GREMLIN Database
Q9HNC9 - Uncharacterized protein
UniProt: Q9HNC9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 361 (339)
Sequences: 221 (162)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_V69_A4.9941.00
37_A50_F4.2010.99
26_R57_D4.1650.99
9_L81_N3.9140.98
11_D14_G3.8400.97
51_E131_V3.8000.97
10_D45_D3.3730.94
52_G67_V3.0990.91
227_I264_V3.0540.91
21_T71_T3.0210.90
77_D80_A2.9780.90
16_K36_L2.7870.86
5_L68_A2.7500.85
36_L40_D2.7180.85
232_A278_A2.5720.81
55_L106_V2.5240.80
343_L347_A2.3670.75
16_K40_D2.3460.74
26_R30_E2.3400.74
125_I287_V2.3300.74
5_L196_Y2.2830.72
73_V79_A2.2750.72
125_I193_V2.1900.69
70_V88_V2.1820.69
130_R147_K2.0930.65
12_D72_G2.0820.65
271_A279_G2.0500.64
169_I200_R2.0380.63
264_V267_L2.0100.62
42_E152_D1.9630.60
147_K164_G1.9560.60
52_G139_L1.9540.60
84_V224_V1.9150.58
105_V146_L1.9090.58
6_C52_G1.8730.56
113_E130_R1.8670.56
23_V228_T1.8440.55
11_D16_K1.8140.54
13_L71_T1.8120.54
57_D109_G1.7770.52
51_E106_V1.7650.52
203_G292_L1.7620.52
204_L328_T1.7540.51
71_T239_G1.7540.51
26_R53_V1.7480.51
58_R312_A1.6720.48
7_V263_V1.6660.47
12_D45_D1.6610.47
76_G80_A1.6590.47
72_G108_D1.6450.47
4_V78_V1.6250.46
33_A36_L1.6110.45
159_I200_R1.5990.45
130_R164_G1.5920.44
118_V131_V1.5860.44
26_R36_L1.5710.43
33_A109_G1.5650.43
44_S121_S1.5500.43
5_L200_R1.5420.42
24_V89_D1.5380.42
7_V68_A1.5270.42
58_R61_D1.5240.41
57_D153_P1.5190.41
49_L69_A1.5000.40
45_D109_G1.4960.40
122_R126_E1.4900.40
156_R202_L1.4810.40
119_I171_P1.4670.39
81_N127_A1.4660.39
267_L316_T1.4620.39
21_T92_L1.4590.39
21_T139_L1.4580.39
107_T123_V1.4500.38
12_D16_K1.4490.38
8_D12_D1.4420.38
67_V129_K1.4350.38
146_L202_L1.4350.38
104_V165_I1.4320.38
38_E106_V1.4050.37
23_V172_L1.4010.36
17_T40_D1.4010.36
55_L58_R1.3910.36
30_E53_V1.3850.36
104_V117_P1.3820.36
88_V206_R1.3780.36
130_R219_L1.3760.35
290_E300_Y1.3700.35
280_L314_L1.3680.35
111_Q166_L1.3590.35
26_R109_G1.3580.35
36_L109_G1.3570.35
30_E191_A1.3520.35
200_R349_A1.3510.34
29_V70_V1.3360.34
237_V338_T1.2950.32
11_D32_A1.2860.32
32_A125_I1.2840.32
7_V125_I1.2830.32
84_V154_E1.2810.32
241_V244_A1.2790.32
3_L42_E1.2780.32
208_A295_R1.2660.31
16_K42_E1.2630.31
31_H35_S1.2580.31
139_L171_P1.2490.31
4_V288_T1.2310.30
21_T78_V1.2300.30
50_F149_V1.2260.30
5_L15_R1.2210.30
205_E243_G1.2170.29
277_A284_L1.2140.29
221_T233_A1.2140.29
162_P311_A1.2130.29
4_V19_V1.2120.29
5_L103_A1.2070.29
102_R126_E1.2020.29
198_L228_T1.2010.29
63_E239_G1.1990.29
21_T77_D1.1940.29
116_V280_L1.1930.29
78_V127_A1.1930.29
36_L110_A1.1900.29
114_S200_R1.1900.29
146_L272_V1.1890.28
27_N71_T1.1880.28
73_V168_L1.1800.28
7_V77_D1.1740.28
