GREMLIN Database
CRTY - Lycopene beta-cyclase
UniProt: Q9HNE5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (229)
Sequences: 136 (106)
Seq/√Len: 7.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_G140_G5.2810.99
8_F182_A3.9250.95
161_L227_I3.3960.90
9_L15_P3.3240.89
176_T216_F2.9910.83
48_Y149_V2.8420.80
16_P90_L2.8160.79
17_L89_L2.6110.73
184_R205_L2.5520.72
94_W174_V2.4920.70
146_A221_F2.4030.67
57_I76_M2.3960.66
56_L141_A2.3410.65
139_I213_A2.3080.63
56_L61_V2.2640.62
4_S149_V2.2210.60
195_A200_T2.1270.57
23_V213_A2.1000.56
148_P154_W1.9720.51
221_F229_Y1.9610.50
5_Y8_F1.9610.50
127_G220_V1.9340.49
158_W231_W1.8920.48
139_I186_A1.8750.47
91_T219_N1.8430.46
31_D34_R1.8340.46
202_I226_L1.8280.45
211_E215_F1.7570.43
54_N74_W1.7480.42
13_V153_Q1.7450.42
72_R144_A1.7360.42
54_N75_Q1.7340.42
88_T162_W1.7050.41
53_D56_L1.6760.40
161_L224_Q1.6500.39
45_A207_L1.6490.39
126_G200_T1.6450.39
147_A165_R1.6320.38
84_V194_L1.5270.34
157_G231_W1.5270.34
87_Q145_W1.5200.34
50_T81_Y1.5130.34
9_L14_G1.4770.33
137_F141_A1.4710.32
123_V202_I1.4660.32
118_L170_A1.4600.32
54_N73_L1.4420.31
92_G105_G1.4350.31
69_V119_A1.4230.31
20_L23_V1.4160.31
200_T213_A1.4060.30
35_A39_G1.3990.30
34_R37_G1.3910.30
51_P64_Y1.3780.29
118_L204_V1.3730.29
110_R150_L1.3690.29
54_N58_A1.3480.28
46_L85_I1.3470.28
72_R172_V1.3340.28
69_V72_R1.3210.28
130_L229_Y1.3160.27
172_V224_Q1.3130.27
53_D142_I1.3040.27
113_A139_I1.3020.27
60_G122_L1.2890.27
157_G161_L1.2860.27
54_N172_V1.2770.26
81_Y97_A1.2760.26
51_P87_Q1.2740.26
17_L90_L1.2590.26
97_A110_R1.2560.26
4_S17_L1.2530.26
71_G79_E1.2490.25
94_W217_V1.2460.25
9_L84_V1.2430.25
180_S216_F1.2390.25
62_W179_L1.2160.25
13_V230_A1.2060.24
199_T208_P1.2020.24
18_V126_G1.2010.24
40_I153_Q1.2010.24
152_L206_G1.1940.24
217_V227_I1.1710.23
81_Y137_F1.1600.23
4_S7_T1.1560.23
41_L88_T1.1530.23
49_T145_W1.1450.23
16_P206_G1.1440.23
53_D76_M1.1420.22
4_S8_F1.1420.22
49_T87_Q1.1410.22
72_R156_V1.1410.22
14_G18_V1.1320.22
125_C202_I1.1310.22
67_G206_G1.1160.22
53_D179_L1.1020.21
209_I233_L1.1010.21
85_I182_A1.1000.21
119_A220_V1.0940.21
211_E214_F1.0870.21
24_R90_L1.0830.21
95_V149_V1.0790.21
102_P167_V1.0770.21
44_L94_W1.0760.21
57_I74_W1.0750.21
24_R96_Q1.0720.21
5_Y10_A1.0720.21
178_F186_A1.0660.21
153_Q184_R1.0400.20
102_P105_G1.0350.20
176_T225_G1.0350.20
132_T144_A1.0340.20
138_Y145_W1.0340.20
116_G161_L1.0310.20
36_A44_L1.0270.20
18_V69_V1.0220.19
152_L156_V1.0200.19
