GREMLIN Database
VATB - V-type ATP synthase beta chain
UniProt: Q9HNE4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 471 (416)
Sequences: 7175 (2471)
Seq/√Len: 121.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_D93_N7.8661.00
141_R248_H4.6881.00
188_G234_A4.4701.00
336_N349_N4.1501.00
17_V53_I3.8731.00
132_G348_V3.3771.00
378_L414_F3.1951.00
27_E70_F3.1781.00
86_R96_D3.0261.00
29_V53_I2.9461.00
81_E245_K2.8741.00
73_E76_K2.7291.00
428_D431_E2.6911.00
41_G53_I2.6481.00
81_E247_Y2.5891.00
23_I43_V2.5791.00
124_E141_R2.5751.00
186_V238_A2.5551.00
30_E69_R2.5181.00
235_L308_P2.4931.00
29_V68_V2.4611.00
139_L307_I2.3451.00
362_I372_G2.3371.00
82_D104_D2.2831.00
157_D423_F2.2761.00
76_K106_R2.2741.00
238_A304_V2.2571.00
377_Q380_A2.2461.00
17_V68_V2.2271.00
88_L237_T2.2181.00
207_T211_E2.2061.00
131_S427_R2.1891.00
216_F237_T2.1531.00
16_Y50_F2.0991.00
339_L344_V2.0691.00
386_E389_R2.0691.00
184_A247_Y2.0501.00
317_D334_M2.0481.00
198_N202_D2.0441.00
7_I62_V1.9891.00
107_V111_G1.9531.00
136_M378_L1.9511.00
202_D205_E1.9341.00
411_A415_E1.9331.00
377_Q406_R1.9321.00
369_A373_D1.8891.00
208_G211_E1.8791.00
24_G27_E1.8691.00
107_V240_Y1.8661.00
9_E16_Y1.8591.00
139_L333_I1.8571.00
240_Y245_K1.8301.00
184_A214_V1.8181.00
201_M215_V1.8111.00
239_E293_R1.8031.00
30_E38_V1.7931.00
135_G432_T1.7881.00
107_V236_T1.7871.00
184_A241_L1.7721.00
214_V237_T1.7711.00
438_E441_S1.7691.00
127_Q134_D1.7651.00
4_Y67_S1.7571.00
126_I183_F1.7451.00
392_V408_L1.7391.00
344_V420_D1.7371.00
27_E72_G1.7351.00
135_G418_F1.7291.00
107_V244_E1.7211.00
8_T18_E1.7181.00
32_E67_S1.7081.00
98_G205_E1.7011.00
389_R393_N1.6921.00
31_I41_G1.6791.00
202_D206_R1.6621.00
124_E296_R1.6601.00
342_Q415_E1.6551.00
374_V437_W1.6531.00
344_V415_E1.6531.00
343_G376_D1.6141.00
310_L325_T1.6131.00
86_R98_G1.6011.00
186_V237_T1.5851.00
88_L216_F1.5671.00
78_P106_R1.5661.00
32_E69_R1.5351.00
150_G153_L1.5251.00
86_R99_P1.5041.00
94_P99_P1.4971.00
81_E240_Y1.4801.00
138_T358_M1.4771.00
77_M237_T1.4761.00
146_P329_T1.4731.00
83_L237_T1.4651.00
32_E38_V1.4211.00
6_T67_S1.4201.00
82_D102_V1.4121.00
8_T50_F1.4101.00
190_M230_T1.4081.00
248_H303_S1.4061.00
358_M375_S1.4061.00
17_V20_D1.4051.00
128_T139_L1.4021.00
409_D412_D1.3951.00
7_I66_A1.3921.00
89_D222_D1.3921.00
203_D360_D1.3851.00
188_G253_L1.3761.00
105_D244_E1.3701.00
231_P290_L1.3671.00
30_E71_L1.3661.00
86_R94_P1.3631.00
82_D103_P1.3501.00
384_E387_E1.3261.00
10_V62_V1.3231.00
75_L109_I1.3231.00
59_T62_V1.3151.00
376_D379_Y1.3081.00
23_I51_V1.3071.00
87_V201_M1.3061.00
422_G425_T1.3041.00
235_L294_A1.3031.00
