GREMLIN Database
Q9HND4 - Uncharacterized protein
UniProt: Q9HND4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (344)
Sequences: 191 (171)
Seq/√Len: 9.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
312_D339_S3.0750.92
317_E355_R2.9300.90
347_L367_I2.8690.89
341_A345_Q2.8510.89
176_V371_G2.6770.85
354_G361_I2.5940.83
361_I368_S2.5920.83
343_V346_V2.5630.83
312_D359_L2.5250.82
358_K367_I2.5190.81
55_V157_V2.4940.81
343_V347_L2.4900.81
339_S359_L2.4810.80
336_T343_V2.3870.78
340_T361_I2.3790.77
336_T346_V2.3020.75
347_L358_K2.2870.74
333_V348_S2.2840.74
312_D347_L2.2540.73
312_D336_T2.2440.73
332_I343_V2.2210.72
87_F123_R2.2010.71
105_V118_V2.1750.70
332_I367_I2.1690.70
314_E341_A2.1660.70
123_R140_L2.1270.69
339_S347_L2.1040.68
351_D359_L2.0690.66
339_S358_K2.0240.65
332_I336_T2.0170.64
341_A370_P2.0080.64
336_T339_S1.9970.64
179_P182_Y1.9730.63
347_L359_L1.9630.62
359_L367_I1.9550.62
85_T234_A1.9480.61
330_S366_L1.9080.60
189_P200_W1.9060.60
332_I359_L1.8910.59
312_D358_K1.8900.59
312_D343_V1.8590.58
311_S341_A1.8500.57
312_D367_I1.8240.56
336_T347_L1.8110.56
245_A249_S1.7890.55
332_I347_L1.7730.54
200_W328_K1.7560.53
84_S336_T1.7450.53
343_V359_L1.7420.53
306_D327_M1.7410.53
326_R338_W1.7230.52
339_S367_I1.7210.52
332_I358_K1.7170.52
327_M348_S1.7160.51
336_T359_L1.6830.50
339_S351_D1.6790.50
330_S340_T1.6570.49
172_Q336_T1.6460.48
343_V366_L1.6100.47
123_R346_V1.6050.47
118_V345_Q1.6050.47
228_A239_G1.5920.46
312_D351_D1.5510.44
182_Y314_E1.5450.44
152_N233_A1.5400.44
172_Q367_I1.5400.44
308_E328_K1.5380.44
332_I339_S1.5330.43
330_S339_S1.5240.43
148_A200_W1.5220.43
72_G353_D1.5220.43
148_A157_V1.5200.43
312_D346_V1.5200.43
336_T367_I1.5190.43
69_Y101_F1.5130.43
311_S314_E1.5090.42
351_D366_L1.5090.42
350_M359_L1.5080.42
230_T248_Y1.4800.41
94_A155_I1.4780.41
339_S343_V1.4760.41
332_I346_V1.4620.40
25_G55_V1.4610.40
312_D332_I1.4580.40
330_S359_L1.4570.40
332_I366_L1.4500.40
141_R242_G1.4360.39
333_V347_L1.4300.39
279_S282_P1.4240.39
123_R343_V1.4180.39
101_F164_W1.4150.38
84_S346_V1.3990.38
340_T345_Q1.3770.37
330_S351_D1.3650.36
101_F140_L1.3630.36
172_Q343_V1.3590.36
172_Q346_V1.3550.36
345_Q361_I1.3340.35
339_S346_V1.3290.35
336_T366_L1.3250.35
13_C16_A1.3220.35
235_A245_A1.3200.35
359_L366_L1.3030.34
341_A361_I1.3030.34
140_L373_G1.2950.34
49_V157_V1.2940.34
84_S343_V1.2930.34
312_D330_S1.2920.33
343_V358_K1.2910.33
113_G244_T1.2890.33
346_V359_L1.2820.33
339_S350_M1.2800.33
327_M336_T1.2800.33
236_V299_E1.2760.33
123_R368_S1.2750.33
53_V61_A1.2740.33
216_V352_E1.2710.33
343_V367_I1.2630.32
73_D210_E1.2600.32
172_Q359_L1.2500.32
347_L351_D1.2420.32
123_R359_L1.2420.32
282_P293_G1.2330.31
160_F358_K1.2320.31
314_E340_T1.2170.31
179_P361_I1.2170.31
