Q9HND2 - HALSA - GREMLIN Contacts

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Q9HND2 - Electron transfer flavoprotein subunit alpha

UniProt:	Q9HND2	Sequences: MSVLAVADHRRGELRGVSFELLTAGRELADAMDTELHAAVVSGDTDGFADELNRAGVDHVHAVEHGAEFNHDVYVQAVAALAGDLDAAVVLTPNSVNGLDYAPAVATRTGRTYVSDAIGLDHGDTLEVTREMYGSKVETTMEVSDGPYVVSIRGAEWPAAEGVGDAEISTFDADIDEDAIGATVNGFEEVGGGDVDIADAEFLVSVGRGIEEEENIALIEALAETTGATLSSSRPIVDNGWLAKNRQVGQSGKQVTPDVYLAVGISGAVQHVAGMKGADTIIAVNTDPNAPIFDIADYGIVGDLFDVVPALIEEFGGEAPSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	322 (305)
Sequences:	4048 (2434)
Seq/√Len:	139.3

ECOLI - YDIR FIXB YGCQ
BACSU - ETFA
HALSA - Q9HND2
SULSO - Q97V19 Q97V72

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
302_G	307_V	5.071	1.00
293_F	299_G	3.602	1.00
263_V	284_V	3.406	1.00
201_E	258_D	3.252	1.00
205_S	265_I	3.232	1.00
92_T	102_A	3.160	1.00
59_H	169_S	2.836	1.00
203_L	255_V	2.607	1.00
37_H	61_H	2.596	1.00
206_V	216_I	2.580	1.00
263_V	308_V	2.526	1.00
25_G	36_L	2.516	1.00
24_A	27_E	2.471	1.00
225_T	312_I	2.419	1.00
23_T	160_A	2.408	1.00
82_A	90_V	2.252	1.00
46_D	170_T	2.128	1.00
7_A	18_S	2.117	1.00
43_G	64_E	2.101	1.00
26_R	30_D	2.096	1.00
242_L	246_R	2.070	1.00
217_A	220_E	2.053	1.00
7_A	38_A	2.050	1.00
217_A	221_A	2.027	1.00
53_N	166_A	2.025	1.00
221_A	312_I	2.005	1.00
206_V	219_I	1.968	1.00
272_V	295_I	1.938	1.00
232_S	242_L	1.929	1.00
21_L	91_L	1.913	1.00
7_A	14_L	1.912	1.00
233_S	265_I	1.904	1.00
283_A	296_A	1.893	1.00
280_T	298_Y	1.887	1.00
35_E	59_H	1.885	1.00
117_A	150_V	1.879	1.00
202_F	228_A	1.878	1.00
220_E	230_L	1.876	1.00
259_V	282_I	1.858	1.00
222_L	312_I	1.852	1.00
43_G	67_A	1.808	1.00
219_I	263_V	1.768	1.00
263_V	304_L	1.761	1.00
75_V	108_R	1.761	1.00
205_S	262_A	1.754	1.00
222_L	308_V	1.749	1.00
215_N	305_F	1.746	1.00
210_I	219_I	1.743	1.00
59_H	167_E	1.738	1.00
79_A	108_R	1.725	1.00
205_S	248_V	1.712	1.00
129_T	138_E	1.705	1.00
283_A	292_I	1.692	1.00
119_G	129_T	1.683	1.00
260_Y	271_H	1.682	1.00
258_D	279_D	1.662	1.00
37_H	87_A	1.643	1.00
44_D	64_E	1.639	1.00
79_A	105_V	1.630	1.00
255_V	275_M	1.624	1.00
43_G	66_G	1.621	1.00
161_E	164_G	1.603	1.00
196_D	199_D	1.597	1.00
204_V	222_L	1.591	1.00
275_M	278_A	1.578	1.00
203_L	231_S	1.572	1.00
222_L	226_T	1.568	1.00
197_I	203_L	1.557	1.00
84_D	171_F	1.556	1.00
