GREMLIN Database
VATC - V-type ATP synthase subunit C
UniProt: Q9HNE1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (322)
Sequences: 1012 (783)
Seq/√Len: 43.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_K182_D9.6141.00
335_G345_I7.5821.00
82_L94_A4.1861.00
144_S147_T4.0451.00
189_L210_L3.9931.00
215_D242_G3.9681.00
36_G39_E3.5361.00
74_L78_F3.2051.00
40_I333_A3.1801.00
11_Y15_R3.0731.00
40_I336_R3.0201.00
235_A238_F3.0021.00
194_P207_A2.8171.00
33_L346_Q2.7931.00
259_D262_S2.6651.00
24_F32_L2.5721.00
332_I345_I2.4441.00
262_S265_Q2.4281.00
24_F44_M2.4161.00
24_F28_E2.3371.00
102_A181_V2.3351.00
73_G76_A2.2881.00
25_G28_E2.2591.00
110_R178_E2.2411.00
219_A264_I2.2051.00
205_L312_V2.1701.00
29_Y328_N2.1100.99
32_L329_I2.0930.99
97_L101_D2.0460.99
78_F322_K2.0270.99
270_G274_S2.0060.99
74_L323_E2.0000.99
67_E70_L1.9830.99
42_R46_D1.9810.99
70_L326_V1.9660.99
19_R80_A1.9620.99
104_N129_G1.9510.99
160_Y188_N1.9160.99
222_A238_F1.9080.99
100_F323_E1.9070.99
218_N239_I1.8970.99
11_Y14_A1.8330.99
219_A229_G1.8270.98
77_E318_Y1.7920.98
28_E43_F1.7910.98
101_D129_G1.7850.98
32_L209_F1.7670.98
126_V129_G1.7590.98
22_G48_T1.7160.98
73_G322_K1.6830.97
211_T243_T1.6710.97
73_G77_E1.6190.97
81_L319_V1.6130.97
212_A216_F1.6120.97
24_F47_S1.6120.97
16_I23_L1.6110.97
99_K213_E1.6080.97
334_R338_A1.5900.96
136_L248_S1.5550.96
193_Q210_L1.5340.95
225_L235_A1.5290.95
220_R331_A1.5200.95
15_R84_W1.5170.95
317_A329_I1.4900.95
288_G340_M1.4710.94
196_T202_P1.4650.94
324_R331_A1.4400.94
57_A65_L1.4360.94
190_N241_G1.4350.94
342_E345_I1.4320.93
30_R346_Q1.4260.93
214_I218_N1.4180.93
238_F250_M1.4150.93
16_I81_L1.3840.92
26_D30_R1.3800.92
324_R328_N1.3700.92
63_M337_E1.3680.92
13_V314_P1.3460.91
186_Y239_I1.3220.90
161_L181_V1.3050.90
257_Q260_L1.2850.89
101_D330_R1.2760.89
70_L224_R1.2700.88
309_P312_V1.2670.88
332_I349_L1.2660.88
259_D318_Y1.2600.88
10_E14_A1.2580.88
83_S176_P1.2510.88
71_N330_R1.2420.87
186_Y241_G1.2320.87
305_S317_A1.2250.87
311_S314_P1.2080.86
98_R188_N1.2060.86
330_R336_R1.1990.85
315_V331_A1.1980.85
257_Q262_S1.1980.85
216_F297_L1.1840.85
225_L230_V1.1800.84
259_D340_M1.1790.84
129_G242_G1.1750.84
49_Y325_E1.1750.84
191_P248_S1.1750.84
29_Y131_F1.1700.84
209_F320_L1.1690.84
102_A188_N1.1670.84
128_A239_I1.1610.83
110_R180_A1.1500.83
83_S173_S1.1450.83
36_G243_T1.1400.82
131_F245_F1.1390.82
190_N211_T1.1340.82
106_K125_L1.1320.82
220_R265_Q1.1250.81
186_Y310_T1.1220.81
294_D327_D1.1150.81
105_V132_D1.1110.81
96_Y260_L1.1050.80
301_S317_A1.0970.80
144_S208_E1.0910.79
