GREMLIN Database
Q9HND0 - Putative isopentenyl pyrophosphate isomerase
UniProt: Q9HND0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (266)
Sequences: 9711 (6453)
Seq/√Len: 395.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_C81_A3.4231.00
199_D202_A3.2521.00
190_E207_G3.1311.00
106_E116_A2.9871.00
186_R207_G2.8461.00
169_T172_E2.4841.00
186_R211_E2.3931.00
107_L112_A2.3631.00
178_R211_E2.3521.00
236_P239_V2.3351.00
147_C190_E2.2911.00
190_E203_V2.2781.00
133_E136_A2.2321.00
229_D232_A2.1461.00
262_L273_A2.1111.00
147_C194_I2.1101.00
291_L294_F2.1041.00
102_I159_E2.0501.00
256_P287_Y2.0451.00
50_V206_F2.0341.00
193_A206_F2.0311.00
212_R295_V2.0261.00
262_L265_E1.9751.00
144_A191_L1.9511.00
189_A210_A1.8891.00
50_V189_A1.8891.00
119_G122_P1.8821.00
175_E179_R1.8711.00
143_R203_V1.8371.00
276_E281_D1.8371.00
14_R83_D1.8241.00
14_R86_V1.7621.00
252_T287_Y1.7561.00
259_L281_D1.7271.00
54_A202_A1.7251.00
252_T284_A1.7111.00
204_E208_E1.7081.00
98_V127_S1.6761.00
208_E212_R1.6341.00
170_E252_T1.6271.00
98_V128_D1.5981.00
136_A150_D1.5721.00
187_A191_L1.5681.00
159_E162_E1.5571.00
122_P160_A1.5491.00
261_R265_E1.5381.00
140_R146_E1.5331.00
223_V288_L1.5161.00
239_V243_L1.5121.00
139_S145_M1.5021.00
283_E286_D1.5001.00
168_E172_E1.5001.00
14_R17_E1.4981.00
51_C56_G1.4921.00
83_D140_R1.4851.00
105_S239_V1.4791.00
286_D289_Q1.4781.00
193_A198_A1.4531.00
49_L52_E1.4511.00
32_E36_L1.4391.00
97_V114_A1.4381.00
198_A202_A1.4331.00
161_I175_E1.4301.00
16_T32_E1.4201.00
143_R146_E1.4201.00
262_L266_Q1.4181.00
12_E41_R1.4041.00
186_R190_E1.3721.00
265_E269_R1.3641.00
95_S155_L1.3611.00
228_A233_L1.3551.00
257_D260_N1.3521.00
173_Y177_A1.3501.00
230_S237_A1.3471.00
286_D290_Y1.3461.00
264_G268_E1.3401.00
192_G196_A1.3251.00
146_E150_D1.3181.00
258_A262_L1.3071.00
219_I288_L1.3011.00
273_A276_E1.2921.00
90_L137_L1.2871.00
37_A111_S1.2831.00
290_Y294_F1.2811.00
101_I120_Y1.2801.00
200_G204_E1.2681.00
260_N264_G1.2681.00
143_R200_G1.2671.00
13_Q17_E1.2611.00
230_S236_P1.2591.00
280_P285_K1.2351.00
48_V85_A1.2351.00
26_E164_V1.2241.00
184_L188_A1.2131.00
290_Y293_E1.2091.00
54_A196_A1.2051.00
178_R215_V1.1851.00
143_R194_I1.1661.00
30_Q114_A1.1641.00
270_A273_A1.1631.00
26_E119_G1.1601.00
258_A261_R1.1551.00
144_A195_A1.1531.00
34_V114_A1.1491.00
279_L284_A1.1471.00
87_G138_F1.1451.00
252_T255_S1.1401.00
165_A176_L1.1371.00
50_V54_A1.1331.00
224_L233_L1.1251.00
84_Y191_L1.1211.00
33_H117_E1.1181.00
154_E179_R1.1131.00
28_G32_E1.1101.00
48_V82_L1.0971.00
287_Y290_Y1.0951.00
84_Y144_A1.0941.00
255_S287_Y1.0911.00
202_A205_R1.0881.00
252_T256_P1.0841.00
271_L275_A1.0731.00
183_A186_R1.0731.00
189_A206_F1.0641.00
54_A192_G1.0621.00
261_R264_G1.0611.00
272_G275_A1.0591.00
175_E178_R1.0591.00
284_A287_Y1.0531.00
170_E255_S1.0501.00
161_I176_L1.0491.00
223_V227_T1.0461.00
147_C187_A1.0411.00
