GREMLIN Database
Q9HNB6 - Uncharacterized protein
UniProt: Q9HNB6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 390 (345)
Sequences: 1143 (894)
Seq/√Len: 48.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_G129_V5.3451.00
79_L129_V4.0251.00
251_V335_A3.6021.00
330_A338_A3.4921.00
254_V332_A3.4131.00
250_T253_D3.3311.00
131_V166_A3.2771.00
133_L137_A3.2681.00
211_G226_A3.2651.00
335_A347_L3.1141.00
120_L124_L2.8831.00
256_T364_D2.7651.00
87_V121_C2.6971.00
186_L195_A2.6811.00
201_E204_K2.6661.00
326_I330_A2.6281.00
72_G154_V2.4661.00
180_R183_R2.4511.00
251_V360_I2.3591.00
169_N177_D2.2221.00
166_A169_N2.2131.00
206_F210_L2.1981.00
169_N172_P2.1371.00
79_L83_G2.1331.00
307_A310_R2.1241.00
172_P175_P2.1181.00
97_A108_S2.1001.00
221_I226_A2.0661.00
254_V360_I2.0070.99
314_R317_D1.9950.99
119_E123_A1.9800.99
85_S107_A1.9740.99
93_F122_I1.9690.99
134_A163_L1.9670.99
172_P177_D1.9530.99
71_V75_V1.9230.99
309_E313_M1.9070.99
327_P330_A1.8440.99
56_L59_G1.8270.99
280_H285_Y1.7920.99
119_E183_R1.7870.99
174_F177_D1.7580.99
270_V318_V1.7550.99
137_A140_V1.7480.99
183_R187_A1.7470.99
200_A237_A1.7220.98
174_F183_R1.7210.98
170_L181_V1.7190.98
124_L181_V1.7140.98
282_H346_R1.7080.98
205_L209_V1.7050.98
178_G183_R1.7050.98
85_S89_M1.7050.98
99_T102_V1.7000.98
345_G362_R1.6850.98
119_E180_R1.6820.98
85_S95_I1.6700.98
169_N175_P1.6610.98
169_N176_M1.6570.98
286_P361_T1.6500.98
162_N169_N1.6250.98
117_D121_C1.6190.98
207_A226_A1.6170.98
162_N165_L1.5460.97
173_G177_D1.5400.97
162_N177_D1.5270.97
172_P178_G1.5030.96
165_L177_D1.5020.96
256_T359_L1.4970.96
21_L25_P1.4760.96
268_A272_D1.4740.96
271_A275_D1.4720.96
95_I109_L1.4590.95
282_H359_L1.4540.95
80_H168_F1.4530.95
25_P29_Y1.4500.95
219_N222_L1.4440.95
183_R196_T1.4310.95
221_I225_V1.4270.95
197_K204_K1.4150.95
297_V318_V1.4140.95
138_Y159_A1.4110.95
69_A73_L1.4110.95
282_H285_Y1.4080.95
351_D355_E1.4050.94
84_H88_A1.4030.94
73_L77_V1.3940.94
170_L174_F1.3930.94
168_F177_D1.3790.94
67_A71_V1.3750.94
272_D275_D1.3570.93
166_A170_L1.3550.93
301_D320_S1.3540.93
80_H177_D1.3510.93
32_G62_R1.3470.93
256_T282_H1.3200.92
174_F180_R1.3190.92
83_G125_A1.3130.92
20_F187_A1.3110.92
162_N172_P1.3060.92
162_N175_P1.3000.92
252_A351_D1.2980.92
252_A329_S1.2970.92
125_A128_A1.2890.91
6_I13_P1.2860.91
287_V315_V1.2850.91
133_L136_V1.2700.91
206_F213_A1.2690.91
80_H84_H1.2620.91
199_A204_K1.2550.90
282_H286_P1.2530.90
134_A138_Y1.2500.90
80_H169_N1.2450.90
81_E169_N1.2430.90
287_V319_M1.2260.89
99_T105_G1.2260.89
206_F217_S1.2200.89
205_L213_A1.2110.89
128_A135_A1.2090.89
115_E118_Q1.1970.88
140_V144_L1.1940.88
168_F175_P1.1850.88
275_D279_E1.1820.87
204_K210_L1.1780.87
32_G63_W1.1780.87
100_L106_V1.1750.87
282_H364_D1.1570.86
