GREMLIN Database
Q9HNC4 - Mannose-1-phosphate guanylyltransferase
UniProt: Q9HNC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (224)
Sequences: 3623 (2848)
Seq/√Len: 190.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_D71_T4.2671.00
193_V196_L4.1151.00
212_D215_R3.6691.00
69_A73_S3.5531.00
176_A179_N3.2181.00
49_E61_A3.1111.00
73_S77_D2.9541.00
186_K200_A2.9121.00
177_T194_D2.8951.00
136_A139_V2.8421.00
215_R218_D2.5201.00
176_A190_V2.3911.00
200_A205_V2.3681.00
60_V139_V2.3101.00
49_E62_V2.2831.00
97_A136_A2.1711.00
50_P81_L2.1251.00
190_V198_V2.0621.00
149_D159_R2.0301.00
102_P131_A1.9721.00
167_V173_T1.9371.00
49_E80_C1.9291.00
64_R75_L1.9171.00
71_T74_R1.9091.00
175_D212_D1.9051.00
24_V57_H1.8781.00
30_G140_R1.8711.00
30_G138_D1.8371.00
98_A132_V1.8151.00
100_S137_A1.8051.00
195_D209_P1.8011.00
99_R107_V1.7991.00
181_L188_V1.7981.00
81_L141_V1.7281.00
48_I141_V1.7091.00
94_F128_V1.7031.00
102_P126_V1.6991.00
178_G195_D1.6871.00
194_D209_P1.6851.00
158_G163_G1.6611.00
181_L190_V1.6601.00
11_G147_D1.6581.00
174_I222_A1.5871.00
94_F98_A1.5721.00
218_D221_A1.5661.00
21_A88_A1.5571.00
90_T93_A1.5251.00
116_P119_A1.5161.00
50_P58_S1.4581.00
13_G16_E1.4551.00
192_G212_D1.4481.00
190_V193_V1.4141.00
70_E73_S1.3921.00
209_P212_D1.3891.00
197_V210_R1.3771.00
97_A138_D1.3741.00
94_F132_V1.3731.00
2_L88_A1.3701.00
96_D99_R1.3681.00
49_E78_R1.3651.00
89_W94_F1.3581.00
173_T190_V1.3451.00
12_D145_A1.3421.00
127_S130_Y1.3371.00
74_R78_R1.3351.00
173_T181_L1.3151.00
52_D59_E1.3031.00
155_N213_A1.2861.00
172_T187_H1.2831.00
174_I218_D1.2821.00
119_A122_R1.2761.00
75_L80_C1.2651.00
186_K205_V1.2471.00
36_I84_A1.2421.00
103_L107_V1.2241.00
155_N159_R1.2191.00
178_G194_D1.2041.00
20_T56_D1.2031.00
25_A32_V1.2011.00
110_L113_D1.1931.00
196_L209_P1.1891.00
30_G59_E1.1821.00
151_L160_L1.1811.00
51_G59_E1.1801.00
93_A138_D1.1771.00
179_N182_A1.1681.00
173_T176_A1.1641.00
31_L93_A1.1431.00
48_I60_V1.1251.00
184_D200_A1.1251.00
13_G17_T1.1231.00
191_V219_V1.1131.00
195_D211_A1.1091.00
71_T75_L1.1071.00
198_V207_V1.0941.00
4_L86_M1.0831.00
102_P135_R1.0811.00
201_Y204_R1.0801.00
18_A88_A1.0641.00
181_L198_V1.0621.00
99_R104_D1.0581.00
99_R103_L1.0541.00
197_V213_A1.0511.00
16_E19_E1.0501.00
34_I144_A1.0411.00
12_D147_D1.0381.00
158_G180_V1.0371.00
5_P86_M1.0361.00
16_E20_T1.0301.00
185_D200_A1.0221.00
3_C89_W1.0211.00
102_P124_D1.0201.00
189_S219_V1.0181.00
