.00
62_Q	79_P	3.021	1.00
210_L	232_A	2.989	1.00
243_V	249_E	2.973	1.00
65_Y	79_P	2.921	1.00
38_G	164_T	2.873	1.00
221_D	226_D	2.499	1.00
18_F	92_R	2.498	1.00
290_T	294_D	2.352	1.00
211_F	243_V	2.339	1.00
193_N	244_S	2.322	1.00
235_R	291_A	2.289	1.00
88_E	92_R	2.233	1.00
78_T	81_E	2.191	1.00
59_D	226_D	2.191	1.00
72_D	179_R	2.075	1.00
145_M	182_F	2.058	1.00
84_D	88_E	2.039	1.00
229_I	239_V	2.025	1.00
146_V	272_D	1.974	1.00
39_I	67_S	1.933	1.00
206_R	254_D	1.932	1.00
256_L	268_I	1.921	1.00
145_M	180_N	1.900	1.00
270_Q	273_N	1.872	1.00
88_E	91_Q	1.855	1.00
235_R	287_E	1.852	1.00
201_N	222_G	1.848	1.00
37_S	106_Y	1.770	1.00
58_D	83_T	1.749	1.00
64_F	104_A	1.749	1.00
146_V	247_R	1.735	1.00
197_G	200_E	1.732	1.00
226_D	230_T	1.720	1.00
286_E	290_T	1.690	1.00
69_K	76_E	1.676	1.00
144_V	268_I	1.667	1.00
46_Y	264_E	1.651	1.00
56_R	227_T	1.639	1.00
21_W	27_H	1.619	1.00
68_A	104_A	1.606	1.00
176_E	180_N	1.606	1.00
287_E	291_A	1.595	1.00
251_H	274_V	1.583	1.00
205_V	284_V	1.579	1.00
204_L	245_I	1.570	1.00
144_V	197_G	1.537	1.00
20_D	23_D	1.536	1.00
228_V	259_T	1.535	1.00
256_L	271_V	1.535	1.00
73_L	104_A	1.533	1.00
144_V	186_I	1.531	1.00
62_Q	66_E	1.505	1.00
202_I	256_L	1.500	1.00
142_V	183_T	1.491	1.00
39_I	68_A	1.489	1.00
291_A	294_D	1.488	1.00
85_A	122_V	1.469	1.00
57_W	61_L	1.451	1.00
214_G	244_S	1.449	1.00
197_G	258_F	1.432	1.00
57_W	83_T	1.425	1.00
203_F	259_T	1.424	1.00
193_N	246_S	1.412	1.00
143_D	269_K	1.407	1.00
58_D	62_Q	1.396	1.00
83_T	87_V	1.393	1.00
189_N	193_N	1.389	1.00
143_D	183_T	1.384	1.00
230_T	234_E	1.383	1.00
210_L	237_Y	1.370	1.00
270_Q	275_E	1.355	1.00
66_E	69_K	1.349	1.00
204_L	253_A	1.349	1.00
43_V	54_I	1.347	1.00
225_R	241_D	1.335	1.00
95_L	98_C	1.328	1.00
45_V	90_I	1.301	1.00
186_I	202_I	1.294	1.00
203_F	257_F	1.292	1.00
66_E	221_D	1.291	1.00
217_E	244_S	1.276	1.00
255_E	282_G	1.275	1.00
84_D	87_V	1.273	1.00
54_I	57_W	1.270	1.00
204_L	211_F	1.268	1.00
204_L	256_L	1.267	1.00
32_A	105_Y	1.262	1.00
59_D	62_Q	1.259	1.00
59_D	230_T	1.256	1.00
232_A	237_Y	1.252	1.00
175_E	179_R	1.250	1.00
205_V	210_L	1.236	1.00
56_R	59_D	1.234	1.00
287_E	290_T	1.231	1.00
87_V	91_Q	1.225	1.00
30_T	105_Y	1.219	1.00
32_A	38_G	1.211	1.00
212_T	225_R	1.208	1.00
34_H	101_R	1.203	1.00
89_L	124_I	1.199	1.00
211_F	240_H	1.197	1.00
206_R	252_T	1.170	1.00
260_G	263_A	1.165	1.00
237_Y	284_V	1.148	1.00
45_V	98_C	1.139	1.00
135_D	140_N	1.130	1.00