288_T300_Y1.1680.28
199_F205_E1.1660.28
52_G81_N1.1550.27
125_I175_L1.1540.27
67_V115_V1.1440.27
82_R201_G1.1320.27
110_A162_P1.1220.26
87_E111_Q1.1130.26
110_A201_G1.1130.26
134_R241_V1.1130.26
28_D235_L1.1120.26
207_V292_L1.1090.26
16_K39_A1.1090.26
173_A273_R1.1040.26
272_V329_E1.1030.26
16_K32_A1.0990.25
92_L225_T1.0980.25
145_T173_A1.0940.25
86_R104_V1.0890.25
44_S80_A1.0890.25
9_L52_G1.0820.25
13_L29_V1.0770.25
43_D108_D1.0710.25
110_A152_D1.0670.24
141_S148_Q1.0630.24
170_Y196_Y1.0620.24
281_T308_L1.0590.24
19_V49_L1.0570.24
40_D152_D1.0570.24
51_E67_V1.0550.24
64_D268_T1.0500.24
37_A46_V1.0480.24
121_S133_V1.0420.24
21_T87_E1.0380.23
192_A196_Y1.0370.23
2_L126_E1.0350.23
22_P112_D1.0320.23
203_G305_F1.0290.23
87_E97_P1.0280.23
128_L156_R1.0270.23
8_D25_G1.0250.23
10_D109_G1.0240.23
89_D122_R1.0240.23
117_P121_S1.0160.23
99_D139_L1.0110.23
21_T95_L1.0090.23
4_V208_A1.0030.22
9_L127_A1.0020.22
70_V324_Y1.0010.22
3_L68_A1.0000.22
146_L339_L0.9970.22
90_E168_L0.9890.22
50_F109_G0.9870.22
30_E148_Q0.9830.22
61_D268_T0.9810.22
58_R88_V0.9740.22
12_D43_D0.9710.21
141_S274_W0.9700.21
141_S161_V0.9700.21
228_T285_G0.9690.21
58_R62_D0.9680.21
95_L128_L0.9660.21
132_V148_Q0.9650.21
83_A86_R0.9650.21
132_V228_T0.9650.21
330_L336_A0.9630.21
236_L278_A0.9630.21
106_V233_A0.9530.21
278_A322_L0.9490.21
7_V277_A0.9490.21
38_E200_R0.9480.21
7_V248_D0.9430.21
33_A50_F0.9420.21
243_G317_L0.9370.21
10_D52_G0.9340.20
84_V175_L0.9320.20
80_A136_A0.9270.20
44_S144_Y0.9250.20
247_L342_V0.9240.20
14_G32_A0.9220.20
36_L196_Y0.9210.20
233_A238_I0.9150.20
161_V202_L0.9150.20
10_D56_H0.9150.20
74_D230_V0.9140.20
238_I346_L0.9070.20
162_P274_W0.9070.20
164_G201_G0.9030.20
98_T208_A0.9020.20
87_E119_I0.9010.20
334_L345_T0.9010.20
11_D60_S0.9010.20
86_R90_E0.9000.19
103_A152_D0.8990.19
289_D305_F0.8980.19
11_D176_A0.8960.19
33_A57_D0.8830.19
55_L227_I0.8800.19
67_V150_M0.8750.19
4_V220_Y0.8720.19
232_A285_G0.8720.19
33_A46_V0.8710.19
40_D110_A0.8700.19
10_D32_A0.8680.19
23_V280_L0.8660.19
46_V222_G0.8650.19
49_L64_D0.8570.18
138_D161_V0.8530.18
29_V76_G0.8480.18
45_D79_A0.8470.18
27_N92_L0.8470.18
125_I187_G0.8450.18
162_P316_T0.8450.18
138_D201_G0.8440.18
112_D117_P0.8440.18
36_L57_D0.8430.18
171_P289_D0.8410.18
17_T250_V0.8390.18
29_V173_A0.8380.18
19_V217_D0.8370.18
281_T313_V0.8370.18
243_G271_A0.8360.18
110_A118_V0.8340.18
3_L67_V0.8290.18
7_V21_T0.8280.18
160_L313_V0.8240.18
5_L12_D0.8230.17
45_D72_G0.8230.17
89_D342_V0.8180.17
227_I316_T0.8170.17
13_L238_I0.8140.17
9_L42_E0.8140.17
70_V230_V0.8130.17
116_V343_L0.8120.17
130_R135_Q0.8120.17
307_V310_I0.8100.17
34_V49_L0.8090.17
