GREMLIN Database
RF1 - Peptide chain release factor subunit 1
UniProt: Q9HNF0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (401)
Sequences: 396 (238)
Seq/√Len: 11.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_I211_A7.2311.00
43_K47_D5.5711.00
39_I48_V5.0471.00
335_C338_D4.7281.00
356_C359_C4.5381.00
335_C356_C3.8300.99
161_G170_P3.8080.99
58_E72_Q3.7610.99
238_L251_V3.7230.99
378_I381_Q3.5480.98
40_P262_E3.4240.98
25_K139_A3.3400.98
290_E319_R3.3030.98
50_A54_Q2.9450.95
306_E310_R2.8360.94
344_T347_R2.7580.93
342_Y347_R2.7160.92
317_V320_L2.5990.91
88_F164_K2.5900.90
227_V238_L2.5650.90
335_C359_C2.5610.90
343_E347_R2.4720.88
21_I205_Q2.4700.88
225_I247_L2.4060.87
295_L303_Y2.3760.86
250_K412_Y2.3450.85
338_D363_A2.3420.85
153_L158_S2.3380.85
344_T349_N2.2840.84
196_R200_I2.2020.81
12_R96_V2.1400.79
158_S413_S2.0950.78
338_D359_C2.0910.78
17_F137_P2.0460.76
302_T408_G2.0100.75
379_A384_T1.9850.74
146_G223_D1.9410.72
288_M389_I1.9380.72
161_G265_L1.9140.71
299_K413_S1.9010.70
78_I98_S1.8610.69
342_Y346_D1.8500.68
338_D356_C1.8480.68
252_L275_A1.8200.67
205_Q242_Y1.8150.67
287_D387_H1.7960.66
347_R354_H1.7910.66
95_V365_E1.7850.65
198_E202_N1.7840.65
158_S207_V1.7780.65
375_L383_G1.7680.65
256_D259_Y1.7240.62
371_A375_L1.7200.62
13_R20_V1.6960.61
81_R257_V1.6530.59
14_K217_P1.6450.59
185_G194_R1.6350.58
182_Q185_G1.6230.58
133_F165_G1.6180.57
308_T408_G1.6140.57
118_P133_F1.5990.56
226_L272_G1.5960.56
331_V345_I1.5920.56
70_N100_A1.5870.56
81_R112_T1.5860.56
365_E388_F1.5770.55
245_H249_D1.5750.55
150_L268_L1.5740.55
170_P393_F1.5600.55
95_V119_P1.5550.54
343_E346_D1.5480.54
241_D248_Q1.5470.54
310_R313_I1.5420.54
60_S66_Q1.5410.54
192_F196_R1.5360.53
267_D308_T1.5160.52
131_S161_G1.5020.52
62_I71_V1.5000.52
106_G140_E1.4890.51
236_E239_D1.4840.51
331_V344_T1.4640.50
78_I384_T1.4620.50
70_N110_M1.4520.49
345_I348_R1.4500.49
60_S251_V1.4370.48
204_Y232_P1.4260.48
69_T76_T1.4090.47
90_P215_F1.4080.47
10_E13_R1.4050.47
302_T338_D1.4020.47
98_S112_T1.4000.47
99_G118_P1.3760.45
184_K200_I1.3740.45
54_Q57_S1.3650.45
11_D106_G1.3650.45
11_D239_D1.3630.45
379_A399_L1.3600.45
206_E393_F1.3580.44
346_D365_E1.3570.44
29_G34_L1.3490.44
100_A108_T1.3470.44
331_V348_R1.3290.43
29_G32_T1.3260.43
63_K71_V1.3230.43
19_K40_P1.3220.43
342_Y348_R1.3170.42
26_D225_I1.3120.42
163_L167_R1.3080.42
90_P99_G1.3010.42
283_D409_I1.2900.41
19_K376_M1.2890.41
36_T39_I1.2820.41
188_S191_R1.2750.40
73_D400_L1.2730.40
348_R385_E1.2670.40
290_E294_E1.2650.40
188_S192_F1.2650.40