97_S100_T1.2150.31
339_S366_L1.2030.30
316_V326_R1.1980.30
316_V338_W1.1940.30
97_S101_F1.1890.30
244_T289_P1.1860.29
336_T358_K1.1850.29
311_S345_Q1.1810.29
312_D348_S1.1780.29
57_D155_I1.1770.29
172_Q358_K1.1770.29
224_T242_G1.1590.28
358_K366_L1.1580.28
233_A243_V1.1570.28
93_S346_V1.1520.28
314_E370_P1.1520.28
198_Y211_P1.1520.28
326_R363_R1.1400.28
309_L360_R1.1360.28
15_V20_G1.1360.28
347_L350_M1.1340.28
311_S370_P1.1220.27
72_G354_G1.1200.27
113_G146_N1.1120.27
14_L20_G1.1110.27
316_V328_K1.1000.26
123_R336_T1.0990.26
153_E177_R1.0900.26
172_Q339_S1.0840.26
343_V351_D1.0840.26
215_F356_V1.0790.26
314_E345_Q1.0740.26
121_V341_A1.0690.25
312_D366_L1.0650.25
123_R312_D1.0600.25
172_Q312_D1.0540.25
108_A373_G1.0510.25
312_D350_M1.0480.25
333_V358_K1.0430.24
13_C18_P1.0430.24
106_P183_Q1.0410.24
189_P211_P1.0370.24
115_E246_W1.0330.24
14_L300_R1.0200.24
236_V274_G1.0190.24
45_P240_A1.0170.24
340_T351_D1.0140.24
176_V239_G1.0090.23
120_D227_P1.0080.23
44_G94_A1.0050.23
112_V120_D0.9980.23
357_E370_P0.9980.23
96_F328_K0.9960.23
160_F165_F0.9950.23
234_A318_R0.9900.23
123_R351_D0.9860.23
93_S350_M0.9790.22
327_M339_S0.9790.22
137_V352_E0.9760.22
328_K361_I0.9690.22
328_K351_D0.9690.22
21_A24_S0.9690.22
68_T345_Q0.9680.22
333_V337_R0.9650.22
346_V350_M0.9640.22
172_Q332_I0.9640.22
14_L23_G0.9620.22
298_A301_E0.9580.22
177_R231_V0.9580.22
330_S336_T0.9570.22
63_W340_T0.9560.22
340_T347_L0.9560.22
336_T348_S0.9550.22
244_T249_S0.9530.22
93_S343_V0.9510.22
291_D298_A0.9490.22
68_T139_T0.9480.22
123_R339_S0.9430.21
235_A292_G0.9410.21
101_F346_V0.9410.21
332_I351_D0.9360.21
101_F366_L0.9330.21
159_A314_E0.9320.21
323_N332_I0.9270.21
163_S302_D0.9260.21
184_A374_V0.9260.21
348_S358_K0.9230.21
20_G254_T0.9190.21
137_V146_N0.9190.21
330_S346_V0.9180.21
85_T285_D0.9140.21
160_F359_L0.9020.20
275_D287_P0.9000.20
69_Y140_L0.8980.20
210_E354_G0.8960.20
306_D359_L0.8930.20
63_W137_V0.8910.20
340_T366_L0.8910.20
101_F343_V0.8890.20
345_Q370_P0.8880.20
315_R350_M0.8860.20
333_V340_T0.8850.20
336_T351_D0.8810.20
343_V350_M0.8810.20
173_Q188_S0.8770.19
338_W363_R0.8770.19
351_D367_I0.8760.19
317_E330_S0.8750.19
71_L77_S0.8710.19
323_N336_T0.8700.19
113_G228_A0.8660.19
47_S198_Y0.8650.19
141_R356_V0.8650.19
71_L241_A0.8640.19
330_S341_A0.8600.19
88_E105_V0.8590.19
351_D361_I0.8570.19
69_Y341_A0.8530.19
178_P215_F0.8520.19
13_C22_G0.8510.19
89_A237_V0.8420.19
236_V322_D0.8420.19
62_H233_A0.8400.18
160_F367_I0.8380.18
87_F359_L0.8370.18
330_S347_L0.8350.18
91_E278_E0.8350.18
148_A328_K0.8330.18
179_P314_E0.8320.18
323_N327_M0.8310.18
341_A357_E0.8310.18
182_Y361_I0.8300.18
341_A366_L0.8280.18
84_S312_D0.8270.18
123_R172_Q0.8260.18
127_I184_A0.8250.18
14_L18_P0.8250.18
274_G279_S0.8240.18