46_D	50_D	1.539	1.00
310_A	313_E	1.534	1.00
70_N	73_V	1.514	1.00
121_D	129_T	1.485	1.00
216_I	230_L	1.465	1.00
79_A	83_G	1.448	1.00
91_L	150_V	1.443	1.00
102_A	151_S	1.436	1.00
37_H	58_D	1.435	1.00
243_A	246_R	1.424	1.00
114_V	143_V	1.423	1.00
26_R	58_D	1.402	1.00
232_S	236_I	1.367	1.00
3_V	25_G	1.359	1.00
71_H	100_D	1.354	1.00
21_L	93_P	1.352	1.00
194_D	224_E	1.330	1.00
61_H	171_F	1.328	1.00
220_E	224_E	1.326	1.00
262_A	265_I	1.313	1.00
218_L	308_V	1.302	1.00
221_A	225_T	1.298	1.00
17_V	93_P	1.288	1.00
78_V	105_V	1.288	1.00
225_T	315_F	1.282	1.00
8_D	95_S	1.280	1.00
105_V	149_V	1.270	1.00
51_E	54_R	1.265	1.00
47_G	50_D	1.264	1.00
300_I	307_V	1.257	1.00
80_A	84_D	1.249	1.00
80_A	83_G	1.244	1.00
212_E	241_W	1.242	1.00
74_Y	101_Y	1.239	1.00
262_A	271_H	1.239	1.00
35_E	58_D	1.237	1.00
22_L	57_V	1.234	1.00
218_L	221_A	1.229	1.00
118_I	129_T	1.229	1.00
81_L	171_F	1.218	1.00
306_D	310_A	1.216	1.00
310_A	314_E	1.209	1.00
232_S	237_V	1.208	1.00
20_E	155_A	1.208	1.00
54_R	161_E	1.205	1.00
88_A	147_P	1.205	1.00
210_I	215_N	1.195	1.00
63_V	77_A	1.195	1.00
53_N	164_G	1.193	1.00
210_I	304_L	1.184	1.00
6_V	101_Y	1.177	1.00
54_R	162_G	1.174	1.00
116_D	153_R	1.165	0.99
206_V	236_I	1.159	0.99
7_A	52_L	1.153	0.99
62_A	170_T	1.153	0.99
233_S	248_V	1.152	0.99
40_V	48_F	1.149	0.99
231_S	248_V	1.137	0.99
39_A	78_V	1.136	0.99
198_A	253_K	1.132	0.99
205_S	255_V	1.131	0.99
216_I	236_I	1.128	0.99
205_S	233_S	1.117	0.99
4_L	81_L	1.115	0.99
132_M	137_V	1.115	0.99
117_A	152_I	1.114	0.99
9_H	48_F	1.099	0.99
41_V	77_A	1.091	0.99
308_V	312_I	1.075	0.99
27_E	119_G	1.067	0.99
118_I	138_E	1.063	0.99
53_N	60_V	1.063	0.99
18_S	38_A	1.061	0.99
45_T	62_A	1.057	0.99
248_V	262_A	1.057	0.99
218_L	312_I	1.055	0.99
85_L	169_S	1.052	0.99
223_A	230_L	1.044	0.99
64_E	170_T	1.042	0.99
122_H	125_T	1.039	0.99
293_F	301_V	1.035	0.99
5_A	22_L	1.034	0.99
214_E	217_A	1.032	0.99
14_L	19_F	1.030	0.99
235_P	239_N	1.030	0.99
213_E	242_L	1.027	0.99
121_D	140_T	1.027	0.99
49_A	168_I	1.024	0.99
68_E	187_F	1.017	0.99
26_R	36_L	1.001	0.98
80_A	174_D	1.001	0.98
224_E	227_G	0.992	0.98
28_L	91_L	0.992	0.98
176_D	179_A	0.990	0.98
75_V	105_V	0.988	0.98
61_H	85_L	0.985	0.98
184_V	187_F	0.984	0.98
209_G	241_W	0.983	0.98
50_D	54_R	0.982	0.98
284_V	307_V	0.979	0.98
83_G	86_D	0.978	0.98
82_A	109_T	0.976	0.98