37_T69_A1.0910.79
146_E339_G1.0770.79
47_S74_L1.0740.78
269_Y272_E1.0680.78
88_R196_T1.0650.78
111_G116_A1.0630.78
175_V221_N1.0610.78
56_L189_L1.0570.77
330_R334_R1.0520.77
186_Y214_I1.0520.77
30_R33_L1.0490.77
301_S320_L1.0440.76
27_D219_A1.0430.76
294_D321_A1.0360.76
189_L242_G1.0310.75
9_Y202_P1.0310.75
15_R80_A1.0290.75
178_E224_R1.0240.75
110_R175_V1.0120.74
81_L240_E1.0090.74
171_E209_F1.0070.74
152_L160_Y1.0060.74
260_L264_I1.0010.73
169_E177_L0.9940.73
97_L312_V0.9900.72
32_L43_F0.9890.72
183_R187_E0.9870.72
334_R348_E0.9800.72
118_T140_L0.9780.71
102_A152_L0.9710.71
77_E322_K0.9710.71
143_D203_E0.9680.71
32_L319_V0.9650.70
10_E96_Y0.9650.70
51_D266_D0.9620.70
344_E347_A0.9570.70
85_S315_V0.9550.70
276_A349_L0.9500.69
52_A76_A0.9490.69
36_G141_S0.9480.69
105_V283_S0.9470.69
102_A178_E0.9450.69
74_L100_F0.9440.69
217_R221_N0.9380.68
218_N242_G0.9380.68
114_S132_D0.9340.68
37_T337_E0.9310.68
13_V331_A0.9280.67
49_Y215_D0.9260.67
72_E265_Q0.9210.67
17_R221_N0.9200.67
155_T269_Y0.9200.67
64_D275_T0.9180.67
101_D130_E0.9160.66
262_S343_D0.9150.66
211_T233_D0.9100.66
112_L148_V0.9100.66
105_V284_D0.9080.66
149_V157_F0.9070.66
136_L157_F0.9060.66
40_I69_A0.9060.66
18_H93_L0.9030.65
343_D347_A0.8980.65
29_Y95_K0.8950.65
117_D245_F0.8950.65
215_D218_N0.8930.64
189_L214_I0.8880.64
19_R276_A0.8870.64
37_T66_V0.8860.64
68_Y177_L0.8850.64
87_G144_S0.8820.63
66_V177_L0.8800.63
317_A321_A0.8790.63
106_K218_N0.8760.63
87_G91_D0.8700.62
37_T333_A0.8690.62
144_S255_E0.8690.62
191_P254_V0.8670.62
264_I303_H0.8650.62
54_D57_A0.8640.62
209_F293_L0.8620.62
186_Y221_N0.8610.62
140_L343_D0.8600.61
187_E240_E0.8540.61
335_G340_M0.8530.61
95_K273_L0.8520.61
33_L301_S0.8510.61
98_R116_A0.8490.60
234_P348_E0.8470.60
81_L315_V0.8450.60
66_V264_I0.8450.60
214_I241_G0.8440.60
228_S338_A0.8410.60
94_A329_I0.8390.60
260_L339_G0.8340.59
288_G291_H0.8340.59
31_K254_V0.8280.59
98_R156_I0.8240.58
108_V125_L0.8200.58
291_H315_V0.8190.58
32_L143_D0.8190.58
17_R186_Y0.8180.58
218_N224_R0.8150.57
28_E31_K0.8140.57
138_E142_A0.8140.57
231_S234_P0.8120.57
252_T263_R0.8020.56
32_L116_A0.7980.56
101_D128_A0.7970.56
26_D262_S0.7960.56
91_D270_G0.7930.55
108_V140_L0.7920.55
174_L215_D0.7890.55
101_D228_S0.7780.54
128_A152_L0.7770.54
159_T163_P0.7760.54
91_D303_H0.7750.54
101_D131_F0.7740.53
15_R63_M0.7720.53
10_E29_Y0.7690.53
186_Y218_N0.7680.53
52_A147_T0.7660.53
186_Y330_R0.7640.52
138_E301_S0.7630.52
150_D153_S0.7610.52
54_D349_L0.7600.52
35_M39_E0.7590.52
290_E314_P0.7570.52
44_M317_A0.7570.52
34_R349_L0.7540.52
