GREMLIN Database
Q9HNC8 - Uncharacterized protein
UniProt: Q9HNC8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (303)
Sequences: 189 (133)
Seq/√Len: 7.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_T101_H3.9590.97
157_T181_D3.8900.96
94_K125_D3.8470.96
90_L124_L3.5770.94
7_S78_E3.3100.91
159_A182_F2.9600.85
299_A303_L2.9190.85
10_C13_C2.8490.83
45_Q97_F2.8300.83
217_K232_F2.7700.81
302_L306_M2.7030.80
24_Y82_V2.6130.77
302_L305_E2.5710.76
127_I180_A2.5600.76
116_M121_E2.4980.74
169_D222_S2.4820.73
216_S238_K2.3500.69
185_I274_V2.2870.67
7_S232_F2.2260.64
123_G179_A2.1010.60
59_D92_L2.0940.59
50_N67_M2.0670.58
33_F203_Y2.0480.58
130_H246_R2.0030.56
70_L116_M1.9930.56
158_P166_R1.9610.54
129_F151_A1.9560.54
104_H186_N1.9400.53
34_Y220_I1.9260.53
303_L306_M1.9020.52
148_L190_M1.8870.51
78_E81_E1.8260.49
167_A231_Y1.8130.48
20_V104_H1.8050.48
7_S129_F1.7970.48
65_K96_E1.7940.48
36_P71_G1.7930.47
166_R171_F1.7900.47
116_M154_E1.7890.47
130_H186_N1.7780.47
68_D253_N1.7490.46
31_D43_N1.7460.46
104_H130_H1.7460.46
74_I162_I1.7400.45
144_W267_L1.7280.45
295_H311_D1.7280.45
86_T245_S1.7240.45
25_G198_M1.7240.45
21_L49_A1.7110.44
197_R200_E1.7050.44
122_A177_E1.6920.43
7_S151_A1.6690.43
24_Y75_T1.6600.42
66_L224_M1.6540.42
129_F148_L1.6460.42
20_V189_E1.6450.42
162_I185_I1.6320.41
119_L123_G1.5740.39
279_I283_G1.5570.38
18_K104_H1.5430.38
276_A309_D1.5270.37
116_M120_S1.5150.37
113_R153_E1.5010.36
9_G18_K1.5000.36
91_R118_R1.4700.35
284_V287_E1.4700.35
145_E160_F1.4550.34
7_S81_E1.4450.34
282_L309_D1.4430.34
104_H189_E1.4370.34
290_T295_H1.4110.33
10_C16_G1.4100.33
13_C16_G1.4100.33
291_V294_D1.4030.33
51_E239_D1.4030.33
128_R184_N1.3970.32
106_Y128_R1.3970.32
106_Y184_N1.3970.32
20_V130_H1.3840.32
104_H246_R1.3750.32
187_E202_G1.3710.31
23_V298_V1.3680.31
262_T265_G1.3580.31
205_L212_A1.3570.31
20_V186_N1.3530.31
119_L179_A1.3500.31
111_G116_M1.3310.30
261_I296_V1.3290.30
269_Y300_W1.3270.30
64_A305_E1.3220.30
104_H182_F1.3210.30
127_I244_R1.2970.29
86_T103_T1.2960.29
36_P265_G1.2930.29
116_M213_V1.2910.29
286_E308_D1.2770.28
71_G265_G1.2760.28
182_F186_N1.2750.28
148_L164_G1.2740.28
160_F217_K1.2710.28
9_G182_F1.2580.28
45_Q255_R1.2550.28
51_E189_E1.2540.28
237_F247_L1.2540.28
113_R203_Y1.2310.27
116_M150_I1.2290.27
45_Q75_T1.2290.27
36_P189_E1.2270.27
9_G71_G1.2270.27
74_I90_L1.2230.27
130_H189_E1.2220.27
104_H159_A1.2190.26