249_V304_V1.2991.00
133_I162_I1.2981.00
319_H322_P1.2971.00
342_Q389_R1.2941.00
120_E299_G1.2891.00
206_R209_A1.2861.00
77_M233_M1.2821.00
417_E420_D1.2691.00
406_R410_F1.2691.00
73_E106_R1.2631.00
122_P140_V1.2530.99
29_V41_G1.2500.99
291_Y328_I1.2430.99
352_P386_E1.2410.99
157_D424_K1.2410.99
257_T261_E1.2390.99
263_L286_D1.2380.99
23_I29_V1.2380.99
18_E49_G1.2370.99
33_T37_D1.2330.99
205_E210_L1.2260.99
380_A404_D1.2210.99
189_A197_A1.2120.99
359_D372_G1.2050.99
111_G244_E1.2040.99
103_P106_R1.2020.99
137_N333_I1.1930.99
287_L325_T1.1790.99
84_L184_A1.1780.99
267_G275_G1.1780.99
163_A213_S1.1760.99
357_L361_G1.1750.99
40_R93_N1.1710.99
6_T18_E1.1670.99
431_E435_L1.1610.99
78_P103_P1.1600.99
84_L214_V1.1550.99
246_D301_E1.1530.99
377_Q381_A1.1490.99
312_M319_H1.1460.99
368_R429_I1.1440.99
128_T307_I1.1410.99
235_L304_V1.1370.99
30_E40_R1.1300.99
126_I166_A1.1270.99
90_G233_M1.1230.99
32_E66_A1.1180.99
344_V419_I1.1160.99
245_K249_V1.1160.99
133_I333_I1.1150.99
413_R417_E1.1140.99
402_E405_N1.1090.99
358_M362_I1.1080.99
256_M325_T1.1070.99
18_E50_F1.1060.99
120_E123_E1.1050.99
55_V59_T1.0960.99
291_Y325_T1.0900.99
338_D341_S1.0870.99
16_Y47_S1.0860.99
188_G251_V1.0750.98
388_L392_V1.0700.98
118_A300_K1.0600.98
130_V158_L1.0580.98
86_R95_I1.0480.98
150_G337_R1.0460.98
399_A409_D1.0410.98
57_E226_E1.0340.98
125_F361_G1.0290.98
127_Q429_I1.0280.98
17_V29_V1.0270.98
194_A219_L1.0240.98
371_H433_L1.0240.98
222_D226_E1.0200.98
338_D386_E1.0180.98
93_N100_D1.0180.98
139_L305_T1.0140.98
312_M322_P1.0110.98
339_L420_D1.0100.98
232_R286_D0.9990.97
145_L307_I0.9970.97
63_G66_A0.9940.97
256_M291_Y0.9910.97
315_D318_T0.9900.97
38_V42_Q0.9870.97
315_D337_R0.9860.97
349_N352_P0.9810.97
130_V133_I0.9770.97
163_A185_V0.9600.97
83_L214_V0.9520.97
190_M253_L0.9520.97
372_G376_D0.9500.97
371_H429_I0.9480.96
90_G226_E0.9450.96
105_D240_Y0.9370.96
287_L328_I0.9370.96
147_I159_A0.9370.96
227_R265_Q0.9360.96
86_R101_I0.9340.96
98_G101_I0.9310.96
80_T83_L0.9300.96
128_T134_D0.9300.96
406_R409_D0.9290.96
83_L88_L0.9270.96
186_V214_V0.9260.96
214_V241_L0.9240.96
242_A249_V0.9230.96
96_D99_P0.9210.96
132_G419_I0.9210.96
28_I71_L0.9210.96
33_T39_K0.9210.96
235_L251_V0.9180.96
163_A252_I0.9170.96
384_E404_D0.9170.96
90_G95_I0.9150.96
190_M231_P0.9140.96
409_D413_R0.9140.96
31_I66_A0.9130.96
150_G315_D0.9130.96
322_P334_M0.9100.96
250_L307_I0.9080.95
183_F248_H0.9080.95
81_E241_L0.9070.95
90_G222_D0.9070.95
4_Y69_R0.9060.95
209_A213_S0.9000.95
285_T288_A0.9000.95
380_A384_E0.8960.95
331_G356_R0.8960.95
184_A249_V0.8940.95
261_E279_Y0.8920.95
139_L145_L0.8910.95