73_L78_I1.0190.19
153_Q228_L1.0090.19
127_G143_I1.0020.19
210_E214_F1.0010.19
70_V222_V0.9990.19
44_L47_S0.9960.19
6_L221_F0.9930.19
47_S185_Y0.9910.19
44_L165_R0.9880.19
19_A185_Y0.9870.19
130_L140_G0.9860.19
79_E234_A0.9830.19
41_L173_L0.9630.18
7_T149_V0.9570.18
29_D213_A0.9560.18
62_W211_E0.9470.18
16_P46_L0.9370.17
71_G234_A0.9350.17
118_L133_V0.9210.17
71_G78_I0.9200.17
81_Y85_I0.9140.17
201_G226_L0.9060.17
56_L179_L0.9040.17
65_G141_A0.9000.17
109_T165_R0.8990.17
169_A233_L0.8910.16
68_T191_I0.8880.16
67_G153_Q0.8840.16
187_I212_G0.8830.16
95_V199_T0.8770.16
162_W165_R0.8760.16
41_L90_L0.8730.16
93_L142_I0.8700.16
12_A185_Y0.8680.16
37_G227_I0.8680.16
46_L50_T0.8630.16
57_I68_T0.8570.16
140_G143_I0.8560.16
16_P147_A0.8540.16
56_L180_S0.8540.16
28_W34_R0.8450.16
17_L41_L0.8410.15
114_V202_I0.8410.15
176_T218_T0.8370.15
53_D141_A0.8350.15
56_L222_V0.8340.15
184_R231_W0.8290.15
35_A75_Q0.8290.15
14_G17_L0.8250.15
141_A180_S0.8240.15
185_Y209_I0.8200.15
13_V86_T0.8200.15
66_E174_V0.8150.15
49_T64_Y0.8140.15
14_G56_L0.8130.15
178_F207_L0.8120.15
113_A157_G0.8100.15
89_L137_F0.8090.15
27_R233_L0.8070.15
27_R188_A0.8040.15
192_W211_E0.8020.15
119_A177_L0.8010.15
14_G71_G0.8010.15
216_F225_G0.8010.15
207_L212_G0.7980.15
215_F225_G0.7970.15
98_L146_A0.7960.15
9_L223_S0.7900.14
15_P84_V0.7890.14
132_T156_V0.7840.14
179_L211_E0.7810.14
104_A149_V0.7790.14
58_A75_Q0.7770.14
115_L181_A0.7740.14
63_W150_L0.7730.14
198_Y230_A0.7730.14
47_S128_A0.7730.14
221_F224_Q0.7690.14
63_W78_I0.7690.14
37_G191_I0.7690.14
94_W141_A0.7670.14
18_V177_L0.7600.14
98_L124_G0.7600.14
49_T57_I0.7590.14
72_R204_V0.7560.14
136_T146_A0.7550.14
114_V152_L0.7510.14
103_T203_T0.7500.14
31_D59_T0.7480.14
148_P201_G0.7440.14
139_I143_I0.7420.14
109_T114_V0.7390.14
62_W215_F0.7380.14
55_Y141_A0.7330.13
37_G231_W0.7310.13
201_G221_F0.7290.13
201_G206_G0.7280.13
34_R153_Q0.7260.13
105_G124_G0.7260.13
44_L67_G0.7250.13
54_N81_Y0.7240.13
66_E147_A0.7240.13
19_A129_V0.7200.13
81_Y208_P0.7180.13
176_T219_N0.7170.13
6_L117_A0.7140.13
38_V222_V0.7080.13
121_V124_G0.6990.13
150_L170_A0.6990.13
82_L191_I0.6970.13
73_L79_E0.6930.13
125_C134_D0.6880.13
10_A129_V0.6820.13
109_T217_V0.6810.13
29_D92_G0.6800.13
81_Y136_T0.6790.12
123_V126_G0.6770.12
113_A133_V0.6760.12
86_T167_V0.6730.12
50_T232_V0.6720.12
73_L105_G0.6720.12
127_G157_G0.6720.12
19_A109_T0.6710.12
116_G154_W0.6690.12
123_V209_I0.6660.12
152_L163_R0.6660.12
10_A220_V0.6640.12