86_T	100_I	1.128	1.00
246_S	249_E	1.123	1.00
13_W	85_A	1.119	1.00
81_E	84_D	1.108	1.00
86_T	124_I	1.107	1.00
54_I	86_T	1.098	1.00
67_S	161_A	1.086	1.00
80_D	84_D	1.078	1.00
13_W	18_F	1.070	1.00
245_I	249_E	1.066	1.00
144_V	258_F	1.060	1.00
149_W	176_E	1.059	1.00
39_I	64_F	1.058	1.00
255_E	285_T	1.057	1.00
173_A	187_V	1.052	1.00
214_G	243_V	1.051	1.00
232_A	288_L	1.044	1.00
18_F	89_L	1.037	1.00
85_A	124_I	1.028	1.00
89_L	126_A	1.024	1.00
33_L	105_Y	1.023	1.00
141_G	269_K	1.021	1.00
174_G	178_R	1.018	1.00
225_R	229_I	1.012	1.00
206_R	249_E	1.010	1.00
70_P	161_A	1.010	1.00
281_R	286_E	1.004	1.00
203_F	225_R	1.002	1.00
103_L	123_A	1.001	1.00
79_P	83_T	0.995	1.00
147_S	185_A	0.990	1.00
184_E	198_P	0.989	1.00
73_L	119_P	0.988	1.00
61_L	83_T	0.984	1.00
258_F	268_I	0.982	1.00
211_F	245_I	0.979	1.00
189_N	218_S	0.973	1.00
66_E	160_N	0.970	1.00
203_F	229_I	0.964	1.00
192_G	248_G	0.963	1.00
233_E	241_D	0.963	1.00
148_T	176_E	0.958	1.00
70_P	160_N	0.956	1.00
89_L	93_Q	0.952	1.00
13_W	77_F	0.950	1.00
40_F	167_Y	0.945	1.00
58_D	79_P	0.944	1.00
232_A	239_V	0.938	1.00
282_G	285_T	0.937	1.00
214_G	241_D	0.936	1.00
186_I	250_L	0.936	1.00
39_I	104_A	0.933	1.00
90_I	98_C	0.928	1.00
194_V	202_I	0.928	1.00
47_D	96_G	0.928	1.00
65_Y	69_K	0.928	1.00
213_P	245_I	0.926	1.00
104_A	122_V	0.921	1.00
289_Q	293_F	0.920	1.00
62_Q	65_Y	0.917	1.00
215_L	225_R	0.915	1.00
176_E	179_R	0.913	1.00
14_M	24_A	0.901	1.00
12_I	21_W	0.895	1.00
286_E	289_Q	0.893	1.00
65_Y	76_E	0.892	1.00
30_T	107_G	0.891	1.00
215_L	221_D	0.885	1.00
142_V	266_T	0.872	1.00
222_G	259_T	0.871	1.00
248_G	252_T	0.870	1.00
233_E	238_T	0.862	1.00
61_L	86_T	0.855	1.00
91_Q	94_D	0.854	1.00
201_N	259_T	0.852	1.00
61_L	79_P	0.850	1.00
153_A	190_K	0.844	1.00
72_D	175_E	0.841	1.00
59_D	227_T	0.841	1.00
26_V	33_L	0.840	1.00
208_G	238_T	0.838	1.00
103_L	164_T	0.838	1.00
65_Y	82_L	0.835	1.00
34_H	103_L	0.834	1.00
44_R	97_S	0.834	1.00
77_F	81_E	0.834	1.00
23_D	27_H	0.833	1.00
283_P	287_E	0.832	1.00
188_L	247_R	0.829	1.00
230_T	233_E	0.829	1.00
61_L	65_Y	0.829	1.00
234_E	291_A	0.822	1.00
66_E	70_P	0.813	1.00
283_P	286_E	0.810	1.00
144_V	184_E	0.810	1.00
98_C	126_A	0.809	1.00
114_S	117_D	0.801	1.00
34_H	125_A	0.800	1.00
68_A	73_L	0.795	1.00
17_E	25_Q	0.793	1.00
211_F	249_E	0.793	1.00
45_V	54_I	0.791	1.00
43_V	86_T	0.790	1.00
59_D	223_I	0.790	1.00
81_E	85_A	0.787	1.00
173_A	198_P	0.781	1.00
205_V	255_E	0.780	1.00
