GREMLIN Database
BLH - Probable beta-carotene 15,15'-dioxygenase Blh
UniProt: Q9HNE6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (291)
Sequences: 213 (184)
Seq/√Len: 10.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
241_P257_H4.0510.99
122_W245_V3.5270.98
72_L88_V3.2210.96
241_P327_L3.1250.95
68_D253_H2.9950.94
61_G253_H2.9950.94
61_G121_H2.9950.94
68_D121_H2.9950.94
121_H253_H2.9950.94
61_G68_D2.9950.94
228_E256_R2.8690.92
123_G153_G2.8400.92
257_H335_V2.4570.85
118_T122_W2.3730.83
257_H327_L2.3660.83
126_D257_H2.1960.77
254_S261_A2.1740.77
118_T245_V2.1380.75
175_F250_C2.0890.74
125_G256_R2.0810.73
61_G114_F2.0750.73
114_F253_H2.0750.73
114_F121_H2.0750.73
68_D114_F2.0750.73
99_Y326_V2.0490.72
241_P256_R2.0350.72
250_C323_L1.9680.69
99_Y324_I1.9210.67
257_H261_A1.8620.64
57_A325_A1.8460.64
118_T326_V1.8340.63
126_D256_R1.8280.63
99_Y325_A1.7930.61
153_G330_P1.7610.60
122_W253_H1.7510.59
61_G122_W1.7510.59
68_D122_W1.7510.59
102_A116_A1.7510.59
168_Y321_L1.7430.59
37_P42_V1.7350.59
103_W323_L1.7310.59
67_I284_F1.7110.58
103_W126_D1.7060.57
107_P114_F1.7030.57
256_R329_L1.6860.56
67_I261_A1.6770.56
152_R236_F1.6750.56
241_P335_V1.6640.55
236_F244_A1.6640.55
245_V321_L1.6640.55
102_A110_A1.6610.55
71_A234_V1.6500.55
232_L248_Y1.6470.55
250_C254_S1.6360.54
122_W321_L1.6300.54
257_H328_T1.6290.54
116_A202_A1.6000.52
103_W114_F1.5910.52
103_W107_P1.5900.52
112_F162_L1.5850.52
127_L335_V1.5630.51
56_S232_L1.5550.50
117_I254_S1.5500.50
63_P103_W1.5470.50
160_P295_A1.5380.49
198_G242_V1.5380.49
66_A328_T1.5330.49
42_V51_A1.4970.48
108_V294_A1.4970.48
48_A51_A1.4900.47
99_Y103_W1.4830.47
103_W250_C1.4560.46
125_G260_R1.4520.45
260_R335_V1.4340.45
56_S103_W1.4180.44
324_I328_T1.4150.44
88_V103_W1.4120.44
121_H328_T1.4010.43
61_G328_T1.4010.43
253_H328_T1.4010.43
68_D328_T1.4010.43
122_W168_Y1.3960.43
160_P241_P1.3850.42
206_V209_L1.3770.42
156_P322_V1.3670.41
32_S230_L1.3660.41
69_Y252_W1.3520.41
92_Y331_H1.3390.40
96_G241_P1.3360.40
114_F325_A1.3330.40
67_I257_H1.3020.38
126_D241_P1.3020.38
52_P97_G1.2940.38
62_M227_A1.2920.38
162_L209_L1.2880.38
53_L56_S1.2850.38
172_V254_S1.2790.37
327_L332_V1.2600.37
125_G168_Y1.2440.36
61_G66_A1.2310.35
66_A121_H1.2310.35
66_A253_H1.2310.35
103_W325_A1.2260.35
61_G64_H1.2250.35
64_H121_H1.2250.35
64_H68_D1.2250.35
64_H253_H1.2250.35
57_A328_T1.2230.35
171_V332_V1.2130.35
64_H92_Y1.2110.34
202_A211_A1.2050.34
114_F254_S1.1920.34
65_G92_Y1.1780.33
175_F323_L1.1730.33
56_S122_W1.1710.33
53_L246_G1.1650.32
99_Y323_L1.1600.32
103_W292_T1.1480.32
168_Y260_R1.1400.31
161_L252_W1.1360.31
40_T208_V1.1270.31
126_D172_V1.1260.31
251_V254_S1.1250.31
63_P125_G1.1180.31
145_R199_V1.1140.30
327_L335_V1.1130.30
202_A205_T1.1080.30
118_T335_V1.1060.30
296_L302_L1.1050.30
139_L147_A1.0940.30
93_L201_F1.0940.30
103_W115_V1.0930.30
92_Y249_F1.0900.29
64_H331_H1.0890.29
107_P325_A1.0880.29
125_G257_H1.0850.29
154_G158_L1.0690.29
172_V252_W1.0600.28
65_G331_H1.0570.28
104_F293_A1.0550.28
236_F258_V1.0430.28
72_L332_V1.0420.28
95_L115_V1.0380.27
103_W321_L1.0130.26
234_V238_V1.0090.26
156_P241_P1.0080.26
