GREMLIN Database
Q9HND6 - Membrane protein
UniProt: Q9HND6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (181)
Sequences: 24428 (17962)
Seq/√Len: 1335.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_R78_H3.0101.00
86_P106_F2.8501.00
63_C81_G2.7351.00
142_R189_Y2.7071.00
80_Y119_F2.5921.00
135_V186_E2.4581.00
62_G127_S2.3631.00
140_E143_R2.2621.00
92_A104_F2.2501.00
59_L119_F2.2481.00
82_L107_G2.1891.00
141_L151_V2.1821.00
120_D146_K2.1791.00
89_L104_F2.1361.00
69_T79_V2.1051.00
145_A149_S2.0941.00
80_Y105_H2.0761.00
122_V141_L1.9891.00
86_P90_T1.9801.00
74_K99_H1.9751.00
78_H103_A1.9681.00
89_L106_F1.9561.00
114_F119_F1.9211.00
24_K85_S1.8371.00
91_K94_E1.8081.00
56_D121_V1.7891.00
70_E96_F1.7841.00
134_P183_M1.7781.00
135_V139_R1.7621.00
61_V141_L1.7451.00
53_D56_D1.6971.00
96_F104_F1.6841.00
181_D185_R1.6561.00
57_R80_Y1.6511.00
24_K87_H1.6451.00
122_V145_A1.6421.00
83_D89_L1.6401.00
140_E144_V1.6311.00
34_N37_I1.6241.00
61_V109_A1.6181.00
133_H136_Q1.5671.00
135_V183_M1.5491.00
145_A151_V1.5311.00
58_V72_L1.5301.00
70_E95_K1.5271.00
87_H90_T1.4821.00
63_C69_T1.4691.00
58_V121_V1.4681.00
84_Q108_D1.4651.00
89_L93_W1.4561.00
57_R146_K1.4451.00
57_R120_D1.4241.00
69_T81_G1.4151.00
80_Y103_A1.4131.00
182_R186_E1.4081.00
124_S127_S1.3771.00
176_D179_E1.3421.00
116_P143_R1.3231.00
57_R119_F1.3131.00
71_G74_K1.3071.00
107_G113_P1.2931.00
127_S131_W1.2821.00
138_L184_F1.2691.00
31_D95_K1.2561.00
136_Q139_R1.2391.00
109_A127_S1.2301.00
131_W137_G1.2091.00
108_D111_R1.2091.00
145_A189_Y1.1771.00
73_L101_P1.1721.00
31_D65_T1.1601.00
129_E155_G1.1521.00
105_H114_F1.1371.00
90_T93_W1.1281.00
59_L122_V1.1021.00
96_F102_V1.0821.00
55_E77_E1.0751.00
135_V187_A1.0721.00
71_G75_H1.0641.00
115_K118_S1.0621.00
57_R118_S1.0611.00
181_D194_H1.0511.00
126_G129_E1.0471.00
122_V144_V1.0461.00
62_G124_S1.0461.00
113_P140_E1.0461.00
44_A48_S1.0301.00
142_R187_A1.0161.00
82_L112_L1.0161.00
137_G141_L1.0071.00
110_E133_H1.0061.00
182_R185_R1.0031.00
63_C92_A0.9981.00
70_E99_H0.9871.00
56_D77_E0.9871.00
94_E98_K0.9831.00
81_G104_F0.9821.00
112_L140_E0.9691.00
45_E48_S0.9611.00
46_A152_L0.9501.00
93_W97_G0.9501.00
126_G130_Y0.9441.00
49_M195_R0.9421.00
60_D63_C0.9371.00
70_E74_K0.9361.00
68_G125_S0.9351.00
82_L105_H0.9331.00
39_T42_M0.9321.00
85_S88_Q0.9321.00
167_L170_A0.9271.00
23_Y130_Y0.9171.00
39_T43_R0.9141.00
139_R187_A0.9131.00
168_A171_I0.9071.00
90_T94_E0.9041.00
109_A131_W0.8941.00
81_G92_A0.8941.00
47_L75_H0.8931.00
112_L144_V0.8871.00
41_E44_A0.8841.00
45_E49_M0.8741.00
128_I131_W0.8681.00
58_V123_W0.8661.00
68_G123_W0.8641.00
179_E182_R0.8631.00
44_A71_G0.8611.00
126_G156_P0.8601.00
83_D88_Q0.8561.00
23_Y129_E0.8541.00
38_W42_M0.8531.00
134_P175_Y0.8431.00
166_K170_A0.8361.00
65_T88_Q0.8351.00
80_Y114_F0.8321.00
56_D120_D0.8271.00
118_S146_K0.8241.00
94_E97_G0.8231.00
69_T102_V0.8181.00
91_K95_K0.8161.00
97_G100_D0.8101.00
114_F144_V0.8051.00
130_Y155_G0.8031.00
125_S154_V0.7981.00
58_V79_V0.7971.00
