GREMLIN Database
Q9HNF7 - Na+/H+ antiporter
UniProt: Q9HNF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 491 (435)
Sequences: 2190 (1445)
Seq/√Len: 69.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_A450_F6.2971.00
138_S141_T4.9341.00
360_E464_L4.0841.00
396_D402_E3.9481.00
256_V277_A3.9121.00
154_G164_T3.4691.00
130_A211_F3.4061.00
143_V429_M3.3441.00
212_G216_L3.2511.00
123_P215_V2.9941.00
178_Q204_R2.9621.00
67_D70_R2.9581.00
358_S361_S2.9311.00
202_G404_D2.9171.00
123_P219_A2.8601.00
151_V161_L2.8061.00
213_L454_L2.8021.00
366_T395_Y2.6681.00
98_T297_F2.6041.00
360_E463_V2.5991.00
289_S292_A2.5631.00
90_F319_I2.4401.00
364_A464_L2.4051.00
351_H354_R2.3931.00
257_T274_G2.3771.00
114_G237_S2.3571.00
122_L163_M2.3391.00
340_E389_V2.3091.00
77_A341_R2.2861.00
125_T150_F2.2671.00
442_S446_A2.2511.00
126_A211_F2.2271.00
107_G246_L2.2231.00
374_N416_T2.2121.00
375_A420_F2.1961.00
167_A218_Y2.1901.00
449_Y452_G2.1791.00
193_N402_E2.1571.00
367_G412_A2.1511.00
369_A391_L2.1341.00
279_A293_A2.1001.00
367_G460_F2.0811.00
450_F454_L2.0631.00
107_G111_Y2.0361.00
259_G263_R2.0261.00
77_A80_R1.9791.00
194_A402_E1.9721.00
400_L404_D1.9561.00
74_A341_R1.9461.00
101_S296_I1.9441.00
274_G278_G1.9351.00
98_T275_V1.9241.00
44_A48_P1.9051.00
20_L351_H1.9011.00
60_A71_V1.8991.00
216_L220_V1.8951.00
210_A454_L1.8691.00
213_L458_V1.8681.00
240_L246_L1.8331.00
430_T442_S1.8301.00
91_V268_L1.8241.00
219_A223_V1.8101.00
245_A248_P1.8021.00
107_G251_F1.7841.00
195_D198_D1.7841.00
104_T253_P1.7681.00
206_G411_A1.7671.00
457_L461_G1.7401.00
371_I416_T1.7361.00
20_L348_L1.7271.00
450_F453_I1.7261.00
298_L320_A1.7111.00
403_R470_D1.6811.00
214_S218_Y1.6771.00
295_D299_N1.6610.99
189_A194_A1.6330.99
283_I293_A1.6330.99
159_I164_T1.6320.99
234_T238_G1.6220.99
154_G161_L1.6100.99
260_L273_A1.6080.99
96_I144_G1.5910.99
36_V41_L1.5850.99
323_A327_A1.5810.99
163_M221_L1.5310.99
370_A409_V1.5310.99
346_P350_H1.5290.99
239_P311_N1.5260.99
160_P225_I1.5230.99
111_Y248_P1.5180.99
357_W361_S1.5150.99
82_G333_L1.5130.99
184_T384_I1.5000.99
60_A342_T1.4980.99
35_G39_G1.4950.99
165_A433_L1.4940.99
461_G465_A1.4910.99
29_V55_F1.4870.99
428_F432_A1.4860.99
54_T272_V1.4710.99
363_V404_D1.4630.99
280_L284_A1.4610.99
191_V388_S1.4550.99
198_D403_R1.4390.98
443_W446_A1.4380.98
367_G459_L1.4330.98
98_T279_A1.4290.98
194_A198_D1.4250.98
189_A193_N1.4250.98
213_L217_A1.4150.98
249_L281_T1.4080.98
250_V281_T1.4070.98
449_Y453_I1.4060.98
78_G337_G1.3950.98
177_K410_E1.3940.98
166_G170_S1.3900.98
164_T168_I1.3820.98
170_S218_Y1.3820.98
221_L450_F1.3770.98
90_F323_A1.3740.98
408_A459_L1.3690.98
100_T316_T1.3660.98
98_T278_G1.3630.98
388_S409_V1.3600.98
255_V259_G1.3540.98
217_A221_L1.3510.98
101_S282_T1.3450.98
