VATC - HALSA - GREMLIN Contacts

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VATC - V-type ATP synthase subunit C

UniProt:	Q9HNE1	Sequences: MSASGPANYEYVVARIRHRRAGLFGDDEYRKLLRMGTGEIARFMEDSTYKDAVDSLASRHRGMDLVEYALNEGLAAEFDALLSWSEGRLYDQLAKYLRKFDAWNVKTVFRGLYSHADTDAIRADLVDAGEFDAAFLDELLSADSVETVVDALSGTIFDTYLEPAFADYEDEDSLVPLENAVDRAYYENLNPSQPATAAQDSPEALYAEFLTAEIDFRNARNALRLARSGVSVDPAAYFIEGGTLFEASEMTTLVERQSDLVSRIQDSTYGDELSTALTALEESDSLIGFEHALDRALLSYSDHLSYVYPTSVCPVLAYVLAKEREVDNIRAIARGREAGMSEDEIQAELVML	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	352 (322)
Sequences:	1012 (783)
Seq/√Len:	43.6

HALSA - VATC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
106_K	182_D	9.614	1.00
335_G	345_I	7.582	1.00
82_L	94_A	4.186	1.00
144_S	147_T	4.045	1.00
189_L	210_L	3.993	1.00
215_D	242_G	3.968	1.00
36_G	39_E	3.536	1.00
74_L	78_F	3.205	1.00
40_I	333_A	3.180	1.00
11_Y	15_R	3.073	1.00
40_I	336_R	3.020	1.00
235_A	238_F	3.002	1.00
194_P	207_A	2.817	1.00
33_L	346_Q	2.793	1.00
259_D	262_S	2.665	1.00
24_F	32_L	2.572	1.00
332_I	345_I	2.444	1.00
262_S	265_Q	2.428	1.00
24_F	44_M	2.416	1.00
24_F	28_E	2.337	1.00
102_A	181_V	2.335	1.00
73_G	76_A	2.288	1.00
25_G	28_E	2.259	1.00
110_R	178_E	2.241	1.00
219_A	264_I	2.205	1.00
205_L	312_V	2.170	1.00
29_Y	328_N	2.110	0.99
32_L	329_I	2.093	0.99
97_L	101_D	2.046	0.99
78_F	322_K	2.027	0.99
270_G	274_S	2.006	0.99
74_L	323_E	2.000	0.99
67_E	70_L	1.983	0.99
42_R	46_D	1.981	0.99
70_L	326_V	1.966	0.99
19_R	80_A	1.962	0.99
104_N	129_G	1.951	0.99
160_Y	188_N	1.916	0.99
222_A	238_F	1.908	0.99
100_F	323_E	1.907	0.99
218_N	239_I	1.897	0.99
11_Y	14_A	1.833	0.99
219_A	229_G	1.827	0.98
77_E	318_Y	1.792	0.98
28_E	43_F	1.791	0.98
101_D	129_G	1.785	0.98
32_L	209_F	1.767	0.98
126_V	129_G	1.759	0.98
22_G	48_T	1.716	0.98
73_G	322_K	1.683	0.97
211_T	243_T	1.671	0.97
73_G	77_E	1.619	0.97
81_L	319_V	1.613	0.97
212_A	216_F	1.612	0.97
24_F	47_S	1.612	0.97
16_I	23_L	1.611	0.97
99_K	213_E	1.608	0.97
334_R	338_A	1.590	0.96
136_L	248_S	1.555	0.96
193_Q	210_L	1.534	0.95
225_L	235_A	1.529	0.95
220_R	331_A	1.520	0.95
15_R	84_W	1.517	0.95
317_A	329_I	1.490	0.95
288_G	340_M	1.471	0.94
196_T	202_P	1.465	0.94
324_R	331_A	1.440	0.94
57_A	65_L	1.436	0.94
190_N	241_G	1.435	0.94
342_E	345_I	1.432	0.93
30_R	346_Q	1.426	0.93
214_I	218_N	1.418	0.93
238_F	250_M	1.415	0.93
16_I	81_L	1.384	0.92
26_D	30_R	1.380	0.92
324_R	328_N	1.370	0.92
63_M	337_E	1.368	0.92
13_V	314_P	1.346	0.91
