GREMLIN Database
Q9HNC7 - Uncharacterized protein
UniProt: Q9HNC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 523 (461)
Sequences: 107 (96)
Seq/√Len: 4.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_H126_E4.7820.94
13_H125_K4.0590.87
81_F400_Q3.8590.84
69_L482_V3.6610.81
85_D400_Q3.4490.77
125_K300_Y3.3970.76
456_W500_Y3.0440.67
24_V34_T2.9410.64
88_L124_T2.7990.60
84_K127_S2.7750.59
85_D314_H2.7410.58
83_R305_N2.7220.57
126_E300_Y2.7050.57
77_Y85_D2.6980.57
224_A228_S2.5950.54
126_E236_W2.5670.53
20_V193_F2.5570.52
94_L98_L2.5220.51
10_P309_P2.4420.49
13_H236_W2.4180.48
81_F85_D2.3990.48
266_A294_V2.3480.46
450_A455_P2.3420.46
37_L119_G2.3280.46
83_R292_C2.2940.44
245_A305_N2.2720.44
458_T483_I2.2540.43
24_V38_V2.2420.43
67_A71_C2.2210.42
115_A257_V2.2160.42
13_H300_Y2.1820.41
186_F291_Y2.1730.41
77_Y81_F2.1620.41
313_V356_R2.1480.40
189_V193_F2.1350.40
15_P36_R2.1180.39
305_N308_V2.1120.39
123_A194_Y2.0790.38
77_Y400_Q2.0650.38
189_V194_Y2.0600.38
257_V319_L2.0460.37
270_V473_A2.0400.37
207_W395_V2.0060.36
474_V481_V1.9910.36
245_A248_P1.9620.35
16_L193_F1.9450.34
144_D277_Y1.9390.34
85_D305_N1.9390.34
96_L193_F1.9370.34
93_L354_A1.9280.34
83_R314_H1.9280.34
79_S323_A1.9140.33
134_T308_V1.9060.33
66_G218_P1.9020.33
43_G81_F1.8820.33
83_R318_P1.8730.32
100_V324_A1.8640.32
193_F250_F1.8440.32
299_G481_V1.8280.31
85_D318_P1.8240.31
61_E74_V1.7920.30
27_V41_L1.7770.30
249_Y253_T1.7730.30
303_A396_I1.7720.30
451_R467_S1.7710.30
319_L479_P1.7630.29
14_G36_R1.7610.29
194_Y236_W1.7410.29
72_N261_A1.7290.29
53_F97_G1.7250.29
292_C318_P1.7190.28
313_V405_L1.7180.28
489_E502_R1.7000.28
35_A303_A1.6920.28
81_F104_D1.6710.27
318_P400_Q1.6690.27
16_L20_V1.6670.27
84_K125_K1.6620.27
304_N308_V1.6540.27
182_A410_T1.6220.26
276_R317_V1.6090.26
292_C305_N1.6070.26
13_H127_S1.5970.25
86_L135_W1.5960.25
83_R308_V1.5800.25
109_R362_A1.5780.25
96_L360_A1.5780.25
457_Y500_Y1.5680.25
11_I305_N1.5540.24
16_L170_A1.5420.24
83_R400_Q1.5290.24
106_R115_A1.5290.24
246_Y250_F1.5130.24
127_S300_Y1.5130.24
195_A285_L1.5100.23
133_V193_F1.5090.23
248_P308_V1.5020.23
78_Y188_S1.4970.23
267_L368_V1.4930.23
34_T161_F1.4920.23
101_R398_Y1.4860.23
266_A297_L1.4760.23
29_G398_Y1.4630.22
186_F363_V1.4620.22
83_R236_W1.4570.22
232_A308_V1.4570.22
77_Y83_R1.4470.22
215_A426_L1.4430.22
37_L46_L1.4420.22
77_Y482_V1.4360.22
91_C401_A1.4280.22
