Q9HNB6 - HALSA - GREMLIN Contacts

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Q9HNB6 - Uncharacterized protein

UniProt:	Q9HNB6	Sequences: MRGFRIGRVFGIPIKLDVTFLLVLPVFAYLIGTQLEVWVSTLNGAPFAAGLDATALTAGSVRWVLGAAAAVGLFVGVVLHELGHSVVAMRYDFTIDAITLWVLGGVASLTDQPEEWDQELCIALAGPAVSVALAAVAYGVLAVLPSSLDTVRFVFGYLALMNLALAAFNLLPGFPMDGGRVLRALLARTRTFARATKIAAEVGKLFAFVLGIAGLLSFNVILIGVAFFIYIGAAGEAQRTAMNAAFEGVTVADVMTPASDVHTVAATASVADLMDSMLEHRHTGYPVFRDATAVGMVTLDDARSVRAVERDAMRVADVMSDDVYTIPGSADATDALDALQEHSVGRLLVVDADGEMVGLITRSDLMDAFGIIQSTGAAVSRESLDLPSRP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	390 (345)
Sequences:	1143 (894)
Seq/√Len:	48.1

BACSU - SP4FB
HALSA - Q9HNB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
83_G	129_V	5.345	1.00
79_L	129_V	4.025	1.00
251_V	335_A	3.602	1.00
330_A	338_A	3.492	1.00
254_V	332_A	3.413	1.00
250_T	253_D	3.331	1.00
131_V	166_A	3.277	1.00
133_L	137_A	3.268	1.00
211_G	226_A	3.265	1.00
335_A	347_L	3.114	1.00
120_L	124_L	2.883	1.00
256_T	364_D	2.765	1.00
87_V	121_C	2.697	1.00
186_L	195_A	2.681	1.00
201_E	204_K	2.666	1.00
326_I	330_A	2.628	1.00
72_G	154_V	2.466	1.00
180_R	183_R	2.451	1.00
251_V	360_I	2.359	1.00
169_N	177_D	2.222	1.00
166_A	169_N	2.213	1.00
206_F	210_L	2.198	1.00
169_N	172_P	2.137	1.00
79_L	83_G	2.133	1.00
307_A	310_R	2.124	1.00
172_P	175_P	2.118	1.00
97_A	108_S	2.100	1.00
221_I	226_A	2.066	1.00
254_V	360_I	2.007	0.99
314_R	317_D	1.995	0.99
119_E	123_A	1.980	0.99
85_S	107_A	1.974	0.99
93_F	122_I	1.969	0.99
134_A	163_L	1.967	0.99
172_P	177_D	1.953	0.99
71_V	75_V	1.923	0.99
309_E	313_M	1.907	0.99
327_P	330_A	1.844	0.99
56_L	59_G	1.827	0.99
280_H	285_Y	1.792	0.99
119_E	183_R	1.787	0.99
174_F	177_D	1.758	0.99
270_V	318_V	1.755	0.99
137_A	140_V	1.748	0.99
183_R	187_A	1.747	0.99
200_A	237_A	1.722	0.98
174_F	183_R	1.721	0.98
170_L	181_V	1.719	0.98
124_L	181_V	1.714	0.98
282_H	346_R	1.708	0.98
205_L	209_V	1.705	0.98
178_G	183_R	1.705	0.98
85_S	89_M	1.705	0.98
99_T	102_V	1.700	0.98
345_G	362_R	1.685	0.98
119_E	180_R	1.682	0.98
85_S	95_I	1.670	0.98
169_N	175_P	1.661	0.98
169_N	176_M	1.657	0.98
286_P	361_T	1.650	0.98
162_N	169_N	1.625	0.98
117_D	121_C	1.619	0.98
207_A	226_A	1.617	0.98
162_N	165_L	1.546	0.97
173_G	177_D	1.540	0.97
162_N	177_D	1.527	0.97
172_P	178_G	1.503	0.96
165_L	177_D	1.502	0.96
256_T	359_L	1.497	0.96
21_L	25_P	1.476	0.96
268_A	272_D	1.474	0.96
271_A	275_D	1.472	0.96
95_I	109_L	1.459	0.95
282_H	359_L	1.454	0.95
80_H	168_F	1.453	0.95
25_P	29_Y	1.450	0.95
219_N	222_L	1.444	0.95
183_R	196_T	1.431	0.95
221_I	225_V	1.427	0.95
197_K	204_K	1.415	0.95
297_V	318_V	1.414	0.95
138_Y	159_A	1.411	0.95
