GREMLIN Database
Q9HND2 - Electron transfer flavoprotein subunit alpha
UniProt: Q9HND2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (305)
Sequences: 4048 (2434)
Seq/√Len: 139.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_G307_V5.0711.00
293_F299_G3.6021.00
263_V284_V3.4061.00
201_E258_D3.2521.00
205_S265_I3.2321.00
92_T102_A3.1601.00
59_H169_S2.8361.00
203_L255_V2.6071.00
37_H61_H2.5961.00
206_V216_I2.5801.00
263_V308_V2.5261.00
25_G36_L2.5161.00
24_A27_E2.4711.00
225_T312_I2.4191.00
23_T160_A2.4081.00
82_A90_V2.2521.00
46_D170_T2.1281.00
7_A18_S2.1171.00
43_G64_E2.1011.00
26_R30_D2.0961.00
242_L246_R2.0701.00
217_A220_E2.0531.00
7_A38_A2.0501.00
217_A221_A2.0271.00
53_N166_A2.0251.00
221_A312_I2.0051.00
206_V219_I1.9681.00
272_V295_I1.9381.00
232_S242_L1.9291.00
21_L91_L1.9131.00
7_A14_L1.9121.00
233_S265_I1.9041.00
283_A296_A1.8931.00
280_T298_Y1.8871.00
35_E59_H1.8851.00
117_A150_V1.8791.00
202_F228_A1.8781.00
220_E230_L1.8761.00
259_V282_I1.8581.00
222_L312_I1.8521.00
43_G67_A1.8081.00
219_I263_V1.7681.00
263_V304_L1.7611.00
75_V108_R1.7611.00
205_S262_A1.7541.00
222_L308_V1.7491.00
215_N305_F1.7461.00
210_I219_I1.7431.00
59_H167_E1.7381.00
79_A108_R1.7251.00
205_S248_V1.7121.00
129_T138_E1.7051.00
283_A292_I1.6921.00
119_G129_T1.6831.00
260_Y271_H1.6821.00
258_D279_D1.6621.00
37_H87_A1.6431.00
44_D64_E1.6391.00
79_A105_V1.6301.00
255_V275_M1.6241.00
43_G66_G1.6211.00
161_E164_G1.6031.00
196_D199_D1.5971.00
204_V222_L1.5911.00
275_M278_A1.5781.00
203_L231_S1.5721.00
222_L226_T1.5681.00
197_I203_L1.5571.00
84_D171_F1.5561.00
46_D50_D1.5391.00
310_A313_E1.5341.00
70_N73_V1.5141.00
121_D129_T1.4851.00
216_I230_L1.4651.00
79_A83_G1.4481.00
91_L150_V1.4431.00
102_A151_S1.4361.00
37_H58_D1.4351.00
243_A246_R1.4241.00
114_V143_V1.4231.00
26_R58_D1.4021.00
232_S236_I1.3671.00
3_V25_G1.3591.00
71_H100_D1.3541.00
21_L93_P1.3521.00
194_D224_E1.3301.00
61_H171_F1.3281.00
220_E224_E1.3261.00
262_A265_I1.3131.00
218_L308_V1.3021.00
221_A225_T1.2981.00
17_V93_P1.2881.00
78_V105_V1.2881.00
225_T315_F1.2821.00
8_D95_S1.2801.00
105_V149_V1.2701.00
51_E54_R1.2651.00
47_G50_D1.2641.00
300_I307_V1.2571.00
80_A84_D1.2491.00
80_A83_G1.2441.00
212_E241_W1.2421.00
74_Y101_Y1.2391.00
262_A271_H1.2391.00
35_E58_D1.2371.00
22_L57_V1.2341.00
218_L221_A1.2291.00
118_I129_T1.2291.00
81_L171_F1.2181.00
306_D310_A1.2161.00
310_A314_E1.2091.00