227_P243_V0.8220.18
349_G374_V0.8220.18
156_T218_S0.8170.18
180_E298_A0.8140.18
47_S97_S0.8140.18
97_S164_W0.8130.18
336_T350_M0.8130.18
164_W333_V0.8120.18
37_M42_G0.8100.18
20_G23_G0.8090.18
350_M358_K0.8090.18
101_F336_T0.8090.18
87_F339_S0.8060.18
345_Q357_E0.8060.18
87_F312_D0.8050.18
53_V143_T0.8050.18
55_V247_A0.8040.18
66_S87_F0.8020.18
172_Q347_L0.7980.17
343_V348_S0.7950.17
113_G234_A0.7920.17
87_F140_L0.7910.17
354_G375_D0.7860.17
330_S367_I0.7850.17
361_I370_P0.7810.17
251_S298_A0.7790.17
143_T359_L0.7750.17
60_D192_N0.7750.17
347_L366_L0.7740.17
95_G203_G0.7720.17
101_F345_Q0.7720.17
160_F339_S0.7720.17
15_V252_T0.7720.17
118_V341_A0.7700.17
66_S140_L0.7680.17
93_S336_T0.7660.17
351_D358_K0.7650.17
45_P170_A0.7650.17
160_F345_Q0.7620.17
60_D340_T0.7620.17
179_P366_L0.7590.16
309_L341_A0.7580.16
13_C19_V0.7560.16
50_D199_Q0.7550.16
306_D348_S0.7550.16
22_G208_A0.7490.16
316_V335_E0.7490.16
178_P359_L0.7480.16
295_D299_E0.7470.16
362_G365_N0.7440.16
35_T73_D0.7440.16
73_D353_D0.7420.16
237_V283_T0.7410.16
123_R350_M0.7390.16
312_D327_M0.7380.16
197_A236_V0.7380.16
232_G354_G0.7360.16
115_E214_V0.7360.16
89_A239_G0.7360.16
46_Q366_L0.7340.16
55_V154_T0.7330.16
22_G232_G0.7330.16
240_A245_A0.7330.16
218_S237_V0.7320.16
203_G345_Q0.7300.16
327_M368_S0.7300.16
326_R342_K0.7250.16
361_I366_L0.7230.16
93_S172_Q0.7210.16
287_P354_G0.7210.16
150_V328_K0.7210.16
19_V26_H0.7200.16
346_V366_L0.7180.15
83_V331_R0.7180.15
138_L345_Q0.7150.15
296_S302_D0.7150.15
65_V92_T0.7140.15
314_E366_L0.7130.15
21_A294_D0.7130.15
123_R332_I0.7080.15
113_G183_Q0.7070.15
328_K338_W0.7040.15
81_D198_Y0.7030.15
85_T282_P0.7000.15
93_S332_I0.7000.15
59_G150_V0.6990.15
84_S339_S0.6980.15
236_V257_G0.6980.15
224_T354_G0.6970.15
255_L285_D0.6970.15
308_E361_I0.6960.15
87_F373_G0.6960.15
80_F343_V0.6920.15
180_E232_G0.6910.15
14_L21_A0.6890.15
53_V323_N0.6880.15
89_A284_A0.6870.15
250_R276_G0.6860.15
119_T157_V0.6820.15
296_S303_E0.6810.15
87_F358_K0.6790.15
191_T350_M0.6780.15
17_V24_S0.6770.15
314_E317_E0.6750.15
121_V345_Q0.6750.15
237_V278_E0.6750.15
24_S27_G0.6740.14
84_S347_L0.6720.14
17_V26_H0.6700.14
123_R347_L0.6650.14
179_P357_E0.6610.14
55_V290_D0.6610.14
231_V285_D0.6600.14
118_V121_V0.6600.14
182_Y341_A0.6590.14
200_W211_P0.6580.14
201_E355_R0.6570.14
65_V345_Q0.6560.14
74_G102_K0.6550.14
236_V294_D0.6500.14
346_V367_I0.6490.14
283_T299_E0.6470.14
354_G368_S0.6460.14
36_A254_T0.6460.14
356_V361_I0.6450.14
150_V246_W0.6430.14
90_G164_W0.6430.14
330_S358_K0.6430.14
53_V185_D0.6420.14
178_P339_S0.6410.14
126_R281_A0.6380.14
97_S366_L0.6340.14
338_W360_R0.6340.14
179_P341_A0.6330.14
121_V138_L0.6330.14
360_R363_R0.6330.14
223_G244_T0.6320.14
340_T370_P0.6320.14
118_V138_L0.6270.13
