GREMLIN Database
VATD - V-type ATP synthase subunit D
UniProt: Q9HNE7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (202)
Sequences: 911 (571)
Seq/√Len: 40.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_Q144_L6.9131.00
23_E178_H4.9991.00
49_D53_G4.2981.00
53_G141_S3.5981.00
11_N14_E2.8241.00
40_F159_I2.5811.00
57_D137_E2.5711.00
119_Y129_D2.5041.00
15_I181_K2.4351.00
95_M104_Q2.3991.00
195_E198_R2.3281.00
19_I181_K2.2591.00
18_R177_L2.2481.00
194_E200_K2.1260.99
60_T134_A2.1120.99
18_R180_G2.1090.99
48_Q52_S2.0710.99
62_Q135_Y2.0280.99
190_E193_R1.9830.99
12_L181_K1.9310.99
96_N100_V1.9230.99
169_L173_L1.9030.98
28_T32_K1.8930.98
91_T106_E1.8620.98
25_G165_R1.8260.98
39_E95_M1.8210.98
137_E140_E1.8060.98
26_H166_V1.7730.98
20_D23_E1.7730.98
173_L197_F1.7690.98
25_G28_T1.7450.97
184_I188_L1.7230.97
46_Q137_E1.6920.97
56_G59_E1.6910.97
97_I102_V1.6820.97
106_E144_L1.6800.97
196_M200_K1.6630.96
102_V151_A1.6420.96
92_V105_I1.6220.96
34_D68_A1.5820.95
61_A135_Y1.5810.95
32_K162_T1.5730.95
15_I177_L1.5510.95
57_D144_L1.5460.95
25_G32_K1.5430.94
69_R74_D1.5410.94
57_D141_S1.5310.94
53_G137_E1.5280.94
61_A65_I1.5240.94
33_R205_K1.4640.93
26_H170_E1.4350.92
51_R149_E1.4310.92
5_I180_G1.4110.91
36_L154_K1.4070.91
194_E198_R1.3790.90
34_D166_V1.3410.89
106_E140_E1.3200.88
4_D180_G1.3170.88
39_E97_I1.3140.88
119_Y124_T1.3040.88
19_I174_L1.3030.88
30_E40_F1.3020.88
30_E97_I1.3010.88
9_R35_G1.3010.88
180_G183_Y1.2960.87
43_I151_A1.2950.87
6_K11_N1.2780.87
121_I172_K1.2640.86
68_A131_A1.2590.86
24_R27_D1.2400.85
9_R163_K1.2160.84
72_E125_S1.2060.83
72_E128_I1.1990.83
29_L32_K1.1710.81
91_T108_T1.1680.81
32_K100_V1.1670.81
60_T137_E1.1170.78
126_A147_E1.1140.78
130_E134_A1.1140.78
18_R24_R1.0950.77
202_V206_K1.0850.76
109_K140_E1.0720.75
163_K200_K1.0670.75
89_E108_T1.0660.75
203_K207_E1.0570.74
36_L162_T1.0550.74
61_A138_L1.0510.74
165_R188_L1.0480.73
98_M149_E1.0420.73
32_K36_L1.0400.73
64_K134_A1.0360.73
176_E180_G1.0310.72
51_R55_E1.0260.72
163_K187_K0.9850.69
191_K202_V0.9810.68
93_E144_L0.9810.68
22_S103_P0.9790.68
56_G60_T0.9780.68
51_R195_E0.9660.67
90_I105_I0.9650.67
197_F205_K0.9600.67
15_I180_G0.9570.66
57_D134_A0.9520.66
33_R77_V0.9400.65
133_D137_E0.9350.65
198_R201_K0.9310.64
30_E33_R0.9310.64
52_S56_G0.9260.64
52_S90_I0.9240.64
30_E96_N0.9240.64
93_E106_E0.9230.64
34_D171_F0.9220.64
22_S165_R0.9120.63
37_I159_I0.9100.63
9_R40_F0.9060.62
67_M115_D0.9040.62
65_I99_G0.9030.62
177_L180_G0.9010.62
37_I119_Y0.9010.62
99_G155_M0.8970.61
169_L190_E0.8970.61
27_D31_Q0.8970.61
201_K204_D0.8840.60
180_G190_E0.8800.60
50_V77_V0.8790.60
130_E133_D0.8770.60
28_T165_R0.8680.59
46_Q49_D0.8660.59
107_S143_V0.8610.58
40_F97_I0.8530.57
73_G99_G0.8500.57
64_K131_A0.8430.57
133_D141_S0.8430.57
113_S182_E0.8370.56
53_G60_T0.8310.55
73_G200_K0.8290.55
18_R30_E0.8290.55
50_V117_R0.8280.55
64_K138_L0.8170.54
73_G155_M0.8140.54
22_S28_T0.8100.54
45_D48_Q0.8070.53
118_G136_E0.8040.53
10_K25_G0.8030.53
158_E161_T0.7960.52
47_S152_M0.7960.52
49_D115_D0.7950.52
5_I91_T0.7920.52
45_D130_E0.7860.51
110_V114_F0.7810.51
143_V197_F0.7800.51
41_M148_V0.7790.51
85_E189_E0.7770.51
93_E104_Q0.7730.50
68_A72_E0.7710.50
54_L145_A0.7570.49
99_G200_K0.7520.48
6_K9_R0.7510.48
152_M156_L0.7460.48