186_Y	239_I	1.322	0.90
161_L	181_V	1.305	0.90
257_Q	260_L	1.285	0.89
101_D	330_R	1.276	0.89
70_L	224_R	1.270	0.88
309_P	312_V	1.267	0.88
332_I	349_L	1.266	0.88
259_D	318_Y	1.260	0.88
10_E	14_A	1.258	0.88
83_S	176_P	1.251	0.88
71_N	330_R	1.242	0.87
186_Y	241_G	1.232	0.87
305_S	317_A	1.225	0.87
311_S	314_P	1.208	0.86
98_R	188_N	1.206	0.86
330_R	336_R	1.199	0.85
315_V	331_A	1.198	0.85
257_Q	262_S	1.198	0.85
216_F	297_L	1.184	0.85
225_L	230_V	1.180	0.84
259_D	340_M	1.179	0.84
129_G	242_G	1.175	0.84
49_Y	325_E	1.175	0.84
191_P	248_S	1.175	0.84
29_Y	131_F	1.170	0.84
209_F	320_L	1.169	0.84
102_A	188_N	1.167	0.84
128_A	239_I	1.161	0.83
110_R	180_A	1.150	0.83
83_S	173_S	1.145	0.83
36_G	243_T	1.140	0.82
131_F	245_F	1.139	0.82
190_N	211_T	1.134	0.82
106_K	125_L	1.132	0.82
220_R	265_Q	1.125	0.81
186_Y	310_T	1.122	0.81
294_D	327_D	1.115	0.81
105_V	132_D	1.111	0.81
96_Y	260_L	1.105	0.80
301_S	317_A	1.097	0.80
144_S	208_E	1.091	0.79
37_T	69_A	1.091	0.79
146_E	339_G	1.077	0.79
47_S	74_L	1.074	0.78
269_Y	272_E	1.068	0.78
88_R	196_T	1.065	0.78
111_G	116_A	1.063	0.78
175_V	221_N	1.061	0.78
56_L	189_L	1.057	0.77
330_R	334_R	1.052	0.77
186_Y	214_I	1.052	0.77
30_R	33_L	1.049	0.77
301_S	320_L	1.044	0.76
27_D	219_A	1.043	0.76
294_D	321_A	1.036	0.76
189_L	242_G	1.031	0.75
9_Y	202_P	1.031	0.75
15_R	80_A	1.029	0.75
178_E	224_R	1.024	0.75
110_R	175_V	1.012	0.74
81_L	240_E	1.009	0.74
171_E	209_F	1.007	0.74
152_L	160_Y	1.006	0.74
260_L	264_I	1.001	0.73
169_E	177_L	0.994	0.73
97_L	312_V	0.990	0.72
32_L	43_F	0.989	0.72
183_R	187_E	0.987	0.72
334_R	348_E	0.980	0.72
118_T	140_L	0.978	0.71
102_A	152_L	0.971	0.71
77_E	322_K	0.971	0.71
143_D	203_E	0.968	0.71
32_L	319_V	0.965	0.70
10_E	96_Y	0.965	0.70
51_D	266_D	0.962	0.70
344_E	347_A	0.957	0.70
85_S	315_V	0.955	0.70
276_A	349_L	0.950	0.69
52_A	76_A	0.949	0.69
36_G	141_S	0.948	0.69
105_V	283_S	0.947	0.69
102_A	178_E	0.945	0.69
74_L	100_F	0.944	0.69
217_R	221_N	0.938	0.68
218_N	242_G	0.938	0.68
114_S	132_D	0.934	0.68
37_T	337_E	0.931	0.68
13_V	331_A	0.928	0.67
49_Y	215_D	0.926	0.67
72_E	265_Q	0.921	0.67
17_R	221_N	0.920	0.67
155_T	269_Y	0.920	0.67
64_D	275_T	0.918	0.67
101_D	130_E	0.916	0.66
262_S	343_D	0.915	0.66
211_T	233_D	0.910	0.66
112_L	148_V	0.910	0.66
105_V	284_D	0.908	0.66
149_V	157_F	0.907	0.66
136_L	157_F	0.906	0.66
40_I	69_A	0.906	0.66
18_H	93_L	0.903	0.65
343_D	347_A	0.898	0.65
29_Y	95_K	0.895	0.65
117_D	245_F	0.895	0.65