226_L273_L1.4220.22
196_P452_M1.4150.21
69_L148_L1.3930.21
123_A193_F1.3770.21
13_H84_K1.3770.21
253_T315_A1.3760.21
31_T168_A1.3750.21
363_V481_V1.3750.21
398_Y508_D1.3710.21
88_L127_S1.3680.21
88_L181_L1.3660.20
24_V297_L1.3620.20
96_L450_A1.3500.20
135_W193_F1.3480.20
355_V454_L1.3410.20
158_L226_L1.3370.20
125_K236_W1.3360.20
267_L415_A1.3340.20
43_G75_L1.3180.20
59_D62_L1.3150.19
84_K126_E1.3130.19
16_L31_T1.3040.19
303_A393_S1.2960.19
28_V488_L1.2960.19
15_P310_W1.2940.19
36_R310_W1.2940.19
319_L503_E1.2920.19
148_L355_V1.2900.19
79_S125_K1.2900.19
198_A205_G1.2890.19
6_W303_A1.2810.19
310_W453_P1.2810.19
13_H508_D1.2790.19
197_R301_P1.2770.19
268_A341_R1.2740.19
21_N113_A1.2720.19
357_A380_Y1.2630.18
78_Y397_Y1.2590.18
245_A260_G1.2570.18
89_A326_G1.2490.18
101_R291_Y1.2490.18
17_F84_K1.2410.18
463_A467_S1.2380.18
180_V441_R1.2360.18
16_L194_Y1.2330.18
119_G131_W1.2310.18
114_S454_L1.2310.18
84_K296_A1.2300.18
127_S305_N1.2290.18
294_V359_L1.2260.18
18_A44_A1.2220.18
262_S364_L1.2160.18
116_V355_V1.2080.18
34_T366_S1.2070.17
454_L507_L1.2030.17
235_Y240_S1.2020.17
126_E235_Y1.1950.17
83_R304_N1.1930.17
93_L337_R1.1910.17
93_L99_L1.1840.17
96_L437_S1.1840.17
127_S296_A1.1840.17
66_G73_P1.1750.17
134_T394_D1.1720.17
54_R109_R1.1650.17
380_Y400_Q1.1620.17
249_Y305_N1.1580.17
286_V481_V1.1530.17
32_D41_L1.1430.16
162_R258_I1.1420.16
467_S510_I1.1420.16
363_V473_A1.1410.16
18_A84_K1.1410.16
100_V265_A1.1400.16
90_A189_V1.1380.16
129_L246_Y1.1360.16
52_L324_A1.1330.16
10_P303_A1.1320.16
307_P311_S1.1270.16
6_W309_P1.1240.16
12_L452_M1.1200.16
65_L320_T1.1150.16
303_A394_D1.1150.16
32_D83_R1.1140.16
47_P301_P1.1120.16
183_A354_A1.1070.16
119_G355_V1.1060.16
179_G481_V1.1050.16
271_G288_F1.1030.16
247_L302_L1.1030.16
144_D276_R1.1010.16
309_P314_H1.1000.16
236_W296_A1.0970.16
14_G126_E1.0860.15
113_A130_L1.0850.15
28_V54_R1.0800.15
158_L263_G1.0790.15
40_A83_R1.0770.15
120_V393_S1.0770.15
245_A249_Y1.0770.15
357_A408_V1.0750.15
125_K194_Y1.0730.15
181_L271_G1.0650.15
129_L245_A1.0630.15
111_L505_H1.0600.15
85_D467_S1.0580.15
78_Y141_L1.0520.15
185_V365_L1.0510.15
79_S288_F1.0490.15
293_G322_P1.0490.15
161_F164_L1.0480.15
106_R225_T1.0430.15
314_H324_A1.0420.15
451_R455_P1.0360.15
97_G136_L1.0300.15
32_D54_R1.0230.14
74_V312_T1.0230.14
397_Y452_M1.0130.14
274_W298_V1.0110.14
58_R392_G1.0070.14
10_P85_D1.0060.14