136_W301_W1.2160.26
9_G13_C1.2100.26
124_L232_F1.2100.26
55_E203_Y1.2020.26
22_F151_A1.1940.26
186_N189_E1.1920.26
91_R177_E1.1870.25
160_F234_T1.1750.25
91_R148_L1.1750.25
159_A186_N1.1740.25
48_Y239_D1.1730.25
48_Y218_D1.1720.25
11_E148_L1.1650.25
18_K159_A1.1510.24
165_I203_Y1.1370.24
116_M151_A1.1340.24
19_M23_V1.1320.24
279_I288_Y1.1310.24
186_N246_R1.1310.24
170_E309_D1.1290.24
11_E17_G1.1160.23
70_L102_H1.1070.23
52_R279_I1.1060.23
120_S178_G1.1020.23
249_R266_T1.1020.23
160_F175_L1.1010.23
80_Q150_I1.0960.23
164_G188_F1.0920.23
130_H182_F1.0920.23
60_I191_S1.0860.23
20_V75_T1.0780.22
224_M230_V1.0770.22
56_D89_Y1.0740.22
83_L305_E1.0720.22
33_F123_G1.0700.22
20_V246_R1.0610.22
59_D249_R1.0570.22
189_E244_R1.0460.21
54_V60_I1.0400.21
41_R247_L1.0340.21
120_S150_I1.0320.21
34_Y249_R1.0260.21
136_W259_D1.0190.21
90_L123_G1.0180.21
9_G159_A1.0080.20
25_G38_G1.0070.20
201_A225_A1.0050.20
108_G151_A1.0030.20
168_E185_I1.0020.20
25_G36_P1.0000.20
160_F287_E0.9970.20
191_S237_F0.9930.20
38_G243_H0.9860.20
37_L193_G0.9850.20
112_G305_E0.9760.20
283_G308_D0.9750.20
23_V137_G0.9690.19
130_H159_A0.9670.19
102_H157_T0.9650.19
160_F203_Y0.9590.19
25_G265_G0.9510.19
201_A222_S0.9510.19
51_E246_R0.9340.19
48_Y250_M0.9290.18
108_G227_H0.9260.18
47_V281_E0.9250.18
185_I190_M0.9240.18
42_K144_W0.9230.18
30_R105_L0.9210.18
186_N247_L0.9150.18
88_R112_G0.9120.18
108_G129_F0.9050.18
63_E130_H0.9020.18
75_T104_H0.9010.18
190_M240_A0.9000.18
94_K97_F0.8950.18
99_E146_E0.8950.18
65_K181_D0.8860.17
41_R50_N0.8790.17
151_A154_E0.8780.17
95_D296_V0.8770.17
117_R213_V0.8770.17
101_H234_T0.8770.17
25_G159_A0.8730.17
108_G311_D0.8700.17
276_A279_I0.8690.17
34_Y71_G0.8640.17
33_F124_L0.8640.17
78_E110_T0.8560.17
218_D228_E0.8530.17
71_G189_E0.8450.16
224_M227_H0.8440.16
117_R219_A0.8440.16
80_Q105_L0.8440.16
38_G41_R0.8410.16
17_G249_R0.8390.16
124_L190_M0.8360.16
111_G164_G0.8350.16
288_Y302_L0.8310.16
105_L165_I0.8310.16
92_L213_V0.8280.16
19_M49_A0.8250.16
291_V296_V0.8240.16
22_F275_G0.8210.16
80_Q148_L0.8200.16
68_D92_L0.8160.16
72_T111_G0.8160.16
212_A264_D0.8160.16
59_D103_T0.8120.16
262_T267_L0.8090.16
158_P171_F0.8090.16
230_V248_K0.8070.16
102_H122_A0.8060.16
80_Q154_E0.8020.16
9_G25_G0.8000.16
189_E246_R0.7990.15
124_L162_I0.7980.15
17_G103_T0.7970.15
170_E177_E0.7930.15
182_F246_R0.7890.15
237_F274_V0.7850.15
74_I86_T0.7840.15
