GREMLIN Database
VATE - V-type ATP synthase subunit E
UniProt: Q9HNE0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (184)
Sequences: 758 (545)
Seq/√Len: 40.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_D28_R4.2601.00
137_I141_Y3.9021.00
126_G134_I3.7601.00
28_R31_E3.3781.00
106_R140_D3.2461.00
102_E136_E3.2341.00
77_A80_D3.0391.00
37_E41_D2.9401.00
109_L124_V2.9101.00
97_D100_E2.7341.00
17_R20_E2.5691.00
22_R26_D2.4321.00
92_R95_A2.4161.00
112_A158_V2.3571.00
88_A91_D2.2261.00
30_D34_A2.1700.99
131_E135_S2.1360.99
33_V37_E2.0490.99
14_A18_A1.9790.99
8_E11_R1.9640.99
26_D30_D1.8840.98
173_S176_A1.8760.98
23_A27_E1.7970.98
101_R171_F1.7720.98
152_C172_D1.6710.96
91_D98_G1.6670.96
103_E106_R1.6490.96
152_C170_T1.6240.96
143_G146_Y1.6060.96
88_A92_R1.5670.95
184_K187_S1.5420.94
93_I133_L1.5240.94
138_L142_D1.5160.94
128_A132_A1.4700.93
59_R62_Q1.4560.93
104_L108_L1.4540.92
185_A188_A1.3960.91
101_R130_D1.3940.91
124_V156_V1.3590.90
83_Q87_S1.3530.89
35_E39_D1.3490.89
70_A169_N1.3450.89
71_K174_I1.3200.88
121_T161_D1.3180.88
154_G169_N1.2810.87
143_G158_V1.2640.86
66_A85_V1.2630.86
125_F159_E1.2530.85
75_L192_D1.2470.85
15_R19_K1.2310.84
97_D129_D1.2290.84
82_L86_R1.2280.84
168_N173_S1.2250.84
169_N174_I1.2190.84
78_R81_A1.2190.84
55_I62_Q1.2140.84
123_R147_A1.1960.83
123_R145_E1.1870.82
78_R142_D1.1750.82
87_S128_A1.1730.81
87_S91_D1.1700.81
170_T181_N1.1600.81
20_E24_D1.1580.81
23_A40_A1.1530.80
12_D41_D1.1400.80
128_A131_E1.1370.79
98_G103_E1.1370.79
106_R110_D1.1350.79
85_V179_W1.1280.79
16_E19_K1.1260.79
65_S68_L1.1250.79
93_I145_E1.1220.78
131_E146_Y1.1180.78
25_A29_A1.1050.77
121_T160_S1.1050.77
66_A182_N1.1030.77
134_I142_D1.0960.77
85_V182_N1.0940.77
132_A135_S1.0860.76
20_E31_E1.0800.76
26_D29_A1.0770.76
43_I47_A1.0760.75
16_E30_D1.0750.75
77_A81_A1.0640.75
44_I48_E1.0630.75
31_E35_E1.0610.74
118_G122_V1.0490.74
84_S87_S1.0460.73
19_K35_E1.0450.73
103_E107_E1.0380.73
17_R21_I1.0040.70
61_Q190_L1.0020.70
135_S146_Y1.0010.70
12_D15_R1.0010.70
69_E80_D0.9940.69
138_L141_Y0.9880.69
182_N185_A0.9780.68
86_R179_W0.9760.68
10_I14_A0.9760.68
145_E148_G0.9740.68
131_E144_Y0.9710.68
30_D33_V0.9690.67
34_A38_A0.9660.67
84_S89_V0.9650.67
34_A49_A0.9580.67
98_G129_D0.9490.66
22_R33_V0.9450.65
131_E136_E0.9420.65
15_R18_A0.9360.65
116_F174_I0.9310.64
84_S88_A0.9230.64
38_A41_D0.9220.64
24_D31_E0.9210.63
92_R120_D0.9130.63
20_E35_E0.9070.62
120_D161_D0.9040.62
20_E27_E0.9030.62
39_D45_A0.9010.62
13_E16_E0.8990.62
34_A37_E0.8950.61
25_A28_R0.8930.61
49_A52_T0.8890.61
52_T56_D0.8850.60
112_A167_V0.8780.60
22_R50_E0.8650.59
78_R82_L0.8540.58
68_L171_F0.8440.57
95_A132_A0.8430.57
168_N179_W0.8390.56
110_D141_Y0.8390.56
63_L81_A0.8220.55
68_L78_R0.8170.54
69_E72_Q0.8160.54
109_L156_V0.8130.54
128_A150_Y0.8120.54
8_E15_R0.8120.54
131_E173_S0.8080.53
125_F145_E0.8080.53
26_D46_D0.8070.53
46_D50_E0.8060.53
10_I75_L0.8050.53
85_V131_E0.8040.53
13_E52_T0.7980.52
44_I62_Q0.7940.52
76_E181_N0.7920.52
38_A115_E0.7890.52