118_P165_G1.2590.40
18_R151_I1.2590.40
32_T71_V1.2580.40
256_D264_G1.2540.39
226_L275_A1.2510.39
347_R368_R1.2500.39
281_L412_Y1.2450.39
342_Y345_I1.2420.39
13_R16_E1.2290.38
343_E365_E1.2250.38
337_N359_C1.2240.38
80_D108_T1.2200.38
22_E26_D1.2140.37
51_H125_F1.2040.37
332_I367_D1.2020.37
73_D98_S1.2000.37
84_Y258_S1.1840.36
129_C165_G1.1830.36
262_E296_N1.1790.36
106_G373_D1.1760.36
308_T407_A1.1720.36
350_T366_V1.1700.35
32_T63_K1.1690.35
99_G133_F1.1690.35
55_E63_K1.1590.35
152_V257_V1.1550.35
177_L232_P1.1540.35
135_T348_R1.1480.34
366_V384_T1.1470.34
126_R225_I1.1460.34
32_T62_I1.1440.34
291_F295_L1.1370.34
336_P361_E1.1330.34
355_T362_E1.1320.34
39_I82_L1.1280.34
239_D298_G1.1230.33
65_K69_T1.1220.33
344_T348_R1.1190.33
374_H378_I1.1170.33
63_K74_A1.1130.33
12_R317_V1.1120.33
321_L386_T1.1090.33
197_L245_H1.1080.33
341_E377_S1.0960.32
337_N372_I1.0900.32
302_T392_D1.0860.32
155_R228_G1.0830.32
355_T388_F1.0740.31
317_V408_G1.0710.31
178_V237_F1.0680.31
125_F135_T1.0680.31
33_Q308_T1.0680.31
204_Y237_F1.0670.31
329_D368_R1.0550.30
14_K17_F1.0540.30
112_T239_D1.0540.30
341_E363_A1.0470.30
307_Q310_R1.0460.30
102_D113_E1.0450.30
309_R322_V1.0440.30
388_F413_S1.0440.30
314_M322_V1.0410.30
220_H250_K1.0390.30
134_L137_P1.0350.30
191_R229_G1.0330.29
335_C363_A1.0300.29
338_D341_E1.0260.29
290_E306_E1.0200.29
319_R385_E1.0120.29
118_P129_C0.9980.28
25_K135_T0.9940.28
98_S253_G0.9940.28
95_V140_E0.9930.28
220_H384_T0.9900.28
329_D344_T0.9880.28
40_P166_K0.9850.28
59_A71_V0.9840.27
25_K147_L0.9840.27
181_K234_K0.9810.27
10_E38_Y0.9810.27
207_V243_L0.9770.27
183_R189_A0.9770.27
157_E246_E0.9770.27
199_A272_G0.9710.27
154_D181_K0.9690.27
358_D377_S0.9680.27
205_Q209_G0.9670.27
312_L317_V0.9630.27
253_G371_A0.9620.27
180_G230_P0.9590.26
90_P118_P0.9550.26
140_E322_V0.9540.26
225_I380_D0.9480.26
74_A99_G0.9460.26
14_K289_E0.9430.26
155_R200_I0.9410.26
34_L38_Y0.9390.26
101_V375_L0.9390.26
182_Q188_S0.9360.26
200_I227_V0.9340.26
148_Y168_V0.9300.25
36_T126_R0.9290.25
27_Y125_F0.9290.25
76_T308_T0.9270.25
78_I220_H0.9260.25
63_K129_C0.9240.25
384_T408_G0.9230.25
10_E14_K0.9210.25
174_A207_V0.9210.25
12_R373_D0.9190.25
212_D220_H0.9180.25
14_K296_N0.9150.25
274_A406_Y0.9140.25
186_G191_R0.9140.25
11_D110_M0.9090.25
312_L320_L0.9080.25
252_L363_A0.9080.25
191_R196_R0.9070.25
343_E348_R0.9060.24
176_S260_T0.9060.24
357_S364_T0.9030.24
21_I241_D0.8980.24
158_S250_K0.8950.24
202_N308_T0.8950.24
343_E349_N0.8940.24
331_V347_R0.8930.24
216_V246_E0.8900.24