254_V368_A1.1530.86
255_M286_P1.1480.86
26_V32_G1.1440.86
128_A347_L1.1410.85
293_A348_L1.1410.85
167_A170_L1.1320.85
204_K215_L1.1310.85
315_V319_M1.1300.85
162_N168_F1.1270.85
131_V135_A1.1270.85
162_N178_G1.1260.85
170_L177_D1.1230.85
339_L365_L1.1220.85
180_R196_T1.1220.85
151_V155_F1.1180.84
326_I335_A1.1110.84
206_F209_V1.1090.84
194_R198_I1.0970.83
127_P177_D1.0930.83
214_G218_F1.0930.83
251_V349_V1.0910.83
165_L169_N1.0910.83
13_P21_L1.0890.83
326_I347_L1.0850.82
29_Y33_T1.0810.82
346_R364_D1.0810.82
31_I157_Y1.0760.82
81_E175_P1.0660.81
103_L130_S1.0660.81
169_N174_F1.0650.81
127_P175_P1.0610.81
6_I28_A1.0590.81
204_K208_F1.0530.81
162_N174_F1.0530.81
76_G133_L1.0500.80
20_F236_E1.0500.80
20_F24_L1.0470.80
31_I62_R1.0460.80
269_S312_A1.0450.80
96_D120_L1.0400.80
12_I15_K1.0400.80
195_A199_A1.0370.79
59_G62_R1.0350.79
186_L198_I1.0300.79
229_I236_E1.0270.79
127_P169_N1.0240.79
37_V62_R1.0220.78
93_F109_L1.0210.78
82_L125_A1.0130.78
261_V282_H1.0080.78
167_A321_D1.0060.77
91_Y121_C1.0030.77
124_L128_A1.0000.77
198_I203_G0.9930.76
169_N173_G0.9930.76
261_V356_M0.9930.76
123_A127_P0.9870.76
269_S314_R0.9850.76
187_A192_F0.9850.76
297_V317_D0.9800.75
80_H175_P0.9790.75
172_P183_R0.9700.75
139_G142_A0.9690.75
20_F101_W0.9630.74
105_G127_P0.9600.74
76_G80_H0.9580.74
261_V364_D0.9550.74
206_F225_V0.9520.73
94_T243_N0.9490.73
204_K207_A0.9480.73
328_G357_V0.9430.73
238_Q242_M0.9360.72
228_F233_A0.9280.71
175_P183_R0.9270.71
293_A350_V0.9260.71
31_I37_V0.9250.71
128_A132_A0.9230.71
173_G236_E0.9190.71
114_E118_Q0.9190.71
177_D183_R0.9100.70
32_G36_E0.9090.70
180_R195_A0.9060.70
274_M310_R0.9050.69
284_G346_R0.9000.69
265_A268_A0.8990.69
27_F31_I0.8960.69
143_V209_V0.8930.68
251_V332_A0.8910.68
297_V305_V0.8890.68
127_P162_N0.8880.68
10_F22_L0.8760.67
266_A294_V0.8750.67
163_L167_A0.8730.67
84_H168_F0.8690.66
81_E127_P0.8650.66
197_K200_A0.8630.66
87_V95_I0.8610.66
176_M187_A0.8590.65
198_I201_E0.8580.65
84_H89_M0.8580.65
69_A157_Y0.8550.65
83_G88_A0.8500.65
168_F172_P0.8490.65
204_K217_S0.8490.65
84_H169_N0.8440.64
266_A289_R0.8430.64
324_Y338_A0.8430.64
174_F196_T0.8420.64
170_L178_G0.8400.64
199_A207_A0.8380.63
84_H87_V0.8360.63
80_H127_P0.8340.63
172_P176_M0.8300.63
273_L303_R0.8300.63
241_A365_L0.8290.63
175_P178_G0.8250.62
104_G295_G0.8250.62
204_K214_G0.8240.62
78_V102_V0.8220.62
107_A183_R0.8200.62
62_R66_G0.8160.61
158_L162_N0.8160.61
213_A217_S0.8160.61
294_V319_M0.8150.61
156_G166_A0.8140.61
267_T316_A0.8090.61
66_G73_L0.8090.61
135_A138_Y0.8050.60
122_I127_P0.8040.60
84_H105_G0.8020.60
131_V144_L0.8020.60
85_S109_L0.7990.60
215_L218_F0.7970.60
301_D359_L0.7960.59
294_V350_V0.7930.59
200_A236_E0.7930.59
83_G107_A0.7920.59
196_T210_L0.7920.59