30_T	109_E	0.776	1.00
194_V	204_L	0.771	1.00
77_F	85_A	0.767	1.00
57_W	86_T	0.765	1.00
191_E	244_S	0.765	1.00
206_R	211_F	0.761	1.00
32_A	164_T	0.761	1.00
28_V	123_A	0.760	1.00
173_A	185_A	0.760	1.00
207_D	254_D	0.758	1.00
278_S	281_R	0.757	1.00
253_A	256_L	0.757	1.00
232_A	235_R	0.755	1.00
14_M	123_A	0.753	1.00
147_S	176_E	0.753	1.00
25_Q	28_V	0.751	1.00
45_V	100_I	0.746	1.00
150_R	155_S	0.746	1.00
120_T	123_A	0.745	1.00
44_R	264_E	0.743	1.00
229_I	241_D	0.743	1.00
284_V	287_E	0.739	1.00
185_A	198_P	0.737	0.99
31_H	37_S	0.736	0.99
18_F	85_A	0.735	0.99
145_M	272_D	0.735	0.99
80_D	83_T	0.733	0.99
71_Y	163_T	0.733	0.99
44_R	261_S	0.730	0.99
105_Y	123_A	0.729	0.99
37_S	171_M	0.728	0.99
61_L	82_L	0.728	0.99
55_F	227_T	0.727	0.99
24_A	123_A	0.727	0.99
42_G	262_A	0.721	0.99
184_E	197_G	0.720	0.99
146_V	188_L	0.718	0.99
231_L	235_R	0.718	0.99
227_T	230_T	0.714	0.99
82_L	122_V	0.714	0.99
71_Y	168_V	0.713	0.99
99_Y	262_A	0.713	0.99
205_V	257_F	0.712	0.99
229_I	233_E	0.709	0.99
21_W	29_L	0.709	0.99
282_G	286_E	0.707	0.99
43_V	102_P	0.707	0.99
200_E	258_F	0.704	0.99
149_W	152_H	0.699	0.99
203_F	212_T	0.694	0.99
196_E	220_L	0.692	0.99
46_Y	97_S	0.685	0.99
143_D	182_F	0.682	0.99
46_Y	55_F	0.681	0.99
114_S	178_R	0.680	0.99
99_Y	127_W	0.680	0.99
115_P	175_E	0.677	0.99
163_T	168_V	0.676	0.99
250_L	271_V	0.672	0.99
202_I	213_P	0.670	0.99
251_H	272_D	0.666	0.99
184_E	200_E	0.665	0.99
192_G	247_R	0.664	0.99
18_F	88_E	0.663	0.99
248_G	251_H	0.663	0.99
208_G	254_D	0.660	0.99
31_H	106_Y	0.659	0.99
177_A	181_G	0.656	0.99
116_G	119_P	0.654	0.99
42_G	260_G	0.653	0.99
206_R	253_A	0.652	0.99
69_K	74_D	0.652	0.99
263_A	266_T	0.651	0.99
188_L	194_V	0.650	0.99
42_G	99_Y	0.649	0.99
269_K	281_R	0.648	0.99
250_L	256_L	0.647	0.99
142_V	258_F	0.647	0.99
86_T	102_P	0.643	0.99
234_E	295_L	0.643	0.99
36_G	166_L	0.641	0.99
41_E	67_S	0.640	0.99
272_D	275_E	0.639	0.99
249_E	252_T	0.639	0.99
85_A	88_E	0.639	0.99
256_L	276_I	0.638	0.99
24_A	28_V	0.637	0.99
228_V	288_L	0.635	0.99
147_S	173_A	0.634	0.98
277_G	282_G	0.633	0.98
62_Q	226_D	0.632	0.98
152_H	156_Q	0.631	0.98
114_S	118_C	0.630	0.98
39_I	71_Y	0.629	0.98
135_D	183_T	0.626	0.98
14_M	19_V	0.625	0.98
89_L	92_R	0.624	0.98
194_V	245_I	0.624	0.98
26_V	30_T	0.624	0.98
174_G	199_G	0.622	0.98
175_E	178_R	0.621	0.98
277_G	281_R	0.620	0.98
186_I	256_L	0.618	0.98
113_V	170_S	0.618	0.98
264_E	293_F	0.617	0.98
