GREMLIN Database
Q9HNB8 - Uncharacterized protein
UniProt: Q9HNB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (111)
Sequences: 201 (178)
Seq/√Len: 16.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_P115_V4.8171.00
80_A112_L3.8951.00
25_R29_R3.1200.99
20_D25_R2.7590.98
48_R69_V2.7310.97
80_A109_V2.7080.97
84_A104_F2.6970.97
104_F108_F2.2510.92
54_E63_T2.2360.92
41_A45_A1.9810.86
27_T31_L1.8600.82
87_R111_D1.8450.82
82_T85_A1.8430.82
47_G72_E1.7850.79
101_A108_F1.7100.76
78_V82_T1.5660.70
22_A26_D1.5250.67
25_R101_A1.5220.67
84_A108_F1.4930.66
85_A114_G1.4190.62
55_V64_A1.4110.61
57_S60_T1.4050.61
34_R88_T1.3970.60
7_R11_A1.3440.57
8_A11_A1.3220.56
29_R101_A1.2990.55
57_S62_E1.2740.53
80_A116_T1.2700.53
19_F51_I1.2660.53
58_D82_T1.2610.52
53_G78_V1.2210.50
29_R53_G1.2190.50
32_I79_D1.2140.50
83_T112_L1.1940.48
72_E76_F1.1870.48
83_T86_E1.1770.47
83_T87_R1.1660.47
44_R75_A1.1310.45
25_R28_L1.1300.45
36_V73_T1.1220.44
49_A112_L1.1140.44
6_R13_G1.1100.43
49_A70_T1.0980.43
63_T109_V1.0880.42
32_I114_G1.0860.42
15_L86_E1.0820.42
14_H17_P1.0700.41
98_Q102_T1.0690.41
30_S94_P1.0690.41
45_A107_D1.0680.41
52_W67_R1.0620.41
51_I109_V1.0510.40
15_L30_S1.0430.40
98_Q103_A1.0170.38
5_A9_L1.0140.38
79_D112_L1.0100.38
67_R81_A1.0070.38
49_A73_T1.0060.37
85_A88_T1.0030.37
82_T113_D1.0010.37
70_T76_F0.9880.36
10_R35_F0.9800.36
27_T51_I0.9670.35
44_R73_T0.9420.34
20_D29_R0.9410.34
56_S63_T0.9390.34
8_A81_A0.9340.34
95_P98_Q0.9080.32
17_P78_V0.9040.32
14_H107_D0.8950.32
55_V66_S0.8900.31
17_P24_V0.8890.31
83_T108_F0.8850.31
18_L97_Y0.8700.30
68_L85_A0.8680.30
40_D94_P0.8640.30
36_V75_A0.8560.30
6_R32_I0.8530.29
15_L88_T0.8490.29
91_G111_D0.8440.29
62_E76_F0.8370.29
28_L67_R0.8330.28
27_T32_I0.8320.28
18_L94_P0.8100.27
9_L97_Y0.8020.27
78_V83_T0.7990.27
45_A63_T0.7960.27
27_T101_A0.7920.26
29_R33_T0.7800.26
42_D55_V0.7770.26
18_L29_R0.7750.26
18_L107_D0.7580.25
81_A110_T0.7530.25
17_P53_G0.7500.25
81_A101_A0.7460.24
64_A89_L0.7440.24
92_D106_A0.7390.24
58_D61_G0.7360.24
9_L89_L0.7330.24
8_A64_A0.7310.24
90_D111_D0.7230.23
60_T82_T0.7200.23
71_P116_T0.7170.23
41_A82_T0.7170.23
31_L73_T0.7140.23
93_T97_Y0.7110.23
10_R94_P0.7100.23
36_V104_F0.7080.23
68_L115_V0.7070.23
15_L21_A0.7000.22
40_D62_E0.6940.22
88_T97_Y0.6940.22
14_H24_V0.6930.22
20_D24_V0.6840.22
36_V78_V0.6830.22
80_A103_A0.6810.22
81_A92_D0.6810.22
64_A95_P0.6730.21
32_I36_V0.6700.21
68_L80_A0.6680.21
40_D43_E0.6650.21
97_Y111_D0.6630.21
38_G100_P0.6470.20
38_G74_Y0.6470.20
74_Y100_P0.6470.20
70_T110_T0.6410.20
56_S80_A0.6390.20
78_V103_A0.6350.20
56_S110_T0.6290.20
42_D45_A0.6230.19
31_L41_A0.6140.19
50_H67_R0.6080.19
48_R97_Y0.6060.19
36_V52_W0.6030.19
91_G107_D0.6010.19
13_G69_V0.6010.19
16_A98_Q0.5990.19
42_D106_A0.5920.18
107_D110_T0.5900.18
11_A34_R0.5870.18
52_W89_L0.5820.18
91_G95_P0.5780.18
22_A107_D0.5770.18
21_A81_A0.5760.18
9_L88_T0.5740.18
45_A93_T0.5720.18
103_A108_F0.5700.18
71_P110_T0.5690.17
37_D73_T0.5660.17
20_D49_A0.5550.17
33_T104_F0.5510.17
5_A32_I0.5500.17
9_L32_I0.5470.17
53_G72_E0.5470.17
9_L15_L0.5420.17
109_V112_L0.5390.16
11_A73_T0.5380.16
25_R83_T0.5280.16
13_G115_V0.5270.16
21_A40_D0.5240.16
8_A108_F0.5230.16
14_H93_T0.5190.16
29_R51_I0.5150.16
41_A106_A0.5080.15
98_Q113_D0.5070.15
65_V79_D0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4inaA 2 0.9431 96.2 0.851 Contact Map
3abiA 2 0.9024 93.1 0.875 Contact Map
4rl6A 2 0.9675 76.9 0.902 Contact Map
1ff9A 2 0.9756 21.5 0.933 Contact Map
1wu2A 2 0.7642 15.7 0.937 Contact Map
3fgyA 2 0.3984 8 0.944 Contact Map
4f55A 1 0.748 8 0.944 Contact Map
4p9fA 1 0.3659 6.7 0.946 Contact Map
4txdA 1 0.935 6.7 0.946 Contact Map
2eplX 2 0.6585 5.4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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