Q9HNB9 - HALSA - GREMLIN Contacts

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Q9HNB9 - Uncharacterized protein

UniProt:	Q9HNB9	Sequences: MHRRALLGGVAAAAAASLTGCMGAQSDDQYEETRDVEFDLPAEDTAVSVSGKHGDVAVSTHDSEQVAVTARLSGPSEERVDGAEVAGQTGADGLSVALAGTTDGVSAAFDVQVPAGTAVGELETSNGDIDVQDVAGVESATTDNGDVTVQSAGPVSAAETTNGAVTIDEPAPLSGDVTAVSNNGDVSVSLSPDADAEVVARTDNGETGIEDLELSDLRRDGDDGMVRGVLGEGTHEVVAESDNGDVEFDAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	251 (216)
Sequences:	1386 (1214)
Seq/√Len:	82.6

BACSU - LIAG YVLB
HALSA - Q9HNB9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
144_N	183_N	4.743	1.00
162_N	183_N	4.476	1.00
144_N	162_N	4.082	1.00
162_N	204_N	3.877	1.00
143_D	161_T	3.773	1.00
126_N	162_N	3.732	1.00
143_D	182_N	3.662	1.00
126_N	144_N	3.556	1.00
125_S	143_D	3.470	1.00
125_S	161_T	3.280	1.00
183_N	243_N	3.243	1.00
161_T	182_N	3.234	1.00
183_N	204_N	3.200	1.00
161_T	203_D	3.096	1.00
162_N	243_N	3.064	1.00
182_N	203_D	3.017	1.00
182_N	242_D	2.833	1.00
126_N	204_N	2.826	1.00
146_D	185_D	2.713	1.00
126_N	183_N	2.676	1.00
144_N	204_N	2.576	1.00
204_N	243_N	2.535	1.00
53_H	144_N	2.399	1.00
144_N	243_N	2.366	1.00
161_T	242_D	2.308	1.00
53_H	126_N	2.257	1.00
203_D	242_D	2.231	1.00
126_N	243_N	2.088	1.00
68_V	111_V	1.994	1.00
143_D	203_D	1.987	1.00
149_V	152_A	1.948	1.00
53_H	183_N	1.895	1.00
142_T	160_T	1.894	1.00
185_D	245_D	1.881	1.00
125_S	182_N	1.875	1.00
128_D	164_A	1.847	1.00
125_S	203_D	1.846	1.00
164_A	185_D	1.840	1.00
160_T	181_S	1.815	1.00
128_D	146_D	1.793	1.00
164_A	206_E	1.763	1.00
164_A	245_D	1.738	1.00
128_D	185_D	1.724	1.00
53_H	162_N	1.706	1.00
143_D	242_D	1.579	1.00
67_A	112_Q	1.579	1.00
62_D	115_A	1.558	1.00
128_D	206_E	1.540	1.00
87_G	96_V	1.516	0.99
185_D	206_E	1.509	0.99
207_T	246_V	1.506	0.99
146_D	206_E	1.485	0.99
49_V	111_V	1.447	0.99
55_D	146_D	1.442	0.99
54_G	108_A	1.430	0.99
146_D	164_A	1.410	0.99
124_T	181_S	1.401	0.99
160_T	202_T	1.396	0.99
142_T	181_S	1.394	0.99
51_G	54_G	1.387	0.99
125_S	242_D	1.377	0.99
61_H	112_Q	1.373	0.99
69_T	110_D	1.335	0.99
57_A	110_D	1.329	0.99
59_S	112_Q	1.280	0.98
55_D	128_D	1.223	0.98
58_V	113_V	1.192	0.97
128_D	245_D	1.187	0.97
139_S	157_A	1.184	0.97
131_V	134_V	1.179	0.97
54_G	107_A	1.170	0.97
122_L	129_I	1.155	0.96
145_G	184_G	1.152	0.96
206_E	245_D	1.141	0.96
46_A	93_G	1.140	0.96
127_G	134_V	1.116	0.96
59_S	110_D	1.106	0.96
191_S	196_A	1.095	0.95
53_H	204_N	1.058	0.94
165_V	186_V	1.054	0.94
181_S	202_T	0.984	0.92
63_S	67_A	0.983	0.92
231_G	234_T	0.975	0.91
202_T	241_S	0.968	0.91
55_D	164_A	0.967	0.91
138_E	156_S	0.957	0.91
133_D	151_S	0.947	0.90
167_I	188_V	0.934	0.90
128_D	131_V	0.923	0.89
179_A	239_A	0.919	0.89
34_R	72_L	0.916	0.89
53_H	243_N	0.911	0.88
229_V	232_E	0.907	0.88
51_G	108_A	0.894	0.87
60_T	133_D	0.894	0.87
158_A	179_A	0.893	0.87
54_G	109_F	0.889	0.87
