GREMLIN Database
Q9HNB5 - Alcohol dehydrogenase
UniProt: Q9HNB5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 401 (365)
Sequences: 10075 (6978)
Seq/√Len: 365.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
371_A390_R3.8261.00
367_Q394_T3.7751.00
244_R348_A3.6201.00
309_A343_T3.2051.00
86_E90_A3.1581.00
79_T165_H3.0281.00
363_R398_D3.0111.00
249_A252_T2.7621.00
84_A111_A2.7471.00
245_A252_T2.6891.00
242_G258_P2.5681.00
197_A253_P2.5231.00
55_D59_D2.4991.00
389_T392_D2.4971.00
21_P194_V2.4541.00
366_L394_T2.3741.00
284_F397_L2.3251.00
71_E83_D2.3061.00
234_H237_G2.2941.00
394_T398_D2.2881.00
215_G235_G2.2371.00
39_A95_A2.2091.00
26_D29_A2.2021.00
23_S26_D2.1941.00
362_A365_E2.1651.00
354_R357_D2.1531.00
191_A260_L2.0881.00
344_A348_A2.0691.00
229_D318_R2.0491.00
22_D194_V2.0471.00
46_T50_T2.0421.00
211_G239_L1.9821.00
38_T65_L1.9621.00
105_I146_V1.9351.00
88_V142_P1.9181.00
212_L236_V1.9171.00
390_R394_T1.9001.00
370_A394_T1.8921.00
164_A173_D1.8801.00
204_L256_M1.8411.00
96_I108_A1.8131.00
73_T80_T1.8021.00
88_V115_T1.7901.00
369_V397_L1.7871.00
206_G298_V1.7681.00
240_A326_L1.7631.00
311_L382_A1.7441.00
341_A344_A1.7411.00
309_A399_A1.7251.00
395_E399_A1.7171.00
37_D94_D1.7041.00
370_A390_R1.6981.00
244_R248_T1.6881.00
58_R62_G1.6841.00
323_A338_V1.6791.00
21_P253_P1.6741.00
236_V322_L1.6631.00
285_G299_A1.6581.00
367_Q390_R1.6311.00
317_G331_D1.6301.00
55_D58_R1.6291.00
248_T348_A1.6011.00
302_V358_T1.5981.00
347_D353_A1.5831.00
44_G47_V1.5811.00
196_A256_M1.5791.00
80_T83_D1.5481.00
254_E258_P1.5471.00
67_G91_T1.5441.00
82_F120_S1.5341.00
201_R205_A1.5241.00
38_T67_G1.5211.00
87_R91_T1.5181.00
208_A243_L1.5161.00
98_A144_I1.5151.00
48_G70_A1.5131.00
21_P257_A1.5101.00
28_D60_G1.5051.00
83_D86_E1.5011.00
233_S321_R1.4931.00
16_A30_S1.4871.00
31_L95_A1.4811.00
59_D63_D1.4781.00
308_L342_V1.4731.00
291_A368_A1.4671.00
81_A162_I1.4621.00
340_D344_A1.4481.00
395_E398_D1.4411.00
324_A334_P1.4381.00
368_A372_A1.4331.00
39_A97_V1.4271.00
25_R56_P1.4171.00
309_A336_S1.4161.00
365_E368_A1.4071.00
67_G87_R1.3911.00
67_G93_A1.3891.00
202_S298_V1.3881.00
30_S33_A1.3781.00
194_V253_P1.3781.00
116_G140_A1.3661.00
85_A114_L1.3641.00
284_F303_V1.3611.00
209_M346_R1.3571.00
252_T255_T1.3571.00
42_V111_A1.3561.00
98_A108_A1.3551.00
78_L82_F1.3531.00
336_S340_D1.3421.00
245_A249_A1.3371.00
18_R30_S1.3321.00
87_R90_A1.3141.00
196_A260_L1.3141.00
208_A259_I1.3111.00
294_I299_A1.3011.00
201_R247_G1.2911.00
56_P194_V1.2881.00
145_V188_S1.2861.00