69_A	73_L	1.411	0.95
282_H	285_Y	1.408	0.95
351_D	355_E	1.405	0.94
84_H	88_A	1.403	0.94
73_L	77_V	1.394	0.94
170_L	174_F	1.393	0.94
168_F	177_D	1.379	0.94
67_A	71_V	1.375	0.94
272_D	275_D	1.357	0.93
166_A	170_L	1.355	0.93
301_D	320_S	1.354	0.93
80_H	177_D	1.351	0.93
32_G	62_R	1.347	0.93
256_T	282_H	1.320	0.92
174_F	180_R	1.319	0.92
83_G	125_A	1.313	0.92
20_F	187_A	1.311	0.92
162_N	172_P	1.306	0.92
162_N	175_P	1.300	0.92
252_A	351_D	1.298	0.92
252_A	329_S	1.297	0.92
125_A	128_A	1.289	0.91
6_I	13_P	1.286	0.91
287_V	315_V	1.285	0.91
133_L	136_V	1.270	0.91
206_F	213_A	1.269	0.91
80_H	84_H	1.262	0.91
199_A	204_K	1.255	0.90
282_H	286_P	1.253	0.90
134_A	138_Y	1.250	0.90
80_H	169_N	1.245	0.90
81_E	169_N	1.243	0.90
287_V	319_M	1.226	0.89
99_T	105_G	1.226	0.89
206_F	217_S	1.220	0.89
205_L	213_A	1.211	0.89
128_A	135_A	1.209	0.89
115_E	118_Q	1.197	0.88
140_V	144_L	1.194	0.88
168_F	175_P	1.185	0.88
275_D	279_E	1.182	0.87
204_K	210_L	1.178	0.87
32_G	63_W	1.178	0.87
100_L	106_V	1.175	0.87
282_H	364_D	1.157	0.86
254_V	368_A	1.153	0.86
255_M	286_P	1.148	0.86
26_V	32_G	1.144	0.86
128_A	347_L	1.141	0.85
293_A	348_L	1.141	0.85
167_A	170_L	1.132	0.85
204_K	215_L	1.131	0.85
315_V	319_M	1.130	0.85
162_N	168_F	1.127	0.85
131_V	135_A	1.127	0.85
162_N	178_G	1.126	0.85
170_L	177_D	1.123	0.85
339_L	365_L	1.122	0.85
180_R	196_T	1.122	0.85
151_V	155_F	1.118	0.84
326_I	335_A	1.111	0.84
206_F	209_V	1.109	0.84
194_R	198_I	1.097	0.83
127_P	177_D	1.093	0.83
214_G	218_F	1.093	0.83
251_V	349_V	1.091	0.83
165_L	169_N	1.091	0.83
13_P	21_L	1.089	0.83
326_I	347_L	1.085	0.82
29_Y	33_T	1.081	0.82
346_R	364_D	1.081	0.82
31_I	157_Y	1.076	0.82
81_E	175_P	1.066	0.81
103_L	130_S	1.066	0.81
169_N	174_F	1.065	0.81
127_P	175_P	1.061	0.81
6_I	28_A	1.059	0.81
204_K	208_F	1.053	0.81
162_N	174_F	1.053	0.81
76_G	133_L	1.050	0.80
20_F	236_E	1.050	0.80
20_F	24_L	1.047	0.80
31_I	62_R	1.046	0.80
269_S	312_A	1.045	0.80
96_D	120_L	1.040	0.80
12_I	15_K	1.040	0.80
195_A	199_A	1.037	0.79
59_G	62_R	1.035	0.79
186_L	198_I	1.030	0.79
229_I	236_E	1.027	0.79
127_P	169_N	1.024	0.79
37_V	62_R	1.022	0.78
93_F	109_L	1.021	0.78
82_L	125_A	1.013	0.78
261_V	282_H	1.008	0.78
167_A	321_D	1.006	0.77
91_Y	121_C	1.003	0.77
124_L	128_A	1.000	0.77
198_I	203_G	0.993	0.76
169_N	173_G	0.993	0.76
261_V	356_M	0.993	0.76
123_A	127_P	0.987	0.76
269_S	314_R	0.985	0.76
187_A	192_F	0.985	0.76
297_V	317_D	0.980	0.75
80_H	175_P	0.979	0.75
172_P	183_R	0.970	0.75
139_G	142_A	0.969	0.75
20_F	101_W	0.963	0.74
105_G	127_P	0.960	0.74
76_G	80_H	0.958	0.74
261_V	364_D	0.955	0.74
206_F	225_V	0.952	0.73
94_T	243_N	0.949	0.73