188_V	209_I	0.889	0.87
51_G	109_F	0.877	0.86
21_C	24_A	0.869	0.86
66_V	70_A	0.869	0.86
190_L	235_H	0.864	0.86
174_S	196_A	0.858	0.85
154_P	175_G	0.855	0.85
97_A	100_G	0.851	0.85
183_N	186_V	0.849	0.85
37_E	69_T	0.847	0.84
191_S	194_A	0.842	0.84
146_D	245_D	0.839	0.84
52_K	143_D	0.822	0.83
63_S	112_Q	0.816	0.82
230_L	234_T	0.816	0.82
216_D	237_V	0.810	0.82
137_V	155_V	0.803	0.81
124_T	160_T	0.802	0.81
230_L	233_G	0.796	0.81
129_I	132_Q	0.796	0.81
60_T	115_A	0.793	0.80
55_D	185_D	0.787	0.80
116_G	135_A	0.785	0.80
230_L	245_D	0.784	0.80
160_T	241_S	0.783	0.79
21_C	25_Q	0.781	0.79
52_K	125_S	0.777	0.79
15_A	24_A	0.775	0.79
129_I	134_V	0.773	0.79
18_L	24_A	0.770	0.78
186_V	246_V	0.765	0.78
48_S	93_G	0.758	0.77
12_A	15_A	0.758	0.77
127_G	131_V	0.754	0.77
60_T	113_V	0.751	0.77
52_K	161_T	0.749	0.76
89_T	94_L	0.748	0.76
39_D	65_Q	0.748	0.76
166_T	187_S	0.747	0.76
208_G	247_E	0.746	0.76
145_G	244_G	0.745	0.76
19_T	22_M	0.744	0.76
54_G	58_V	0.743	0.76
105_V	109_F	0.742	0.76
157_A	178_T	0.742	0.76
10_V	13_A	0.741	0.76
127_G	145_G	0.736	0.75
56_V	122_L	0.735	0.75
121_E	139_S	0.734	0.75
16_A	20_G	0.734	0.75
124_T	129_I	0.732	0.75
184_G	244_G	0.731	0.75
155_V	176_D	0.721	0.74
140_A	144_N	0.720	0.74
141_T	180_V	0.719	0.73
47_V	96_V	0.717	0.73
186_V	239_A	0.709	0.72
147_V	158_A	0.705	0.72
71_R	108_A	0.703	0.72
46_A	92_D	0.702	0.72
241_S	246_V	0.700	0.71
130_D	134_V	0.699	0.71
70_A	107_A	0.698	0.71
69_T	112_Q	0.695	0.71
11_A	15_A	0.694	0.71
51_G	107_A	0.687	0.70
132_Q	150_Q	0.684	0.70
175_G	196_A	0.683	0.70
110_D	119_V	0.678	0.69
71_R	110_D	0.674	0.69
113_V	117_T	0.674	0.69
37_E	67_A	0.673	0.68
71_R	129_I	0.672	0.68
174_S	191_S	0.671	0.68
70_A	85_V	0.671	0.68
48_S	95_S	0.670	0.68
137_V	156_S	0.668	0.68
124_T	127_G	0.667	0.68
46_A	118_A	0.667	0.68
15_A	21_C	0.666	0.68
14_A	18_L	0.665	0.68
78_E	83_A	0.664	0.67
89_T	96_V	0.662	0.67
202_T	207_T	0.661	0.67
12_A	24_A	0.661	0.67
52_K	56_V	0.659	0.67
72_L	107_A	0.656	0.66
11_A	14_A	0.655	0.66
15_A	18_L	0.654	0.66
156_S	177_V	0.652	0.66
128_D	134_V	0.651	0.66
245_D	248_F	0.651	0.66
199_V	238_V	0.650	0.66
160_T	186_V	0.650	0.66
122_L	133_D	0.646	0.65
70_A	105_V	0.643	0.65
20_G	25_Q	0.639	0.64
41_P	65_Q	0.638	0.64
130_D	133_D	0.637	0.64
83_A	105_V	0.636	0.64
122_L	140_A	0.634	0.64
119_V	134_V	0.634	0.64
10_V	14_A	0.632	0.64
177_V	237_V	0.630	0.63
43_E	112_Q	0.629	0.63
72_L	109_F	0.629	0.63
127_G	132_Q	0.628	0.63
49_V	62_D	0.626	0.63
216_D	248_F	0.621	0.62
184_G	202_T	0.620	0.62
181_S	241_S	0.616	0.62
142_T	146_D	0.615	0.61
55_D	245_D	0.614	0.61
119_V	122_L	0.614	0.61
70_A	109_F	0.612	0.61
135_A	153_G	0.610	0.61
58_V	131_V	0.609	0.61
45_T	117_T	0.609	0.61
54_G	145_G	0.607	0.60
124_T	142_T	0.604	0.60
205_G	244_G	0.603	0.60
12_A	17_S	0.602	0.60
48_S	121_E	0.598	0.59
47_V	111_V	0.598	0.59
200_A	239_A	0.597	0.59
