GREMLIN Database
Q9HNF3 - Uncharacterized protein
UniProt: Q9HNF3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (299)
Sequences: 310 (159)
Seq/√Len: 9.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_D239_R5.1191.00
182_R198_E4.7781.00
48_R51_R4.2460.99
181_E184_T3.9250.98
142_L153_T3.6350.97
180_P184_T3.4480.96
175_V204_M3.1060.92
181_E232_W2.7550.87
166_R202_D2.6740.85
142_L145_A2.5790.83
249_A266_P2.5560.82
95_I122_P2.5450.82
91_V142_L2.4880.80
119_A225_Q2.4150.78
13_P24_Q2.4090.78
229_N232_W2.3870.77
210_K213_T2.3010.75
32_A38_T2.2890.74
50_H118_E2.2830.74
33_M111_V2.2730.74
223_G270_D2.2310.72
119_A275_A2.2220.72
155_L168_C2.2000.71
195_D199_R2.1700.70
285_S304_T2.1680.70
88_E92_D2.1060.68
272_L289_E2.0530.66
86_D194_D2.0040.64
177_V217_L1.9970.63
84_W138_H1.9550.62
138_H141_E1.9050.60
62_N161_R1.9000.59
175_V207_L1.8330.57
88_E145_A1.8320.56
231_D281_H1.8140.56
298_L303_D1.8090.55
21_T90_V1.7950.55
67_F222_V1.7950.55
252_H264_A1.6950.50
25_T135_L1.6560.49
89_A93_A1.6430.48
122_P298_L1.6240.47
80_D155_L1.6160.47
165_L217_L1.6110.47
163_A166_R1.5910.46
165_L210_K1.5800.45
219_T237_F1.5750.45
119_A138_H1.5570.44
183_A187_D1.5510.44
81_G104_G1.5280.43
21_T85_D1.5180.43
95_I99_R1.5070.42
105_F294_R1.5020.42
139_L164_V1.4870.41
279_K298_L1.4790.41
57_P133_P1.4780.41
235_G239_R1.4610.40
98_Q152_T1.4590.40
184_T230_P1.4570.40
204_M217_L1.4510.40
17_H21_T1.4500.40
18_E21_T1.4490.40
116_F279_K1.4490.40
165_L170_P1.4210.39
95_I149_R1.4130.38
201_V239_R1.4070.38
111_V276_R1.3950.38
33_M249_A1.3890.37
81_G142_L1.3810.37
62_N160_T1.3780.37
165_L177_V1.3490.36
247_L296_A1.3450.36
149_R157_S1.3390.35
113_R117_E1.3310.35
261_G264_A1.3190.34
184_T233_Y1.3140.34
106_G116_F1.3130.34
140_P164_V1.3070.34
30_A299_A1.3070.34
145_A249_A1.3030.34
116_F275_A1.3010.34
90_V142_L1.2990.34
247_L275_A1.2980.34
8_K102_L1.2940.33
158_N214_R1.2810.33
178_D189_V1.2770.33
303_D306_V1.2540.32
18_E24_Q1.2490.32
96_R100_K1.2460.32
54_Q160_T1.2390.31
206_V280_T1.2380.31
203_T253_V1.2350.31
138_H206_V1.2310.31
230_P234_A1.2250.31
17_H43_A1.2150.30
273_A276_R1.2120.30
176_S251_M1.2120.30
59_V82_V1.1940.30
87_P90_V1.1940.30
159_G185_F1.1880.29
245_V298_L1.1870.29
177_V203_T1.1760.29
301_D305_W1.1760.29
31_N35_G1.1740.29
84_W137_P1.1720.29
214_R243_D1.1660.29
230_P278_V1.1660.29
42_H53_I1.1620.29
180_P183_A1.1460.28
243_D268_H1.1360.28
94_S185_F1.1320.27