364_A460_F1.3420.98
392_R396_D1.3260.97
169_V426_A1.3210.97
281_T285_V1.3100.97
417_G425_G1.3080.97
203_M410_E1.3000.97
158_G161_L1.3000.97
111_Y251_F1.2980.97
22_E63_H1.2980.97
446_A453_I1.2860.97
202_G403_R1.2840.97
417_G423_H1.2780.97
288_A296_I1.2730.97
393_T397_E1.2590.96
282_T288_A1.2530.96
207_T455_S1.2480.96
415_P455_S1.2460.96
87_L268_L1.2430.96
237_S241_A1.2410.96
127_I215_V1.2310.96
250_V285_V1.2290.96
210_A455_S1.2280.96
122_L159_I1.2220.96
462_L468_G1.2150.96
147_G165_A1.2140.96
419_F453_I1.2040.95
177_K414_T1.2000.95
215_V219_A1.1920.95
25_V55_F1.1870.95
442_S445_W1.1810.95
97_A101_S1.1810.95
76_L80_R1.1790.95
217_A454_L1.1770.95
151_V165_A1.1700.95
320_A324_W1.1620.94
45_P48_P1.1610.94
214_S454_L1.1590.94
411_A459_L1.1550.94
248_P255_V1.1540.94
407_R411_A1.1530.94
94_G297_F1.1520.94
362_L394_L1.1490.94
68_W269_P1.1480.94
360_E460_F1.1470.94
308_E312_N1.1450.94
111_Y246_L1.1370.94
173_Y429_M1.1370.94
193_N392_R1.1340.94
185_T410_E1.1280.93
299_N320_A1.1270.93
73_D80_R1.1250.93
24_L28_L1.1220.93
174_A410_E1.1200.93
130_A174_A1.1190.93
340_E346_P1.1150.93
70_R73_D1.1140.93
370_A413_G1.1000.93
453_I457_L1.0990.93
320_A323_A1.0980.92
379_Q383_S1.0980.92
394_L397_E1.0930.92
18_P347_T1.0920.92
204_R208_A1.0880.92
75_A334_S1.0860.92
252_L281_T1.0730.92
150_F168_I1.0720.92
56_T338_L1.0700.92
410_E414_T1.0690.91
249_L252_L1.0660.91
45_P49_L1.0620.91
162_P444_W1.0560.91
151_V435_T1.0560.91
85_A381_Y1.0440.90
29_V59_F1.0410.90
125_T167_A1.0410.90
154_G158_G1.0390.90
173_Y423_H1.0310.90
169_V377_S1.0250.90
358_S398_Y1.0240.90
19_T22_E1.0220.90
116_L124_V1.0200.89
363_V463_V1.0180.89
359_P398_Y1.0180.89
104_T250_V1.0150.89
107_G250_V1.0140.89
69_E73_D1.0130.89
451_F455_S1.0100.89
325_T425_G1.0040.89
347_T351_H1.0030.89
252_L277_A1.0020.89
69_E127_I0.9980.88
454_L458_V0.9980.88
128_L150_F0.9960.88
394_L398_Y0.9940.88
199_H406_S0.9900.88
236_I310_V0.9850.88
247_G250_V0.9840.88
86_I326_I0.9830.88
50_L94_G0.9790.87
210_A458_V0.9760.87
43_L48_P0.9720.87
419_F449_Y0.9680.87
112_G244_Y0.9660.87
74_A337_G0.9650.87
43_L46_H0.9600.86
364_A368_V0.9590.86
260_L265_Y0.9550.86
129_A146_L0.9410.85
129_A133_A0.9400.85
178_Q208_A0.9400.85
380_Q456_P0.9390.85
209_I212_G0.9350.85
291_T295_D0.9320.85
207_T410_E0.9250.84
19_T23_A0.9230.84
415_P451_F0.9220.84
187_L384_I0.9190.84
206_G407_R0.9190.84
73_D77_A0.9150.84
57_G61_R0.9150.84
151_V155_S0.9150.84
458_V461_G0.9140.84
91_V275_V0.9140.84
79_L87_L0.9090.83
192_T406_S0.9080.83
93_Y322_S0.9070.83
420_F423_H0.9010.83
57_G338_L0.8990.83
359_P400_L0.8980.82
360_E364_A0.8970.82
86_I329_V0.8940.82
214_S217_A0.8920.82
235_A238_G0.8900.82
130_A134_F0.8870.82
393_T396_D0.8870.82
165_A435_T0.8870.82
356_I361_S0.8850.82
22_E64_L0.8830.81