47_T88_V1.0381.00
253_D279_L1.0371.00
223_V254_R1.0351.00
161_I179_R1.0241.00
177_A215_V1.0241.00
38_G41_R1.0211.00
46_L189_A1.0211.00
12_E15_I1.0201.00
10_A78_G1.0141.00
223_V289_Q1.0121.00
13_Q16_T1.0111.00
112_A116_A1.0071.00
26_E29_D1.0071.00
51_C196_A1.0041.00
10_A82_L1.0021.00
226_A249_V0.9981.00
201_R205_R0.9921.00
190_E194_I0.9901.00
115_W120_Y0.9891.00
170_E291_L0.9891.00
10_A79_E0.9871.00
173_Y251_V0.9831.00
193_A203_V0.9821.00
57_A78_G0.9801.00
14_R18_A0.9781.00
9_A12_E0.9741.00
102_I125_V0.9741.00
84_Y138_F0.9711.00
56_G78_G0.9701.00
285_K289_Q0.9691.00
48_V81_A0.9671.00
16_T36_L0.9661.00
275_A280_P0.9651.00
174_M178_R0.9561.00
151_S187_A0.9551.00
170_E174_M0.9541.00
57_A80_D0.9491.00
223_V285_K0.9461.00
291_L295_V0.9441.00
47_T81_A0.9401.00
54_A198_A0.9351.00
188_A192_G0.9341.00
226_A241_E0.9301.00
272_G276_E0.9181.00
113_S116_A0.9171.00
107_L230_S0.9131.00
57_A79_E0.9091.00
18_A83_D0.9071.00
138_F144_A0.9061.00
101_I124_I0.9061.00
282_G285_K0.9041.00
136_A153_V0.9031.00
215_V295_V0.9021.00
220_R292_A0.8981.00
165_A172_E0.8981.00
166_R246_P0.8951.00
167_P244_D0.8941.00
176_L245_R0.8871.00
41_R44_P0.8821.00
90_L133_E0.8791.00
279_L282_G0.8721.00
9_A13_Q0.8721.00
84_Y195_A0.8711.00
44_P93_N0.8701.00
189_A209_Y0.8691.00
233_L237_A0.8661.00
11_I86_V0.8621.00
259_L282_G0.8591.00
8_R12_E0.8581.00
94_A131_L0.8561.00
273_A277_L0.8551.00
114_A117_E0.8541.00
31_L130_L0.8541.00
253_D284_A0.8531.00
190_E204_E0.8531.00
112_A117_E0.8511.00
10_A13_Q0.8441.00
162_E245_R0.8431.00
174_M215_V0.8431.00
11_I15_I0.8411.00
12_E16_T0.8391.00
147_C150_D0.8341.00
260_N263_A0.8221.00
104_R120_Y0.8211.00
161_I165_A0.8191.00
170_E287_Y0.8191.00
31_L129_G0.8191.00
29_D33_H0.8161.00
186_R210_A0.8141.00
289_Q293_E0.8141.00
97_V123_G0.8131.00
248_I288_L0.8101.00
52_E78_G0.8061.00
208_E211_E0.8061.00
111_S117_E0.8011.00
136_A140_R0.7921.00
227_T260_N0.7911.00
56_G81_A0.7891.00
46_L213_V0.7871.00
18_A140_R0.7851.00
164_V168_E0.7821.00
139_S146_E0.7821.00
205_R209_Y0.7821.00
53_A206_F0.7811.00
43_R217_F0.7801.00
204_E207_G0.7791.00
86_V137_L0.7791.00
228_A232_A0.7701.00
106_E115_W0.7681.00
224_L228_A0.7661.00
211_E215_V0.7561.00
33_H111_S0.7541.00
203_V207_G0.7491.00
18_A137_L0.7481.00
91_V148_V0.7471.00
26_E122_P0.7471.00
194_I203_V0.7461.00
257_D261_R0.7451.00
95_S184_L0.7441.00
220_R289_Q0.7441.00
47_T85_A0.7431.00
253_D282_G0.7421.00
114_A118_Y0.7421.00
34_V97_V0.7411.00
47_T188_A0.7391.00
8_R45_T0.7391.00
227_T285_K0.7371.00
221_D224_L0.7371.00
11_I48_V0.7361.00
147_C151_S0.7361.00
171_R174_M0.7351.00
136_A146_E0.7351.00
31_L126_A0.7341.00
266_Q269_R0.7301.00
248_I291_L0.7251.00
36_L111_S0.7251.00
263_A266_Q0.7181.00
280_P286_D0.7171.00
207_G211_E0.7171.00
97_V101_I0.7151.00
148_V191_L0.7141.00
81_A195_A0.7131.00
129_G156_G0.7131.00
170_E248_I0.7091.00
33_H118_Y0.7091.00
135_F149_T0.7061.00