242_E342_V0.8060.17
308_L346_L0.8050.17
62_D150_M0.8020.17
269_Y343_L0.8020.17
12_D108_D0.8010.17
168_L339_L0.7990.17
170_Y182_P0.7970.17
38_E51_E0.7960.17
99_D349_A0.7960.17
68_A115_V0.7960.17
80_A87_E0.7960.17
87_E141_S0.7900.17
284_L288_T0.7890.17
278_A304_P0.7880.17
52_G277_A0.7870.17
6_C141_S0.7760.16
161_V199_F0.7660.16
13_L84_V0.7620.16
131_V276_A0.7540.16
45_D108_D0.7530.16
192_A340_V0.7510.16
247_L267_L0.7500.16
141_S162_P0.7470.16
11_D340_V0.7440.16
171_P191_A0.7440.16
12_D36_L0.7410.16
131_V337_G0.7400.16
126_E162_P0.7400.16
27_N342_V0.7370.15
115_V330_L0.7370.15
246_R277_A0.7360.15
13_L26_R0.7340.15
134_R161_V0.7310.15
107_T154_E0.7300.15
14_G45_D0.7300.15
146_L205_E0.7270.15
222_G305_F0.7260.15
99_D103_A0.7230.15
7_V10_D0.7220.15
32_A69_A0.7200.15
82_R304_P0.7180.15
50_F315_Y0.7180.15
267_L309_S0.7180.15
45_D56_H0.7110.15
86_R332_A0.7110.15
238_I321_F0.7090.15
269_Y319_G0.7090.15
224_V288_T0.7080.15
118_V152_D0.7070.15
53_V75_R0.7030.15
58_R273_R0.7030.15
60_S281_T0.7010.15
198_L285_G0.7010.15
139_L204_L0.6980.15
116_V196_Y0.6970.15
94_S252_A0.6960.15
96_S118_V0.6910.14
231_V239_G0.6910.14
89_D102_R0.6910.14
238_I347_A0.6840.14
16_K72_G0.6820.14
88_V330_L0.6800.14
64_D189_S0.6790.14
40_D144_Y0.6780.14
70_V314_L0.6770.14
208_A347_A0.6740.14
32_A45_D0.6730.14
278_A288_T0.6730.14
211_A320_F0.6720.14
190_S204_L0.6700.14
7_V52_G0.6680.14
250_V292_L0.6620.14
13_L65_V0.6620.14
7_V12_D0.6620.14
284_L301_L0.6590.14
91_V145_T0.6580.14
24_V244_A0.6580.14
112_D119_I0.6570.14
23_V75_R0.6550.14
119_I157_G0.6550.14
172_L340_V0.6540.14
118_V159_I0.6530.14
136_A156_R0.6530.14
14_G36_L0.6510.14
80_A163_L0.6500.14
37_A145_T0.6500.14
85_G122_R0.6490.14
5_L48_V0.6480.14
150_M269_Y0.6480.14
127_A161_V0.6450.14
29_V80_A0.6450.14
55_L324_Y0.6450.14
11_D72_G0.6400.13
13_L24_V0.6390.13
92_L123_V0.6380.13
165_I192_A0.6380.13
54_H58_R0.6360.13
13_L217_D0.6360.13
334_L337_G0.6350.13
69_A77_D0.6340.13
44_S72_G0.6320.13
71_T204_L0.6310.13
152_D267_L0.6300.13
13_L69_A0.6290.13
219_L279_G0.6290.13
63_E67_V0.6270.13
158_T162_P0.6270.13
63_E258_L0.6240.13
107_T203_G0.6230.13
59_Y106_V0.6230.13
78_V147_K0.6220.13
44_S170_Y0.6210.13
84_V193_V0.6200.13
111_Q140_E0.6200.13
266_A270_G0.6190.13
186_L330_L0.6180.13
229_Y289_D0.6170.13
185_V286_Q0.6140.13
72_G109_G0.6140.13
4_V308_L0.6120.13
150_M282_T0.6100.13
292_L301_L0.6090.13
26_R153_P0.6070.13
167_L222_G0.6070.13
196_Y200_R0.6070.13
161_V201_G0.6060.13
150_M279_G0.6050.13
4_V71_T0.6050.13
239_G283_S0.6040.13
175_L208_A0.6020.13
48_V148_Q0.6000.13
58_R329_E0.5990.13
76_G111_Q0.5990.13
65_V115_V0.5980.13
2_L163_L0.5980.13
154_E308_L0.5980.13