215_D	218_N	0.893	0.64
189_L	214_I	0.888	0.64
19_R	276_A	0.887	0.64
37_T	66_V	0.886	0.64
68_Y	177_L	0.885	0.64
87_G	144_S	0.882	0.63
66_V	177_L	0.880	0.63
317_A	321_A	0.879	0.63
106_K	218_N	0.876	0.63
87_G	91_D	0.870	0.62
37_T	333_A	0.869	0.62
144_S	255_E	0.869	0.62
191_P	254_V	0.867	0.62
264_I	303_H	0.865	0.62
54_D	57_A	0.864	0.62
209_F	293_L	0.862	0.62
186_Y	221_N	0.861	0.62
140_L	343_D	0.860	0.61
187_E	240_E	0.854	0.61
335_G	340_M	0.853	0.61
95_K	273_L	0.852	0.61
33_L	301_S	0.851	0.61
98_R	116_A	0.849	0.60
234_P	348_E	0.847	0.60
81_L	315_V	0.845	0.60
66_V	264_I	0.845	0.60
214_I	241_G	0.844	0.60
228_S	338_A	0.841	0.60
94_A	329_I	0.839	0.60
260_L	339_G	0.834	0.59
288_G	291_H	0.834	0.59
31_K	254_V	0.828	0.59
98_R	156_I	0.824	0.58
108_V	125_L	0.820	0.58
291_H	315_V	0.819	0.58
32_L	143_D	0.819	0.58
17_R	186_Y	0.818	0.58
218_N	224_R	0.815	0.57
28_E	31_K	0.814	0.57
138_E	142_A	0.814	0.57
231_S	234_P	0.812	0.57
252_T	263_R	0.802	0.56
32_L	116_A	0.798	0.56
101_D	128_A	0.797	0.56
26_D	262_S	0.796	0.56
91_D	270_G	0.793	0.55
108_V	140_L	0.792	0.55
174_L	215_D	0.789	0.55
101_D	228_S	0.778	0.54
128_A	152_L	0.777	0.54
159_T	163_P	0.776	0.54
91_D	303_H	0.775	0.54
101_D	131_F	0.774	0.53
15_R	63_M	0.772	0.53
10_E	29_Y	0.769	0.53
186_Y	218_N	0.768	0.53
52_A	147_T	0.766	0.53
186_Y	330_R	0.764	0.52
138_E	301_S	0.763	0.52
150_D	153_S	0.761	0.52
54_D	349_L	0.760	0.52
35_M	39_E	0.759	0.52
290_E	314_P	0.757	0.52
44_M	317_A	0.757	0.52
34_R	349_L	0.754	0.52
9_Y	173_S	0.754	0.52
37_T	102_A	0.752	0.51
105_V	344_E	0.752	0.51
36_G	266_D	0.751	0.51
108_V	129_G	0.750	0.51
18_H	21_A	0.750	0.51
100_F	182_D	0.749	0.51
39_E	129_G	0.748	0.51
222_A	226_A	0.748	0.51
87_G	110_R	0.747	0.51
42_R	101_D	0.747	0.51
14_A	21_A	0.746	0.51
28_E	105_V	0.744	0.51
52_A	269_Y	0.739	0.50
204_A	207_A	0.737	0.50
64_D	233_D	0.737	0.50
262_S	266_D	0.734	0.50
322_K	325_E	0.734	0.50
186_Y	190_N	0.733	0.50
223_L	260_L	0.729	0.49
216_F	293_L	0.729	0.49
100_F	128_A	0.726	0.49
93_L	229_G	0.726	0.49
69_A	329_I	0.723	0.49
15_R	46_D	0.721	0.48
184_A	290_E	0.719	0.48
27_D	36_G	0.715	0.48
11_Y	104_N	0.715	0.48
269_Y	309_P	0.713	0.48
151_A	310_T	0.713	0.48
101_D	104_N	0.712	0.48
328_N	349_L	0.712	0.48
25_G	105_V	0.711	0.47
153_S	162_E	0.711	0.47
32_L	332_I	0.710	0.47
115_H	195_A	0.709	0.47
207_A	252_T	0.709	0.47
215_D	241_G	0.706	0.47
23_L	93_L	0.705	0.47
207_A	211_T	0.704	0.47
31_K	43_F	0.704	0.47
214_I	316_L	0.702	0.47