185_V481_V1.0030.14
79_S127_S1.0010.14
78_Y399_A1.0000.14
257_V265_A0.9970.14
14_G310_W0.9960.14
7_E99_L0.9930.14
25_F400_Q0.9900.14
177_H478_P0.9870.14
260_G311_S0.9860.14
132_M492_V0.9840.14
27_V60_A0.9840.14
68_A288_F0.9840.14
9_R452_M0.9810.14
71_C224_A0.9790.14
36_R453_P0.9770.14
15_P453_P0.9770.14
73_P236_W0.9760.14
150_A154_D0.9670.14
77_Y318_P0.9660.14
76_V447_A0.9640.14
6_W113_A0.9630.14
28_V266_A0.9600.14
101_R312_T0.9580.14
27_V332_R0.9560.13
57_L313_V0.9530.13
360_A495_A0.9520.13
62_L512_D0.9490.13
23_L290_F0.9490.13
94_L296_A0.9450.13
40_A54_R0.9440.13
58_R494_A0.9440.13
54_R83_R0.9420.13
408_V481_V0.9410.13
271_G313_V0.9410.13
143_L160_A0.9400.13
20_V179_G0.9370.13
245_A510_I0.9370.13
283_R372_G0.9350.13
13_H36_R0.9350.13
191_V268_A0.9340.13
6_W508_D0.9310.13
360_A481_V0.9300.13
47_P50_A0.9300.13
81_F318_P0.9290.13
180_V328_A0.9280.13
328_A442_P0.9260.13
180_V234_D0.9250.13
249_Y410_T0.9230.13
120_V448_W0.9220.13
135_W251_T0.9190.13
118_L297_L0.9170.13
87_P156_D0.9170.13
451_R508_D0.9160.13
61_E452_M0.9120.13
189_V331_Y0.9120.13
82_M127_S0.9110.13
142_V449_H0.9100.13
25_F316_I0.9090.13
13_H235_Y0.9050.13
295_A379_S0.9020.13
249_Y304_N0.8990.13
67_A496_I0.8980.13
8_Y14_G0.8950.13
220_V244_H0.8920.13
127_S397_Y0.8920.13
97_G261_A0.8910.13
331_Y481_V0.8900.13
86_L97_G0.8890.13
180_V338_L0.8860.13
3_H401_A0.8860.13
414_R474_V0.8850.13
44_A94_L0.8790.12
113_A116_V0.8780.12
226_L229_L0.8760.12
272_F291_Y0.8730.12
467_S508_D0.8700.12
397_Y401_A0.8690.12
445_T467_S0.8650.12
129_L311_S0.8570.12
147_L296_A0.8560.12
76_V264_V0.8550.12
357_A365_L0.8550.12
37_L43_G0.8520.12
67_A369_A0.8520.12
141_L291_Y0.8500.12
6_W12_L0.8500.12
117_T130_L0.8480.12
125_K508_D0.8450.12
22_S117_T0.8440.12
134_T221_V0.8430.12
357_A367_A0.8430.12
29_G36_R0.8430.12
15_P29_G0.8430.12
365_L501_E0.8420.12
41_L94_L0.8370.12
244_H248_P0.8340.12
85_D308_V0.8330.12
377_E383_P0.8290.12
41_L479_P0.8270.12
261_A459_E0.8270.12
270_V326_G0.8250.12
119_G458_T0.8210.12
405_L442_P0.8210.12
111_L115_A0.8200.12
30_A462_D0.8200.12
113_A225_T0.8190.12
272_F286_V0.8180.12
205_G376_T0.8180.12
311_S394_D0.8180.12
471_P502_R0.8170.12
236_W300_Y0.8130.12
161_F364_L0.8080.12
137_G305_N0.8080.12
22_S92_M0.8070.11
6_W189_V0.8060.11
135_W219_A0.8030.11
96_L119_G0.8030.11
6_W225_T0.8010.11
167_R444_A0.8010.11
270_V356_R0.7980.11
33_A107_R0.7980.11
137_G299_G0.7950.11