9_Y173_S0.7540.52
37_T102_A0.7520.51
105_V344_E0.7520.51
36_G266_D0.7510.51
108_V129_G0.7500.51
18_H21_A0.7500.51
100_F182_D0.7490.51
39_E129_G0.7480.51
222_A226_A0.7480.51
87_G110_R0.7470.51
42_R101_D0.7470.51
14_A21_A0.7460.51
28_E105_V0.7440.51
52_A269_Y0.7390.50
204_A207_A0.7370.50
64_D233_D0.7370.50
262_S266_D0.7340.50
322_K325_E0.7340.50
186_Y190_N0.7330.50
223_L260_L0.7290.49
216_F293_L0.7290.49
100_F128_A0.7260.49
93_L229_G0.7260.49
69_A329_I0.7230.49
15_R46_D0.7210.48
184_A290_E0.7190.48
27_D36_G0.7150.48
11_Y104_N0.7150.48
269_Y309_P0.7130.48
151_A310_T0.7130.48
101_D104_N0.7120.48
328_N349_L0.7120.48
25_G105_V0.7110.47
153_S162_E0.7110.47
32_L332_I0.7100.47
115_H195_A0.7090.47
207_A252_T0.7090.47
215_D241_G0.7060.47
23_L93_L0.7050.47
207_A211_T0.7040.47
31_K43_F0.7040.47
214_I316_L0.7020.47
329_I344_E0.7000.46
183_R222_A0.7000.46
228_S334_R0.6990.46
29_Y40_I0.6980.46
66_V78_F0.6970.46
92_Q315_V0.6940.46
222_A253_L0.6940.46
22_G249_E0.6900.45
135_F338_A0.6870.45
33_L332_I0.6850.45
148_V180_A0.6840.45
41_A268_T0.6830.45
194_P252_T0.6830.45
191_P207_A0.6830.45
145_V177_L0.6790.44
264_I273_L0.6770.44
331_A337_E0.6750.44
185_Y189_L0.6740.44
111_G121_I0.6730.44
12_V81_L0.6720.44
225_L313_C0.6680.43
85_S318_Y0.6660.43
306_Y316_L0.6640.43
153_S239_I0.6630.43
308_Y313_C0.6630.43
13_V313_C0.6630.43
284_D319_V0.6610.43
166_A271_D0.6600.43
62_G65_L0.6580.42
163_P253_L0.6570.42
161_L164_A0.6560.42
177_L242_G0.6560.42
169_E223_L0.6550.42
55_S264_I0.6550.42
17_R20_R0.6540.42
74_L223_L0.6440.41
67_E218_N0.6380.41
72_E79_D0.6350.40
138_E231_S0.6350.40
42_R349_L0.6330.40
109_F211_T0.6330.40
208_E219_A0.6330.40
111_G179_N0.6310.40
276_A292_A0.6300.40
101_D218_N0.6280.40
172_D214_I0.6270.40
253_L260_L0.6250.39
110_R139_L0.6240.39
302_D326_V0.6230.39
171_E233_D0.6220.39
289_F292_A0.6220.39
78_F173_S0.6220.39
306_Y338_A0.6220.39
245_F267_S0.6190.39
147_T150_D0.6180.39
127_D181_V0.6170.39
193_Q341_S0.6160.39
65_L347_A0.6150.38
251_T254_V0.6150.38
146_E246_E0.6150.38
35_M206_Y0.6140.38
145_V183_R0.6130.38
56_L69_A0.6130.38
218_N238_F0.6120.38
100_F108_V0.6110.38
32_L37_T0.6100.38
108_V128_A0.6080.38
36_G161_L0.6070.38
103_W230_V0.6070.38
122_R137_D0.6060.38
104_N330_R0.6050.38
50_K302_D0.6040.37
78_F85_S0.6040.37
79_D191_P0.6030.37
216_F340_M0.6010.37
160_Y180_A0.5990.37
209_F321_A0.5990.37
17_R314_P0.5990.37
203_E207_A0.5980.37
55_S257_Q0.5980.37
229_G257_Q0.5970.37
131_F148_V0.5960.37
44_M96_Y0.5940.37
73_G326_V0.5920.36
67_E224_R0.5910.36
107_T173_S0.5910.36
44_M65_L0.5910.36
25_G246_E0.5900.36