112_F192_R1.0060.26
58_V295_A1.0060.26
65_G122_W1.0000.26
153_G325_A0.9990.26
112_F301_V0.9940.26
295_A332_V0.9910.26
120_L243_F0.9870.26
175_F320_Y0.9850.25
50_Y161_L0.9780.25
90_V94_V0.9750.25
88_V242_V0.9750.25
192_R204_A0.9710.25
92_Y253_H0.9700.25
68_D92_Y0.9700.25
92_Y121_H0.9700.25
61_G92_Y0.9700.25
260_R339_D0.9690.25
249_F331_H0.9610.25
125_G335_V0.9580.24
206_V302_L0.9570.24
118_T332_V0.9560.24
104_F175_F0.9490.24
116_A166_E0.9360.24
139_L333_A0.9360.24
324_I334_V0.9340.24
172_V241_P0.9320.24
69_Y261_A0.9290.23
244_A260_R0.9290.23
314_E317_A0.9260.23
253_H321_L0.9260.23
68_D321_L0.9260.23
61_G321_L0.9260.23
121_H321_L0.9260.23
145_R232_L0.9230.23
103_W172_V0.9220.23
151_I154_G0.9200.23
250_C257_H0.9180.23
67_I327_L0.9140.23
250_C328_T0.9120.23
93_L102_A0.9010.23
160_P327_L0.8980.22
62_M248_Y0.8980.22
175_F318_A0.8800.22
244_A252_W0.8790.22
123_G248_Y0.8740.22
152_R160_P0.8740.22
145_R149_V0.8740.22
157_M245_V0.8740.22
113_A308_N0.8740.22
97_G170_S0.8730.22
321_L325_A0.8620.21
118_T291_M0.8620.21
323_L327_L0.8580.21
160_P256_R0.8580.21
57_A326_V0.8560.21
252_W334_V0.8560.21
294_A326_V0.8510.21
298_L302_L0.8460.21
111_A122_W0.8440.21
60_F90_V0.8420.21
206_V300_G0.8410.21
213_R297_A0.8360.20
253_H331_H0.8350.20
68_D331_H0.8350.20
61_G331_H0.8350.20
121_H331_H0.8350.20
54_V154_G0.8350.20
105_F300_G0.8260.20
168_Y254_S0.8250.20
188_V192_R0.8230.20
60_F173_D0.8140.20
66_A302_L0.8120.20
118_T171_V0.8110.20
93_L259_A0.8110.20
299_G323_L0.8100.20
90_V210_A0.8090.20
124_Q241_P0.8090.20
55_A150_L0.8080.20
235_F303_W0.8060.20
57_A250_C0.8050.20
247_V254_S0.8030.19
53_L254_S0.8030.19
257_H323_L0.8010.19
27_G30_A0.7960.19
209_L306_V0.7950.19
103_W327_L0.7920.19
94_V150_L0.7910.19
108_V210_A0.7790.19
75_A172_V0.7770.19
163_G290_P0.7730.19
64_H249_F0.7730.19
71_A317_A0.7720.19
65_G249_F0.7690.18
244_A330_P0.7680.18
254_S258_V0.7600.18
128_Y173_D0.7550.18
96_G257_H0.7510.18
125_G322_V0.7490.18
160_P257_H0.7380.18
241_P332_V0.7340.17
103_W291_M0.7260.17
244_A258_V0.7260.17
196_W300_G0.7250.17
66_A321_L0.7230.17
108_V176_A0.7230.17
29_V324_I0.7210.17
244_A261_A0.7190.17
68_D241_P0.7180.17
61_G241_P0.7180.17
121_H241_P0.7180.17
241_P253_H0.7180.17
244_A256_R0.7100.17
67_I250_C0.7080.17
175_F328_T0.7080.17
228_E246_G0.7070.17
57_A110_A0.7050.17
163_G205_T0.7040.17
111_A321_L0.7030.17
246_G252_W0.7030.17
67_I103_W0.7010.17
163_G300_G0.7000.17
99_Y329_L0.7000.17
110_A114_F0.6950.16
35_A39_I0.6930.16
111_A263_A0.6900.16
100_A204_A0.6900.16
102_A246_G0.6890.16
195_L209_L0.6870.16
250_C322_V0.6870.16
90_V214_R0.6830.16
89_G204_A0.6820.16
117_I171_V0.6810.16
88_V245_V0.6790.16
94_V142_R0.6730.16
239_V252_W0.6680.16
90_V102_A0.6670.16
209_L230_L0.6670.16
122_W157_M0.6650.16
57_A99_Y0.6630.16
111_A172_V0.6630.16
56_S70_L0.6620.16
111_A245_V0.6590.16
32_S319_L0.6540.15
122_W328_T0.6540.15
109_P207_A0.6540.15
190_D203_A0.6530.15
153_G248_Y0.6530.15
119_W149_V0.6520.15
143_P203_A0.6520.15
122_W320_Y0.6510.15
264_V295_A0.6460.15
92_Y330_P0.6430.15
126_D250_C0.6420.15
66_A297_A0.6390.15
52_P56_S0.6370.15
95_L117_I0.6370.15
143_P192_R0.6370.15