67_M250_M0.7700.15
150_I174_F0.7650.15
301_W305_E0.7640.15
25_G186_N0.7610.15
143_E308_D0.7600.15
20_V51_E0.7590.15
79_P216_S0.7590.15
20_V159_A0.7580.15
185_I272_T0.7570.15
21_L71_G0.7560.15
186_N235_S0.7550.15
36_P239_D0.7520.15
124_L165_I0.7480.14
192_D241_A0.7480.14
123_G216_S0.7440.14
295_H306_M0.7440.14
95_D134_E0.7370.14
150_I232_F0.7340.14
34_Y159_A0.7340.14
87_C113_R0.7310.14
5_M179_A0.7300.14
295_H302_L0.7280.14
8_K108_G0.7270.14
91_R254_V0.7270.14
62_S263_D0.7260.14
58_E91_R0.7260.14
87_C278_R0.7250.14
93_L103_T0.7240.14
51_E104_H0.7190.14
25_G34_Y0.7180.14
19_M47_V0.7150.14
41_R98_G0.7140.14
18_K186_N0.7130.14
20_V25_G0.7100.14
251_A261_I0.7050.14
230_V311_D0.7000.14
27_C163_P0.6980.13
27_C161_E0.6980.13
27_C126_E0.6980.13
27_C233_C0.6980.13
32_C76_G0.6980.13
126_E163_P0.6980.13
126_E161_E0.6980.13
32_C77_G0.6980.13
32_C126_E0.6980.13
32_C163_P0.6980.13
32_C233_C0.6980.13
126_E233_C0.6980.13
163_P233_C0.6980.13
76_G163_P0.6980.13
76_G161_E0.6980.13
76_G126_E0.6980.13
77_G126_E0.6980.13
32_C161_E0.6980.13
161_E233_C0.6980.13
77_G161_E0.6980.13
76_G233_C0.6980.13
27_C76_G0.6980.13
77_G233_C0.6980.13
77_G163_P0.6980.13
27_C32_C0.6980.13
27_C77_G0.6980.13
146_E254_V0.6970.13
69_A104_H0.6970.13
50_N246_R0.6950.13
25_G71_G0.6940.13
18_K189_E0.6920.13
252_R306_M0.6860.13
20_V182_F0.6850.13
235_S303_L0.6810.13
122_A190_M0.6790.13
120_S214_D0.6780.13
73_S250_M0.6780.13
25_G104_H0.6770.13
36_P130_H0.6760.13
122_A216_S0.6750.13
72_T155_G0.6730.13
117_R177_E0.6720.13
56_D201_A0.6670.13
231_Y241_A0.6660.13
292_K306_M0.6640.13
124_L127_I0.6640.13
113_R169_D0.6630.13
113_R197_R0.6620.13
108_G232_F0.6610.13
152_R237_F0.6600.13
295_H312_I0.6570.13
73_S243_H0.6560.13
104_H239_D0.6560.13
57_D88_R0.6550.13
14_A237_F0.6510.13
12_Q24_Y0.6510.13
78_E183_C0.6450.13
42_K247_L0.6440.13
36_P104_H0.6440.13
297_E307_I0.6420.12
113_R117_R0.6410.12
157_T180_A0.6370.12
280_R289_Y0.6370.12
154_E162_I0.6340.12
89_Y183_C0.6300.12
54_V92_L0.6300.12
145_E170_E0.6290.12
25_G246_R0.6260.12
110_T269_Y0.6250.12
71_G249_R0.6210.12
56_D83_L0.6210.12
67_M268_V0.6200.12
63_E246_R0.6190.12
289_Y296_V0.6180.12
84_D276_A0.6150.12
190_M216_S0.6150.12
208_G236_V0.6140.12
221_L232_F0.6100.12
20_V94_K0.6100.12
41_R104_H0.6090.12
73_S189_E0.6060.12
34_Y265_G0.6020.12
129_F185_I0.6010.12
80_Q84_D0.6000.12
24_Y270_G0.6000.12
108_G221_L0.5990.12
101_H215_G0.5990.12
232_F292_K0.5980.12