116_L120_V0.8820.81
317_G321_G0.8820.81
256_V259_G0.8810.81
430_T441_I0.8800.81
157_L164_T0.8750.81
371_I375_A0.8740.81
234_T237_S0.8730.81
122_L160_P0.8730.81
288_A292_A0.8710.80
177_K207_T0.8700.80
169_V429_M0.8680.80
155_S161_L0.8650.80
351_H355_A0.8620.80
238_G241_A0.8580.79
184_T410_E0.8570.79
199_H410_E0.8570.79
209_I458_V0.8560.79
133_A142_T0.8540.79
356_I362_L0.8510.79
353_T397_E0.8500.79
350_H397_E0.8460.79
210_A214_S0.8450.78
205_L467_R0.8420.78
426_A445_W0.8420.78
130_A133_A0.8360.78
45_P424_A0.8300.77
235_A239_P0.8270.77
173_Y218_Y0.8250.77
308_E311_N0.8240.77
367_G463_V0.8220.76
58_L63_H0.8180.76
177_K199_H0.8160.76
245_A284_A0.8150.76
363_V469_Y0.8100.75
434_Y442_S0.8100.75
247_G285_V0.8090.75
356_I365_G0.8070.75
102_A281_T0.8060.75
140_W428_F0.8050.75
135_A258_F0.8050.75
26_P30_V0.7960.74
127_I241_A0.7940.74
277_A281_T0.7920.74
202_G400_L0.7890.73
465_A468_G0.7880.73
214_S457_L0.7860.73
462_L465_A0.7830.73
139_S183_D0.7820.73
460_F464_L0.7800.73
139_S184_T0.7800.73
53_I335_L0.7790.73
324_W327_A0.7780.72
458_V462_L0.7770.72
56_T59_F0.7760.72
384_I414_T0.7750.72
79_L330_V0.7730.72
139_S172_A0.7720.72
28_L259_G0.7690.72
22_E25_V0.7690.72
18_P21_T0.7680.71
355_A358_S0.7660.71
373_T387_P0.7630.71
265_Y273_A0.7590.71
289_S457_L0.7580.70
97_A293_A0.7580.70
86_I105_I0.7570.70
239_P242_G0.7570.70
256_V273_A0.7560.70
157_L222_G0.7550.70
102_A400_L0.7540.70
267_A313_L0.7530.70
22_E59_F0.7500.70
94_G275_V0.7490.70
185_T188_A0.7490.70
66_Y70_R0.7470.69
416_T452_G0.7470.69
309_L312_N0.7440.69
380_Q425_G0.7420.69
98_T293_A0.7420.69
176_D410_E0.7380.68
53_I331_A0.7370.68
160_P448_Y0.7350.68
47_A52_S0.7350.68
395_Y405_L0.7340.68
169_V449_Y0.7320.68
19_T63_H0.7310.68
178_Q184_T0.7290.67
298_L324_W0.7270.67
216_L308_E0.7260.67
441_I444_W0.7250.67
138_S381_Y0.7250.67
193_N396_D0.7250.67
185_T200_I0.7250.67
292_A296_I0.7240.67
379_Q417_G0.7220.67
384_I409_V0.7190.66
316_T321_G0.7190.66
95_L271_L0.7180.66
88_I92_I0.7170.66
142_T172_A0.7170.66
60_A260_L0.7160.66
26_P56_T0.7150.66
259_G262_F0.7150.66
430_T445_W0.7150.66
367_G371_I0.7140.66
379_Q423_H0.7130.66
183_D188_A0.7130.66
379_Q424_A0.7120.66
32_V243_S0.7120.66
205_L209_I0.7090.65
380_Q417_G0.7080.65
372_A397_E0.7070.65
194_A401_N0.7070.65
395_Y408_A0.7060.65
447_P450_F0.7060.65
138_S380_Q0.7030.65
230_A234_T0.7030.65
154_G157_L0.7030.65
151_V168_I0.7020.65
30_V34_L0.7010.64
192_T402_E0.7010.64
418_P452_G0.6970.64
426_A430_T0.6940.64
177_K183_D0.6930.64
362_L366_T0.6910.63
387_P413_G0.6910.63
78_G333_L0.6890.63
129_A142_T0.6860.63
142_T381_Y0.6850.63
319_I327_A0.6850.63
131_V255_V0.6850.63
199_H203_M0.6830.62
120_V123_P0.6810.62
221_L225_I0.6810.62
33_S48_P0.6770.62
282_T293_A0.6760.62
212_G289_S0.6760.62
