GREMLIN Database
Q9HNB9 - Uncharacterized protein
UniProt: Q9HNB9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (216)
Sequences: 1386 (1214)
Seq/√Len: 82.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_N183_N4.7431.00
162_N183_N4.4761.00
144_N162_N4.0821.00
162_N204_N3.8771.00
143_D161_T3.7731.00
126_N162_N3.7321.00
143_D182_N3.6621.00
126_N144_N3.5561.00
125_S143_D3.4701.00
125_S161_T3.2801.00
183_N243_N3.2431.00
161_T182_N3.2341.00
183_N204_N3.2001.00
161_T203_D3.0961.00
162_N243_N3.0641.00
182_N203_D3.0171.00
182_N242_D2.8331.00
126_N204_N2.8261.00
146_D185_D2.7131.00
126_N183_N2.6761.00
144_N204_N2.5761.00
204_N243_N2.5351.00
53_H144_N2.3991.00
144_N243_N2.3661.00
161_T242_D2.3081.00
53_H126_N2.2571.00
203_D242_D2.2311.00
126_N243_N2.0881.00
68_V111_V1.9941.00
143_D203_D1.9871.00
149_V152_A1.9481.00
53_H183_N1.8951.00
142_T160_T1.8941.00
185_D245_D1.8811.00
125_S182_N1.8751.00
128_D164_A1.8471.00
125_S203_D1.8461.00
164_A185_D1.8401.00
160_T181_S1.8151.00
128_D146_D1.7931.00
164_A206_E1.7631.00
164_A245_D1.7381.00
128_D185_D1.7241.00
53_H162_N1.7061.00
143_D242_D1.5791.00
67_A112_Q1.5791.00
62_D115_A1.5581.00
128_D206_E1.5401.00
87_G96_V1.5160.99
185_D206_E1.5090.99
207_T246_V1.5060.99
146_D206_E1.4850.99
49_V111_V1.4470.99
55_D146_D1.4420.99
54_G108_A1.4300.99
146_D164_A1.4100.99
124_T181_S1.4010.99
160_T202_T1.3960.99
142_T181_S1.3940.99
51_G54_G1.3870.99
125_S242_D1.3770.99
61_H112_Q1.3730.99
69_T110_D1.3350.99
57_A110_D1.3290.99
59_S112_Q1.2800.98
55_D128_D1.2230.98
58_V113_V1.1920.97
128_D245_D1.1870.97
139_S157_A1.1840.97
131_V134_V1.1790.97
54_G107_A1.1700.97
122_L129_I1.1550.96
145_G184_G1.1520.96
206_E245_D1.1410.96
46_A93_G1.1400.96
127_G134_V1.1160.96
59_S110_D1.1060.96
191_S196_A1.0950.95
53_H204_N1.0580.94
165_V186_V1.0540.94
181_S202_T0.9840.92
63_S67_A0.9830.92
231_G234_T0.9750.91
202_T241_S0.9680.91
55_D164_A0.9670.91
138_E156_S0.9570.91
133_D151_S0.9470.90
167_I188_V0.9340.90
128_D131_V0.9230.89
179_A239_A0.9190.89
34_R72_L0.9160.89
53_H243_N0.9110.88
229_V232_E0.9070.88
51_G108_A0.8940.87
60_T133_D0.8940.87
158_A179_A0.8930.87
54_G109_F0.8890.87
188_V209_I0.8890.87
51_G109_F0.8770.86
21_C24_A0.8690.86
66_V70_A0.8690.86
190_L235_H0.8640.86
174_S196_A0.8580.85
154_P175_G0.8550.85
97_A100_G0.8510.85
183_N186_V0.8490.85
37_E69_T0.8470.84
191_S194_A0.8420.84
146_D245_D0.8390.84
52_K143_D0.8220.83
63_S112_Q0.8160.82
230_L234_T0.8160.82
216_D237_V0.8100.82
137_V155_V0.8030.81
124_T160_T0.8020.81
230_L233_G0.7960.81
129_I132_Q0.7960.81
60_T115_A0.7930.80
55_D185_D0.7870.80
116_G135_A0.7850.80
230_L245_D0.7840.80
160_T241_S0.7830.79
21_C25_Q0.7810.79
52_K125_S0.7770.79
15_A24_A0.7750.79
129_I134_V0.7730.79
18_L24_A0.7700.78
186_V246_V0.7650.78
48_S93_G0.7580.77
12_A15_A0.7580.77
127_G131_V0.7540.77
60_T113_V0.7510.77
52_K161_T0.7490.76
89_T94_L0.7480.76
39_D65_Q0.7480.76
166_T187_S0.7470.76
208_G247_E0.7460.76
145_G244_G0.7450.76
19_T22_M0.7440.76
54_G58_V0.7430.76
105_V109_F0.7420.76
157_A178_T0.7420.76
10_V13_A0.7410.76
127_G145_G0.7360.75
56_V122_L0.7350.75
121_E139_S0.7340.75
16_A20_G0.7340.75
124_T129_I0.7320.75
184_G244_G0.7310.75
155_V176_D0.7210.74
140_A144_N0.7200.74
141_T180_V0.7190.73
47_V96_V0.7170.73
186_V239_A0.7090.72
147_V158_A0.7050.72
71_R108_A0.7030.72
46_A92_D0.7020.72
241_S246_V0.7000.71
130_D134_V0.6990.71
70_A107_A0.6980.71
69_T112_Q0.6950.71
11_A15_A0.6940.71
51_G107_A0.6870.70
132_Q150_Q0.6840.70
175_G196_A0.6830.70
110_D119_V0.6780.69
71_R110_D0.6740.69
113_V117_T0.6740.69
37_E67_A0.6730.68