205_S	231_S	0.974	0.98
164_G	167_E	0.973	0.98
38_A	52_L	0.973	0.98
37_H	59_H	0.972	0.98
41_V	74_Y	0.969	0.98
206_V	210_I	0.968	0.98
256_T	277_G	0.962	0.98
109_T	149_V	0.962	0.98
46_D	64_E	0.953	0.98
304_L	309_P	0.952	0.98
78_V	101_Y	0.950	0.98
6_V	78_V	0.948	0.98
237_V	247_Q	0.946	0.98
211_E	305_F	0.943	0.98
113_Y	149_V	0.943	0.98
231_S	246_R	0.942	0.98
48_F	51_E	0.940	0.98
206_V	242_L	0.940	0.98
76_Q	179_A	0.939	0.98
49_A	53_N	0.937	0.98
69_F	74_Y	0.933	0.97
124_D	142_E	0.933	0.97
60_V	166_A	0.931	0.97
302_G	306_D	0.918	0.97
75_V	104_A	0.911	0.97
124_D	148_Y	0.907	0.97
216_I	242_L	0.907	0.97
99_L	116_D	0.904	0.97
197_I	231_S	0.904	0.97
79_A	109_T	0.902	0.97
53_N	161_E	0.899	0.97
76_Q	176_D	0.899	0.97
261_L	284_V	0.895	0.97
61_H	169_S	0.890	0.97
114_V	117_A	0.889	0.97
76_Q	80_A	0.887	0.97
215_N	218_L	0.886	0.97
219_I	230_L	0.878	0.96
112_T	143_V	0.874	0.96
104_A	108_R	0.872	0.96
163_V	166_A	0.870	0.96
236_I	241_W	0.863	0.96
229_T	246_R	0.862	0.96
102_A	113_Y	0.858	0.96
117_A	120_L	0.856	0.96
236_I	242_L	0.855	0.96
125_T	142_E	0.854	0.96
111_R	149_V	0.851	0.96
84_D	169_S	0.848	0.96
73_V	180_I	0.846	0.96
212_E	215_N	0.845	0.95
45_T	48_F	0.840	0.95
26_R	55_A	0.838	0.95
22_L	160_A	0.838	0.95
175_I	180_I	0.836	0.95
112_T	145_D	0.834	0.95
19_F	51_E	0.831	0.95
42_S	45_T	0.829	0.95
85_L	171_F	0.825	0.95
216_I	219_I	0.823	0.95
197_I	253_K	0.820	0.95
113_Y	151_S	0.820	0.95
45_T	64_E	0.815	0.95
94_N	116_D	0.812	0.94
11_R	45_T	0.812	0.94
154_G	254_Q	0.807	0.94
221_A	230_L	0.807	0.94
210_I	216_I	0.807	0.94
218_L	263_V	0.804	0.94
10_R	15_R	0.800	0.94
54_R	163_V	0.795	0.94
39_A	81_L	0.791	0.94
218_L	309_P	0.789	0.94
30_D	35_E	0.786	0.93
53_N	168_I	0.786	0.93
209_G	215_N	0.785	0.93
92_T	151_S	0.779	0.93
20_E	159_A	0.777	0.93
143_V	148_Y	0.769	0.93
210_I	213_E	0.767	0.93
94_N	98_G	0.765	0.92
51_E	55_A	0.764	0.92
4_L	39_A	0.762	0.92
126_L	150_V	0.759	0.92
203_L	229_T	0.758	0.92
88_A	146_G	0.758	0.92
72_D	181_G	0.755	0.92
106_A	113_Y	0.753	0.92
69_F	100_D	0.748	0.92
257_P	278_A	0.747	0.92
4_L	85_L	0.745	0.91
22_L	38_A	0.739	0.91
8_D	15_R	0.739	0.91
50_D	53_N	0.739	0.91
129_T	140_T	0.737	0.91
30_D	36_L	0.737	0.91
238_D	247_Q	0.734	0.91
7_A	40_V	0.733	0.91
19_F	55_A	0.733	0.91
14_L	48_F	0.730	0.91
9_H	18_S	0.727	0.90
25_G	91_L	0.726	0.90
38_A	57_V	0.723	0.90