392_D395_E1.2711.00
204_L250_D1.2611.00
88_V93_A1.2601.00
242_G245_A1.2531.00
95_A145_V1.2501.00
112_A141_L1.2471.00
73_T77_R1.2391.00
82_F86_E1.2351.00
241_A258_P1.2351.00
119_Q123_A1.2301.00
209_M351_L1.2271.00
30_S188_S1.2261.00
239_L259_I1.2241.00
312_F336_S1.2231.00
40_L93_A1.2231.00
81_A107_V1.2221.00
17_L264_L1.2121.00
42_V72_T1.2091.00
96_I112_A1.2091.00
242_G255_T1.2081.00
368_A371_A1.2001.00
62_G66_A1.2001.00
47_V50_T1.1941.00
391_A394_T1.1841.00
310_H392_D1.1801.00
194_V197_A1.1761.00
23_S190_V1.1761.00
88_V111_A1.1701.00
38_T91_T1.1661.00
233_S237_G1.1641.00
86_E89_A1.1611.00
306_H399_A1.1581.00
58_R66_A1.1571.00
108_A144_I1.1541.00
151_L204_L1.1521.00
77_R80_T1.1451.00
42_V108_A1.1441.00
119_Q124_V1.1401.00
218_T269_G1.1361.00
280_L388_L1.1321.00
18_R26_D1.1321.00
193_P257_A1.1201.00
230_A234_H1.1151.00
40_L87_R1.1101.00
284_F393_A1.1051.00
204_L246_L1.1021.00
85_A89_A1.0981.00
320_D334_P1.0971.00
316_D332_P1.0891.00
21_P197_A1.0871.00
32_D64_R1.0821.00
57_V99_V1.0791.00
59_D62_G1.0791.00
312_F335_A1.0791.00
24_V147_V1.0711.00
44_G50_T1.0651.00
201_R248_T1.0621.00
156_I264_L1.0591.00
320_D331_D1.0581.00
46_T49_T1.0581.00
234_H238_T1.0541.00
38_T92_D1.0541.00
22_D25_R1.0531.00
374_V390_R1.0521.00
45_S71_E1.0501.00
233_S325_A1.0461.00
159_G180_D1.0461.00
199_T203_V1.0461.00
281_T304_T1.0451.00
20_G23_S1.0421.00
292_S365_E1.0361.00
371_A375_A1.0351.00
45_S70_A1.0321.00
391_A395_E1.0301.00
77_R165_H1.0281.00
215_G266_V1.0271.00
219_L321_R1.0241.00
45_S49_T1.0171.00
78_L165_H1.0061.00
41_V54_M1.0031.00
322_L338_V1.0021.00
245_A254_E1.0011.00
27_L57_V1.0011.00
40_L88_V0.9961.00
205_A247_G0.9941.00
366_L398_D0.9911.00
240_A341_A0.9851.00
313_D384_D0.9811.00
291_A372_A0.9771.00
43_T70_A0.9751.00
229_D232_A0.9731.00
321_R324_A0.9711.00
281_T300_H0.9701.00
24_V56_P0.9681.00
31_L145_V0.9681.00
79_T166_P0.9661.00
209_M301_A0.9641.00
72_T107_V0.9551.00
202_S206_G0.9541.00
212_L239_L0.9401.00
41_V66_A0.9381.00
218_T229_D0.9361.00
75_E293_P0.9351.00
29_A64_R0.9301.00
245_A255_T0.9281.00
313_D332_P0.9271.00
337_A340_D0.9251.00
239_L262_G0.9211.00
146_V186_P0.9191.00
250_D256_M0.9191.00
156_I189_V0.9151.00
85_A111_A0.9141.00
25_R60_G0.9141.00
333_D337_A0.9111.00
235_G266_V0.9101.00
353_A357_D0.9061.00
98_A146_V0.9041.00
324_A331_D0.9031.00
197_A251_P0.9031.00
22_D192_D0.9001.00
280_L307_V0.8991.00
39_A94_D0.8961.00
16_A33_A0.8961.00
320_D335_A0.8941.00
247_G350_G0.8931.00
367_Q371_A0.8921.00
320_D324_A0.8901.00
238_T258_P0.8861.00
73_T83_D0.8831.00