13_H240_S0.7920.11
86_L461_L0.7910.11
17_F303_A0.7900.11
126_E508_D0.7900.11
301_P401_A0.7900.11
221_V470_D0.7890.11
29_G307_P0.7890.11
246_Y305_N0.7890.11
30_A263_G0.7880.11
114_S177_H0.7870.11
37_L77_Y0.7850.11
260_G275_D0.7840.11
275_D287_A0.7810.11
324_A504_T0.7810.11
399_A502_R0.7780.11
8_Y231_K0.7780.11
148_L267_L0.7780.11
261_A328_A0.7770.11
137_G300_Y0.7760.11
303_A405_L0.7760.11
13_H130_L0.7740.11
53_F89_A0.7720.11
50_A77_Y0.7720.11
75_L182_A0.7720.11
57_L83_R0.7720.11
252_D256_T0.7700.11
105_T317_V0.7680.11
268_A293_G0.7660.11
225_T269_V0.7650.11
254_A295_A0.7640.11
136_L188_S0.7630.11
316_I401_A0.7620.11
245_A394_D0.7610.11
302_L364_L0.7610.11
375_L494_A0.7610.11
248_P252_D0.7580.11
13_H194_Y0.7570.11
269_V288_F0.7550.11
143_L360_A0.7550.11
35_A305_N0.7540.11
121_A414_R0.7530.11
27_V66_G0.7530.11
458_T499_G0.7520.11
121_A124_T0.7510.11
260_G309_P0.7490.11
84_K236_W0.7460.11
427_Y444_A0.7460.11
321_V502_R0.7440.11
45_L180_V0.7440.11
52_L57_L0.7420.11
247_L260_G0.7410.11
262_S405_L0.7380.11
256_T481_V0.7380.11
60_A139_S0.7370.11
166_R436_E0.7360.11
27_V234_D0.7350.11
180_V327_A0.7350.11
86_L99_L0.7330.11
33_A119_G0.7320.11
82_M129_L0.7320.11
135_W413_E0.7320.11
52_L293_G0.7310.11
245_A304_N0.7310.11
167_R468_V0.7310.11
4_G401_A0.7300.11
75_L455_P0.7300.11
310_W456_W0.7280.11
90_A286_V0.7280.11
53_F136_L0.7270.11
318_P395_V0.7260.11
126_E240_S0.7250.11
457_Y482_V0.7230.10
144_D372_G0.7220.10
62_L471_P0.7210.10
307_P398_Y0.7190.10
63_I185_V0.7180.10
83_R296_A0.7160.10
228_S510_I0.7150.10
333_W367_A0.7140.10
43_G182_A0.7130.10
341_R391_P0.7130.10
51_W106_R0.7110.10
132_M180_V0.7100.10
463_A468_V0.7100.10
301_P322_P0.7100.10
253_T311_S0.7100.10
77_Y101_R0.7090.10
180_V295_A0.7090.10
123_A170_A0.7090.10
79_S267_L0.7080.10
35_A398_Y0.7080.10
61_E283_R0.7070.10
130_L294_V0.7060.10
119_G410_T0.7060.10
12_L236_W0.7040.10
41_L357_A0.7040.10
161_F234_D0.7040.10
107_R221_V0.7040.10
148_L360_A0.7040.10
18_A390_D0.7020.10
94_L105_T0.7020.10
256_T311_S0.7010.10
232_A248_P0.7010.10
96_L331_Y0.6970.10
28_V375_L0.6970.10
269_V364_L0.6960.10
38_V287_A0.6940.10
163_S437_S0.6920.10
289_N301_P0.6920.10
111_L143_L0.6880.10
94_L504_T0.6860.10
239_G311_S0.6850.10
264_V301_P0.6850.10
267_L440_D0.6840.10
393_S396_I0.6830.10
12_L305_N0.6830.10
331_Y378_T0.6810.10
132_M142_V0.6810.10
107_R471_P0.6790.10
362_A366_S0.6780.10
93_L404_D0.6780.10