329_I	344_E	0.700	0.46
183_R	222_A	0.700	0.46
228_S	334_R	0.699	0.46
29_Y	40_I	0.698	0.46
66_V	78_F	0.697	0.46
92_Q	315_V	0.694	0.46
222_A	253_L	0.694	0.46
22_G	249_E	0.690	0.45
135_F	338_A	0.687	0.45
33_L	332_I	0.685	0.45
148_V	180_A	0.684	0.45
41_A	268_T	0.683	0.45
194_P	252_T	0.683	0.45
191_P	207_A	0.683	0.45
145_V	177_L	0.679	0.44
264_I	273_L	0.677	0.44
331_A	337_E	0.675	0.44
185_Y	189_L	0.674	0.44
111_G	121_I	0.673	0.44
12_V	81_L	0.672	0.44
225_L	313_C	0.668	0.43
85_S	318_Y	0.666	0.43
306_Y	316_L	0.664	0.43
153_S	239_I	0.663	0.43
308_Y	313_C	0.663	0.43
13_V	313_C	0.663	0.43
284_D	319_V	0.661	0.43
166_A	271_D	0.660	0.43
62_G	65_L	0.658	0.42
163_P	253_L	0.657	0.42
161_L	164_A	0.656	0.42
177_L	242_G	0.656	0.42
169_E	223_L	0.655	0.42
55_S	264_I	0.655	0.42
17_R	20_R	0.654	0.42
74_L	223_L	0.644	0.41
67_E	218_N	0.638	0.41
72_E	79_D	0.635	0.40
138_E	231_S	0.635	0.40
42_R	349_L	0.633	0.40
109_F	211_T	0.633	0.40
208_E	219_A	0.633	0.40
111_G	179_N	0.631	0.40
276_A	292_A	0.630	0.40
101_D	218_N	0.628	0.40
172_D	214_I	0.627	0.40
253_L	260_L	0.625	0.39
110_R	139_L	0.624	0.39
302_D	326_V	0.623	0.39
171_E	233_D	0.622	0.39
289_F	292_A	0.622	0.39
78_F	173_S	0.622	0.39
306_Y	338_A	0.622	0.39
245_F	267_S	0.619	0.39
147_T	150_D	0.618	0.39
127_D	181_V	0.617	0.39
193_Q	341_S	0.616	0.39
65_L	347_A	0.615	0.38
251_T	254_V	0.615	0.38
146_E	246_E	0.615	0.38
35_M	206_Y	0.614	0.38
145_V	183_R	0.613	0.38
56_L	69_A	0.613	0.38
218_N	238_F	0.612	0.38
100_F	108_V	0.611	0.38
32_L	37_T	0.610	0.38
108_V	128_A	0.608	0.38
36_G	161_L	0.607	0.38
103_W	230_V	0.607	0.38
122_R	137_D	0.606	0.38
104_N	330_R	0.605	0.38
50_K	302_D	0.604	0.37
78_F	85_S	0.604	0.37
79_D	191_P	0.603	0.37
216_F	340_M	0.601	0.37
160_Y	180_A	0.599	0.37
209_F	321_A	0.599	0.37
17_R	314_P	0.599	0.37
203_E	207_A	0.598	0.37
55_S	257_Q	0.598	0.37
229_G	257_Q	0.597	0.37
131_F	148_V	0.596	0.37
44_M	96_Y	0.594	0.37
73_G	326_V	0.592	0.36
67_E	224_R	0.591	0.36
107_T	173_S	0.591	0.36
44_M	65_L	0.591	0.36
25_G	246_E	0.590	0.36
55_S	115_H	0.590	0.36
40_I	53_V	0.590	0.36
65_L	217_R	0.589	0.36
90_Y	159_T	0.587	0.36
127_D	166_A	0.584	0.36
25_G	34_R	0.582	0.35
82_L	316_L	0.581	0.35
137_D	141_S	0.579	0.35
223_L	310_T	0.578	0.35
230_V	234_P	0.576	0.35
190_N	214_I	0.575	0.35
27_D	30_R	0.575	0.35
178_E	326_V	0.575	0.35
121_I	124_D	0.575	0.35
32_L	181_V	0.574	0.35
63_M	220_R	0.574	0.35
99_K	323_E	0.573	0.35
79_D	132_D	0.573	0.35
272_E	300_Y	0.573	0.35