146_F219_T1.1290.27
29_T185_F1.1240.27
22_A249_A1.1230.27
201_V224_G1.1210.27
53_I151_L1.1200.27
63_E178_D1.1110.27
105_F119_A1.1090.27
27_G31_N1.1070.27
276_R280_T1.1060.27
219_T244_F1.1060.27
13_P22_A1.1000.26
54_Q63_E1.0960.26
99_R121_E1.0910.26
95_I145_A1.0890.26
88_E143_I1.0890.26
76_T188_V1.0880.26
86_D138_H1.0870.26
144_E169_D1.0850.26
184_T229_N1.0790.26
208_H273_A1.0780.26
256_S294_R1.0670.25
286_V298_L1.0660.25
165_L276_R1.0620.25
100_K117_E1.0560.25
76_T271_V1.0550.25
38_T240_A1.0500.25
138_H291_P1.0460.25
269_E283_P1.0430.24
203_T291_P1.0390.24
187_D263_A1.0340.24
214_R244_F1.0270.24
73_S251_M1.0220.24
91_V96_R1.0190.24
59_V284_H1.0180.24
143_I183_A1.0150.24
204_M237_F1.0130.23
63_E185_F1.0110.23
300_R306_V1.0080.23
183_A252_H1.0070.23
157_S170_P1.0060.23
152_T217_L0.9940.23
256_S260_L0.9900.23
30_A264_A0.9900.23
147_H175_V0.9900.23
88_E165_L0.9890.23
269_E304_T0.9870.23
219_T251_M0.9830.23
201_V236_F0.9790.22
178_D210_K0.9760.22
275_A282_L0.9740.22
280_T305_W0.9640.22
67_F71_D0.9640.22
273_A277_A0.9610.22
99_R122_P0.9610.22
104_G159_G0.9540.22
265_M294_R0.9480.22
187_D300_R0.9440.21
53_I146_F0.9430.21
287_L299_A0.9420.21
25_T36_E0.9360.21
151_L299_A0.9310.21
50_H122_P0.9310.21
31_N290_Q0.9280.21
51_R269_E0.9240.21
268_H271_V0.9180.21
122_P303_D0.9170.21
184_T196_A0.9150.21
177_V200_L0.9130.20
223_G263_A0.9120.20
113_R141_E0.9100.20
90_V306_V0.9090.20
253_V271_V0.9090.20
18_E242_P0.9050.20
91_V235_G0.9030.20
93_A96_R0.9030.20
117_E121_E0.9000.20
165_L206_V0.9000.20
54_Q295_V0.8950.20
272_L296_A0.8910.20
185_F196_A0.8900.20
13_P249_A0.8870.20
180_P233_Y0.8770.19
62_N157_S0.8760.19
204_M260_L0.8750.19
25_T101_L0.8680.19
185_F189_V0.8670.19
205_D245_V0.8660.19
22_A227_M0.8650.19
236_F240_A0.8620.19
125_V146_F0.8570.19
43_A251_M0.8560.19
143_I155_L0.8540.19
201_V272_L0.8520.19
67_F299_A0.8500.19
15_Y26_C0.8480.19
75_H130_D0.8480.19
279_K283_P0.8450.19
287_L295_V0.8430.19
224_G298_L0.8420.19
29_T108_N0.8370.18
257_R294_R0.8350.18
219_T247_L0.8340.18
112_P270_D0.8340.18
66_V185_F0.8310.18
25_T43_A0.8300.18
188_V208_H0.8290.18
283_P301_D0.8280.18
231_D239_R0.8220.18
243_D300_R0.8200.18
22_A56_T0.8170.18
145_A296_A0.8140.18
18_E23_A0.8130.18
181_E224_G0.8070.18
165_L187_D0.8050.18
143_I153_T0.8050.18
234_A237_F0.8000.17
277_A291_P0.7990.17
250_Y259_R0.7940.17
53_I124_H0.7920.17
97_L102_L0.7920.17
85_D95_I0.7910.17
