GREMLIN Database
Q9HNF5 - GTP cyclohydrolase II
UniProt: Q9HNF5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 168 (149)
Sequences: 3377 (1686)
Seq/√Len: 138.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V20_A3.9831.00
134_D145_D3.5931.00
108_Q164_V3.1701.00
2_R9_I2.8301.00
76_A124_P2.6071.00
114_G127_V2.6031.00
134_D139_G2.3751.00
149_Y153_H2.3381.00
11_V73_L2.3191.00
15_D102_P2.2111.00
18_A99_R2.1991.00
2_R133_L2.1541.00
78_A89_F2.1461.00
19_D99_R2.1381.00
8_L61_I2.0491.00
101_A106_A2.0421.00
70_I95_V2.0381.00
68_L72_E2.0121.00
13_L18_A1.9561.00
72_E89_F1.9501.00
103_S106_A1.9261.00
147_K151_S1.9231.00
147_K157_Y1.8851.00
52_V73_L1.8851.00
15_D19_D1.8501.00
3_T6_G1.8461.00
18_A23_L1.8241.00
54_H72_E1.8101.00
51_T96_H1.7821.00
15_D99_R1.7401.00
72_E75_Q1.7001.00
100_A115_I1.6781.00
79_D87_A1.6661.00
8_L96_H1.5221.00
16_A102_P1.5111.00
117_L158_V1.4911.00
143_V157_Y1.4691.00
70_I128_V1.3831.00
67_A71_A1.3701.00
132_M146_A1.3551.00
105_S116_A1.3211.00
132_M141_R1.3051.00
25_F99_R1.2971.00
79_D88_T1.2891.00
150_A157_Y1.2881.00
54_H57_T1.2661.00
68_L71_A1.2631.00
55_R90_R1.2571.00
134_D141_R1.2471.00
3_T136_D1.2091.00
104_L116_A1.2041.00
74_G126_A1.1921.00
14_G125_P1.1891.00
145_D148_R1.1730.99
11_V70_I1.1640.99
58_Y65_D1.1570.99
143_V147_K1.1530.99
4_D149_Y1.1270.99
9_I130_C1.1270.99
56_D68_L1.1050.99
102_P106_A1.0900.99
22_A91_A1.0840.99
114_G129_V1.0820.99
18_A25_F1.0760.99
4_D152_R1.0700.99
13_L126_A1.0630.99
17_V124_P1.0350.99
12_A129_V1.0150.99
13_L73_L1.0140.98
12_A115_I1.0040.98
57_T65_D1.0010.98
118_A126_A0.9960.98
113_L160_G0.9950.98
4_D136_D0.9840.98
72_E78_A0.9770.98
11_V95_V0.9730.98
11_V52_V0.9590.98
33_P90_R0.9540.98
143_V159_E0.9420.98
120_A163_L0.9330.97
64_D139_G0.9330.97
6_G133_L0.9290.97
32_H90_R0.9230.97
118_A123_V0.9220.97
108_Q161_S0.9220.97
14_G17_V0.9200.97
146_A157_Y0.9180.97
54_H89_F0.9050.97
2_R6_G0.8860.96
148_R151_S0.8740.96
53_N89_F0.8700.96
150_A155_I0.8700.96
32_H44_D0.8700.96
5_A149_Y0.8680.96
31_D91_A0.8630.96
162_D165_A0.8480.95
8_L130_C0.8460.95
114_G118_A0.8440.95
161_S165_A0.8380.95
110_H160_G0.8300.95
148_R152_R0.8230.95
5_A130_C0.8130.94
78_A88_T0.8110.94
134_D137_T0.8070.94
111_T131_E0.8030.94
24_P28_D0.7990.94
161_S164_V0.7940.94
95_V128_V0.7920.94
58_Y142_S0.7910.93
33_P44_D0.7870.93
23_L73_L0.7760.93
8_L48_F0.7750.93
25_F47_S0.7730.93
144_A147_K0.7710.93
11_V74_G0.7690.92
75_Q78_A0.7680.92
53_N91_A0.7640.92
48_F96_H0.7630.92