32_D292_C0.6770.10
69_L77_Y0.6770.10
12_L126_E0.6760.10
14_G453_P0.6760.10
364_L498_A0.6760.10
262_S404_D0.6760.10
75_L410_T0.6740.10
29_G393_S0.6730.10
236_W240_S0.6720.10
58_R74_V0.6720.10
8_Y400_Q0.6710.10
123_A165_L0.6710.10
301_P459_E0.6670.10
248_P309_P0.6660.10
307_P510_I0.6640.10
80_R310_W0.6640.10
16_L25_F0.6630.10
82_M85_D0.6600.10
219_A266_A0.6600.10
150_A483_I0.6600.10
368_V417_A0.6560.10
25_F79_S0.6530.10
126_E130_L0.6530.10
27_V113_A0.6520.10
225_T266_A0.6500.10
68_A476_D0.6490.10
39_V283_R0.6480.10
41_L215_A0.6470.10
228_S249_Y0.6430.10
54_R400_Q0.6420.10
175_W492_V0.6410.10
114_S405_L0.6400.10
394_D439_V0.6390.10
12_L297_L0.6380.10
85_D304_N0.6380.10
359_L410_T0.6370.10
230_H297_L0.6370.10
97_G283_R0.6360.10
168_A183_A0.6330.10
457_Y483_I0.6320.09
224_A303_A0.6310.09
314_H482_V0.6310.09
328_A467_S0.6310.09
455_P496_I0.6300.09
228_S309_P0.6220.09
115_A119_G0.6220.09
35_A468_V0.6210.09
53_F322_P0.6190.09
132_M362_A0.6180.09
472_T477_T0.6170.09
50_A379_S0.6150.09
86_L271_G0.6150.09
116_V494_A0.6140.09
76_V467_S0.6140.09
253_T307_P0.6120.09
93_L357_A0.6110.09
358_V374_T0.6110.09
33_A360_A0.6110.09
117_T172_A0.6100.09
483_I505_H0.6090.09
288_F457_Y0.6090.09
16_L302_L0.6090.09
292_C400_Q0.6060.09
43_G46_L0.6060.09
307_P403_A0.6050.09
130_L512_D0.6050.09
264_V294_V0.6040.09
57_L100_V0.6030.09
299_G305_N0.6030.09
174_D482_V0.6030.09
39_V311_S0.6020.09
35_A228_S0.5990.09
248_P311_S0.5990.09
248_P302_L0.5990.09
77_Y80_R0.5980.09
252_D309_P0.5980.09
335_R436_E0.5980.09
112_Y265_A0.5950.09
236_W292_C0.5940.09
309_P510_I0.5940.09
114_S359_L0.5930.09
99_L270_V0.5930.09
396_I406_R0.5900.09
319_L483_I0.5890.09
248_P260_G0.5880.09
85_D395_V0.5870.09
16_L123_A0.5870.09
116_V149_R0.5870.09
106_R266_A0.5870.09
25_F47_P0.5860.09
70_A76_V0.5850.09
14_G78_Y0.5850.09
236_W400_Q0.5840.09
17_F21_N0.5830.09
362_A503_E0.5820.09
117_T186_F0.5810.09
282_P334_G0.5800.09
166_R312_T0.5800.09
6_W10_P0.5780.09
70_A73_P0.5780.09
18_A297_L0.5770.09
129_L305_N0.5760.09
186_F399_A0.5760.09
127_S236_W0.5750.09
103_S340_A0.5730.09
149_R415_A0.5730.09
393_S402_P0.5720.09
448_W459_E0.5720.09
242_Q260_G0.5710.09
270_V474_V0.5700.09
149_R362_A0.5700.09
178_H465_V0.5700.09
396_I449_H0.5690.09
256_T309_P0.5670.09
190_V473_A0.5670.09
190_V268_A0.5670.09
190_V428_A0.5660.09
69_L93_L0.5660.09
187_L205_G0.5640.09
40_A80_R0.5620.09
483_I502_R0.5610.09