185_V188_G0.8880.95
38_V43_V0.8850.95
38_V41_G0.8820.95
287_L324_L0.8790.95
115_N118_A0.8780.95
163_A187_F0.8780.95
410_F441_S0.8760.95
150_G323_D0.8740.94
75_L229_V0.8740.94
261_E313_P0.8720.94
138_T429_I0.8700.94
359_D379_Y0.8670.94
334_M337_R0.8670.94
167_S248_H0.8660.94
164_R168_V0.8630.94
399_A408_L0.8620.94
39_K57_E0.8600.94
317_D322_P0.8570.94
193_T196_E0.8560.94
133_I137_N0.8540.94
341_S352_P0.8530.94
395_V405_N0.8510.94
427_R435_L0.8490.94
14_L270_R0.8450.93
199_E360_D0.8410.93
124_E248_H0.8410.93
120_E296_R0.8400.93
296_R303_S0.8400.93
374_V433_L0.8390.93
10_V109_I0.8330.93
125_F138_T0.8330.93
384_E388_L0.8300.93
294_A306_Q0.8290.93
192_I196_E0.8290.93
40_R43_V0.8270.93
27_E74_T0.8260.93
162_I250_L0.8260.93
234_A251_V0.8240.93
136_M375_S0.8230.92
385_G411_A0.8230.92
248_H296_R0.8230.92
358_M371_H0.8190.92
88_L101_I0.8190.92
357_L362_I0.8170.92
255_D309_I0.8170.92
135_G436_G0.8150.92
260_C287_L0.8150.92
134_D432_T0.8140.92
140_V357_L0.8130.92
317_D352_P0.8120.92
14_L52_A0.8120.92
15_V31_I0.8120.92
127_Q436_G0.8110.92
259_Y290_L0.8090.92
370_D437_W0.8080.92
378_L440_L0.8080.92
159_A252_I0.8000.91
57_E93_N0.7950.91
27_E134_D0.7930.91
150_G316_D0.7920.91
27_E71_L0.7910.91
393_N402_E0.7910.91
201_M205_E0.7880.91
390_D396_G0.7880.91
79_V236_T0.7870.91
148_F322_P0.7820.90
138_T362_I0.7820.90
11_S394_I0.7790.90
76_K108_D0.7730.90
95_I217_M0.7720.90
380_A420_D0.7710.90
164_R212_R0.7710.90
400_L405_N0.7680.90
42_Q45_E0.7610.89
429_I433_L0.7610.89
82_D105_D0.7600.89
78_P104_D0.7560.89
314_G319_H0.7520.89
283_M286_D0.7510.89
120_E301_E0.7500.89
87_V95_I0.7500.89
373_D376_D0.7500.89
249_V265_Q0.7490.88
442_M445_K0.7490.88
209_A212_R0.7440.88
233_M236_T0.7430.88
150_G278_G0.7430.88
39_K42_Q0.7420.88
74_T108_D0.7410.88
381_A414_F0.7380.88
390_D393_N0.7370.88
75_L134_D0.7350.88
382_Y414_F0.7330.87
279_Y316_D0.7320.87
7_I15_V0.7310.87
218_N222_D0.7300.87
128_T133_I0.7290.87
109_I233_M0.7280.87
86_R100_D0.7280.87
42_Q56_F0.7270.87
324_L396_G0.7240.87
232_R259_Y0.7220.87
373_D377_Q0.7210.87
56_F226_E0.7200.86
192_I258_N0.7200.86
374_V436_G0.7180.86
316_D323_D0.7150.86
259_Y286_D0.7140.86
38_V69_R0.7120.86
141_R303_S0.7120.86
91_S94_P0.7070.85
370_D444_P0.7050.85
33_T66_A0.7040.85
57_E223_P0.7040.85
47_S52_A0.7030.85
75_L233_M0.7030.85
184_A212_R0.7020.85
197_A217_M0.7020.85
54_Q266_I0.6990.85
427_R432_T0.6970.85
26_D43_V0.6960.85
16_Y52_A0.6960.85
138_T371_H0.6950.84
121_Y360_D0.6950.84
239_E242_A0.6930.84
427_R433_L0.6930.84
46_S52_A0.6930.84
382_Y386_E0.6920.84
89_D95_I0.6870.84
430_E434_D0.6860.84
84_L210_L0.6850.84
101_I104_D0.6840.84
95_I100_D0.6830.83