61_H	81_L	0.718	0.90
209_G	213_E	0.718	0.90
10_R	13_E	0.718	0.90
6_V	38_A	0.713	0.90
275_M	295_I	0.711	0.89
213_E	241_W	0.704	0.89
25_G	29_A	0.704	0.89
6_V	18_S	0.698	0.89
17_V	95_S	0.696	0.88
58_D	164_G	0.696	0.88
5_A	91_L	0.695	0.88
24_A	157_W	0.694	0.88
292_I	299_G	0.692	0.88
71_H	104_A	0.687	0.88
233_S	272_V	0.685	0.88
261_L	282_I	0.682	0.87
98_G	101_Y	0.678	0.87
210_I	241_W	0.671	0.87
262_A	292_I	0.668	0.86
49_A	60_V	0.665	0.86
272_V	294_D	0.664	0.86
216_I	232_S	0.658	0.85
82_A	147_P	0.657	0.85
233_S	262_A	0.657	0.85
255_V	278_A	0.656	0.85
206_V	232_S	0.651	0.85
19_F	159_A	0.649	0.85
210_I	305_F	0.648	0.85
16_G	199_D	0.648	0.85
3_V	28_L	0.648	0.85
210_I	218_L	0.644	0.84
83_G	147_P	0.644	0.84
47_G	51_E	0.642	0.84
76_Q	175_I	0.642	0.84
225_T	228_A	0.640	0.84
131_E	153_R	0.637	0.84
92_T	105_V	0.637	0.84
69_F	101_Y	0.635	0.83
74_Y	97_N	0.635	0.83
82_A	87_A	0.635	0.83
212_E	305_F	0.633	0.83
204_V	230_L	0.631	0.83
102_A	105_V	0.631	0.83
70_N	184_V	0.631	0.83
208_R	235_P	0.630	0.83
143_V	146_G	0.629	0.83
68_E	184_V	0.629	0.83
280_T	297_D	0.627	0.83
6_V	90_V	0.627	0.83
57_V	60_V	0.624	0.82
248_V	275_M	0.620	0.82
46_D	62_A	0.620	0.82
153_R	250_Q	0.617	0.82
209_G	218_L	0.615	0.81
13_E	51_E	0.615	0.81
83_G	109_T	0.613	0.81
6_V	92_T	0.613	0.81
113_Y	117_A	0.610	0.81
4_L	90_V	0.609	0.81
92_T	98_G	0.608	0.81
29_A	36_L	0.605	0.80
3_V	91_L	0.603	0.80
77_A	80_A	0.603	0.80
40_V	60_V	0.600	0.80
205_S	271_H	0.600	0.80
226_T	261_L	0.598	0.80
5_A	21_L	0.596	0.79
173_A	176_D	0.594	0.79
216_I	250_Q	0.593	0.79
75_V	79_A	0.591	0.79
213_E	217_A	0.590	0.79
42_S	64_E	0.589	0.79
204_V	225_T	0.587	0.78
126_L	148_Y	0.585	0.78
194_D	197_I	0.584	0.78
213_E	220_E	0.583	0.78
134_G	153_R	0.581	0.78
53_N	57_V	0.581	0.78
13_E	48_F	0.580	0.78
12_G	45_T	0.579	0.77
260_Y	265_I	0.578	0.77
195_V	203_L	0.578	0.77
55_A	161_E	0.578	0.77
6_V	74_Y	0.577	0.77
16_G	20_E	0.576	0.77
52_L	60_V	0.575	0.77
215_N	221_A	0.575	0.77
202_F	227_G	0.574	0.77
206_V	263_V	0.574	0.77
307_V	310_A	0.574	0.77
65_H	175_I	0.573	0.77
41_V	78_V	0.573	0.77
82_A	149_V	0.570	0.76
222_L	225_T	0.570	0.76
3_V	36_L	0.567	0.76
303_D	306_D	0.566	0.76
99_L	115_S	0.565	0.76
69_F	97_N	0.564	0.76
121_D	124_D	0.564	0.76
109_T	147_P	0.562	0.75
204_V	226_T	0.562	0.75
6_V	9_H	0.562	0.75
130_R	270_Q	0.561	0.75
238_D	244_K	0.561	0.75