231_I238_Q0.7900.59
168_F228_F0.7900.59
31_I35_L0.7890.59
114_E129_V0.7820.58
8_R355_E0.7820.58
264_V268_A0.7810.58
269_S290_D0.7800.58
127_P172_P0.7760.58
64_V67_A0.7750.57
81_E177_D0.7750.57
243_N347_L0.7750.57
309_E312_A0.7740.57
67_A361_T0.7720.57
80_H162_N0.7690.57
331_D334_D0.7660.57
73_L161_M0.7650.56
249_V253_D0.7590.56
85_S88_A0.7580.56
315_V320_S0.7560.56
323_V362_R0.7550.55
334_D337_D0.7530.55
20_F28_A0.7530.55
366_M370_G0.7500.55
35_L54_T0.7490.55
298_T301_D0.7480.55
212_I215_L0.7470.55
173_G186_L0.7470.55
165_L172_P0.7460.55
301_D304_S0.7430.54
81_E105_G0.7420.54
173_G187_A0.7380.54
10_F13_P0.7350.53
141_L144_L0.7340.53
211_G217_S0.7330.53
22_L29_Y0.7320.53
94_T110_T0.7300.53
184_A187_A0.7260.53
103_L110_T0.7240.52
207_A214_G0.7230.52
176_M190_R0.7230.52
264_V273_L0.7210.52
130_S133_L0.7200.52
286_P359_L0.7180.52
155_F159_A0.7160.52
332_A365_L0.7140.51
207_A218_F0.7130.51
65_L69_A0.7110.51
88_A162_N0.7100.51
61_V64_V0.7100.51
22_L35_L0.7080.51
199_A215_L0.7070.51
183_R186_L0.7070.51
32_G59_G0.7050.50
12_I85_S0.7050.50
119_E174_F0.7040.50
99_T103_L0.7040.50
204_K216_L0.7040.50
166_A172_P0.6990.50
7_G251_V0.6970.50
182_L187_A0.6950.49
237_A240_T0.6950.49
202_V210_L0.6950.49
6_I9_V0.6930.49
187_A190_R0.6920.49
285_Y346_R0.6900.49
231_I234_A0.6890.49
314_R365_L0.6880.49
86_V89_M0.6870.49
149_D155_F0.6860.49
100_L180_R0.6850.48
273_L315_V0.6850.48
359_L364_D0.6850.48
211_G215_L0.6830.48
81_E178_G0.6830.48
81_E162_N0.6820.48
31_I56_L0.6810.48
87_V92_D0.6800.48
138_Y141_L0.6800.48
207_A230_Y0.6790.48
81_E172_P0.6780.48
186_L189_T0.6730.47
217_S223_I0.6720.47
165_L168_F0.6710.47
182_L202_V0.6700.47
28_A32_G0.6690.47
98_I107_A0.6680.47
272_D276_S0.6640.46
83_G93_F0.6630.46
346_R359_L0.6620.46
188_R251_V0.6620.46
105_G169_N0.6610.46
96_D110_T0.6600.46
364_D367_D0.6600.46
206_F215_L0.6570.46
136_V235_G0.6550.45
186_L222_L0.6550.45
255_M356_M0.6550.45
141_L145_P0.6540.45
328_G351_D0.6540.45
185_L188_R0.6530.45
209_V216_L0.6530.45
36_E62_R0.6520.45
64_V68_A0.6510.45
207_A213_A0.6510.45
74_F98_I0.6490.45
277_M302_A0.6480.45
7_G10_F0.6450.44
229_I233_A0.6430.44
91_Y125_A0.6430.44
88_A99_T0.6430.44
10_F350_V0.6410.44
170_L175_P0.6400.44
84_H162_N0.6400.44
16_L366_M0.6390.44
286_P364_D0.6390.44
211_G214_G0.6370.44
175_P180_R0.6360.44
93_F112_Q0.6360.44
337_D341_E0.6340.43
84_H177_D0.6340.43
176_M189_T0.6330.43
205_L210_L0.6320.43
119_E196_T0.6320.43
113_P180_R0.6320.43
103_L108_S0.6320.43
70_A73_L0.6310.43
162_N170_L0.6280.43
31_I34_Q0.6260.43
124_L142_A0.6240.42
208_F212_I0.6220.42
325_T350_V0.6210.42
18_V31_I0.6210.42
204_K209_V0.6200.42
223_I226_A0.6180.42
298_T339_L0.6170.42
12_I97_A0.6160.42
112_Q187_A0.6160.42
195_A198_I0.6140.41
251_V347_L0.6110.41
101_W130_S0.6110.41