204_K	207_A	0.948	0.73
328_G	357_V	0.943	0.73
238_Q	242_M	0.936	0.72
228_F	233_A	0.928	0.71
175_P	183_R	0.927	0.71
293_A	350_V	0.926	0.71
31_I	37_V	0.925	0.71
128_A	132_A	0.923	0.71
173_G	236_E	0.919	0.71
114_E	118_Q	0.919	0.71
177_D	183_R	0.910	0.70
32_G	36_E	0.909	0.70
180_R	195_A	0.906	0.70
274_M	310_R	0.905	0.69
284_G	346_R	0.900	0.69
265_A	268_A	0.899	0.69
27_F	31_I	0.896	0.69
143_V	209_V	0.893	0.68
251_V	332_A	0.891	0.68
297_V	305_V	0.889	0.68
127_P	162_N	0.888	0.68
10_F	22_L	0.876	0.67
266_A	294_V	0.875	0.67
163_L	167_A	0.873	0.67
84_H	168_F	0.869	0.66
81_E	127_P	0.865	0.66
197_K	200_A	0.863	0.66
87_V	95_I	0.861	0.66
176_M	187_A	0.859	0.65
198_I	201_E	0.858	0.65
84_H	89_M	0.858	0.65
69_A	157_Y	0.855	0.65
83_G	88_A	0.850	0.65
168_F	172_P	0.849	0.65
204_K	217_S	0.849	0.65
84_H	169_N	0.844	0.64
266_A	289_R	0.843	0.64
324_Y	338_A	0.843	0.64
174_F	196_T	0.842	0.64
170_L	178_G	0.840	0.64
199_A	207_A	0.838	0.63
84_H	87_V	0.836	0.63
80_H	127_P	0.834	0.63
172_P	176_M	0.830	0.63
273_L	303_R	0.830	0.63
241_A	365_L	0.829	0.63
175_P	178_G	0.825	0.62
104_G	295_G	0.825	0.62
204_K	214_G	0.824	0.62
78_V	102_V	0.822	0.62
107_A	183_R	0.820	0.62
62_R	66_G	0.816	0.61
158_L	162_N	0.816	0.61
213_A	217_S	0.816	0.61
294_V	319_M	0.815	0.61
156_G	166_A	0.814	0.61
267_T	316_A	0.809	0.61
66_G	73_L	0.809	0.61
135_A	138_Y	0.805	0.60
122_I	127_P	0.804	0.60
84_H	105_G	0.802	0.60
131_V	144_L	0.802	0.60
85_S	109_L	0.799	0.60
215_L	218_F	0.797	0.60
301_D	359_L	0.796	0.59
294_V	350_V	0.793	0.59
200_A	236_E	0.793	0.59
83_G	107_A	0.792	0.59
196_T	210_L	0.792	0.59
231_I	238_Q	0.790	0.59
168_F	228_F	0.790	0.59
31_I	35_L	0.789	0.59
114_E	129_V	0.782	0.58
8_R	355_E	0.782	0.58
264_V	268_A	0.781	0.58
269_S	290_D	0.780	0.58
127_P	172_P	0.776	0.58
64_V	67_A	0.775	0.57
81_E	177_D	0.775	0.57
243_N	347_L	0.775	0.57
309_E	312_A	0.774	0.57
67_A	361_T	0.772	0.57
80_H	162_N	0.769	0.57
331_D	334_D	0.766	0.57
73_L	161_M	0.765	0.56
249_V	253_D	0.759	0.56
85_S	88_A	0.758	0.56
315_V	320_S	0.756	0.56
323_V	362_R	0.755	0.55
334_D	337_D	0.753	0.55
20_F	28_A	0.753	0.55
366_M	370_G	0.750	0.55
35_L	54_T	0.749	0.55
298_T	301_D	0.748	0.55
212_I	215_L	0.747	0.55
173_G	186_L	0.747	0.55
165_L	172_P	0.746	0.55
301_D	304_S	0.743	0.54
81_E	105_G	0.742	0.54
173_G	187_A	0.738	0.54
10_F	13_P	0.735	0.53
141_L	144_L	0.734	0.53
211_G	217_S	0.733	0.53
22_L	29_Y	0.732	0.53
94_T	110_T	0.730	0.53
184_A	187_A	0.726	0.53
103_L	110_T	0.724	0.52
207_A	214_G	0.723	0.52
176_M	190_R	0.723	0.52
264_V	273_L	0.721	0.52
130_S	133_L	0.720	0.52
286_P	359_L	0.718	0.52
155_F	159_A	0.716	0.52
332_A	365_L	0.714	0.51
207_A	218_F	0.713	0.51