158_G210_R1.0141.00
31_L136_A1.0101.00
161_L166_A1.0001.00
37_E145_A0.9990.99
2_L18_A0.9970.99
32_V140_R0.9940.99
187_H204_R0.9850.99
126_V130_Y0.9820.99
172_T222_A0.9820.99
176_A181_L0.9520.99
23_D27_R0.9470.99
92_T96_D0.9460.99
64_R71_T0.9380.99
112_T116_P0.9300.99
51_G58_S0.9270.99
97_A100_S0.9270.99
96_D100_S0.9200.99
221_A225_A0.9130.99
93_A96_D0.9110.99
15_Q19_E0.9050.99
217_R221_A0.9030.99
183_S188_V0.8970.99
20_T23_D0.8920.99
104_D107_V0.8900.99
24_V140_R0.8880.99
20_T142_V0.8840.99
62_V80_C0.8750.99
195_D210_R0.8740.99
31_L89_W0.8730.99
87_F133_L0.8680.99
167_V171_A0.8530.98
171_A190_V0.8490.98
36_I144_A0.8420.98
20_T55_G0.8410.98
21_A142_V0.8400.98
221_A224_D0.8370.98
74_R77_D0.8370.98
155_N211_A0.8340.98
44_G214_Q0.8320.98
104_D108_D0.8310.98
165_N168_L0.8280.98
179_N196_L0.8280.98
24_V28_T0.8260.98
49_E64_R0.8240.98
222_A225_A0.8230.98
168_L182_A0.8220.98
107_V111_A0.8220.98
105_P119_A0.8150.98
21_A32_V0.8110.98
103_L106_L0.8100.98
51_G61_A0.8100.98
176_A193_V0.8080.98
103_L109_A0.8020.98
105_P118_T0.7970.98
174_I219_V0.7960.97
188_V205_V0.7950.97
191_V216_V0.7940.97
102_P132_V0.7880.97
33_T133_L0.7780.97
197_V208_V0.7760.97
165_N169_G0.7760.97
112_T115_D0.7740.97
167_V181_L0.7720.97
190_V196_L0.7710.97
158_G166_A0.7710.97
14_F18_A0.7700.97
111_A115_D0.7670.97
175_D192_G0.7660.97
2_L34_I0.7650.97
17_T146_F0.7640.97
163_G166_A0.7580.97
96_D138_D0.7570.97
1_M91_P0.7560.97
13_G145_A0.7560.97
42_A214_Q0.7530.97
216_V220_V0.7500.96
31_L94_F0.7440.96
59_E140_R0.7350.96
3_C31_L0.7270.96
29_D90_T0.7260.96
188_V200_A0.7250.96
50_P78_R0.7200.96
41_P69_A0.7190.95
175_D191_V0.7180.95
98_A102_P0.7160.95
112_T119_A0.7160.95
128_V132_V0.7150.95
186_K202_D0.7100.95
126_V131_A0.7050.95
4_L14_F0.6950.95
97_A137_A0.6940.95
9_V160_L0.6940.95
196_L207_V0.6930.94
17_T144_A0.6930.94
106_L109_A0.6930.94
58_S61_A0.6920.94
22_V27_R0.6890.94
87_F129_D0.6880.94
40_R159_R0.6880.94
109_A113_D0.6840.94
116_P120_F0.6820.94
1_M94_F0.6810.94
118_T121_E0.6800.94
32_V142_V0.6790.94
154_W157_L0.6780.94
106_L123_V0.6780.94
29_D96_D0.6760.94
108_D112_T0.6760.94
53_D56_D0.6740.94
34_I88_A0.6740.94
50_P141_V0.6710.93
57_H142_V0.6710.93
200_A203_D0.6670.93
133_L136_A0.6650.93
220_V223_L0.6650.93
95_L103_L0.6600.93
17_T142_V0.6590.93
17_T145_A0.6590.93
204_R223_L0.6580.93
98_A131_A0.6550.93
161_L168_L0.6540.93
103_L110_L0.6530.93
31_L139_V0.6520.92
33_T60_V0.6510.92