232_S237_V1.2081.00
20_E155_A1.2081.00
54_R161_E1.2051.00
88_A147_P1.2051.00
210_I215_N1.1951.00
63_V77_A1.1951.00
53_N164_G1.1931.00
210_I304_L1.1841.00
6_V101_Y1.1771.00
54_R162_G1.1741.00
116_D153_R1.1650.99
206_V236_I1.1590.99
7_A52_L1.1530.99
62_A170_T1.1530.99
233_S248_V1.1520.99
40_V48_F1.1490.99
231_S248_V1.1370.99
39_A78_V1.1360.99
198_A253_K1.1320.99
205_S255_V1.1310.99
216_I236_I1.1280.99
205_S233_S1.1170.99
4_L81_L1.1150.99
132_M137_V1.1150.99
117_A152_I1.1140.99
9_H48_F1.0990.99
41_V77_A1.0910.99
308_V312_I1.0750.99
27_E119_G1.0670.99
118_I138_E1.0630.99
53_N60_V1.0630.99
18_S38_A1.0610.99
45_T62_A1.0570.99
248_V262_A1.0570.99
218_L312_I1.0550.99
85_L169_S1.0520.99
223_A230_L1.0440.99
64_E170_T1.0420.99
122_H125_T1.0390.99
293_F301_V1.0350.99
5_A22_L1.0340.99
214_E217_A1.0320.99
14_L19_F1.0300.99
235_P239_N1.0300.99
213_E242_L1.0270.99
121_D140_T1.0270.99
49_A168_I1.0240.99
68_E187_F1.0170.99
26_R36_L1.0010.98
80_A174_D1.0010.98
224_E227_G0.9920.98
28_L91_L0.9920.98
176_D179_A0.9900.98
75_V105_V0.9880.98
61_H85_L0.9850.98
184_V187_F0.9840.98
209_G241_W0.9830.98
50_D54_R0.9820.98
284_V307_V0.9790.98
83_G86_D0.9780.98
82_A109_T0.9760.98
205_S231_S0.9740.98
164_G167_E0.9730.98
38_A52_L0.9730.98
37_H59_H0.9720.98
41_V74_Y0.9690.98
206_V210_I0.9680.98
256_T277_G0.9620.98
109_T149_V0.9620.98
46_D64_E0.9530.98
304_L309_P0.9520.98
78_V101_Y0.9500.98
6_V78_V0.9480.98
237_V247_Q0.9460.98
211_E305_F0.9430.98
113_Y149_V0.9430.98
231_S246_R0.9420.98
48_F51_E0.9400.98
206_V242_L0.9400.98
76_Q179_A0.9390.98
49_A53_N0.9370.98
69_F74_Y0.9330.97
124_D142_E0.9330.97
60_V166_A0.9310.97
302_G306_D0.9180.97
75_V104_A0.9110.97
124_D148_Y0.9070.97
216_I242_L0.9070.97
99_L116_D0.9040.97
197_I231_S0.9040.97
79_A109_T0.9020.97
53_N161_E0.8990.97
76_Q176_D0.8990.97
261_L284_V0.8950.97
61_H169_S0.8900.97
114_V117_A0.8890.97
76_Q80_A0.8870.97
215_N218_L0.8860.97
219_I230_L0.8780.96
112_T143_V0.8740.96
104_A108_R0.8720.96
163_V166_A0.8700.96
236_I241_W0.8630.96
229_T246_R0.8620.96
102_A113_Y0.8580.96
117_A120_L0.8560.96
236_I242_L0.8550.96
125_T142_E0.8540.96
111_R149_V0.8510.96
84_D169_S0.8480.96
73_V180_I0.8460.96
212_E215_N0.8450.95
45_T48_F0.8400.95
26_R55_A0.8380.95
22_L160_A0.8380.95
175_I180_I0.8360.95
112_T145_D0.8340.95
19_F51_E0.8310.95
42_S45_T0.8290.95
85_L171_F0.8250.95
216_I219_I0.8230.95
197_I253_K0.8200.95
113_Y151_S0.8200.95
45_T64_E0.8150.95