65_L	69_A	0.711	0.51
88_A	162_N	0.710	0.51
61_V	64_V	0.710	0.51
22_L	35_L	0.708	0.51
199_A	215_L	0.707	0.51
183_R	186_L	0.707	0.51
32_G	59_G	0.705	0.50
12_I	85_S	0.705	0.50
119_E	174_F	0.704	0.50
99_T	103_L	0.704	0.50
204_K	216_L	0.704	0.50
166_A	172_P	0.699	0.50
7_G	251_V	0.697	0.50
182_L	187_A	0.695	0.49
237_A	240_T	0.695	0.49
202_V	210_L	0.695	0.49
6_I	9_V	0.693	0.49
187_A	190_R	0.692	0.49
285_Y	346_R	0.690	0.49
231_I	234_A	0.689	0.49
314_R	365_L	0.688	0.49
86_V	89_M	0.687	0.49
149_D	155_F	0.686	0.49
100_L	180_R	0.685	0.48
273_L	315_V	0.685	0.48
359_L	364_D	0.685	0.48
211_G	215_L	0.683	0.48
81_E	178_G	0.683	0.48
81_E	162_N	0.682	0.48
31_I	56_L	0.681	0.48
87_V	92_D	0.680	0.48
138_Y	141_L	0.680	0.48
207_A	230_Y	0.679	0.48
81_E	172_P	0.678	0.48
186_L	189_T	0.673	0.47
217_S	223_I	0.672	0.47
165_L	168_F	0.671	0.47
182_L	202_V	0.670	0.47
28_A	32_G	0.669	0.47
98_I	107_A	0.668	0.47
272_D	276_S	0.664	0.46
83_G	93_F	0.663	0.46
346_R	359_L	0.662	0.46
188_R	251_V	0.662	0.46
105_G	169_N	0.661	0.46
96_D	110_T	0.660	0.46
364_D	367_D	0.660	0.46
206_F	215_L	0.657	0.46
136_V	235_G	0.655	0.45
186_L	222_L	0.655	0.45
255_M	356_M	0.655	0.45
141_L	145_P	0.654	0.45
328_G	351_D	0.654	0.45
185_L	188_R	0.653	0.45
209_V	216_L	0.653	0.45
36_E	62_R	0.652	0.45
64_V	68_A	0.651	0.45
207_A	213_A	0.651	0.45
74_F	98_I	0.649	0.45
277_M	302_A	0.648	0.45
7_G	10_F	0.645	0.44
229_I	233_A	0.643	0.44
91_Y	125_A	0.643	0.44
88_A	99_T	0.643	0.44
10_F	350_V	0.641	0.44
170_L	175_P	0.640	0.44
84_H	162_N	0.640	0.44
16_L	366_M	0.639	0.44
286_P	364_D	0.639	0.44
211_G	214_G	0.637	0.44
175_P	180_R	0.636	0.44
93_F	112_Q	0.636	0.44
337_D	341_E	0.634	0.43
84_H	177_D	0.634	0.43
176_M	189_T	0.633	0.43
205_L	210_L	0.632	0.43
119_E	196_T	0.632	0.43
113_P	180_R	0.632	0.43
103_L	108_S	0.632	0.43
70_A	73_L	0.631	0.43
162_N	170_L	0.628	0.43
31_I	34_Q	0.626	0.43
124_L	142_A	0.624	0.42
208_F	212_I	0.622	0.42
325_T	350_V	0.621	0.42
18_V	31_I	0.621	0.42
204_K	209_V	0.620	0.42
223_I	226_A	0.618	0.42
298_T	339_L	0.617	0.42
12_I	97_A	0.616	0.42
112_Q	187_A	0.616	0.42
195_A	198_I	0.614	0.41
251_V	347_L	0.611	0.41
101_W	130_S	0.611	0.41
15_K	18_V	0.611	0.41
326_I	349_V	0.609	0.41
255_M	357_V	0.608	0.41
105_G	175_P	0.607	0.41
197_K	210_L	0.607	0.41
183_R	195_A	0.606	0.41
158_L	168_F	0.606	0.41
106_V	109_L	0.605	0.41
12_I	82_L	0.604	0.40
144_L	155_F	0.604	0.40
100_L	105_G	0.603	0.40
210_L	214_G	0.603	0.40
105_G	199_A	0.603	0.40
22_L	25_P	0.602	0.40
80_H	184_A	0.596	0.40
313_M	318_V	0.596	0.40
193_A	197_K	0.595	0.40
135_A	139_G	0.594	0.39
171_L	206_F	0.594	0.39
80_H	88_A	0.592	0.39
330_A	334_D	0.592	0.39