126_V135_R0.6490.92
22_V88_A0.6480.92
68_D74_R0.6470.92
9_V166_A0.6460.92
149_D158_G0.6450.92
42_A45_Y0.6420.92
52_D61_A0.6400.92
154_W182_A0.6400.92
198_V205_V0.6360.92
23_D28_T0.6300.91
175_D215_R0.6260.91
188_V198_V0.6220.91
19_E22_V0.6220.91
4_L8_H0.6210.91
64_R80_C0.6190.90
161_L180_V0.6160.90
97_A101_G0.6140.90
133_L139_V0.6130.90
192_G215_R0.6130.90
12_D16_E0.6110.90
33_T87_F0.6110.90
117_A121_E0.6090.90
22_V25_A0.6060.90
125_P221_A0.6040.89
81_L143_P0.6020.89
19_E23_D0.6000.89
15_Q18_A0.5970.89
93_A136_A0.5950.89
57_H140_R0.5900.88
24_V30_G0.5890.88
189_S206_L0.5860.88
123_V126_V0.5850.88
43_T69_A0.5780.87
155_N158_G0.5750.87
161_L182_A0.5750.87
51_G57_H0.5720.87
25_A29_D0.5680.86
174_I215_R0.5680.86
191_V208_V0.5660.86
93_A97_A0.5640.86
31_L157_L0.5600.86
99_R108_D0.5590.85
109_A119_A0.5580.85
156_A159_R0.5560.85
83_N87_F0.5550.85
66_K72_A0.5530.85
3_C6_S0.5520.85
34_I140_R0.5500.84
40_R155_N0.5490.84
54_H57_H0.5480.84
191_V206_L0.5460.84
120_F123_V0.5460.84
180_V197_V0.5460.84
33_T84_A0.5450.84
216_V219_V0.5430.84
118_T122_R0.5410.84
108_D122_R0.5410.84
5_P125_P0.5380.83
19_E27_R0.5370.83
20_T57_H0.5360.83
10_V86_M0.5340.83
105_P124_D0.5330.83
116_P131_A0.5330.83
155_N210_R0.5320.83
17_T34_I0.5300.82
213_A216_V0.5280.82
67_P72_A0.5270.82
106_L110_L0.5250.82
5_P127_S0.5250.82
101_G135_R0.5250.82
89_W98_A0.5240.82
157_L199_A0.5230.81
105_P122_R0.5230.81
37_E143_P0.5210.81
84_A183_S0.5190.81
143_P214_Q0.5190.81
83_N129_D0.5190.81
98_A128_V0.5180.81
178_G210_R0.5180.81
31_L97_A0.5170.81
182_A200_A0.5170.81
169_G205_V0.5160.81
191_V209_P0.5140.80
33_T141_V0.5130.80
97_A139_V0.5130.80
11_G151_L0.5130.80
43_T214_Q0.5110.80
114_A121_E0.5110.80
105_P123_V0.5090.80
45_Y127_S0.5080.80
12_D146_F0.5080.80
5_P85_G0.5060.79
180_V210_R0.5060.79
104_D111_A0.5060.79
38_P41_P0.5050.79
29_D93_A0.5040.79
182_A185_D0.5020.79
106_L113_D0.5010.79
149_D160_L0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x65A 2 0.9736 100 0.319 Contact Map
2cu2A 2 0.978 100 0.331 Contact Map
2qh5A 1 0.6388 100 0.645 Contact Map
3jukA 3 0.6344 99.4 0.822 Contact Map
3pnnA 1 0.7577 99.4 0.823 Contact Map
2e3dA 3 0.7093 99.3 0.826 Contact Map
2ux8A 4 0.7048 99.3 0.828 Contact Map
1jv1A 2 0.8987 99.2 0.837 Contact Map
2pa4A 3 0.7445 99.2 0.839 Contact Map
1yp2A 4 0.8722 99.1 0.842 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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