109_L134_I0.7850.51
9_D13_E0.7780.51
126_G156_V0.7770.51
71_K79_R0.7680.50
18_A33_V0.7670.50
43_I46_D0.7670.50
33_V52_T0.7660.50
19_K26_D0.7650.49
44_I187_S0.7640.49
19_K22_R0.7620.49
131_E161_D0.7590.49
113_S129_D0.7550.49
39_D171_F0.7520.48
20_E28_R0.7420.47
95_A99_D0.7370.47
81_A190_L0.7360.47
123_R152_C0.7220.46
114_T165_I0.7210.45
98_G132_A0.7190.45
16_E52_T0.7140.45
17_R174_I0.7140.45
142_D183_L0.7090.44
8_E73_M0.7070.44
10_I66_A0.7040.44
31_E49_A0.7020.44
23_A34_A0.7000.44
156_V174_I0.6920.43
123_R159_E0.6920.43
112_A145_E0.6910.43
144_Y185_A0.6860.42
10_I146_Y0.6840.42
134_I137_I0.6840.42
99_D132_A0.6810.42
9_D12_D0.6770.41
139_D186_I0.6710.41
73_M76_E0.6700.41
45_A49_A0.6700.41
91_D129_D0.6690.41
31_E62_Q0.6690.41
169_N184_K0.6690.41
71_K150_Y0.6690.41
15_R129_D0.6680.41
44_I55_I0.6630.40
16_E45_A0.6630.40
147_A166_R0.6610.40
89_V163_S0.6550.40
81_A84_S0.6530.39
24_D48_E0.6490.39
111_A115_E0.6470.39
9_D14_A0.6440.39
74_R92_R0.6410.38
23_A39_D0.6400.38
112_A116_F0.6370.38
21_I28_R0.6360.38
105_T170_T0.6320.38
51_V56_D0.6300.37
158_V161_D0.6290.37
86_R90_E0.6260.37
95_A128_A0.6260.37
51_V55_I0.6220.37
121_T143_G0.6190.36
47_A71_K0.6180.36
149_E170_T0.6150.36
23_A26_D0.6120.36
83_Q164_R0.6120.36
126_G167_V0.6120.36
9_D55_I0.6110.36
10_I23_A0.6110.36
14_A41_D0.6110.36
157_V168_N0.6090.36
147_A163_S0.6090.36
18_A181_N0.6080.35
90_E179_W0.6080.35
40_A61_Q0.6050.35
53_A103_E0.6020.35
54_E63_L0.5970.35
158_V182_N0.5970.35
9_D15_R0.5960.34
45_A56_D0.5920.34
99_D156_V0.5900.34
131_E138_L0.5890.34
17_R40_A0.5880.34
22_R183_L0.5860.34
121_T162_A0.5820.33
149_E152_C0.5810.33
65_S77_A0.5810.33
70_A159_E0.5660.32
100_E107_E0.5660.32
84_S162_A0.5620.32
39_D55_I0.5600.32
125_F128_A0.5600.32
133_L158_V0.5580.31
110_D128_A0.5580.31
84_S94_V0.5540.31
117_D171_F0.5530.31
41_D45_A0.5500.31
84_S135_S0.5500.31
99_D131_E0.5490.31
92_R104_L0.5480.31
72_Q154_G0.5460.30
126_G130_D0.5430.30
35_E38_A0.5400.30
9_D179_W0.5380.30
62_Q109_L0.5380.30
159_E187_S0.5360.30
108_L114_T0.5330.29
160_S182_N0.5310.29
56_D61_Q0.5300.29
77_A152_C0.5280.29
68_L72_Q0.5270.29
118_G190_L0.5250.29
111_A169_N0.5230.29
91_D95_A0.5220.29
14_A40_A0.5210.29
123_R160_S0.5190.28
61_Q152_C0.5160.28
11_R14_A0.5140.28
125_F148_G0.5120.28
168_N186_I0.5120.28
98_G147_A0.5110.28
21_I31_E0.5110.28
113_S122_V0.5090.28
48_E71_K0.5090.28
151_D166_R0.5060.27
104_L162_A0.5030.27
63_L86_R0.5030.27
67_E158_V0.5020.27
134_I138_L0.5020.27
103_E109_L0.5010.27
147_A150_Y0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4efaE 1 0.9795 100 0.295 Contact Map
2dm9A 2 0.5744 100 0.317 Contact Map
3v6iA 1 0.9538 100 0.325 Contact Map
3lg8A 1 0.4821 99.9 0.544 Contact Map
2kk7A 1 0.241 97.7 0.827 Contact Map
1l2pA 1 0.3128 94.3 0.876 Contact Map
4efaG 1 0.4769 78.7 0.906 Contact Map
2wssS 1 0.7231 76.6 0.908 Contact Map
3v6iB 1 0.4667 67.5 0.914 Contact Map
2k6iA 1 0.2256 27.4 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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