GREMLIN Database
Q9HNF1 - Cell division inhibitor
UniProt: Q9HNF1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (237)
Sequences: 13601 (8556)
Seq/√Len: 555.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_D113_Y4.2461.00
202_P229_A4.0221.00
21_A117_I3.6991.00
31_A235_Y3.3571.00
28_M115_C2.9861.00
20_T230_Y2.9851.00
7_A135_A2.9361.00
216_P219_S2.8911.00
33_R115_C2.8881.00
4_R137_E2.5271.00
173_R203_E2.5221.00
36_V113_Y2.4981.00
178_A181_A2.4941.00
22_V47_V2.2591.00
50_V147_A2.2551.00
143_T173_R2.2451.00
77_A83_D2.2401.00
37_L47_V2.2341.00
30_E231_R2.2281.00
27_V234_A2.1751.00
21_A37_L2.1551.00
20_T170_V2.1301.00
8_V24_V2.1191.00
27_V218_V2.1031.00
170_V233_L2.0831.00
206_R209_D2.0651.00
25_A37_L2.0301.00
199_G236_T1.9721.00
31_A231_R1.9161.00
34_S114_D1.8971.00
137_E167_A1.7421.00
187_D191_A1.7231.00
33_R238_L1.7101.00
175_T203_E1.6921.00
70_A73_D1.6761.00
25_A117_I1.6621.00
49_H150_A1.6401.00
40_A131_P1.6331.00
199_G233_L1.6261.00
72_T112_R1.6231.00
60_T63_D1.6101.00
22_V50_V1.5971.00
28_M117_I1.5951.00
24_V237_L1.5901.00
171_V186_G1.5831.00
8_V139_V1.5581.00
188_A192_T1.5571.00
40_A118_V1.5571.00
7_A120_T1.5421.00
24_V234_A1.5141.00
204_D226_A1.5121.00
198_L236_T1.5101.00
29_A82_F1.5031.00
189_A193_L1.4811.00
33_R114_D1.4761.00
186_G190_A1.4611.00
8_V21_A1.4151.00
40_A61_L1.3951.00
25_A47_V1.3801.00
139_V170_V1.3471.00
144_R171_V1.3361.00
138_T159_V1.3341.00
16_G172_T1.3331.00
5_V118_V1.3321.00
206_R221_A1.3301.00
31_A238_L1.3291.00
9_A155_T1.3281.00
20_T172_T1.3191.00
215_T220_L1.3181.00
196_D240_E1.3071.00
224_S227_A1.3041.00
188_A191_A1.2981.00
46_N151_N1.2641.00
137_E168_G1.2611.00
205_S209_D1.2611.00
174_V200_L1.2561.00
51_V82_F1.2461.00
20_T24_V1.2431.00
4_R136_D1.2421.00
22_V51_V1.2171.00
207_V226_A1.2161.00
201_I226_A1.2021.00
180_G183_A1.2001.00
102_L105_V1.1991.00
228_Q231_R1.1921.00
59_A63_D1.1651.00
145_Q148_A1.1491.00
29_A81_G1.1411.00
27_V231_R1.1391.00
204_D224_S1.1361.00
225_P228_Q1.1291.00
69_A73_D1.1261.00
18_T47_V1.1231.00
9_A120_T1.1201.00
18_T50_V1.1131.00
120_T131_P1.1061.00
89_T154_K1.1051.00
8_V20_T1.0931.00
71_L85_I1.0911.00
80_A83_D1.0901.00
36_V75_T1.0901.00
233_L237_L1.0721.00
103_P107_A1.0671.00
61_L64_V1.0621.00
28_M234_A1.0461.00
232_E236_T1.0421.00
172_T230_Y1.0281.00
176_D185_H1.0231.00
181_A185_H1.0081.00
46_N147_A1.0061.00
64_V74_A1.0001.00
28_M35_V0.9961.00
235_Y239_D0.9961.00
201_I229_A0.9921.00
231_R235_Y0.9891.00
105_V108_T0.9881.00
6_F115_C0.9871.00
115_C238_L0.9841.00
95_G125_S0.9831.00
26_A30_E0.9801.00