331_V387_H0.8830.24
42_D103_S0.8830.24
344_T350_T0.8780.23
157_E228_G0.8770.23
341_E368_R0.8760.23
53_T305_F0.8750.23
69_T73_D0.8730.23
331_V346_D0.8720.23
346_D357_S0.8680.23
311_N381_Q0.8640.23
134_L222_I0.8630.23
272_G409_I0.8590.23
40_P48_V0.8590.23
259_Y264_G0.8530.23
197_L363_A0.8510.22
228_G335_C0.8510.22
43_K48_V0.8500.22
99_G165_G0.8460.22
230_P267_D0.8360.22
158_S203_F0.8360.22
26_D347_R0.8360.22
331_V343_E0.8300.22
257_V335_C0.8300.22
345_I353_E0.8260.22
14_K342_Y0.8260.22
197_L341_E0.8260.22
343_E361_E0.8210.21
173_S262_E0.8210.21
90_P133_F0.8180.21
331_V342_Y0.8170.21
235_D238_L0.8110.21
30_S33_Q0.8090.21
63_K187_Q0.8080.21
334_E412_Y0.8040.21
332_I356_C0.8040.21
36_T373_D0.8020.21
188_S234_K0.8020.21
207_V247_L0.8020.21
29_G129_C0.8000.21
248_Q376_M0.7990.21
191_R194_R0.7970.21
220_H225_I0.7960.21
32_T61_N0.7950.21
186_G194_R0.7930.21
22_E322_V0.7930.21
45_I409_I0.7920.20
17_F46_S0.7900.20
54_Q406_Y0.7870.20
234_K256_D0.7860.20
97_F112_T0.7860.20
153_L294_E0.7860.20
195_L199_A0.7840.20
375_L391_T0.7830.20
291_F325_D0.7830.20
96_V112_T0.7810.20
312_L315_G0.7790.20
336_P342_Y0.7760.20
135_T400_L0.7750.20
265_L269_V0.7750.20
300_L404_G0.7730.20
239_D343_E0.7730.20
248_Q289_E0.7720.20
23_E242_Y0.7700.20
238_L365_E0.7680.20
274_A367_D0.7670.20
39_I54_Q0.7650.20
99_G129_C0.7630.20
284_D387_H0.7630.20
341_E346_D0.7610.20
331_V400_L0.7600.19
255_F407_A0.7560.19
389_I399_L0.7560.19
306_E349_N0.7560.19
331_V365_E0.7560.19
343_E397_E0.7540.19
346_D351_S0.7500.19
104_G394_E0.7500.19
15_Y30_S0.7500.19
55_E74_A0.7490.19
165_G188_S0.7470.19
104_G302_T0.7460.19
255_F268_L0.7460.19
154_D285_K0.7460.19
85_Y115_L0.7450.19
218_K373_D0.7420.19
363_A377_S0.7410.19
339_H357_S0.7390.19
128_H132_A0.7380.19
145_K244_H0.7360.19
303_Y408_G0.7330.19
344_T366_V0.7330.19
185_G234_K0.7320.19
21_I106_G0.7300.19
59_A196_R0.7290.19
302_T319_R0.7290.19
36_T343_E0.7290.19
365_E377_S0.7280.18
239_D348_R0.7240.18
35_V294_E0.7220.18
365_E368_R0.7220.18
374_H386_T0.7220.18
12_R16_E0.7210.18
94_M244_H0.7200.18
129_C276_L0.7200.18
126_R141_M0.7190.18
165_G234_K0.7190.18
288_M304_G0.7180.18
69_T302_T0.7150.18
115_L284_D0.7140.18
106_G126_R0.7130.18
343_E354_H0.7130.18
109_D275_A0.7120.18
10_E331_V0.7120.18
290_E365_E0.7100.18
100_A109_D0.7100.18
60_S72_Q0.7100.18
243_L257_V0.7100.18
19_K372_I0.7090.18
239_D349_N0.7090.18
345_I351_S0.7070.18
36_T298_G0.7050.18
17_F336_P0.7050.18
83_R129_C0.7030.18
12_R73_D0.7030.18
189_A265_L0.7020.18
399_L407_A0.7020.18
205_Q240_G0.7010.18
55_E61_N0.6990.18