188_N	192_S	0.573	0.35
175_V	178_E	0.572	0.35
62_G	337_E	0.572	0.35
14_A	121_I	0.572	0.35
14_A	71_N	0.572	0.35
108_V	145_V	0.571	0.35
9_Y	312_V	0.570	0.34
106_K	174_L	0.569	0.34
14_A	319_V	0.565	0.34
322_K	326_V	0.563	0.34
137_D	145_V	0.562	0.34
8_N	84_W	0.560	0.34
193_Q	207_A	0.559	0.33
291_H	294_D	0.559	0.33
51_D	231_S	0.558	0.33
77_E	109_F	0.558	0.33
79_D	97_L	0.558	0.33
214_I	335_G	0.558	0.33
20_R	23_L	0.557	0.33
122_R	329_I	0.557	0.33
72_E	286_L	0.556	0.33
185_Y	188_N	0.556	0.33
301_S	337_E	0.555	0.33
15_R	135_F	0.555	0.33
212_A	300_Y	0.553	0.33
93_L	182_D	0.553	0.33
15_R	67_E	0.552	0.33
54_D	262_S	0.552	0.33
44_M	329_I	0.551	0.33
92_Q	316_L	0.549	0.33
16_I	268_T	0.548	0.33
248_S	252_T	0.547	0.32
135_F	299_S	0.546	0.32
51_D	296_A	0.543	0.32
146_E	301_S	0.543	0.32
168_Y	252_T	0.543	0.32
241_G	330_R	0.542	0.32
67_E	337_E	0.541	0.32
170_D	185_Y	0.540	0.32
9_Y	16_I	0.540	0.32
88_R	245_F	0.539	0.32
311_S	315_V	0.539	0.32
15_R	101_D	0.538	0.32
49_Y	186_Y	0.538	0.32
44_M	323_E	0.537	0.32
219_A	293_L	0.535	0.31
226_A	254_V	0.533	0.31
57_A	69_A	0.532	0.31
250_M	254_V	0.532	0.31
49_Y	318_Y	0.532	0.31
263_R	341_S	0.531	0.31
15_R	240_E	0.531	0.31
334_R	337_E	0.529	0.31
78_F	327_D	0.528	0.31
9_Y	86_E	0.528	0.31
296_A	300_Y	0.528	0.31
104_N	108_V	0.525	0.31
225_L	318_Y	0.522	0.30
90_Y	110_R	0.521	0.30
173_S	176_P	0.520	0.30
125_L	182_D	0.519	0.30
72_E	76_A	0.519	0.30
25_G	223_L	0.518	0.30
240_E	264_I	0.517	0.30
183_R	225_L	0.515	0.30
164_A	177_L	0.515	0.30
43_F	145_V	0.515	0.30
113_Y	232_V	0.513	0.30
237_Y	305_S	0.512	0.30
245_F	265_Q	0.511	0.30
103_W	327_D	0.510	0.29
219_A	273_L	0.509	0.29
147_T	284_D	0.508	0.29
139_L	151_A	0.508	0.29
275_T	292_A	0.508	0.29
29_Y	139_L	0.508	0.29
40_I	329_I	0.507	0.29
37_T	63_M	0.506	0.29
20_R	307_V	0.504	0.29
173_S	290_E	0.503	0.29
136_L	140_L	0.503	0.29
111_G	333_A	0.502	0.29
182_D	331_A	0.502	0.29
214_I	242_G	0.500	0.29
73_G	179_N	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3j9tQ	1	0.9489	100	0.225	Contact Map
1v9mA	1	0.8807	100	0.225	Contact Map
1m9iA	1	0.6818	27.8	0.956	Contact Map
1yiiA	1	0.6733	19.7	0.959	Contact Map
1w3wA	1	0.6364	17.3	0.96	Contact Map
3hzrA	2	0.2898	13.1	0.962	Contact Map
3i05A	2	0.2415	8.8	0.965	Contact Map
3focA	4	0.2926	8.8	0.965	Contact Map
3tzeA	2	0.2756	7.7	0.966	Contact Map
2zhjA	2	0.696	7.7	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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