64_R139_L0.7890.17
208_H212_D0.7870.17
116_F263_A0.7870.17
17_H296_A0.7850.17
30_A244_F0.7850.17
168_C191_A0.7840.17
222_V233_Y0.7840.17
148_D269_E0.7780.17
275_A296_A0.7750.17
15_Y28_W0.7680.17
63_E189_V0.7660.17
180_P200_L0.7660.17
14_D266_P0.7650.17
171_T244_F0.7630.17
206_V209_A0.7630.17
198_E224_G0.7620.16
91_V187_D0.7600.16
114_E121_E0.7580.16
153_T198_E0.7570.16
260_L298_L0.7560.16
86_D155_L0.7540.16
144_E182_R0.7540.16
21_T124_H0.7530.16
201_V270_D0.7510.16
101_L268_H0.7480.16
257_R295_V0.7480.16
232_W245_V0.7450.16
45_Y220_T0.7450.16
164_V203_T0.7440.16
184_T228_A0.7440.16
105_F150_G0.7440.16
230_P277_A0.7420.16
150_G224_G0.7390.16
141_E232_W0.7380.16
83_A152_T0.7370.16
33_M269_E0.7360.16
64_R178_D0.7350.16
230_P245_V0.7340.16
256_S259_R0.7330.16
119_A201_V0.7300.16
105_F291_P0.7290.16
141_E205_D0.7280.16
33_M125_V0.7240.16
206_V222_V0.7240.16
104_G259_R0.7230.16
270_D305_W0.7220.16
159_G203_T0.7210.16
259_R275_A0.7200.15
148_D273_A0.7190.15
135_L275_A0.7190.15
300_R303_D0.7180.15
247_L271_V0.7170.15
141_E208_H0.7120.15
88_E148_D0.7120.15
189_V216_V0.7100.15
55_M94_S0.7070.15
182_R205_D0.7060.15
56_T190_G0.7050.15
22_A217_L0.7050.15
100_K183_A0.7030.15
204_M256_S0.7030.15
97_L105_F0.7030.15
35_G53_I0.7020.15
278_V305_W0.7010.15
145_A300_R0.7000.15
162_P216_V0.6990.15
101_L122_P0.6990.15
85_D94_S0.6970.15
17_H92_D0.6970.15
34_R56_T0.6960.15
64_R271_V0.6930.15
187_D286_V0.6920.15
143_I227_M0.6900.15
14_D203_T0.6890.15
11_D116_F0.6890.15
91_V145_A0.6860.15
84_W206_V0.6850.15
29_T173_L0.6850.15
32_A141_E0.6830.15
130_D189_V0.6810.15
55_M224_G0.6810.15
64_R74_G0.6800.15
170_P256_S0.6790.15
21_T296_A0.6790.15
91_V151_L0.6720.14
105_F170_P0.6710.14
286_V296_A0.6690.14
228_A247_L0.6670.14
38_T168_C0.6660.14
78_E275_A0.6650.14
30_A181_E0.6640.14
251_M290_Q0.6640.14
175_V203_T0.6630.14
89_A280_T0.6620.14
63_E152_T0.6610.14
244_F299_A0.6600.14
90_V153_T0.6590.14
212_D229_N0.6580.14
32_A161_R0.6570.14
237_F245_V0.6560.14
180_P217_L0.6520.14
169_D238_E0.6490.14
38_T42_H0.6490.14
269_E273_A0.6460.14
187_D269_E0.6460.14
122_P224_G0.6410.14
101_L243_D0.6400.14
208_H241_A0.6350.14
8_K224_G0.6340.14
267_D270_D0.6340.14
18_E85_D0.6330.14
45_Y50_H0.6300.14
20_H85_D0.6290.14
36_E109_D0.6290.14
145_A302_E0.6290.14
170_P243_D0.6290.14
158_N178_D0.6280.13
202_D206_V0.6280.13
104_G250_Y0.6280.13
99_R238_E0.6260.13
188_V230_P0.6240.13