172_P	180_R	0.589	0.39
128_A	202_V	0.589	0.39
27_F	299_L	0.588	0.39
84_H	92_D	0.586	0.39
18_V	26_V	0.585	0.39
56_L	62_R	0.584	0.38
17_D	24_L	0.581	0.38
264_V	287_V	0.580	0.38
17_D	36_E	0.579	0.38
106_V	270_V	0.577	0.38
10_F	14_I	0.576	0.38
75_V	79_L	0.573	0.37
209_V	213_A	0.572	0.37
132_A	136_V	0.572	0.37
10_F	16_L	0.571	0.37
121_C	274_M	0.571	0.37
34_Q	37_V	0.570	0.37
6_I	71_V	0.569	0.37
162_N	173_G	0.568	0.37
29_Y	139_G	0.567	0.37
289_R	314_R	0.567	0.37
26_V	225_V	0.566	0.37
105_G	168_F	0.566	0.37
202_V	205_L	0.564	0.37
178_G	182_L	0.563	0.37
99_T	158_L	0.560	0.36
173_G	179_G	0.559	0.36
26_V	29_Y	0.557	0.36
137_A	141_L	0.557	0.36
111_D	125_A	0.556	0.36
174_F	178_G	0.555	0.36
114_E	197_K	0.554	0.36
95_I	112_Q	0.552	0.35
181_V	228_F	0.551	0.35
166_A	177_D	0.551	0.35
234_A	238_Q	0.550	0.35
128_A	366_M	0.548	0.35
24_L	30_L	0.548	0.35
200_A	292_T	0.548	0.35
332_A	335_A	0.548	0.35
156_G	160_L	0.548	0.35
60_S	64_V	0.547	0.35
275_D	311_D	0.546	0.35
175_P	179_G	0.545	0.35
260_D	279_E	0.543	0.35
28_A	221_I	0.543	0.35
18_V	34_Q	0.543	0.35
16_L	29_Y	0.542	0.35
112_Q	120_L	0.541	0.34
203_G	215_L	0.541	0.34
208_F	216_L	0.541	0.34
165_L	170_L	0.540	0.34
291_A	341_E	0.539	0.34
158_L	177_D	0.539	0.34
105_G	108_S	0.537	0.34
196_T	206_F	0.534	0.34
153_F	176_M	0.534	0.34
163_L	181_V	0.533	0.34
32_G	35_L	0.532	0.34
328_G	348_L	0.532	0.34
250_T	281_R	0.532	0.34
77_V	219_N	0.531	0.34
288_F	350_V	0.531	0.34
184_A	207_A	0.530	0.33
245_A	369_F	0.530	0.33
210_L	213_A	0.530	0.33
282_H	361_T	0.529	0.33
169_N	178_G	0.526	0.33
83_G	99_T	0.526	0.33
29_Y	37_V	0.525	0.33
313_M	317_D	0.525	0.33
16_L	30_L	0.523	0.33
76_G	84_H	0.523	0.33
204_K	213_A	0.523	0.33
6_I	15_K	0.520	0.33
175_P	233_A	0.520	0.33
167_A	172_P	0.520	0.33
345_G	363_S	0.519	0.33
58_A	246_F	0.518	0.32
79_L	359_L	0.516	0.32
228_F	232_G	0.515	0.32
167_A	296_M	0.513	0.32
199_A	203_G	0.512	0.32
130_S	175_P	0.512	0.32
151_V	154_V	0.510	0.32
165_L	222_L	0.510	0.32
343_S	348_L	0.510	0.32
9_V	143_V	0.508	0.32
195_A	206_F	0.505	0.31
256_T	284_G	0.502	0.31
346_R	361_T	0.500	0.31
155_F	170_L	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3b4rA	2	0.5564	100	0.591	Contact Map
3orgA	2	0.8231	100	0.714	Contact Map
1jcnA	6	0.4538	99.9	0.748	Contact Map
3lqnA	2	0.3333	99.9	0.758	Contact Map
2ef7A	3	0.3308	99.9	0.758	Contact Map
3l2bA	2	0.2974	99.9	0.758	Contact Map
1o50A	2	0.3333	99.9	0.759	Contact Map
3lfrA	2	0.3256	99.9	0.761	Contact Map
3fv6A	2	0.3615	99.9	0.762	Contact Map
2p9mA	2	0.3256	99.9	0.762	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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