162_T166_K0.7971.00
29_V32_R0.7951.00
67_F71_G0.7941.00
139_R143_R0.7891.00
52_I56_D0.7881.00
40_E44_A0.7881.00
111_R136_Q0.7811.00
126_G154_V0.7781.00
69_T104_F0.7681.00
59_L144_V0.7621.00
163_V171_I0.7511.00
141_L145_A0.7471.00
87_H91_K0.7461.00
45_E195_R0.7431.00
129_E156_P0.7381.00
136_Q140_E0.7381.00
172_M175_Y0.7361.00
128_I138_L0.7351.00
138_L187_A0.7341.00
20_R24_K0.7311.00
38_W41_E0.7291.00
66_G92_A0.7281.00
63_C83_D0.7281.00
28_K91_K0.7251.00
72_L123_W0.7221.00
161_S165_R0.7181.00
107_G112_L0.7171.00
21_T25_Y0.7141.00
95_K99_H0.7101.00
49_M193_Q0.6951.00
177_E181_D0.6931.00
164_F168_A0.6931.00
44_A75_H0.6911.00
27_S88_Q0.6911.00
177_E196_V0.6891.00
121_V150_Q0.6891.00
164_F170_A0.6881.00
183_M187_A0.6821.00
93_W103_A0.6801.00
121_V149_S0.6721.00
128_I137_G0.6691.00
167_L171_I0.6691.00
163_V169_D0.6681.00
96_F100_D0.6671.00
128_I153_V0.6671.00
138_L180_A0.6641.00
43_R47_L0.6601.00
20_R106_F0.6591.00
151_V184_F0.6581.00
95_K98_K0.6481.00
29_V33_V0.6461.00
57_R77_E0.6461.00
166_K169_D0.6421.00
42_M46_A0.6401.00
57_R117_D0.6381.00
67_F95_K0.6381.00
161_S164_F0.6341.00
24_K86_P0.6311.00
58_V77_E0.6261.00
66_G104_F0.6241.00
62_G84_Q0.6211.00
155_G180_A0.6201.00
191_E194_H0.6151.00
61_V82_L0.6151.00
96_F99_H0.6081.00
162_T165_R0.6071.00
20_R84_Q0.6061.00
158_Y176_D0.6031.00
40_E43_R0.6031.00
116_P144_V0.6021.00
42_M45_E0.5951.00
128_I155_G0.5941.00
39_T46_A0.5931.00
70_E73_L0.5931.00
164_F169_D0.5911.00
65_T95_K0.5901.00
61_V122_V0.5891.00
165_R168_A0.5881.00
119_F144_V0.5841.00
124_S131_W0.5791.00
112_L119_F0.5791.00
86_P93_W0.5781.00
19_A23_Y0.5761.00
48_S75_H0.5751.00
157_D196_V0.5731.00
60_D130_Y0.5711.00
63_C104_F0.5701.00
76_T79_V0.5691.00
114_F118_S0.5671.00
93_W104_F0.5641.00
163_V167_L0.5601.00
60_D123_W0.5591.00
138_L183_M0.5591.00
73_L102_V0.5581.00
178_D181_D0.5531.00
43_R46_A0.5491.00
110_E137_G0.5411.00
178_D182_R0.5411.00
116_P140_E0.5401.00
28_K87_H0.5401.00
84_Q106_F0.5361.00
31_D91_K0.5351.00
63_C89_L0.5351.00
124_S153_V0.5291.00
53_D77_E0.5291.00
88_Q126_G0.5291.00
156_P172_M0.5251.00
68_G72_L0.5241.00
151_V189_Y0.5241.00
60_D79_V0.5241.00
117_D146_K0.5191.00
89_L92_A0.5171.00
124_S141_L0.5151.00
60_D81_G0.5141.00
160_A163_V0.5141.00
184_F187_A0.5131.00
163_V170_A0.5121.00
161_S166_K0.5101.00
60_D82_L0.5081.00
117_D147_P0.5061.00
118_S144_V0.5061.00
51_D150_Q0.5051.00
93_W96_F0.5051.00
183_M186_E0.5051.00
111_R140_E0.5051.00
163_V168_A0.5021.00
40_E71_G0.5021.00
70_E104_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pneA 2 0.9725 100 0.368 Contact Map
4obxA 2 0.8532 100 0.373 Contact Map
2o57A 2 0.9495 100 0.39 Contact Map
3ujcA 1 0.922 100 0.397 Contact Map
3busA 1 0.8532 100 0.398 Contact Map
3bkxA 2 0.9174 100 0.398 Contact Map
1vl5A 1 0.8211 100 0.401 Contact Map
1xxlA 1 0.8257 100 0.401 Contact Map
3hemA 2 0.9404 100 0.401 Contact Map
3l8dA 2 0.8303 100 0.401 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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