10_E344_T0.6990.18
391_T400_L0.6980.18
122_I324_E0.6980.18
190_Q193_A0.6960.18
18_R331_V0.6960.18
134_L225_I0.6940.17
245_H293_E0.6930.17
151_I373_D0.6920.17
244_H280_D0.6920.17
136_E140_E0.6910.17
23_E217_P0.6910.17
32_T55_E0.6910.17
37_I302_T0.6890.17
78_I413_S0.6870.17
40_P44_Q0.6870.17
50_A204_Y0.6860.17
143_G345_I0.6860.17
71_V118_P0.6850.17
144_D342_Y0.6840.17
198_E232_P0.6820.17
342_Y349_N0.6810.17
230_P233_T0.6810.17
38_Y300_L0.6810.17
129_C187_Q0.6780.17
319_R408_G0.6780.17
32_T74_A0.6740.17
351_S355_T0.6730.17
63_K133_F0.6710.17
256_D403_F0.6700.17
27_Y111_V0.6700.17
78_I88_F0.6700.17
184_K393_F0.6690.17
217_P286_S0.6680.17
14_K248_Q0.6630.17
13_R218_K0.6630.17
215_F256_D0.6630.17
304_G412_Y0.6620.17
11_D197_L0.6610.17
289_E302_T0.6600.17
17_F104_G0.6590.16
344_T354_H0.6570.16
291_F309_R0.6570.16
338_D377_S0.6550.16
345_I349_N0.6530.16
239_D248_Q0.6490.16
345_I389_I0.6480.16
259_Y403_F0.6460.16
345_I354_H0.6440.16
95_V241_D0.6410.16
160_V174_A0.6400.16
350_T397_E0.6400.16
146_G239_D0.6390.16
204_Y309_R0.6370.16
63_K118_P0.6370.16
22_E27_Y0.6360.16
14_K106_G0.6340.16
341_E344_T0.6340.16
96_V255_F0.6330.16
39_I171_V0.6320.16
329_D347_R0.6320.16
32_T129_C0.6300.16
350_T356_C0.6290.16
217_P239_D0.6290.16
32_T259_Y0.6280.16
75_L183_R0.6270.16
158_S236_E0.6270.16
273_Q292_F0.6260.16
331_V368_R0.6250.16
29_G64_S0.6240.16
71_V187_Q0.6220.16
55_E181_K0.6200.15
254_K263_S0.6190.15
129_C264_G0.6190.15
193_A338_D0.6170.15
58_E67_T0.6170.15
108_T309_R0.6170.15
81_R87_T0.6160.15
222_I225_I0.6160.15
96_V274_A0.6140.15
241_D360_G0.6140.15
129_C154_D0.6140.15
224_G276_L0.6130.15
397_E407_A0.6130.15
61_N129_C0.6120.15
136_E144_D0.6120.15
347_R353_E0.6100.15
55_E62_I0.6100.15
196_R269_V0.6080.15
21_I227_V0.6070.15
14_K347_R0.6060.15
360_G367_D0.6060.15
11_D289_E0.6050.15
60_S130_D0.6030.15
32_T67_T0.6030.15
13_R348_R0.6010.15
188_S229_G0.6010.15
100_A111_V0.6000.15
161_G169_Q0.6000.15
99_G264_G0.5990.15
51_H240_G0.5990.15
96_V275_A0.5980.15
13_R254_K0.5980.15
100_A110_M0.5980.15
229_G237_F0.5970.15
338_D385_E0.5960.15
106_G319_R0.5950.15
192_F195_L0.5940.15
317_V394_E0.5930.15
214_L322_V0.5920.15
109_D344_T0.5910.15
32_T187_Q0.5900.15
62_I259_Y0.5890.15
155_R196_R0.5880.15
98_S384_T0.5880.15
160_V250_K0.5860.15
37_I52_V0.5850.15
251_V318_D0.5850.15
62_I187_Q0.5850.15
12_R331_V0.5840.15
373_D389_I0.5830.15
68_R251_V0.5810.14
69_T200_I0.5790.14
32_T234_K0.5790.14
356_C394_E0.5780.14
42_D217_P0.5780.14
191_R195_L0.5750.14
223_D245_H0.5750.14
30_S50_A0.5730.14