244_A296_L0.6350.15
58_V106_A0.6340.15
105_F226_A0.6320.15
63_P240_P0.6320.15
99_Y118_T0.6310.15
92_Y153_G0.6310.15
89_G265_D0.6310.15
168_Y245_V0.6300.15
61_G65_G0.6290.15
65_G253_H0.6290.15
65_G68_D0.6290.15
65_G121_H0.6290.15
80_V295_A0.6280.15
125_G156_P0.6270.15
96_G327_L0.6260.15
51_A206_V0.6250.15
34_A308_N0.6250.15
228_E236_F0.6250.15
245_V324_I0.6240.15
67_I328_T0.6230.15
65_G245_V0.6220.15
85_L176_A0.6210.15
94_V98_G0.6210.15
49_R206_V0.6210.15
216_T229_T0.6210.15
123_G231_L0.6200.15
114_F321_L0.6190.15
31_I298_L0.6180.15
79_T84_W0.6180.15
122_W172_V0.6160.14
156_P261_A0.6160.14
94_V238_V0.6160.14
248_Y317_A0.6110.14
103_W322_V0.6110.14
111_A287_E0.6100.14
106_A289_A0.6070.14
206_V221_A0.6070.14
49_R315_S0.6050.14
303_W338_M0.6050.14
94_V282_A0.6050.14
58_V154_G0.6020.14
164_F242_V0.6020.14
259_A304_W0.6020.14
254_S292_T0.6010.14
31_I109_P0.5980.14
122_W324_I0.5970.14
148_T243_F0.5940.14
228_E335_V0.5910.14
56_S128_Y0.5910.14
36_L39_I0.5910.14
118_T307_P0.5900.14
92_Y123_G0.5900.14
126_D327_L0.5830.14
115_V171_V0.5820.14
118_T328_T0.5810.14
69_Y284_F0.5790.14
70_L150_L0.5790.14
58_V236_F0.5780.14
328_T334_V0.5750.14
192_R293_A0.5750.14
199_V223_R0.5720.13
121_H257_H0.5720.13
253_H257_H0.5720.13
68_D257_H0.5720.13
61_G257_H0.5720.13
307_P322_V0.5710.13
55_A219_P0.5710.13
55_A196_W0.5690.13
125_G236_F0.5680.13
293_A338_M0.5670.13
114_F122_W0.5670.13
241_P250_C0.5630.13
235_F243_F0.5600.13
263_A294_A0.5590.13
325_A335_V0.5580.13
171_V334_V0.5570.13
26_L154_G0.5570.13
57_A323_L0.5560.13
33_I36_L0.5550.13
91_L151_I0.5520.13
208_V211_A0.5520.13
166_E238_V0.5520.13
105_F115_V0.5510.13
100_A239_V0.5490.13
284_F292_T0.5480.13
55_A188_V0.5410.13
205_T213_R0.5380.13
292_T325_A0.5380.13
119_W236_F0.5360.13
197_L294_A0.5350.13
93_L112_F0.5330.13
65_G328_T0.5310.13
113_A318_A0.5300.13
294_A298_L0.5300.13
124_Q284_F0.5260.12
68_D245_V0.5240.12
61_G245_V0.5240.12
121_H245_V0.5240.12
245_V253_H0.5240.12
102_A191_P0.5220.12
267_S301_V0.5220.12
54_V156_P0.5200.12
202_A278_L0.5190.12
87_V91_L0.5190.12
172_V245_V0.5170.12
52_P83_R0.5170.12
213_R300_G0.5160.12
214_R251_V0.5150.12
160_P244_A0.5150.12
156_P321_L0.5140.12
127_L321_L0.5130.12
103_W253_H0.5120.12
103_W121_H0.5120.12
61_G103_W0.5120.12
68_D103_W0.5120.12
246_G321_L0.5120.12
126_D261_A0.5110.12
53_L60_F0.5100.12
56_S246_G0.5100.12
236_F252_W0.5090.12
69_Y250_C0.5080.12
31_I206_V0.5070.12
151_I169_R0.5060.12
152_R228_E0.5040.12
47_T211_A0.5030.12
42_V242_V0.5030.12
319_L323_L0.5030.12
79_T126_D0.5030.12
59_V319_L0.5020.12
117_I151_I0.5010.12
153_G331_H0.5010.12
90_V233_W0.5010.12
236_F239_V0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yevC 1 0.1623 3.3 0.975 Contact Map
2wwbC 1 0.1043 3.1 0.976 Contact Map
3rlfG 1 0.3507 2.8 0.976 Contact Map
2ww9C 1 0.0609 2.7 0.976 Contact Map
3j2wE 1 0.1333 1.8 0.979 Contact Map
2kluA 1 0.2 1.8 0.979 Contact Map
4p6vB 1 0.1942 1.6 0.979 Contact Map
3tx3A 2 0.3681 1.5 0.98 Contact Map
2kogA 1 0.1304 1.4 0.98 Contact Map
4by8A 1 0.0319 1.4 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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