186_N190_A0.6750.62
385_V420_F0.6730.61
186_N196_L0.6730.61
173_Y452_G0.6720.61
216_L219_A0.6710.61
251_F278_G0.6710.61
89_L173_Y0.6690.61
93_Y318_G0.6690.61
149_A330_V0.6690.61
65_G68_W0.6680.61
245_A285_V0.6680.61
296_I319_I0.6670.61
289_S296_I0.6660.60
163_M170_S0.6650.60
207_T411_A0.6650.60
333_L374_N0.6620.60
24_L27_V0.6600.60
101_S104_T0.6590.60
92_I143_V0.6560.59
383_S387_P0.6560.59
89_L326_I0.6560.59
404_D463_V0.6550.59
241_A276_F0.6530.59
412_A459_L0.6520.59
125_T129_A0.6500.59
292_A295_D0.6490.59
415_P456_P0.6490.59
89_L92_I0.6490.59
69_E350_H0.6480.58
217_A220_V0.6480.58
435_T444_W0.6470.58
23_A358_S0.6460.58
57_G60_A0.6450.58
27_V376_F0.6440.58
185_T199_H0.6440.58
374_N383_S0.6430.58
404_D462_L0.6430.58
23_A347_T0.6420.58
374_N417_G0.6420.58
141_T253_P0.6410.58
123_P133_A0.6410.58
173_Y416_T0.6390.57
49_L89_L0.6390.57
18_P22_E0.6380.57
188_A199_H0.6370.57
202_G470_D0.6360.57
261_A278_G0.6350.57
106_P244_Y0.6340.57
126_A141_T0.6340.57
49_L59_F0.6340.57
20_L347_T0.6340.57
143_V271_L0.6330.57
374_N380_Q0.6300.56
63_H66_Y0.6270.56
184_T189_A0.6260.56
408_A412_A0.6260.56
21_T26_P0.6250.56
130_A215_V0.6240.56
141_T380_Q0.6240.56
86_I330_V0.6240.56
333_L388_S0.6230.55
26_P344_V0.6220.55
141_T381_Y0.6220.55
246_L250_V0.6210.55
202_G407_R0.6210.55
204_R217_A0.6200.55
213_L280_L0.6200.55
144_G148_V0.6180.55
47_A386_V0.6180.55
280_L396_D0.6160.55
435_T442_S0.6150.54
418_P429_M0.6130.54
40_Y218_Y0.6130.54
97_A250_V0.6130.54
242_G276_F0.6130.54
170_S449_Y0.6110.54
220_V235_A0.6110.54
370_A387_P0.6100.54
228_G256_V0.6090.54
218_Y451_F0.6080.54
311_N314_L0.6080.54
372_A376_F0.6080.54
266_P269_P0.6070.54
133_A294_W0.6060.53
457_L460_F0.6050.53
108_L183_D0.6040.53
353_T356_I0.6040.53
120_V124_V0.6020.53
441_I446_A0.6020.53
253_P261_A0.6010.53
376_F418_P0.6010.53
122_L154_G0.6010.53
151_V432_A0.6000.53
117_T124_V0.5980.52
101_S288_A0.5970.52
126_A253_P0.5970.52
134_F183_D0.5960.52
87_L105_I0.5950.52
72_S105_I0.5930.52
156_G236_I0.5920.52
139_S142_T0.5910.52
85_A141_T0.5900.51
218_Y450_F0.5890.51
140_W417_G0.5890.51
220_V243_S0.5870.51
60_A365_G0.5870.51
378_A417_G0.5850.51
133_A180_P0.5850.51
169_V423_H0.5850.51
112_G149_A0.5840.51
150_F427_V0.5830.51
194_A376_F0.5820.51
176_D182_S0.5810.50
339_L342_T0.5800.50
291_T450_F0.5800.50
173_Y418_P0.5780.50
260_L270_S0.5770.50
221_L448_Y0.5770.50
404_D408_A0.5770.50
332_A336_G0.5750.50
207_T414_T0.5750.50
220_V224_L0.5740.50
57_G71_V0.5730.49
174_A466_G0.5720.49
329_V382_M0.5720.49
110_Y114_G0.5710.49
400_L405_L0.5710.49
195_D201_N0.5710.49
53_I452_G0.5700.49
206_G459_L0.5680.49
239_P310_V0.5640.48
323_A326_I0.5630.48
366_T408_A0.5630.48
50_L331_A0.5620.48
141_T382_M0.5620.48
121_F161_L0.5620.48
430_T435_T0.5610.48