80_D106_G0.5730.14
225_I282_M0.5730.14
15_Y38_Y0.5730.14
34_L67_T0.5730.14
133_F163_L0.5710.14
310_R314_M0.5700.14
49_V79_K0.5680.14
197_L252_L0.5670.14
142_L206_E0.5670.14
314_M408_G0.5670.14
185_G188_S0.5660.14
252_L286_S0.5640.14
344_T365_E0.5630.14
66_Q130_D0.5630.14
328_E345_I0.5620.14
98_S258_S0.5600.14
189_A208_A0.5590.14
48_V400_L0.5590.14
182_Q209_G0.5570.14
65_K262_E0.5570.14
56_H153_L0.5570.14
35_V106_G0.5560.14
347_R369_E0.5560.14
361_E381_Q0.5560.14
349_N357_S0.5550.14
29_G59_A0.5550.14
11_D345_I0.5540.14
45_I140_E0.5540.14
31_G117_S0.5540.14
52_V321_L0.5540.14
182_Q194_R0.5520.14
190_Q194_R0.5510.14
331_V341_E0.5490.14
97_F119_P0.5470.14
216_V222_I0.5470.14
254_K408_G0.5460.14
148_Y277_A0.5450.14
224_G234_K0.5430.14
189_A211_A0.5420.14
34_L70_N0.5420.14
61_N71_V0.5410.13
198_E308_T0.5390.13
59_A159_N0.5390.13
203_F217_P0.5380.13
187_Q203_F0.5380.13
96_V270_D0.5370.13
284_D388_F0.5350.13
349_N365_E0.5350.13
180_G185_G0.5340.13
99_G187_Q0.5320.13
14_K343_E0.5310.13
16_E261_D0.5310.13
342_Y352_P0.5300.13
347_R352_P0.5290.13
129_C133_F0.5290.13
62_I133_F0.5290.13
63_K93_G0.5280.13
344_T353_E0.5280.13
219_R302_T0.5270.13
95_V113_E0.5270.13
176_S203_F0.5270.13
87_T213_D0.5270.13
113_E243_L0.5270.13
350_T364_T0.5270.13
80_D409_I0.5260.13
17_F343_E0.5260.13
150_L265_L0.5250.13
214_L408_G0.5250.13
14_K265_L0.5250.13
339_H346_D0.5230.13
337_N351_S0.5210.13
345_I350_T0.5210.13
299_K357_S0.5210.13
35_V123_E0.5200.13
10_E377_S0.5200.13
19_K26_D0.5180.13
209_G308_T0.5170.13
182_Q393_F0.5170.13
37_I324_E0.5170.13
133_F161_G0.5170.13
45_I305_F0.5170.13
239_D253_G0.5160.13
64_S129_C0.5160.13
168_V178_V0.5150.13
62_I188_S0.5140.13
14_K364_T0.5140.13
181_K256_D0.5130.13
359_C370_D0.5130.13
41_P257_V0.5110.13
102_D226_L0.5100.13
80_D321_L0.5100.13
63_K67_T0.5100.13
125_F227_V0.5090.13
65_K407_A0.5090.13
107_R241_D0.5070.13
236_E312_L0.5070.13
26_D406_Y0.5050.13
104_G364_T0.5040.13
197_L236_E0.5040.13
385_E397_E0.5030.13
214_L391_T0.5000.13
200_I237_F0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dt9A 1 0.9423 100 0.252 Contact Map
4crnX 1 0.9856 100 0.276 Contact Map
3e20C 1 0.5962 100 0.283 Contact Map
4af1A 1 0.9736 100 0.304 Contact Map
3agkA 1 0.8197 100 0.351 Contact Map
2qi2A 1 0.7091 100 0.489 Contact Map
4crmX 1 0.6514 100 0.51 Contact Map
3mcaB 1 0.75 100 0.525 Contact Map
2vgnA 1 0.774 100 0.53 Contact Map
3obyA 1 0.7428 100 0.537 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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