57_T72_E0.7610.92
6_G61_I0.7580.92
13_L17_V0.7550.92
6_G132_M0.7550.92
74_G124_P0.7550.92
22_A87_A0.7520.92
150_A156_P0.7480.91
113_L163_L0.7400.91
12_A114_G0.7390.91
4_D153_H0.7360.91
3_T152_R0.7360.91
26_I51_T0.7350.91
5_A8_L0.7300.90
47_S101_A0.7290.90
16_A20_A0.7270.90
15_D18_A0.7250.90
8_L51_T0.7210.90
57_T89_F0.7210.90
44_D110_H0.7200.90
147_K150_A0.7170.90
141_R145_D0.7160.90
64_D68_L0.7040.89
57_T90_R0.7020.89
110_H113_L0.6960.88
54_H68_L0.6950.88
44_D90_R0.6920.88
98_L129_V0.6780.87
32_H45_R0.6770.87
113_L158_V0.6750.87
119_G125_P0.6720.86
98_L111_T0.6690.86
2_R5_A0.6660.86
16_A125_P0.6600.85
50_L91_A0.6580.85
5_A133_L0.6570.85
25_F30_L0.6530.85
107_R110_H0.6530.85
12_A98_L0.6490.84
46_S131_E0.6480.84
53_N57_T0.6480.84
65_D68_L0.6460.84
12_A126_A0.6430.84
14_G18_A0.6410.84
80_P91_A0.6380.83
57_T68_L0.6320.83
23_L52_V0.6310.83
148_R154_D0.6270.82
71_A74_G0.6260.82
11_V126_A0.6230.82
9_I133_L0.6190.82
52_V89_F0.6130.81
47_S129_V0.6120.81
14_G119_G0.6110.81
27_A91_A0.6040.80
26_I96_H0.6020.80
67_A74_G0.6010.80
120_A166_A0.5950.79
107_R111_T0.5930.79
46_S140_A0.5920.79
2_R61_I0.5910.79
31_D90_R0.5900.78
18_A49_S0.5850.78
80_P87_A0.5840.78
151_S154_D0.5840.78
32_H53_N0.5830.78
151_S157_Y0.5800.77
118_A124_P0.5720.76
134_D152_R0.5700.76
20_A124_P0.5700.76
1_M5_A0.5610.75
72_E88_T0.5610.75
2_R132_M0.5590.75
22_A80_P0.5560.74
2_R8_L0.5550.74
14_G102_P0.5500.73
143_V150_A0.5440.73
134_D138_G0.5420.72
131_E140_A0.5410.72
23_L45_R0.5390.72
46_S111_T0.5350.71
137_T142_S0.5310.71
143_V161_S0.5310.71
98_L110_H0.5300.71
110_H114_G0.5280.70
61_I140_A0.5250.70
106_A164_V0.5240.70
144_A148_R0.5230.70
56_D90_R0.5220.70
26_I49_S0.5220.70
10_C48_F0.5210.69
110_H131_E0.5210.69
22_A79_D0.5180.69
55_R88_T0.5180.69
103_S108_Q0.5150.69
17_V126_A0.5140.68
107_R112_E0.5120.68
130_C140_A0.5120.68
10_C129_V0.5100.68
109_G112_E0.5080.68
12_A130_C0.5060.67
73_L126_A0.5050.67
52_V74_G0.5040.67
158_V162_D0.5030.67
6_G129_V0.5020.67
56_D88_T0.5010.66
22_A28_D0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1snnA 2 0.994 100 0.108 Contact Map
4ffjA 2 0.8571 100 0.134 Contact Map
1k4iA 2 0.9048 100 0.137 Contact Map
3mioA 2 0.8333 100 0.14 Contact Map
4p6dA 2 0.8393 100 0.141 Contact Map
1g57A 2 0.8988 100 0.142 Contact Map
1tksA 2 0.869 100 0.145 Contact Map
4i14A 2 0.8452 100 0.153 Contact Map
2jisA 2 0.9345 48.2 0.939 Contact Map
4ritB 2 0.9286 44.5 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.