140_W424_A0.5610.48
380_Q451_F0.5600.48
154_G159_I0.5590.48
211_F451_F0.5590.48
105_I332_A0.5580.48
105_I274_G0.5570.48
102_A251_F0.5570.48
142_T156_G0.5560.47
290_F299_N0.5550.47
64_L89_L0.5550.47
186_N387_P0.5540.47
53_I57_G0.5530.47
144_G432_A0.5530.47
66_Y341_R0.5520.47
153_I156_G0.5510.47
196_L427_V0.5500.47
273_A277_A0.5500.47
130_A294_W0.5490.47
363_V408_A0.5490.47
281_T284_A0.5480.46
53_I75_A0.5480.46
274_G385_V0.5460.46
367_G408_A0.5460.46
361_S464_L0.5450.46
190_A456_P0.5450.46
356_I398_Y0.5450.46
31_V373_T0.5450.46
28_L31_V0.5440.46
199_H414_T0.5430.46
38_S45_P0.5420.46
89_L139_S0.5390.45
116_L128_L0.5390.45
287_G319_I0.5390.45
121_F157_L0.5390.45
79_L222_G0.5390.45
126_A214_S0.5380.45
116_L139_S0.5380.45
392_R402_E0.5370.45
122_L167_A0.5350.45
293_A296_I0.5330.45
123_P160_P0.5330.45
104_T191_V0.5330.45
164_T294_W0.5330.45
353_T394_L0.5320.45
218_Y221_L0.5320.45
44_A324_W0.5320.45
41_L290_F0.5300.44
127_I453_I0.5290.44
435_T446_A0.5280.44
154_G160_P0.5280.44
245_A249_L0.5270.44
74_A328_V0.5270.44
85_A374_N0.5260.44
123_P419_F0.5250.44
144_G428_F0.5250.44
153_I244_Y0.5250.44
216_L359_P0.5240.44
258_F262_F0.5240.44
89_L190_A0.5240.44
256_V260_L0.5230.43
311_N328_V0.5230.43
465_A469_Y0.5220.43
369_A406_S0.5220.43
37_G43_L0.5220.43
244_Y286_Q0.5220.43
47_A61_R0.5210.43
140_W455_S0.5210.43
462_L467_R0.5210.43
375_A416_T0.5210.43
364_A367_G0.5180.43
178_Q200_I0.5180.43
25_V246_L0.5180.43
34_L38_S0.5180.43
26_P250_V0.5170.43
254_L271_L0.5170.43
177_K185_T0.5170.43
274_G413_G0.5160.43
238_G242_G0.5160.43
123_P382_M0.5160.43
234_T326_I0.5150.42
352_L369_A0.5150.42
151_V160_P0.5150.42
189_A192_T0.5140.42
149_A366_T0.5140.42
121_F165_A0.5140.42
60_A344_V0.5130.42
178_Q410_E0.5130.42
374_N381_Y0.5120.42
76_L83_L0.5120.42
174_A178_Q0.5120.42
65_G212_G0.5120.42
276_F280_L0.5120.42
71_V342_T0.5110.42
79_L269_P0.5110.42
167_A210_A0.5110.42
107_G466_G0.5110.42
327_A390_S0.5110.42
214_S450_F0.5100.42
363_V366_T0.5100.42
400_L470_D0.5090.42
50_L333_L0.5070.42
150_F193_N0.5060.41
203_M348_L0.5060.41
30_V451_F0.5060.41
166_G386_V0.5060.41
26_P52_S0.5050.41
58_L61_R0.5050.41
250_V254_L0.5050.41
61_R71_V0.5040.41
105_I109_M0.5030.41
112_G180_P0.5000.41
442_S447_P0.5000.41
108_L192_T0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8208 99.9 0.812 Contact Map
4r1iA 2 0.8921 99.9 0.833 Contact Map
4r0cA 3 0.4582 99.7 0.865 Contact Map
3qe7A 2 0.7169 86 0.964 Contact Map
4pd6A 3 0.4521 75.1 0.968 Contact Map
2kncA 1 0.1059 24.7 0.977 Contact Map
3zuxA 1 0.6008 18.6 0.978 Contact Map
2l9xA 1 0.0591 17.5 0.978 Contact Map
4czbA 2 0.666 16.6 0.979 Contact Map
4tphA 2 0.778 16.4 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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