197_Q208_P0.6600.12
27_R90_L0.6590.12
80_E183_D0.6580.12
77_P80_E0.6580.12
77_P183_D0.6580.12
56_L137_F0.6580.12
57_I145_W0.6560.12
23_V118_L0.6530.12
93_L127_G0.6520.12
60_G229_Y0.6500.12
17_L54_N0.6480.12
83_F179_L0.6470.12
10_A124_G0.6460.12
87_Q218_T0.6430.12
81_Y151_A0.6360.12
32_R104_A0.6360.12
127_G153_Q0.6350.12
40_I142_I0.6330.12
140_G153_Q0.6330.12
8_F230_A0.6280.12
32_R227_I0.6270.12
63_W125_C0.6250.12
122_L174_V0.6250.12
54_N76_M0.6230.12
110_R121_V0.6210.12
119_A188_A0.6200.12
55_Y88_T0.6150.11
162_W220_V0.6140.11
44_L113_A0.6120.11
79_E179_L0.6100.11
50_T89_L0.6050.11
118_L129_V0.6030.11
119_A200_T0.6020.11
195_A199_T0.6000.11
96_Q140_G0.6000.11
90_L96_Q0.5980.11
48_Y87_Q0.5970.11
72_R163_R0.5970.11
65_G176_T0.5970.11
141_A221_F0.5960.11
38_V128_A0.5940.11
31_D191_I0.5930.11
207_L225_G0.5920.11
139_I220_V0.5910.11
110_R125_C0.5900.11
129_V169_A0.5890.11
150_L217_V0.5870.11
73_L180_S0.5830.11
207_L214_F0.5810.11
59_T157_G0.5780.11
126_G147_A0.5740.11
105_G160_Y0.5720.11
192_W215_F0.5710.11
107_S168_F0.5700.11
180_S212_G0.5690.11
158_W181_A0.5680.11
47_S143_I0.5650.11
106_F134_D0.5640.11
11_V233_L0.5620.11
131_L134_D0.5580.11
88_T100_L0.5580.11
55_Y158_W0.5570.11
47_S147_A0.5550.11
143_I194_L0.5510.11
125_C133_V0.5500.10
83_F138_Y0.5500.10
139_I200_T0.5490.10
192_W210_E0.5480.10
40_I120_G0.5460.10
73_L233_L0.5450.10
64_Y192_W0.5440.10
28_W234_A0.5440.10
125_C217_V0.5420.10
218_T225_G0.5420.10
73_L89_L0.5400.10
62_W83_F0.5370.10
48_Y90_L0.5370.10
17_L91_T0.5350.10
98_L139_I0.5340.10
194_L207_L0.5340.10
201_G225_G0.5330.10
55_Y191_I0.5310.10
125_C173_L0.5310.10
179_L215_F0.5300.10
28_W230_A0.5300.10
89_L185_Y0.5270.10
22_V188_A0.5230.10
63_W189_D0.5220.10
79_E191_I0.5220.10
130_L220_V0.5200.10
44_L109_T0.5190.10
156_V225_G0.5160.10
124_G173_L0.5160.10
65_G82_L0.5130.10
62_W138_Y0.5090.10
17_L185_Y0.5090.10
67_G140_G0.5070.10
12_A158_W0.5040.10
69_V73_L0.5030.10
146_A219_N0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kv5A 1 0.1392 2.9 0.979 Contact Map
4f35D 2 0.4051 1.8 0.981 Contact Map
2imuA 1 0.1857 1.8 0.981 Contact Map
3ieyB 1 0.211 1.7 0.981 Contact Map
4nawA 1 0.2785 1.7 0.981 Contact Map
3rdyA 1 0.1139 1.3 0.983 Contact Map
2ju0B 1 0.2194 1.2 0.983 Contact Map
2micA 2 0.1435 1.2 0.983 Contact Map
4b19A 1 0.1266 1.2 0.983 Contact Map
2mk9A 2 0.1392 0.9 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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