153_L337_R0.6820.83
28_I40_R0.6810.83
371_H375_S0.6810.83
230_T234_A0.6800.83
368_R371_H0.6780.83
211_E214_V0.6770.83
389_R415_E0.6760.83
381_A406_R0.6750.83
17_V51_V0.6740.83
23_I70_F0.6720.82
105_D245_K0.6720.82
33_T38_V0.6720.82
126_I139_L0.6680.82
125_F357_L0.6680.82
228_T263_L0.6680.82
45_E52_A0.6680.82
137_N354_L0.6680.82
193_T258_N0.6670.82
159_A309_I0.6670.82
402_E406_R0.6670.82
223_P226_E0.6660.82
128_T294_A0.6660.82
378_L436_G0.6650.82
185_V252_I0.6640.82
253_L290_L0.6640.82
237_T241_L0.6630.82
83_L103_P0.6620.82
72_G75_L0.6610.81
240_Y244_E0.6580.81
164_R424_K0.6570.81
385_G415_E0.6560.81
252_I309_I0.6530.81
397_R405_N0.6520.81
404_D412_D0.6510.80
227_R239_E0.6490.80
29_V51_V0.6490.80
185_V213_S0.6480.80
28_I75_L0.6480.80
11_S14_L0.6470.80
276_R324_L0.6460.80
323_D326_G0.6460.80
374_V440_L0.6460.80
439_L443_F0.6460.80
385_G389_R0.6450.80
130_V423_F0.6430.80
102_V105_D0.6430.80
369_A422_G0.6420.80
19_T23_I0.6410.79
381_A407_Y0.6400.79
84_L247_Y0.6400.79
251_V294_A0.6390.79
127_Q432_T0.6370.79
15_V59_T0.6370.79
244_E304_V0.6370.79
260_C321_I0.6360.79
86_R97_G0.6350.79
151_S328_I0.6330.79
125_F429_I0.6320.78
122_P357_L0.6320.78
137_N348_V0.6320.78
261_E396_G0.6310.78
235_L253_L0.6310.78
435_L438_E0.6300.78
52_A270_R0.6300.78
165_Q426_N0.6270.78
388_L393_N0.6270.78
151_S396_G0.6260.78
112_E289_Q0.6260.78
160_L217_M0.6260.78
334_M352_P0.6250.78
140_V356_R0.6230.77
29_V43_V0.6230.77
368_R433_L0.6220.77
370_D374_V0.6220.77
336_N352_P0.6210.77
261_E324_L0.6190.77
93_N106_R0.6160.77
368_R437_W0.6150.77
24_G63_G0.6140.76
418_F435_L0.6130.76
272_E295_G0.6130.76
398_E401_S0.6120.76
147_I333_I0.6110.76
98_G210_L0.6090.76
149_S161_Q0.6070.76
46_S64_K0.6060.76
228_T266_I0.6060.76
203_D236_T0.6050.75
154_P254_T0.6050.75
77_M80_T0.6040.75
231_P253_L0.6030.75
54_Q270_R0.6020.75
31_I68_V0.6010.75
206_R210_L0.6010.75
135_G138_T0.6010.75
382_Y411_A0.6000.75
33_T62_V0.5980.75
108_D236_T0.5950.74
95_I222_D0.5940.74
235_L239_E0.5930.74
151_S261_E0.5910.74
389_R408_L0.5900.74
111_G236_T0.5900.74
327_Y354_L0.5900.74
105_D108_D0.5900.74
187_F197_A0.5880.73
381_A384_E0.5880.73
94_P98_G0.5880.73
155_H254_T0.5880.73
145_L331_G0.5870.73
132_G350_V0.5860.73
81_E214_V0.5850.73
56_F232_R0.5850.73
350_V382_Y0.5850.73
184_A245_K0.5850.73
242_A304_V0.5830.73
351_L382_Y0.5830.73
88_L91_S0.5820.73
410_F413_R0.5810.72
39_K58_G0.5810.72
441_S444_P0.5800.72
33_T61_G0.5800.72
128_T166_A0.5800.72
90_G94_P0.5790.72
106_R406_R0.5770.72
160_L200_F0.5770.72
54_Q396_G0.5750.72
7_I10_V0.5730.71
94_P100_D0.5720.71
30_E37_D0.5710.71
183_F247_Y0.5690.71
264_R321_I0.5690.71