158_A	165_V	0.596	0.59
70_A	188_V	0.595	0.59
13_A	18_L	0.594	0.59
45_T	92_D	0.594	0.59
11_A	18_L	0.593	0.59
123_E	159_E	0.592	0.59
138_E	149_V	0.588	0.58
14_A	19_T	0.588	0.58
166_T	186_V	0.586	0.58
96_V	109_F	0.584	0.58
232_E	236_E	0.583	0.57
74_G	79_R	0.581	0.57
35_D	56_V	0.580	0.57
163_G	184_G	0.576	0.57
91_A	133_D	0.573	0.56
47_V	118_A	0.572	0.56
131_V	141_T	0.571	0.56
178_T	238_V	0.570	0.56
196_A	230_L	0.570	0.56
167_I	172_P	0.570	0.56
238_V	247_E	0.568	0.55
138_E	141_T	0.567	0.55
85_V	96_V	0.566	0.55
19_T	24_A	0.566	0.55
140_A	158_A	0.563	0.55
19_T	23_G	0.561	0.55
85_V	109_F	0.560	0.54
157_A	180_V	0.558	0.54
64_E	68_V	0.558	0.54
178_T	208_G	0.557	0.54
190_L	196_A	0.557	0.54
174_S	194_A	0.557	0.54
104_G	159_E	0.557	0.54
47_V	117_T	0.557	0.54
60_T	82_G	0.556	0.54
129_I	140_A	0.555	0.54
41_P	44_D	0.554	0.54
168_D	189_S	0.553	0.54
36_V	129_I	0.553	0.54
45_T	89_T	0.552	0.53
59_S	140_A	0.552	0.53
176_D	197_E	0.550	0.53
63_S	134_V	0.549	0.53
41_P	159_E	0.548	0.53
177_V	198_V	0.548	0.53
127_G	130_D	0.548	0.53
142_T	241_S	0.545	0.52
18_L	21_C	0.544	0.52
124_T	128_D	0.542	0.52
116_G	138_E	0.539	0.52
14_A	22_M	0.539	0.52
109_F	136_G	0.538	0.52
90_G	208_G	0.537	0.51
142_T	192_P	0.537	0.51
39_D	47_V	0.534	0.51
16_A	23_G	0.533	0.51
216_D	229_V	0.531	0.51
64_E	86_A	0.526	0.50
174_S	190_L	0.526	0.50
38_F	109_F	0.526	0.50
68_V	181_S	0.524	0.50
141_T	201_R	0.523	0.50
11_A	113_V	0.523	0.50
202_T	246_V	0.523	0.50
244_G	248_F	0.522	0.49
122_L	131_V	0.522	0.49
54_G	136_G	0.521	0.49
111_V	119_V	0.520	0.49
135_A	141_T	0.520	0.49
19_T	159_E	0.519	0.49
148_T	166_T	0.518	0.49
180_V	201_R	0.518	0.49
22_M	25_Q	0.518	0.49
16_A	24_A	0.517	0.49
149_V	167_I	0.517	0.49
17_S	24_A	0.517	0.49
179_A	200_A	0.516	0.49
235_H	246_V	0.516	0.49
229_V	247_E	0.516	0.49
231_G	247_E	0.516	0.49
236_E	242_D	0.514	0.48
168_D	209_I	0.514	0.48
61_H	67_A	0.514	0.48
174_S	179_A	0.511	0.48
10_V	15_A	0.511	0.48
90_G	95_S	0.511	0.48
149_V	198_V	0.510	0.48
124_T	202_T	0.510	0.48
140_A	149_V	0.510	0.48
49_V	181_S	0.509	0.48
51_G	124_T	0.508	0.48
159_E	201_R	0.508	0.48
13_A	17_S	0.508	0.48
55_D	206_E	0.507	0.47
56_V	87_G	0.506	0.47
177_V	188_V	0.506	0.47
50_S	68_V	0.505	0.47
32_E	186_V	0.502	0.47
180_V	240_E	0.502	0.47
122_L	126_N	0.502	0.47
142_T	202_T	0.501	0.47
90_G	148_T	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lycA	2	0.8088	99.3	0.686	Contact Map
4qrkA	1	0.7689	99.2	0.694	Contact Map
3jx8A	4	0.8207	99.2	0.695	Contact Map
4yguA	3	0.6653	99.2	0.702	Contact Map
3petA	2	0.8167	99.1	0.715	Contact Map
4opwA	1	0.8247	98.9	0.733	Contact Map
4peuA	1	0.7251	93.2	0.872	Contact Map
1y0gA	2	0.6335	42.3	0.92	Contact Map
4uu4A	1	0.5179	22.3	0.931	Contact Map
4m0nA	1	0.7291	19.7	0.933	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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