120_D195_G0.6270.13
178_P312_D0.6260.13
295_D300_R0.6250.13
330_S343_V0.6250.13
317_E341_A0.6240.13
160_F347_L0.6240.13
80_F346_V0.6210.13
308_E356_V0.6210.13
309_L328_K0.6210.13
160_F209_D0.6210.13
225_G240_A0.6190.13
97_S211_P0.6170.13
346_V351_D0.6140.13
81_D256_P0.6140.13
300_R371_G0.6110.13
157_V160_F0.6070.13
178_P351_D0.6040.13
226_I233_A0.6040.13
16_A241_A0.6020.13
160_F312_D0.6010.13
75_N249_S0.6010.13
230_T352_E0.6000.13
146_N295_D0.5980.13
319_L323_N0.5980.13
87_F317_E0.5930.13
14_L34_T0.5920.13
97_S137_V0.5880.13
231_V287_P0.5870.13
163_S341_A0.5830.13
338_W342_K0.5780.13
304_R357_E0.5760.12
19_V298_A0.5760.12
314_E371_G0.5760.12
339_S348_S0.5750.12
200_W351_D0.5720.12
327_M358_K0.5720.12
53_V130_H0.5710.12
151_D235_A0.5710.12
90_G101_F0.5700.12
73_D235_A0.5700.12
357_E361_I0.5690.12
229_T368_S0.5680.12
178_P183_Q0.5680.12
197_A233_A0.5680.12
18_P28_P0.5680.12
340_T348_S0.5670.12
50_D367_I0.5670.12
366_L370_P0.5650.12
306_D323_N0.5640.12
255_L288_E0.5620.12
130_H352_E0.5620.12
326_R360_R0.5600.12
187_V208_A0.5590.12
326_R359_L0.5590.12
82_R85_T0.5590.12
323_N359_L0.5530.12
34_T74_G0.5530.12
273_T285_D0.5520.12
25_G28_P0.5510.12
101_F330_S0.5500.12
55_V215_F0.5500.12
80_F123_R0.5480.12
69_Y340_T0.5460.12
230_T237_V0.5450.12
227_P253_L0.5450.12
333_V353_D0.5430.12
230_T293_G0.5410.12
200_W214_V0.5390.12
317_E345_Q0.5380.12
179_P345_Q0.5380.12
19_V25_G0.5360.12
80_F172_Q0.5350.12
69_Y345_Q0.5340.12
330_S345_Q0.5330.12
14_L22_G0.5330.12
118_V182_Y0.5320.12
314_E330_S0.5320.12
119_T124_A0.5310.12
333_V343_V0.5310.12
237_V241_A0.5310.12
197_A226_I0.5280.12
16_A242_G0.5250.12
334_E356_V0.5240.12
229_T240_A0.5240.12
71_L222_S0.5240.12
64_N197_A0.5220.11
193_V332_I0.5200.11
71_L280_P0.5200.11
236_V288_E0.5200.11
14_L19_V0.5180.11
32_A39_A0.5180.11
140_L368_S0.5180.11
107_G299_E0.5160.11
353_D356_V0.5150.11
58_T281_A0.5150.11
176_V289_P0.5140.11
63_W71_L0.5140.11
327_M346_V0.5130.11
137_V140_L0.5110.11
241_A248_Y0.5090.11
316_V363_R0.5080.11
277_G294_D0.5070.11
104_A169_R0.5060.11
23_G35_T0.5060.11
284_A289_P0.5050.11
59_G148_A0.5050.11
174_L202_G0.5040.11
111_R285_D0.5040.11
182_Y366_L0.5030.11
239_G281_A0.5030.11
109_S117_S0.5030.11
245_A248_Y0.5020.11
309_L345_Q0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qgpA 1 0.1835 96.7 0.946 Contact Map
2mlgA 1 0.1912 96.4 0.948 Contact Map
1q1hA 1 0.2067 96.2 0.949 Contact Map
2lnbA 1 0.2067 96.2 0.949 Contact Map
1p6rA 1 0.2016 96 0.949 Contact Map
4kmfA 1 0.1602 96 0.95 Contact Map
1qbjA 1 0.1602 95.9 0.95 Contact Map
2g9wA 2 0.2067 95.5 0.951 Contact Map
1xmkA 1 0.2016 95.4 0.952 Contact Map
1tbxA 3 0.199 95.3 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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