34_S112_R0.9781.00
147_A211_E0.9731.00
27_V31_A0.9691.00
215_T219_S0.9651.00
74_A85_I0.9641.00
53_C84_V0.9611.00
23_N26_A0.9571.00
110_R136_D0.9481.00
232_E235_Y0.9461.00
25_A82_F0.9451.00
6_F237_L0.9441.00
222_P227_A0.9431.00
38_V116_V0.9421.00
218_V231_R0.9391.00
62_H66_A0.9381.00
145_Q208_A0.9351.00
229_A232_E0.9311.00
8_V117_I0.9251.00
30_E219_S0.9241.00
3_G110_R0.9111.00
197_I200_L0.9001.00
59_A69_A0.8901.00
5_V110_R0.8851.00
176_D179_G0.8851.00
23_N218_V0.8821.00
204_D225_P0.8791.00
64_V105_V0.8771.00
142_S186_G0.8741.00
30_E218_V0.8701.00
9_A128_T0.8641.00
187_D190_A0.8621.00
42_L127_D0.8621.00
115_C241_P0.8611.00
51_V78_A0.8591.00
6_F137_E0.8581.00
213_A220_L0.8531.00
98_D101_A0.8521.00
24_V233_L0.8511.00
45_A87_G0.8481.00
38_V118_V0.8471.00
141_V172_T0.8471.00
78_A83_D0.8421.00
104_D108_T0.8381.00
96_R99_P0.8361.00
5_V136_D0.8351.00
217_L227_A0.8321.00
186_G192_T0.8291.00
105_V109_L0.8241.00
144_R174_V0.8241.00
19_T207_V0.8221.00
40_A102_L0.8181.00
64_V85_I0.8181.00
187_D200_L0.8111.00
236_T240_E0.8101.00
17_K122_G0.8021.00
27_V230_Y0.8021.00
44_M122_G0.8011.00
11_G158_L0.7991.00
23_N216_P0.7991.00
5_V116_V0.7921.00
36_V116_V0.7911.00
157_A160_E0.7911.00
72_T108_T0.7881.00
175_T184_G0.7861.00
15_V148_A0.7841.00
35_V114_D0.7811.00
90_T157_A0.7801.00
69_A74_A0.7791.00
12_K17_K0.7701.00
98_D127_D0.7651.00
160_E163_G0.7651.00
62_H97_A0.7631.00
19_T211_E0.7571.00
209_D213_A0.7571.00
107_A110_R0.7561.00
45_A88_G0.7561.00
40_A127_D0.7561.00
140_L152_T0.7541.00
223_E228_Q0.7541.00
96_R126_H0.7511.00
129_T158_L0.7511.00
167_A241_P0.7491.00
131_P135_A0.7481.00
153_A192_T0.7461.00
70_A108_T0.7381.00
171_V174_V0.7371.00
75_T83_D0.7371.00
143_T148_A0.7371.00
18_T46_N0.7361.00
180_G185_H0.7321.00
221_A224_S0.7281.00
226_A229_A0.7231.00
26_A218_V0.7201.00
75_T113_Y0.7181.00
10_S15_V0.7151.00
37_L51_V0.7141.00
202_P225_P0.7121.00
63_D68_D0.7081.00
73_D76_A0.7071.00
225_P229_A0.7061.00
27_V227_A0.7051.00
186_G200_L0.7041.00
58_T62_H0.7031.00
117_I237_L0.7021.00
20_T141_V0.7001.00
45_A48_D0.6981.00
125_S128_T0.6981.00
137_E241_P0.6961.00
218_V227_A0.6961.00
78_A84_V0.6951.00
4_R167_A0.6941.00
144_R181_A0.6891.00
38_V106_A0.6871.00
190_A200_L0.6861.00
177_D181_A0.6851.00
103_P134_L0.6851.00
36_V109_L0.6791.00
70_A75_T0.6781.00
86_V89_T0.6781.00
49_H147_A0.6721.00
137_E166_V0.6701.00
35_V82_F0.6701.00
140_L156_R0.6691.00
113_Y116_V0.6691.00
3_G116_V0.6691.00
120_T128_T0.6681.00
171_V189_A0.6681.00
83_D86_V0.6661.00
35_V117_I0.6641.00
210_S217_L0.6631.00
153_A157_A0.6621.00