55_S115_H0.5900.36
40_I53_V0.5900.36
65_L217_R0.5890.36
90_Y159_T0.5870.36
127_D166_A0.5840.36
25_G34_R0.5820.35
82_L316_L0.5810.35
137_D141_S0.5790.35
223_L310_T0.5780.35
230_V234_P0.5760.35
190_N214_I0.5750.35
27_D30_R0.5750.35
178_E326_V0.5750.35
121_I124_D0.5750.35
32_L181_V0.5740.35
63_M220_R0.5740.35
99_K323_E0.5730.35
79_D132_D0.5730.35
272_E300_Y0.5730.35
188_N192_S0.5730.35
175_V178_E0.5720.35
62_G337_E0.5720.35
14_A121_I0.5720.35
14_A71_N0.5720.35
108_V145_V0.5710.35
9_Y312_V0.5700.34
106_K174_L0.5690.34
14_A319_V0.5650.34
322_K326_V0.5630.34
137_D145_V0.5620.34
8_N84_W0.5600.34
193_Q207_A0.5590.33
291_H294_D0.5590.33
51_D231_S0.5580.33
77_E109_F0.5580.33
79_D97_L0.5580.33
214_I335_G0.5580.33
20_R23_L0.5570.33
122_R329_I0.5570.33
72_E286_L0.5560.33
185_Y188_N0.5560.33
301_S337_E0.5550.33
15_R135_F0.5550.33
212_A300_Y0.5530.33
93_L182_D0.5530.33
15_R67_E0.5520.33
54_D262_S0.5520.33
44_M329_I0.5510.33
92_Q316_L0.5490.33
16_I268_T0.5480.33
248_S252_T0.5470.32
135_F299_S0.5460.32
51_D296_A0.5430.32
146_E301_S0.5430.32
168_Y252_T0.5430.32
241_G330_R0.5420.32
67_E337_E0.5410.32
170_D185_Y0.5400.32
9_Y16_I0.5400.32
88_R245_F0.5390.32
311_S315_V0.5390.32
15_R101_D0.5380.32
49_Y186_Y0.5380.32
44_M323_E0.5370.32
219_A293_L0.5350.31
226_A254_V0.5330.31
57_A69_A0.5320.31
250_M254_V0.5320.31
49_Y318_Y0.5320.31
263_R341_S0.5310.31
15_R240_E0.5310.31
334_R337_E0.5290.31
78_F327_D0.5280.31
9_Y86_E0.5280.31
296_A300_Y0.5280.31
104_N108_V0.5250.31
225_L318_Y0.5220.30
90_Y110_R0.5210.30
173_S176_P0.5200.30
125_L182_D0.5190.30
72_E76_A0.5190.30
25_G223_L0.5180.30
240_E264_I0.5170.30
183_R225_L0.5150.30
164_A177_L0.5150.30
43_F145_V0.5150.30
113_Y232_V0.5130.30
237_Y305_S0.5120.30
245_F265_Q0.5110.30
103_W327_D0.5100.29
219_A273_L0.5090.29
147_T284_D0.5080.29
139_L151_A0.5080.29
275_T292_A0.5080.29
29_Y139_L0.5080.29
40_I329_I0.5070.29
37_T63_M0.5060.29
20_R307_V0.5040.29
173_S290_E0.5030.29
136_L140_L0.5030.29
111_G333_A0.5020.29
182_D331_A0.5020.29
214_I242_G0.5000.29
73_G179_N0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j9tQ 1 0.9489 100 0.225 Contact Map
1v9mA 1 0.8807 100 0.225 Contact Map
1m9iA 1 0.6818 27.8 0.956 Contact Map
1yiiA 1 0.6733 19.7 0.959 Contact Map
1w3wA 1 0.6364 17.3 0.96 Contact Map
3hzrA 2 0.2898 13.1 0.962 Contact Map
3i05A 2 0.2415 8.8 0.965 Contact Map
3focA 4 0.2926 8.8 0.965 Contact Map
3tzeA 2 0.2756 7.7 0.966 Contact Map
2zhjA 2 0.696 7.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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