114_E178_G0.5970.12
104_H235_S0.5950.12
72_T93_L0.5950.12
19_M92_L0.5950.12
7_S271_K0.5940.12
166_R175_L0.5930.12
20_V265_G0.5910.12
34_Y104_H0.5860.12
203_Y252_R0.5840.11
189_E270_G0.5830.11
137_G225_A0.5830.11
267_L271_K0.5820.11
18_K182_F0.5820.11
18_K130_H0.5800.11
99_E112_G0.5800.11
31_D267_L0.5790.11
75_T125_D0.5780.11
162_I165_I0.5770.11
38_G186_N0.5760.11
287_E290_T0.5710.11
120_S156_L0.5710.11
25_G182_F0.5690.11
56_D95_D0.5690.11
292_K295_H0.5690.11
69_A72_T0.5670.11
221_L228_E0.5670.11
16_G75_T0.5630.11
32_C35_C0.5620.11
35_C233_C0.5620.11
35_C161_E0.5620.11
35_C163_P0.5620.11
35_C77_G0.5620.11
35_C126_E0.5620.11
35_C76_G0.5620.11
27_C35_C0.5620.11
135_L279_I0.5620.11
152_R181_D0.5610.11
189_E265_G0.5580.11
237_F248_K0.5580.11
34_Y130_H0.5560.11
71_G220_I0.5560.11
104_H247_L0.5550.11
169_D223_E0.5550.11
69_A156_L0.5540.11
152_R259_D0.5520.11
62_S199_Q0.5520.11
276_A302_L0.5510.11
119_L124_L0.5500.11
41_R130_H0.5490.11
60_I247_L0.5490.11
43_N202_G0.5480.11
116_M311_D0.5480.11
296_V299_A0.5460.11
293_S308_D0.5440.11
121_E179_A0.5440.11
99_E171_F0.5430.11
71_G104_H0.5430.11
182_F247_L0.5420.11
61_I91_R0.5380.11
122_A176_D0.5370.11
13_C242_Q0.5340.11
10_C242_Q0.5340.11
70_L266_T0.5340.11
5_M87_C0.5320.11
111_G117_R0.5310.11
74_I304_E0.5300.11
158_P179_A0.5280.11
75_T244_R0.5280.11
63_E119_L0.5270.11
7_S300_W0.5270.11
159_A246_R0.5260.11
234_T245_S0.5260.11
53_P177_E0.5260.11
38_G210_M0.5260.11
261_I265_G0.5240.11
78_E162_I0.5230.11
75_T215_G0.5220.11
186_N191_S0.5210.11
84_D113_R0.5210.11
20_V239_D0.5180.10
291_V305_E0.5130.10
23_V41_R0.5120.10
201_A264_D0.5120.10
97_F215_G0.5120.10
72_T301_W0.5100.10
151_A234_T0.5090.10
36_P186_N0.5080.10
279_I282_L0.5080.10
75_T94_K0.5070.10
119_L165_I0.5060.10
267_L289_Y0.5060.10
91_R146_E0.5050.10
25_G189_E0.5040.10
41_R159_A0.5020.10
24_Y189_E0.5020.10
24_Y244_R0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c8fA 1 0.6507 99.7 0.862 Contact Map
2a5hA 4 0.8567 99.6 0.871 Contact Map
2yx0A 1 0.7164 99.6 0.874 Contact Map
4u0oB 1 0.6776 99.5 0.877 Contact Map
1tv8A 2 0.8478 99.5 0.881 Contact Map
2z2uA 1 0.6149 99.4 0.885 Contact Map
3iixA 1 0.7881 99.4 0.886 Contact Map
3t7vA 1 0.8328 99.4 0.889 Contact Map
4k36A 1 0.7463 99.3 0.891 Contact Map
4m7tA 1 0.6687 99.3 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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