11_S270_R0.5680.71
128_T148_F0.5680.71
408_L412_D0.5680.71
427_R431_E0.5680.71
117_H349_N0.5680.71
151_S327_Y0.5670.71
7_I68_V0.5670.71
140_V361_G0.5660.70
108_D111_G0.5620.70
82_D99_P0.5620.70
401_S408_L0.5620.70
437_W440_L0.5620.70
318_T325_T0.5610.70
362_I375_S0.5610.70
82_D101_I0.5610.70
236_T240_Y0.5600.70
147_I387_E0.5590.70
39_K62_V0.5580.69
131_S435_L0.5570.69
434_D438_E0.5570.69
148_F329_T0.5560.69
94_P101_I0.5540.69
15_V41_G0.5540.69
58_G61_G0.5530.69
118_A299_G0.5530.69
123_E301_E0.5530.69
204_F209_A0.5520.69
119_R295_G0.5510.68
441_S445_K0.5510.68
431_E434_D0.5510.68
151_S326_G0.5470.68
259_Y263_L0.5470.68
56_F91_S0.5460.68
164_R201_M0.5460.68
54_Q390_D0.5460.68
362_I433_L0.5460.68
44_L270_R0.5440.67
381_A410_F0.5440.67
124_E301_E0.5430.67
424_K435_L0.5420.67
413_R445_K0.5410.67
16_Y45_E0.5410.67
256_M290_L0.5410.67
166_A248_H0.5410.67
232_R270_R0.5390.67
164_R207_T0.5370.67
39_K61_G0.5360.66
130_V161_Q0.5350.66
216_F233_M0.5350.66
401_S404_D0.5340.66
265_Q279_Y0.5330.66
160_L213_S0.5320.66
202_D207_T0.5300.66
145_L333_I0.5300.66
296_R299_G0.5300.66
51_V68_V0.5300.66
156_S254_T0.5290.65
339_L356_R0.5290.65
379_Y382_Y0.5290.65
123_E296_R0.5270.65
85_G96_D0.5230.64
133_I158_L0.5200.64
205_E211_E0.5200.64
422_G426_N0.5200.64
210_L215_V0.5190.64
71_L74_T0.5190.64
42_Q229_V0.5180.64
385_G392_V0.5180.64
100_D104_D0.5170.64
330_E356_R0.5170.64
188_G306_Q0.5160.63
91_S394_I0.5150.63
125_F362_I0.5140.63
307_I343_G0.5140.63
227_R306_Q0.5130.63
205_E213_S0.5110.63
208_G213_S0.5110.63
12_G278_G0.5110.63
222_D280_P0.5100.63
42_Q196_E0.5100.63
189_A192_I0.5090.62
343_G380_A0.5090.62
127_Q167_S0.5090.62
276_R396_G0.5090.62
279_Y390_D0.5080.62
147_I335_M0.5080.62
432_T435_L0.5080.62
110_V232_R0.5070.62
313_P318_T0.5070.62
359_D423_F0.5070.62
412_D415_E0.5070.62
141_R285_T0.5070.62
14_L163_A0.5060.62
316_D319_H0.5060.62
104_D107_V0.5060.62
84_L87_V0.5050.62
143_Q331_G0.5050.62
188_G231_P0.5040.62
227_R261_E0.5030.62
312_M318_T0.5030.62
220_A291_Y0.5020.61
225_V266_I0.5020.61
138_T354_L0.5010.61
374_V443_F0.5010.61
42_Q75_L0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vr4D 1 0.9575 100 0.114 Contact Map
2c61A 2 0.9257 100 0.117 Contact Map
3gqbB 1 0.9724 100 0.12 Contact Map
3oaaA 2 0.9448 100 0.126 Contact Map
2qe7A 1 0.9406 100 0.131 Contact Map
3j9tB 1 0.9682 100 0.134 Contact Map
2ck3A 1 0.9639 100 0.14 Contact Map
2r9vA 1 0.9469 100 0.144 Contact Map
1fx0A 1 0.9448 100 0.152 Contact Map
3mfyA 1 0.7983 100 0.154 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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