11_N186_Q0.7450.48
150_T160_E0.7430.47
175_P190_E0.7430.47
116_K202_V0.7370.47
19_I178_H0.7340.47
18_R191_K0.7290.46
193_R200_K0.7260.46
97_I198_R0.7250.46
56_G97_I0.7240.46
21_L73_G0.7100.44
176_E196_M0.7090.44
23_E50_V0.7090.44
41_M152_M0.7090.44
141_S144_L0.7090.44
14_E151_A0.7090.44
68_A75_V0.7070.44
64_K67_M0.7070.44
96_N164_R0.7050.44
58_Y65_I0.7050.44
40_F163_K0.7040.44
57_D138_L0.7030.44
80_A108_T0.7030.44
59_E92_V0.7020.44
26_H191_K0.7010.44
19_I160_E0.6950.43
25_G188_L0.6930.43
58_Y138_L0.6900.43
64_K78_S0.6860.42
40_F164_R0.6860.42
100_V162_T0.6840.42
80_A124_T0.6830.42
39_E154_K0.6770.41
30_E170_E0.6760.41
167_N188_L0.6750.41
131_A185_D0.6730.41
30_E191_K0.6720.41
7_P82_A0.6710.41
16_E26_H0.6690.41
174_L178_H0.6680.41
89_E115_D0.6680.41
97_I146_A0.6670.41
131_A134_A0.6670.41
6_K202_V0.6610.40
121_I124_T0.6590.40
6_K14_E0.6580.40
142_I166_V0.6580.40
9_R191_K0.6580.40
33_R73_G0.6570.40
23_E173_L0.6560.40
32_K188_L0.6530.39
164_R170_E0.6470.39
146_A203_K0.6460.39
85_E114_F0.6450.39
67_M90_I0.6420.38
59_E187_K0.6380.38
35_G39_E0.6370.38
37_I41_M0.6370.38
122_L185_D0.6350.38
29_L36_L0.6350.38
89_E110_V0.6330.38
68_A103_P0.6320.37
117_R136_E0.6310.37
29_L154_K0.6310.37
10_K28_T0.6260.37
162_T168_A0.6260.37
13_M99_G0.6130.36
152_M201_K0.6070.35
164_R199_M0.6050.35
173_L177_L0.6030.35
7_P34_D0.6010.35
7_P183_Y0.6010.35
18_R139_L0.5990.35
60_T185_D0.5960.34
20_D113_S0.5940.34
34_D169_L0.5940.34
59_E88_P0.5920.34
192_E207_E0.5900.34
26_H171_F0.5850.34
9_R30_E0.5830.33
204_D207_E0.5800.33
76_A79_G0.5770.33
16_E181_K0.5750.33
59_E157_T0.5720.32
8_T12_L0.5710.32
17_D120_G0.5700.32
35_G135_Y0.5700.32
172_K196_M0.5690.32
51_R156_L0.5650.32
5_I63_Q0.5650.32
125_S169_L0.5640.32
24_R171_F0.5590.31
96_N99_G0.5570.31
83_A197_F0.5540.31
144_L148_V0.5530.31
7_P168_A0.5530.31
68_A97_I0.5520.31
6_K171_F0.5520.31
61_A142_I0.5500.31
59_E63_Q0.5500.31
10_K164_R0.5490.31
163_K170_E0.5470.31
44_L47_S0.5460.30
122_L172_K0.5450.30
80_A87_Y0.5420.30
12_L131_A0.5410.30
134_A137_E0.5390.30
98_M192_E0.5360.30
43_I152_M0.5360.30
107_S139_L0.5350.30
17_D110_V0.5350.30
10_K195_E0.5340.29
165_R168_A0.5330.29
189_E195_E0.5330.29
29_L59_E0.5320.29
93_E137_E0.5290.29
12_L109_K0.5280.29
95_M137_E0.5240.29
31_Q206_K0.5220.29
140_E197_F0.5210.29
23_E60_T0.5190.28
30_E166_V0.5180.28
117_R189_E0.5170.28
41_M173_L0.5160.28
49_D141_S0.5140.28
117_R132_A0.5140.28
81_A105_I0.5130.28
72_E184_I0.5130.28
57_D62_Q0.5110.28
29_L164_R0.5110.28
144_L178_H0.5100.28
34_D66_N0.5100.28
32_K159_I0.5090.28
15_I169_L0.5080.28
71_M152_M0.5070.27
8_T73_G0.5070.27
63_Q66_N0.5060.27
32_K165_R0.5060.27
100_V120_G0.5040.27
150_T200_K0.5040.27
10_K13_M0.5030.27
108_T182_E0.5020.27
100_V189_E0.5020.27
69_R159_I0.5010.27
173_L191_K0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rndA 2 0.7902 100 0.121 Contact Map
3aonA 1 0.8348 100 0.126 Contact Map
3w3aG 1 0.9375 100 0.138 Contact Map
4iloA 3 0.4107 27.3 0.948 Contact Map
4cg4A 2 0.4107 14.1 0.955 Contact Map
3na7A 1 0.4062 13.8 0.955 Contact Map
3wuqA 1 0.2946 11.8 0.956 Contact Map
1yz7A 1 0.5759 9.6 0.958 Contact Map
4cgkA 3 0.7277 8.2 0.959 Contact Map
2wujA 2 0.2232 8.2 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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