235_Y305_N0.5610.09
97_G317_V0.5610.09
10_P14_G0.5610.09
96_L136_L0.5600.09
243_R246_Y0.5600.09
25_F246_Y0.5600.09
244_H249_Y0.5580.09
308_V401_A0.5580.09
25_F235_Y0.5580.09
68_A488_L0.5570.09
304_N397_Y0.5570.09
87_P138_A0.5570.09
91_C95_T0.5560.09
46_L329_V0.5560.09
28_V366_S0.5530.09
250_F256_T0.5520.09
102_A268_A0.5510.09
69_L115_A0.5480.09
7_E87_P0.5470.09
169_V417_A0.5470.09
73_P80_R0.5450.09
82_M246_Y0.5440.09
195_A303_A0.5440.09
32_D318_P0.5440.09
295_A459_E0.5420.09
29_G383_P0.5410.09
3_H492_V0.5400.09
191_V273_L0.5400.09
58_R299_G0.5400.09
71_C439_V0.5390.09
63_I394_D0.5390.09
172_A399_A0.5380.09
308_V452_M0.5380.09
298_V383_P0.5370.09
26_G233_I0.5370.09
45_L198_A0.5340.09
296_A318_P0.5330.09
123_A189_V0.5330.09
246_Y308_V0.5330.09
106_R178_H0.5320.08
176_W192_Y0.5320.08
243_R341_R0.5320.08
266_A356_R0.5320.08
321_V487_A0.5310.08
189_V235_Y0.5290.08
24_V114_S0.5280.08
62_L175_W0.5280.08
332_R427_Y0.5280.08
86_L98_L0.5270.08
43_G288_F0.5270.08
97_G276_R0.5270.08
197_R261_A0.5260.08
460_S510_I0.5250.08
187_L354_A0.5250.08
43_G323_A0.5240.08
227_G315_A0.5230.08
82_M448_W0.5230.08
122_F186_F0.5220.08
39_V86_L0.5220.08
124_T490_S0.5200.08
232_A260_G0.5200.08
50_A401_A0.5190.08
138_A240_S0.5190.08
170_A290_F0.5170.08
35_A317_V0.5160.08
240_S245_A0.5150.08
6_W379_S0.5140.08
146_H284_G0.5130.08
75_L221_V0.5130.08
69_L104_D0.5120.08
402_P439_V0.5110.08
66_G379_S0.5110.08
33_A462_D0.5100.08
266_A458_T0.5100.08
360_A482_V0.5100.08
120_V257_V0.5090.08
378_T405_L0.5090.08
70_A321_V0.5090.08
53_F301_P0.5090.08
78_Y263_G0.5070.08
44_A198_A0.5070.08
138_A394_D0.5060.08
285_L371_G0.5060.08
65_L321_V0.5060.08
33_A143_L0.5060.08
132_M231_K0.5050.08
368_V473_A0.5040.08
111_L361_A0.5030.08
88_L138_A0.5030.08
375_L437_S0.5020.08
16_L125_K0.5020.08
80_R83_R0.5020.08
190_V224_A0.5020.08
102_A285_L0.5010.08
442_P510_I0.5000.08
161_F312_T0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.8184 99.9 0.862 Contact Map
3rceA 1 0.8088 99.7 0.885 Contact Map
3k6vA 1 0.174 12.8 0.983 Contact Map
3tnyA 1 0.2199 6.1 0.985 Contact Map
4m7oA 1 0.1969 5.8 0.985 Contact Map
4mdyA 1 0.2275 5.4 0.985 Contact Map
4jccA 1 0.2237 5.1 0.986 Contact Map
1fxwF 1 0.2428 5 0.986 Contact Map
3gfvA 1 0.2237 5 0.986 Contact Map
2vozA 3 0.1931 4.8 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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