49_H146_T0.6571.00
142_S169_A0.6551.00
4_R33_R0.6541.00
26_A216_P0.6481.00
209_D220_L0.6481.00
217_L226_A0.6471.00
94_F98_D0.6471.00
32_D81_G0.6461.00
228_Q232_E0.6421.00
9_A132_L0.6391.00
5_V135_A0.6331.00
178_A205_S0.6331.00
227_A231_R0.6321.00
20_T201_I0.6301.00
97_A100_S0.6291.00
38_V85_I0.6271.00
174_V186_G0.6261.00
26_A219_S0.6251.00
60_T88_G0.6241.00
64_V67_D0.6241.00
146_T150_A0.6231.00
46_N150_A0.6221.00
23_N230_Y0.6211.00
22_V37_L0.6181.00
3_G34_S0.6151.00
23_N217_L0.6141.00
63_D67_D0.6121.00
205_S208_A0.6111.00
79_P83_D0.6091.00
154_K157_A0.6091.00
48_D82_F0.6061.00
34_S81_G0.6061.00
139_V237_L0.6001.00
171_V197_I0.6001.00
12_K15_V0.5991.00
146_T212_R0.5971.00
12_K147_A0.5941.00
3_G112_R0.5931.00
7_A138_T0.5911.00
78_A81_G0.5901.00
191_A194_Q0.5891.00
190_A198_L0.5881.00
61_L85_I0.5851.00
132_L138_T0.5831.00
59_A73_D0.5821.00
26_A29_A0.5770.99
201_I233_L0.5760.99
27_V30_E0.5730.99
21_A47_V0.5730.99
73_D78_A0.5720.99
48_D86_V0.5710.99
95_G98_D0.5690.99
194_Q197_I0.5690.99
140_L166_V0.5680.99
6_F167_A0.5670.99
28_M238_L0.5670.99
234_A238_L0.5650.99
35_V115_C0.5620.99
187_D197_I0.5580.99
75_T78_A0.5570.99
11_G155_T0.5570.99
34_S113_Y0.5560.99
118_V131_P0.5560.99
210_S220_L0.5540.99
46_N148_A0.5530.99
7_A131_P0.5500.99
58_T63_D0.5470.99
210_S216_P0.5470.99
168_G196_D0.5460.99
175_T205_S0.5460.99
71_L109_L0.5450.99
171_V200_L0.5410.99
66_A97_A0.5350.99
76_A86_V0.5350.99
153_A193_L0.5350.99
59_A62_H0.5330.99
106_A134_L0.5320.99
219_S222_P0.5320.99
101_A105_V0.5310.99
132_L162_V0.5300.99
189_A192_T0.5290.99
110_R116_V0.5290.99
34_S83_D0.5280.99
59_A74_A0.5280.99
31_A234_A0.5260.99
36_V83_D0.5260.99
79_P82_F0.5250.99
207_V217_L0.5240.99
10_S17_K0.5230.99
208_A211_E0.5220.99
180_G208_A0.5190.99
5_V106_A0.5180.99
24_V170_V0.5180.99
177_D180_G0.5180.99
70_A74_A0.5140.99
168_G198_L0.5140.99
26_A82_F0.5130.99
207_V210_S0.5090.99
97_A101_A0.5070.99
201_I230_Y0.5060.99
143_T208_A0.5050.99
217_L220_L0.5050.99
181_A184_G0.5030.99
207_V211_E0.5000.99
138_T166_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g3qA 1 0.7738 100 0.323 Contact Map
1hyqA 1 0.7607 100 0.33 Contact Map
4pfsA 1 0.7607 100 0.333 Contact Map
3ea0A 2 0.7639 100 0.341 Contact Map
4rz3A 2 0.7672 100 0.347 Contact Map
3pg5A 2 0.7016 100 0.352 Contact Map
3q9lA 2 0.8033 100 0.352 Contact Map
4v03A 2 0.7607 100 0.355 Contact Map
1wcv1 2 0.7639 100 0.357 Contact Map
3ez9A 2 0.6721 100 0.38 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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