GREMLIN Database
Q9HNC2 - Uncharacterized protein
UniProt: Q9HNC2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (178)
Sequences: 176 (126)
Seq/√Len: 9.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_T103_A4.5360.99
23_F167_E3.1260.93
80_V104_V3.0970.93
50_V122_L2.8790.90
39_L43_E2.8380.89
176_R179_V2.7050.87
133_S142_A2.6530.86
147_L179_V2.4410.80
18_F78_F2.4090.79
131_E134_V2.3280.77
25_F108_P2.2030.73
8_E36_Y2.1460.70
172_T176_R2.1090.69
28_S33_A2.0950.69
19_N109_R2.0750.68
171_D175_Y1.9830.64
43_E101_Y1.9750.64
46_N86_Q1.8840.60
69_G80_V1.8140.57
48_V161_A1.8000.56
88_E151_E1.7990.56
39_L45_A1.7200.53
159_E162_E1.7110.52
46_N107_K1.7110.52
40_P78_F1.7060.52
45_A48_V1.6490.50
92_A96_A1.6430.49
14_F142_A1.6380.49
110_T118_V1.6250.49
61_G90_A1.6000.47
20_D109_R1.5850.47
15_A75_T1.5830.47
53_T108_P1.5690.46
81_Y84_Q1.5660.46
21_A39_L1.5520.45
82_A101_Y1.5500.45
6_T65_E1.5080.43
13_V122_L1.4520.41
112_E116_G1.4090.39
69_G104_V1.3960.39
103_A120_V1.3830.38
135_R139_V1.3800.38
13_V71_V1.3660.37
9_V123_R1.3590.37
46_N146_T1.3440.36
46_N81_Y1.3350.36
59_D65_E1.3260.36
71_V184_A1.3010.35
37_A185_E1.2920.34
174_A179_V1.2830.34
39_L93_L1.2780.34
120_V167_E1.2740.33
112_E119_N1.2690.33
145_R148_D1.2620.33
73_D76_G1.2610.33
21_A68_R1.2400.32
104_V127_I1.2180.31
136_D139_V1.2110.31
101_Y170_A1.2080.31
176_R184_A1.2010.31
150_I175_Y1.1950.30
143_A146_T1.1830.30
25_F53_T1.1790.30
23_F120_V1.1780.30
93_L135_R1.1730.30
110_T150_I1.1710.30
18_F75_T1.1630.29
17_E42_G1.1620.29
45_A114_D1.1600.29
86_Q123_R1.1570.29
171_D176_R1.1560.29
53_T93_L1.1500.29
180_V184_A1.1430.29
44_R160_Y1.1160.28
19_N120_V1.1040.27
9_V81_Y1.1000.27
157_G165_R1.0980.27
54_L91_A1.0940.27
59_D116_G1.0890.27
110_T184_A1.0770.26
47_R125_E1.0740.26
147_L150_I1.0690.26
69_G90_A1.0690.26
93_L130_V1.0640.26
32_R96_A1.0330.25
50_V166_A1.0290.25
57_T171_D1.0280.25
69_G95_D1.0210.24
18_F108_P1.0200.24
143_A183_L1.0190.24
61_G67_W1.0180.24
174_A181_D1.0160.24
11_R24_T1.0040.24
57_T160_Y1.0010.24
8_E70_R0.9930.23
25_F113_T0.9870.23
62_E150_I0.9860.23
175_Y179_V0.9860.23
87_P123_R0.9850.23
19_N67_W0.9820.23
181_D184_A0.9800.23
140_V144_E0.9780.23
39_L184_A0.9770.23
39_L167_E0.9720.23
51_T99_P0.9650.22
75_T103_A0.9610.22
29_D32_R0.9440.22
125_E138_W0.9330.22
70_R99_P0.9310.21
7_R47_R0.9130.21
69_G87_P0.9080.21
34_P46_N0.9050.21
38_L113_T0.9040.21
66_Y119_N0.9040.21
97_E133_S0.9020.21
83_G107_K0.8940.20
28_S77_T0.8930.20
67_W94_R0.8840.20
162_E175_Y0.8820.20
58_E123_R0.8810.20
96_A159_E0.8740.20
68_R121_S0.8720.20
18_F157_G0.8700.20
108_P113_T0.8660.20
150_I179_V0.8650.20
81_Y135_R0.8630.19
122_L152_A0.8590.19
44_R136_D0.8530.19
108_P137_R0.8530.19
45_A178_A0.8500.19
69_G113_T0.8490.19
59_D67_W0.8430.19
25_F66_Y0.8410.19
57_T113_T0.8390.19
15_A54_L0.8360.19
71_V172_T0.8340.19
118_V132_E0.8290.19
20_D28_S0.8290.19
32_R150_I0.8180.18
81_Y93_L0.8170.18
104_V148_D0.8110.18
18_F30_D0.8090.18