212_T	241_D	0.615	0.98
247_R	251_H	0.614	0.98
65_Y	78_T	0.613	0.98
141_G	266_T	0.613	0.98
231_L	291_A	0.613	0.98
227_T	231_L	0.607	0.98
210_L	257_F	0.607	0.98
204_L	250_L	0.605	0.98
145_M	176_E	0.604	0.98
174_G	184_E	0.602	0.98
162_K	220_L	0.594	0.98
167_Y	170_S	0.592	0.98
111_L	114_S	0.589	0.98
55_F	261_S	0.585	0.97
54_I	87_V	0.583	0.97
215_L	241_D	0.582	0.97
223_I	226_D	0.582	0.97
64_F	102_P	0.580	0.97
153_A	156_Q	0.579	0.97
54_I	100_I	0.579	0.97
162_K	196_E	0.578	0.97
265_V	288_L	0.578	0.97
210_L	284_V	0.577	0.97
93_Q	126_A	0.577	0.97
203_F	210_L	0.576	0.97
180_N	273_N	0.576	0.97
140_N	280_T	0.574	0.97
267_P	282_G	0.573	0.97
43_V	57_W	0.572	0.97
144_V	271_V	0.569	0.97
33_L	123_A	0.569	0.97
33_L	103_L	0.566	0.97
167_Y	220_L	0.564	0.97
216_S	244_S	0.561	0.97
19_V	22_E	0.560	0.97
56_R	223_I	0.558	0.97
115_P	119_P	0.557	0.97
105_Y	164_T	0.557	0.97
208_G	237_Y	0.554	0.96
12_I	24_A	0.552	0.96
57_W	87_V	0.552	0.96
227_T	292_F	0.552	0.96
264_E	292_F	0.551	0.96
122_V	125_A	0.550	0.96
29_L	108_Y	0.547	0.96
233_E	239_V	0.547	0.96
107_G	120_T	0.547	0.96
140_N	183_T	0.544	0.96
173_A	176_E	0.542	0.96
45_V	126_A	0.541	0.96
269_K	276_I	0.540	0.96
47_D	97_S	0.539	0.96
188_L	195_A	0.539	0.96
155_S	191_E	0.539	0.96
27_H	108_Y	0.536	0.96
291_A	295_L	0.535	0.96
224_T	292_F	0.535	0.96
35_Y	166_L	0.535	0.96
211_F	254_D	0.534	0.96
29_L	34_H	0.532	0.96
84_D	91_Q	0.532	0.96
39_I	163_T	0.529	0.95
214_G	217_E	0.528	0.95
201_N	221_D	0.528	0.95
19_V	24_A	0.527	0.95
41_E	64_F	0.525	0.95
43_V	61_L	0.522	0.95
278_S	282_G	0.519	0.95
195_A	219_I	0.516	0.95
205_V	208_G	0.514	0.95
202_I	250_L	0.514	0.95
39_I	161_A	0.514	0.95
160_N	217_E	0.514	0.95
37_S	73_L	0.511	0.95
73_L	106_Y	0.510	0.94
231_L	234_E	0.507	0.94
101_R	167_Y	0.507	0.94
186_I	271_V	0.506	0.94
152_H	169_N	0.505	0.94
21_W	93_Q	0.504	0.94
223_I	227_T	0.504	0.94
170_S	187_V	0.504	0.94
251_H	254_D	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1iyeA	5	0.974	100	0.143	Contact Map
2eiyA	5	0.9773	100	0.147	Contact Map
3u0gA	5	0.9805	100	0.148	Contact Map
4chiA	2	0.9643	100	0.148	Contact Map
3dtgA	2	0.9805	100	0.175	Contact Map
2coiA	2	0.9708	100	0.181	Contact Map
4dqnA	2	0.9708	100	0.188	Contact Map
3uzoA	2	0.9675	100	0.188	Contact Map
5bwxA	2	0.9838	100	0.19	Contact Map
4cmfA	4	0.974	100	0.191	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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