49_A	62_A	0.559	0.75
272_V	275_M	0.558	0.75
80_A	171_F	0.557	0.75
205_S	260_Y	0.557	0.75
63_V	81_L	0.557	0.75
196_D	253_K	0.556	0.75
3_V	35_E	0.555	0.74
112_T	139_T	0.555	0.74
80_A	175_I	0.555	0.74
17_V	20_E	0.553	0.74
220_E	228_A	0.553	0.74
265_I	278_A	0.552	0.74
81_L	84_D	0.550	0.74
78_V	82_A	0.550	0.74
111_R	145_D	0.550	0.74
49_A	166_A	0.549	0.74
114_V	228_A	0.547	0.73
5_A	18_S	0.544	0.73
234_R	247_Q	0.542	0.73
210_I	308_V	0.542	0.73
26_R	29_A	0.542	0.73
205_S	275_M	0.541	0.73
104_A	107_T	0.541	0.73
122_H	142_E	0.540	0.72
298_Y	305_F	0.539	0.72
219_I	248_V	0.538	0.72
283_A	293_F	0.538	0.72
308_V	315_F	0.537	0.72
233_S	286_T	0.537	0.72
204_V	308_V	0.537	0.72
81_L	85_L	0.536	0.72
251_S	269_V	0.536	0.72
190_V	288_P	0.535	0.72
162_G	175_I	0.534	0.72
17_V	154_G	0.534	0.72
23_T	26_R	0.530	0.71
255_V	295_I	0.530	0.71
24_A	152_I	0.530	0.71
188_E	191_G	0.530	0.71
19_F	52_L	0.525	0.70
41_V	63_V	0.525	0.70
288_P	291_P	0.524	0.70
202_F	258_D	0.523	0.70
212_E	236_I	0.522	0.70
76_Q	101_Y	0.522	0.70
59_H	85_L	0.520	0.70
90_V	149_V	0.520	0.70
36_L	57_V	0.520	0.70
195_V	229_T	0.519	0.69
209_G	304_L	0.518	0.69
57_V	166_A	0.518	0.69
209_G	233_S	0.517	0.69
305_F	308_V	0.516	0.69
206_V	230_L	0.515	0.69
130_R	141_M	0.515	0.69
110_G	145_D	0.515	0.69
275_M	292_I	0.514	0.69
244_K	248_V	0.513	0.69
76_Q	180_I	0.513	0.69
83_G	144_S	0.513	0.69
19_F	161_E	0.512	0.68
65_H	172_D	0.512	0.68
37_H	41_V	0.512	0.68
161_E	166_A	0.511	0.68
210_I	236_I	0.511	0.68
97_N	101_Y	0.510	0.68
50_D	165_D	0.510	0.68
90_V	147_P	0.509	0.68
89_V	120_L	0.509	0.68
230_L	246_R	0.506	0.68
9_H	40_V	0.505	0.67
205_S	232_S	0.505	0.67
107_T	277_G	0.505	0.67
23_T	159_A	0.505	0.67
165_D	168_I	0.505	0.67
73_V	76_Q	0.504	0.67
106_A	149_V	0.503	0.67
44_D	50_D	0.501	0.67
215_N	241_W	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l2iA	1	0.9938	100	0.047	Contact Map
1o97D	1	0.9565	100	0.075	Contact Map
1efvA	1	0.9565	100	0.078	Contact Map
1efpA	1	0.941	100	0.086	Contact Map
3ih5A	6	0.6025	100	0.647	Contact Map
3fetA	2	0.5	99.9	0.734	Contact Map
1o97C	1	0.6553	99.9	0.747	Contact Map
4l2iB	1	0.6801	99.9	0.748	Contact Map
1efvB	1	0.6584	99.9	0.749	Contact Map
1efpB	1	0.6398	99.9	0.754	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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