71_R129_I0.6720.68
174_S191_S0.6710.68
70_A85_V0.6710.68
48_S95_S0.6700.68
137_V156_S0.6680.68
124_T127_G0.6670.68
46_A118_A0.6670.68
15_A21_C0.6660.68
14_A18_L0.6650.68
78_E83_A0.6640.67
89_T96_V0.6620.67
202_T207_T0.6610.67
12_A24_A0.6610.67
52_K56_V0.6590.67
72_L107_A0.6560.66
11_A14_A0.6550.66
15_A18_L0.6540.66
156_S177_V0.6520.66
128_D134_V0.6510.66
245_D248_F0.6510.66
199_V238_V0.6500.66
160_T186_V0.6500.66
122_L133_D0.6460.65
70_A105_V0.6430.65
20_G25_Q0.6390.64
41_P65_Q0.6380.64
130_D133_D0.6370.64
83_A105_V0.6360.64
122_L140_A0.6340.64
119_V134_V0.6340.64
10_V14_A0.6320.64
177_V237_V0.6300.63
43_E112_Q0.6290.63
72_L109_F0.6290.63
127_G132_Q0.6280.63
49_V62_D0.6260.63
216_D248_F0.6210.62
184_G202_T0.6200.62
181_S241_S0.6160.62
142_T146_D0.6150.61
55_D245_D0.6140.61
119_V122_L0.6140.61
70_A109_F0.6120.61
135_A153_G0.6100.61
58_V131_V0.6090.61
45_T117_T0.6090.61
54_G145_G0.6070.60
124_T142_T0.6040.60
205_G244_G0.6030.60
12_A17_S0.6020.60
48_S121_E0.5980.59
47_V111_V0.5980.59
200_A239_A0.5970.59
158_A165_V0.5960.59
70_A188_V0.5950.59
13_A18_L0.5940.59
45_T92_D0.5940.59
11_A18_L0.5930.59
123_E159_E0.5920.59
138_E149_V0.5880.58
14_A19_T0.5880.58
166_T186_V0.5860.58
96_V109_F0.5840.58
232_E236_E0.5830.57
74_G79_R0.5810.57
35_D56_V0.5800.57
163_G184_G0.5760.57
91_A133_D0.5730.56
47_V118_A0.5720.56
131_V141_T0.5710.56
178_T238_V0.5700.56
196_A230_L0.5700.56
167_I172_P0.5700.56
238_V247_E0.5680.55
138_E141_T0.5670.55
85_V96_V0.5660.55
19_T24_A0.5660.55
140_A158_A0.5630.55
19_T23_G0.5610.55
85_V109_F0.5600.54
157_A180_V0.5580.54
64_E68_V0.5580.54
178_T208_G0.5570.54
190_L196_A0.5570.54
174_S194_A0.5570.54
104_G159_E0.5570.54
47_V117_T0.5570.54
60_T82_G0.5560.54
129_I140_A0.5550.54
41_P44_D0.5540.54
168_D189_S0.5530.54
36_V129_I0.5530.54
45_T89_T0.5520.53
59_S140_A0.5520.53
176_D197_E0.5500.53
63_S134_V0.5490.53
41_P159_E0.5480.53
177_V198_V0.5480.53
127_G130_D0.5480.53
142_T241_S0.5450.52
18_L21_C0.5440.52
124_T128_D0.5420.52
116_G138_E0.5390.52
14_A22_M0.5390.52
109_F136_G0.5380.52
90_G208_G0.5370.51
142_T192_P0.5370.51
39_D47_V0.5340.51
16_A23_G0.5330.51
216_D229_V0.5310.51
64_E86_A0.5260.50
174_S190_L0.5260.50
38_F109_F0.5260.50
68_V181_S0.5240.50
141_T201_R0.5230.50
11_A113_V0.5230.50
202_T246_V0.5230.50
244_G248_F0.5220.49
122_L131_V0.5220.49
54_G136_G0.5210.49
111_V119_V0.5200.49
135_A141_T0.5200.49
19_T159_E0.5190.49
148_T166_T0.5180.49
180_V201_R0.5180.49
22_M25_Q0.5180.49
16_A24_A0.5170.49
149_V167_I0.5170.49
17_S24_A0.5170.49
179_A200_A0.5160.49
235_H246_V0.5160.49
229_V247_E0.5160.49
231_G247_E0.5160.49
236_E242_D0.5140.48
168_D209_I0.5140.48
61_H67_A0.5140.48
174_S179_A0.5110.48
10_V15_A0.5110.48
90_G95_S0.5110.48
149_V198_V0.5100.48
124_T202_T0.5100.48
140_A149_V0.5100.48
49_V181_S0.5090.48
51_G124_T0.5080.48
159_E201_R0.5080.48
13_A17_S0.5080.48
55_D206_E0.5070.47
56_V87_G0.5060.47
177_V188_V0.5060.47
50_S68_V0.5050.47
32_E186_V0.5020.47
180_V240_E0.5020.47
122_L126_N0.5020.47
142_T202_T0.5010.47
90_G148_T0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lycA 2 0.8088 99.3 0.686 Contact Map
4qrkA 1 0.7689 99.2 0.694 Contact Map
3jx8A 4 0.8207 99.2 0.695 Contact Map
4yguA 3 0.6653 99.2 0.702 Contact Map
3petA 2 0.8167 99.1 0.715 Contact Map
4opwA 1 0.8247 98.9 0.733 Contact Map
4peuA 1 0.7251 93.2 0.872 Contact Map
1y0gA 2 0.6335 42.3 0.92 Contact Map
4uu4A 1 0.5179 22.3 0.931 Contact Map
4m0nA 1 0.7291 19.7 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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