94_N116_D0.8120.94
11_R45_T0.8120.94
154_G254_Q0.8070.94
221_A230_L0.8070.94
210_I216_I0.8070.94
218_L263_V0.8040.94
10_R15_R0.8000.94
54_R163_V0.7950.94
39_A81_L0.7910.94
218_L309_P0.7890.94
30_D35_E0.7860.93
53_N168_I0.7860.93
209_G215_N0.7850.93
92_T151_S0.7790.93
20_E159_A0.7770.93
143_V148_Y0.7690.93
210_I213_E0.7670.93
94_N98_G0.7650.92
51_E55_A0.7640.92
4_L39_A0.7620.92
126_L150_V0.7590.92
203_L229_T0.7580.92
88_A146_G0.7580.92
72_D181_G0.7550.92
106_A113_Y0.7530.92
69_F100_D0.7480.92
257_P278_A0.7470.92
4_L85_L0.7450.91
22_L38_A0.7390.91
8_D15_R0.7390.91
50_D53_N0.7390.91
129_T140_T0.7370.91
30_D36_L0.7370.91
238_D247_Q0.7340.91
7_A40_V0.7330.91
19_F55_A0.7330.91
14_L48_F0.7300.91
9_H18_S0.7270.90
25_G91_L0.7260.90
38_A57_V0.7230.90
61_H81_L0.7180.90
209_G213_E0.7180.90
10_R13_E0.7180.90
6_V38_A0.7130.90
275_M295_I0.7110.89
213_E241_W0.7040.89
25_G29_A0.7040.89
6_V18_S0.6980.89
17_V95_S0.6960.88
58_D164_G0.6960.88
5_A91_L0.6950.88
24_A157_W0.6940.88
292_I299_G0.6920.88
71_H104_A0.6870.88
233_S272_V0.6850.88
261_L282_I0.6820.87
98_G101_Y0.6780.87
210_I241_W0.6710.87
262_A292_I0.6680.86
49_A60_V0.6650.86
272_V294_D0.6640.86
216_I232_S0.6580.85
82_A147_P0.6570.85
233_S262_A0.6570.85
255_V278_A0.6560.85
206_V232_S0.6510.85
19_F159_A0.6490.85
210_I305_F0.6480.85
16_G199_D0.6480.85
3_V28_L0.6480.85
210_I218_L0.6440.84
83_G147_P0.6440.84
47_G51_E0.6420.84
76_Q175_I0.6420.84
225_T228_A0.6400.84
131_E153_R0.6370.84
92_T105_V0.6370.84
69_F101_Y0.6350.83
74_Y97_N0.6350.83
82_A87_A0.6350.83
212_E305_F0.6330.83
204_V230_L0.6310.83
102_A105_V0.6310.83
70_N184_V0.6310.83
208_R235_P0.6300.83
143_V146_G0.6290.83
68_E184_V0.6290.83
280_T297_D0.6270.83
6_V90_V0.6270.83
57_V60_V0.6240.82
248_V275_M0.6200.82
46_D62_A0.6200.82
153_R250_Q0.6170.82
209_G218_L0.6150.81
13_E51_E0.6150.81
83_G109_T0.6130.81
6_V92_T0.6130.81
113_Y117_A0.6100.81
4_L90_V0.6090.81
92_T98_G0.6080.81
29_A36_L0.6050.80
3_V91_L0.6030.80
77_A80_A0.6030.80
40_V60_V0.6000.80
205_S271_H0.6000.80
226_T261_L0.5980.80
5_A21_L0.5960.79
173_A176_D0.5940.79
216_I250_Q0.5930.79
75_V79_A0.5910.79
213_E217_A0.5900.79
42_S64_E0.5890.79
204_V225_T0.5870.78
126_L148_Y0.5850.78
194_D197_I0.5840.78
213_E220_E0.5830.78
134_G153_R0.5810.78
53_N57_V0.5810.78
13_E48_F0.5800.78
12_G45_T0.5790.77
260_Y265_I0.5780.77
195_V203_L0.5780.77
55_A161_E0.5780.77
6_V74_Y0.5770.77
16_G20_E0.5760.77
52_L60_V0.5750.77