15_K18_V0.6110.41
326_I349_V0.6090.41
255_M357_V0.6080.41
105_G175_P0.6070.41
197_K210_L0.6070.41
183_R195_A0.6060.41
158_L168_F0.6060.41
106_V109_L0.6050.41
12_I82_L0.6040.40
144_L155_F0.6040.40
100_L105_G0.6030.40
210_L214_G0.6030.40
105_G199_A0.6030.40
22_L25_P0.6020.40
80_H184_A0.5960.40
313_M318_V0.5960.40
193_A197_K0.5950.40
135_A139_G0.5940.39
171_L206_F0.5940.39
80_H88_A0.5920.39
330_A334_D0.5920.39
172_P180_R0.5890.39
128_A202_V0.5890.39
27_F299_L0.5880.39
84_H92_D0.5860.39
18_V26_V0.5850.39
56_L62_R0.5840.38
17_D24_L0.5810.38
264_V287_V0.5800.38
17_D36_E0.5790.38
106_V270_V0.5770.38
10_F14_I0.5760.38
75_V79_L0.5730.37
209_V213_A0.5720.37
132_A136_V0.5720.37
10_F16_L0.5710.37
121_C274_M0.5710.37
34_Q37_V0.5700.37
6_I71_V0.5690.37
162_N173_G0.5680.37
29_Y139_G0.5670.37
289_R314_R0.5670.37
26_V225_V0.5660.37
105_G168_F0.5660.37
202_V205_L0.5640.37
178_G182_L0.5630.37
99_T158_L0.5600.36
173_G179_G0.5590.36
26_V29_Y0.5570.36
137_A141_L0.5570.36
111_D125_A0.5560.36
174_F178_G0.5550.36
114_E197_K0.5540.36
95_I112_Q0.5520.35
181_V228_F0.5510.35
166_A177_D0.5510.35
234_A238_Q0.5500.35
128_A366_M0.5480.35
24_L30_L0.5480.35
200_A292_T0.5480.35
332_A335_A0.5480.35
156_G160_L0.5480.35
60_S64_V0.5470.35
275_D311_D0.5460.35
175_P179_G0.5450.35
260_D279_E0.5430.35
28_A221_I0.5430.35
18_V34_Q0.5430.35
16_L29_Y0.5420.35
112_Q120_L0.5410.34
203_G215_L0.5410.34
208_F216_L0.5410.34
165_L170_L0.5400.34
291_A341_E0.5390.34
158_L177_D0.5390.34
105_G108_S0.5370.34
196_T206_F0.5340.34
153_F176_M0.5340.34
163_L181_V0.5330.34
32_G35_L0.5320.34
328_G348_L0.5320.34
250_T281_R0.5320.34
77_V219_N0.5310.34
288_F350_V0.5310.34
184_A207_A0.5300.33
245_A369_F0.5300.33
210_L213_A0.5300.33
282_H361_T0.5290.33
169_N178_G0.5260.33
83_G99_T0.5260.33
29_Y37_V0.5250.33
313_M317_D0.5250.33
16_L30_L0.5230.33
76_G84_H0.5230.33
204_K213_A0.5230.33
6_I15_K0.5200.33
175_P233_A0.5200.33
167_A172_P0.5200.33
345_G363_S0.5190.33
58_A246_F0.5180.32
79_L359_L0.5160.32
228_F232_G0.5150.32
167_A296_M0.5130.32
199_A203_G0.5120.32
130_S175_P0.5120.32
151_V154_V0.5100.32
165_L222_L0.5100.32
343_S348_L0.5100.32
9_V143_V0.5080.32
195_A206_F0.5050.31
256_T284_G0.5020.31
346_R361_T0.5000.31
155_F170_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.5564 100 0.591 Contact Map
3orgA 2 0.8231 100 0.714 Contact Map
1jcnA 6 0.4538 99.9 0.748 Contact Map
3lqnA 2 0.3333 99.9 0.758 Contact Map
2ef7A 3 0.3308 99.9 0.758 Contact Map
3l2bA 2 0.2974 99.9 0.758 Contact Map
1o50A 2 0.3333 99.9 0.759 Contact Map
3lfrA 2 0.3256 99.9 0.761 Contact Map
3fv6A 2 0.3615 99.9 0.762 Contact Map
2p9mA 2 0.3256 99.9 0.762 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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