71_T91_V0.5980.13
29_V36_L0.5970.13
64_D87_E0.5960.13
196_Y242_E0.5960.13
192_A330_L0.5910.12
46_V202_L0.5890.12
82_R271_A0.5880.12
117_P127_A0.5880.12
44_S133_V0.5860.12
175_L264_V0.5850.12
310_I339_L0.5840.12
252_A258_L0.5830.12
10_D33_A0.5830.12
131_V164_G0.5830.12
214_R295_R0.5800.12
287_V302_N0.5800.12
6_C120_R0.5790.12
131_V186_L0.5780.12
54_H107_T0.5770.12
37_A314_L0.5760.12
12_D140_E0.5760.12
186_L191_A0.5760.12
239_G292_L0.5750.12
14_G194_G0.5730.12
42_E110_A0.5730.12
52_G117_P0.5730.12
330_L338_T0.5710.12
30_E57_D0.5700.12
119_I137_Q0.5680.12
147_K158_T0.5680.12
23_V118_V0.5660.12
26_R113_E0.5650.12
65_V208_A0.5640.12
18_G123_V0.5630.12
52_G91_V0.5620.12
78_V126_E0.5620.12
218_G280_L0.5610.12
341_S345_T0.5610.12
264_V332_A0.5600.12
118_V189_S0.5600.12
218_G264_V0.5590.12
277_A346_L0.5580.12
48_V124_P0.5580.12
56_H71_T0.5570.12
53_V134_R0.5570.12
205_E227_I0.5560.12
23_V133_V0.5550.12
174_V221_T0.5530.12
5_L109_G0.5520.12
161_V274_W0.5510.12
7_V233_A0.5510.12
4_V18_G0.5490.12
127_A202_L0.5470.12
46_V219_L0.5440.12
158_T192_A0.5440.12
11_D15_R0.5430.12
133_V325_V0.5410.12
105_V202_L0.5410.12
103_A115_V0.5400.12
28_D64_D0.5400.12
81_N187_G0.5390.12
42_E309_S0.5390.12
118_V307_V0.5390.12
52_G275_F0.5380.11
56_H188_V0.5370.11
57_D135_Q0.5370.11
54_H57_D0.5340.11
167_L288_T0.5340.11
65_V185_V0.5330.11
12_D18_G0.5310.11
289_D309_S0.5300.11
119_I233_A0.5300.11
325_V350_V0.5260.11
53_V109_G0.5260.11
244_A305_F0.5260.11
21_T118_V0.5250.11
301_L319_G0.5240.11
288_T346_L0.5240.11
73_V125_I0.5240.11
42_E162_P0.5230.11
243_G285_G0.5220.11
12_D21_T0.5210.11
127_A130_R0.5180.11
70_V119_I0.5180.11
334_L340_V0.5180.11
244_A287_V0.5160.11
227_I320_F0.5150.11
78_V278_A0.5150.11
40_D285_G0.5140.11
51_E116_V0.5140.11
122_R162_P0.5140.11
48_V315_Y0.5130.11
288_T350_V0.5130.11
129_K326_T0.5130.11
83_A244_A0.5130.11
158_T278_A0.5130.11
200_R209_D0.5080.11
182_P196_Y0.5080.11
50_F299_R0.5060.11
5_L224_V0.5060.11
86_R244_A0.5050.11
50_F226_L0.5050.11
109_G114_S0.5040.11
52_G92_L0.5040.11
226_L273_R0.5030.11
135_Q145_T0.5030.11
63_E104_V0.5010.11
5_L320_F0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fvpA 2 0.2521 27.8 0.974 Contact Map
3h90A 3 0.3546 21.1 0.975 Contact Map
3j1zP 8 0.3795 20.9 0.975 Contact Map
2aifA 1 0.133 20.5 0.975 Contact Map
3c8nA 2 0.2576 19.3 0.976 Contact Map
1lucA 1 0.2355 18.6 0.976 Contact Map
2wgkA 2 0.2936 15.5 0.977 Contact Map
1rypB 1 0.2438 14.9 0.977 Contact Map
1rhcA 2 0.2715 11.7 0.978 Contact Map
4nutA 1 0.1385 10.9 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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