86_D168_C0.6240.13
193_E210_K0.6230.13
231_D235_G0.6230.13
51_R259_R0.6220.13
257_R300_R0.6200.13
285_S301_D0.6190.13
230_P281_H0.6140.13
192_T222_V0.6140.13
25_T108_N0.6130.13
212_D244_F0.6110.13
92_D232_W0.6110.13
135_L194_D0.6100.13
77_Y289_E0.6080.13
276_R302_E0.6080.13
42_H135_L0.6050.13
231_D234_A0.6030.13
19_N85_D0.6020.13
250_Y271_V0.6020.13
175_V215_T0.5990.13
221_L227_M0.5980.13
90_V232_W0.5980.13
205_D227_M0.5950.13
24_Q153_T0.5950.13
7_P243_D0.5920.13
115_R118_E0.5870.13
35_G42_H0.5860.13
280_T296_A0.5860.13
86_D95_I0.5850.13
15_Y24_Q0.5850.13
252_H262_R0.5840.13
202_D280_T0.5840.13
167_E275_A0.5820.13
51_R122_P0.5810.13
31_N116_F0.5800.13
23_A106_G0.5780.12
175_V225_Q0.5780.12
144_E276_R0.5780.12
14_D237_F0.5770.12
149_R283_P0.5750.12
223_G266_P0.5740.12
83_A201_V0.5700.12
166_R231_D0.5700.12
43_A288_R0.5700.12
189_V292_A0.5690.12
23_A174_Y0.5670.12
25_T32_A0.5610.12
152_T161_R0.5600.12
36_E215_T0.5590.12
44_F271_V0.5580.12
134_T139_L0.5580.12
222_V286_V0.5570.12
34_R292_A0.5530.12
146_F185_F0.5520.12
187_D282_L0.5500.12
199_R208_H0.5470.12
283_P302_E0.5460.12
163_A281_H0.5460.12
23_A89_A0.5450.12
222_V289_E0.5430.12
8_K208_H0.5420.12
60_R75_H0.5420.12
250_Y294_R0.5400.12
90_V245_V0.5380.12
209_A283_P0.5370.12
27_G203_T0.5360.12
206_V225_Q0.5360.12
266_P274_F0.5350.12
142_L303_D0.5330.12
23_A278_V0.5330.12
181_E228_A0.5320.12
27_G34_R0.5270.12
75_H245_V0.5260.12
234_A276_R0.5250.12
127_I139_L0.5250.12
100_K281_H0.5250.12
234_A304_T0.5230.11
178_D219_T0.5220.11
145_A153_T0.5220.11
22_A275_A0.5200.11
206_V210_K0.5170.11
241_A279_K0.5150.11
124_H284_H0.5140.11
221_L278_V0.5120.11
89_A304_T0.5120.11
32_A43_A0.5110.11
108_N143_I0.5110.11
17_H24_Q0.5060.11
108_N196_A0.5060.11
10_V24_Q0.5050.11
280_T286_V0.5040.11
236_F276_R0.5030.11
102_L123_R0.5030.11
71_D147_H0.5020.11
18_E223_G0.5020.11
22_A286_V0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yx0A 1 0.9477 100 0.621 Contact Map
2z2uA 1 0.8523 100 0.632 Contact Map
3c8fA 1 0.6862 99.8 0.879 Contact Map
3rfaA 1 0.8523 99.8 0.884 Contact Map
1tv8A 2 0.7938 99.6 0.895 Contact Map
3canA 2 0.4646 99.6 0.897 Contact Map
4k36A 1 0.7477 99.4 0.91 Contact Map
2qgqA 1 0.6615 99.4 0.91 Contact Map
4wcxA 1 0.9077 99.3 0.913 Contact Map
3t7vA 1 0.8708 99.3 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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