16_A62_E0.8080.18
38_L108_P0.8070.18
82_A85_Y0.8040.18
35_L92_A0.7990.18
14_F138_W0.7940.18
143_A147_L0.7870.17
27_E33_A0.7790.17
29_D51_T0.7770.17
21_A91_A0.7730.17
44_R179_V0.7720.17
21_A45_A0.7710.17
78_F124_P0.7710.17
65_E69_G0.7680.17
89_A142_A0.7640.17
23_F39_L0.7640.17
36_Y44_R0.7580.17
169_G172_T0.7580.17
150_I183_L0.7560.17
13_V62_E0.7540.17
107_K123_R0.7540.17
82_A106_G0.7530.17
56_E85_Y0.7520.17
144_E175_Y0.7450.16
38_L119_N0.7390.16
100_T178_A0.7350.16
122_L129_M0.7340.16
20_D78_F0.7330.16
23_F77_T0.7270.16
112_E141_E0.7260.16
15_A135_R0.7170.16
51_T130_V0.7160.16
110_T124_P0.7160.16
39_L79_F0.7050.15
12_R123_R0.7040.15
62_E100_T0.6980.15
71_V155_E0.6910.15
103_A145_R0.6840.15
21_A169_G0.6750.15
85_Y93_L0.6740.15
61_G117_S0.6710.15
61_G94_R0.6700.15
96_A104_V0.6700.15
6_T69_G0.6690.15
12_R70_R0.6690.15
54_L134_V0.6670.15
69_G94_R0.6660.15
43_E167_E0.6590.14
30_D150_I0.6570.14
90_A185_E0.6500.14
13_V166_A0.6500.14
40_P82_A0.6500.14
104_V122_L0.6480.14
57_T119_N0.6410.14
20_D153_F0.6390.14
13_V100_T0.6390.14
26_K152_A0.6380.14
54_L83_G0.6370.14
46_N143_A0.6360.14
60_I171_D0.6350.14
71_V152_A0.6340.14
49_F103_A0.6340.14
75_T143_A0.6330.14
86_Q107_K0.6310.14
38_L48_V0.6300.14
141_E150_I0.6300.14
171_D174_A0.6240.14
24_T36_Y0.6230.14
18_F140_V0.6220.14
7_R85_Y0.6220.14
30_D67_W0.6220.14
144_E150_I0.6180.14
101_Y141_E0.6180.14
122_L145_R0.6160.13
82_A89_A0.6160.13
6_T59_D0.6100.13
20_D76_G0.6090.13
106_G115_D0.6090.13
19_N28_S0.6070.13
50_V91_A0.6040.13
39_L119_N0.5920.13
176_R181_D0.5920.13
132_E136_D0.5910.13
80_V152_A0.5900.13
43_E131_E0.5890.13
16_A174_A0.5860.13
53_T113_T0.5830.13
41_T136_D0.5800.13
65_E182_A0.5790.13
85_Y107_K0.5770.13
53_T157_G0.5770.13
108_P160_Y0.5750.13
18_F117_S0.5750.13
44_R142_A0.5690.13
170_A173_S0.5690.13
50_V115_D0.5670.12
58_E74_P0.5640.12
173_S177_Q0.5630.12
45_A160_Y0.5590.12
46_N123_R0.5570.12
58_E118_V0.5480.12
119_N160_Y0.5480.12
171_D185_E0.5460.12
48_V144_E0.5450.12
44_R130_V0.5440.12
9_V90_A0.5420.12
22_T131_E0.5380.12
171_D179_V0.5350.12
103_A143_A0.5350.12
12_R146_T0.5300.12
44_R88_E0.5290.12
130_V136_D0.5280.12
16_A183_L0.5230.12
39_L94_R0.5210.12
53_T119_N0.5210.12
51_T139_V0.5210.12
99_P121_S0.5200.12
173_S176_R0.5190.12
113_T160_Y0.5180.12
25_F79_F0.5160.12
86_Q147_L0.5140.11
33_A36_Y0.5130.11
57_T92_A0.5060.11
143_A179_V0.5050.11
172_T185_E0.5000.11
133_S157_G0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pi2A 1 0.6737 98.2 0.879 Contact Map
4gnxB 1 0.6263 97.8 0.89 Contact Map
3mxnB 1 0.6421 96.9 0.906 Contact Map
3kdfD 2 0.6158 96.9 0.906 Contact Map
4joiA 1 0.6895 95.9 0.915 Contact Map
3kf6A 1 0.6789 90.8 0.931 Contact Map
1txyA 2 0.4211 77.3 0.943 Contact Map
4gs3A 2 0.4316 68.5 0.946 Contact Map
4gn4B 1 0.5368 62.5 0.948 Contact Map
3e0eA 1 0.4579 56.1 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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