259_L262_L0.7011.00
212_R269_R0.7001.00
225_D239_V0.7001.00
82_L86_V0.6991.00
257_D264_G0.6981.00
20_G28_G0.6951.00
121_G163_L0.6800.99
274_L279_L0.6780.99
284_A288_L0.6730.99
131_L156_G0.6710.99
185_F213_V0.6700.99
34_V93_N0.6650.99
217_F221_D0.6610.99
191_L195_A0.6580.99
233_L236_P0.6580.99
285_K288_L0.6580.99
220_R223_V0.6560.99
199_D204_E0.6530.99
83_D137_L0.6530.99
155_L185_F0.6530.99
173_Y248_I0.6480.99
228_A237_A0.6440.99
47_T192_G0.6410.99
132_G156_G0.6390.99
92_H95_S0.6370.99
20_G23_E0.6360.99
176_L179_R0.6320.99
14_R82_L0.6320.99
24_P28_G0.6290.99
102_I156_G0.6290.99
205_R208_E0.6240.99
182_G215_V0.6230.99
179_R183_A0.6230.99
252_T291_L0.6220.99
148_V151_S0.6210.99
15_I36_L0.6210.99
120_Y124_I0.6190.99
20_G32_E0.6160.99
10_A14_R0.6150.99
83_D86_V0.6140.99
230_S233_L0.6120.99
118_Y126_A0.6120.99
135_F138_F0.6100.99
30_Q126_A0.6020.99
147_C207_G0.5990.99
157_E179_R0.5990.99
225_D233_L0.5980.99
150_D190_E0.5980.99
181_T217_F0.5960.99
143_R147_C0.5950.99
94_A132_G0.5940.99
274_L277_L0.5930.99
174_M295_V0.5910.98
47_T51_C0.5890.98
56_G192_G0.5890.98
238_G271_L0.5880.98
105_S236_P0.5870.98
265_E270_A0.5860.98
249_V252_T0.5850.98
97_V130_L0.5850.98
287_Y291_L0.5820.98
266_Q270_A0.5800.98
30_Q122_P0.5800.98
276_E280_P0.5800.98
28_G152_L0.5790.98
221_D235_K0.5770.98
239_V242_A0.5770.98
162_E166_R0.5740.98
160_A164_V0.5710.98
220_R263_A0.5710.98
209_Y212_R0.5690.98
259_L263_A0.5680.98
178_R183_A0.5680.98
248_I252_T0.5660.98
88_V191_L0.5630.98
253_D277_L0.5630.98
140_R150_D0.5610.98
101_I121_G0.5610.98
254_R264_G0.5600.98
105_S225_D0.5580.98
51_C195_A0.5570.98
88_V188_A0.5560.98
133_E153_V0.5550.98
90_L130_L0.5510.98
171_R175_E0.5480.98
11_I82_L0.5460.97
43_R92_H0.5450.97
181_T185_F0.5440.97
137_L140_R0.5430.97
232_A237_A0.5420.97
102_I163_L0.5420.97
165_A168_E0.5410.97
132_G135_F0.5400.97
79_E83_D0.5390.97
154_E157_E0.5380.97
156_G163_L0.5360.97
162_E176_L0.5360.97
40_K217_F0.5350.97
212_R215_V0.5350.97
183_A211_E0.5340.97
37_A93_N0.5320.97
263_A274_L0.5300.97
166_R243_L0.5270.97
94_A102_I0.5250.97
170_E251_V0.5240.97
54_A206_F0.5220.97
176_L246_P0.5210.97
35_V93_N0.5200.97
227_T289_Q0.5170.97
79_E82_L0.5120.96
22_V28_G0.5120.96
259_L266_Q0.5100.96
47_T191_L0.5090.96
34_V247_S0.5080.96
42_V185_F0.5070.96
200_G203_V0.5060.96
225_D236_P0.5060.96
220_R227_T0.5040.96
180_K218_Q0.5040.96
198_A203_V0.5020.96
250_Q267_S0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oyrA 2 0.9267 100 0.113 Contact Map
4jxyA 5 0.8633 100 0.115 Contact Map
1wy0A 2 0.93 100 0.118 Contact Map
3wjkA 2 0.9067 100 0.119 Contact Map
4lobA 2 0.8767 100 0.123 Contact Map
3aqbB 1 0.9233 100 0.126 Contact Map
3mzvA 2 0.9267 100 0.126 Contact Map
3lmdA 2 0.8633 100 0.127 Contact Map
4dhdA 2 0.9033 100 0.128 Contact Map
3nf2A 2 0.9267 100 0.128 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.