215_N221_A0.5750.77
202_F227_G0.5740.77
206_V263_V0.5740.77
307_V310_A0.5740.77
65_H175_I0.5730.77
41_V78_V0.5730.77
82_A149_V0.5700.76
222_L225_T0.5700.76
3_V36_L0.5670.76
303_D306_D0.5660.76
99_L115_S0.5650.76
69_F97_N0.5640.76
121_D124_D0.5640.76
109_T147_P0.5620.75
204_V226_T0.5620.75
6_V9_H0.5620.75
130_R270_Q0.5610.75
238_D244_K0.5610.75
49_A62_A0.5590.75
272_V275_M0.5580.75
80_A171_F0.5570.75
205_S260_Y0.5570.75
63_V81_L0.5570.75
196_D253_K0.5560.75
3_V35_E0.5550.74
112_T139_T0.5550.74
80_A175_I0.5550.74
17_V20_E0.5530.74
220_E228_A0.5530.74
265_I278_A0.5520.74
81_L84_D0.5500.74
78_V82_A0.5500.74
111_R145_D0.5500.74
49_A166_A0.5490.74
114_V228_A0.5470.73
5_A18_S0.5440.73
234_R247_Q0.5420.73
210_I308_V0.5420.73
26_R29_A0.5420.73
205_S275_M0.5410.73
104_A107_T0.5410.73
122_H142_E0.5400.72
298_Y305_F0.5390.72
219_I248_V0.5380.72
283_A293_F0.5380.72
308_V315_F0.5370.72
233_S286_T0.5370.72
204_V308_V0.5370.72
81_L85_L0.5360.72
251_S269_V0.5360.72
190_V288_P0.5350.72
162_G175_I0.5340.72
17_V154_G0.5340.72
23_T26_R0.5300.71
255_V295_I0.5300.71
24_A152_I0.5300.71
188_E191_G0.5300.71
19_F52_L0.5250.70
41_V63_V0.5250.70
288_P291_P0.5240.70
202_F258_D0.5230.70
212_E236_I0.5220.70
76_Q101_Y0.5220.70
59_H85_L0.5200.70
90_V149_V0.5200.70
36_L57_V0.5200.70
195_V229_T0.5190.69
209_G304_L0.5180.69
57_V166_A0.5180.69
209_G233_S0.5170.69
305_F308_V0.5160.69
206_V230_L0.5150.69
130_R141_M0.5150.69
110_G145_D0.5150.69
275_M292_I0.5140.69
244_K248_V0.5130.69
76_Q180_I0.5130.69
83_G144_S0.5130.69
19_F161_E0.5120.68
65_H172_D0.5120.68
37_H41_V0.5120.68
161_E166_A0.5110.68
210_I236_I0.5110.68
97_N101_Y0.5100.68
50_D165_D0.5100.68
90_V147_P0.5090.68
89_V120_L0.5090.68
230_L246_R0.5060.68
9_H40_V0.5050.67
205_S232_S0.5050.67
107_T277_G0.5050.67
23_T159_A0.5050.67
165_D168_I0.5050.67
73_V76_Q0.5040.67
106_A149_V0.5030.67
44_D50_D0.5010.67
215_N241_W0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l2iA 1 0.9938 100 0.047 Contact Map
1o97D 1 0.9565 100 0.075 Contact Map
1efvA 1 0.9565 100 0.078 Contact Map
1efpA 1 0.941 100 0.086 Contact Map
3ih5A 6 0.6025 100 0.647 Contact Map
3fetA 2 0.5 99.9 0.734 Contact Map
1o97C 1 0.6553 99.9 0.747 Contact Map
4l2iB 1 0.6801 99.9 0.748 Contact Map
1efvB 1 0.6584 99.9 0.749 Contact Map
1efpB 1 0.6398 99.9 0.754 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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