283_A379_V0.8781.00
246_L250_D0.8761.00
237_G241_A0.8751.00
98_A105_I0.8751.00
285_G289_S0.8741.00
231_T265_L0.8731.00
370_A374_V0.8721.00
143_P187_A0.8711.00
85_A115_T0.8691.00
41_V58_R0.8681.00
246_L255_T0.8621.00
213_N304_T0.8621.00
166_P173_D0.8601.00
222_A225_T0.8601.00
216_I236_V0.8591.00
247_G349_L0.8571.00
54_M58_R0.8561.00
206_G295_Q0.8501.00
174_T293_P0.8481.00
105_I148_P0.8481.00
28_D63_D0.8461.00
42_V104_S0.8391.00
230_A237_G0.8381.00
120_S123_A0.8351.00
261_R265_L0.8341.00
216_I322_L0.8321.00
133_T136_I0.8311.00
287_A397_L0.8311.00
77_R293_P0.8311.00
310_H384_D0.8311.00
238_T262_G0.8291.00
20_G26_D0.8291.00
107_V111_A0.8281.00
218_T232_A0.8281.00
105_I154_A0.8241.00
146_V189_V0.8241.00
343_T347_D0.8211.00
81_A110_V0.8171.00
112_A142_P0.8161.00
205_A351_L0.8141.00
306_H309_A0.8131.00
115_T142_P0.8131.00
24_V194_V0.8131.00
56_P195_L0.8101.00
220_Y308_L0.8091.00
117_T139_G0.8081.00
112_A144_I0.8051.00
308_L319_R0.8021.00
352_P357_D0.8001.00
24_V195_L0.7991.00
310_H388_L0.7981.00
151_L260_L0.7901.00
245_A248_T0.7891.00
215_G232_A0.7881.00
242_G259_I0.7851.00
331_D334_P0.7841.00
212_L216_I0.7831.00
316_D331_D0.7821.00
328_V337_A0.7791.00
24_V192_D0.7771.00
287_A372_A0.7761.00
309_A339_I0.7681.00
56_P60_G0.7681.00
28_D64_R0.7651.00
201_R350_G0.7651.00
48_G54_M0.7651.00
312_F316_D0.7631.00
79_T83_D0.7621.00
158_Q182_R0.7591.00
62_G65_L0.7571.00
314_S384_D0.7571.00
27_L147_V0.7551.00
241_A244_R0.7541.00
18_R23_S0.7541.00
280_L393_A0.7491.00
210_N296_Q0.7481.00
254_E257_A0.7471.00
219_L233_S0.7471.00
374_V393_A0.7411.00
288_L299_A0.7411.00
69_F83_D0.7391.00
26_D30_S0.7371.00
56_P59_D0.7351.00
144_I187_A0.7331.00
282_H296_Q0.7251.00
322_L342_V0.7241.00
38_T94_D0.7221.00
24_V57_V0.7191.00
328_V341_A0.7181.00
113_A184_L0.7181.00
199_T207_S0.7171.00
344_A347_D0.7150.99
69_F84_A0.7130.99
60_G63_D0.7130.99
303_V396_I0.7120.99
196_A204_L0.7120.99
305_P346_R0.7080.99
242_G254_E0.7060.99
367_Q370_A0.7050.99
82_F85_A0.7050.99
52_A55_D0.7030.99
224_A318_R0.7020.99
308_L338_V0.7010.99
347_D357_D0.6990.99
19_F257_A0.6990.99
315_T319_R0.6930.99
116_G142_P0.6920.99
286_H376_D0.6920.99
240_A244_R0.6890.99
337_A341_A0.6890.99
201_R250_D0.6870.99
298_V352_P0.6860.99
32_D37_D0.6850.99
237_G321_R0.6840.99
65_L68_V0.6840.99
191_A264_L0.6810.99
24_V60_G0.6810.99
38_T93_A0.6780.99
31_L97_V0.6780.99
345_V349_L0.6760.99
244_R247_G0.6740.99
285_G300_H0.6740.99
55_D62_G0.6740.99
219_L318_R0.6720.99
209_M349_L0.6710.99
208_A349_L0.6710.99
301_A346_R0.6660.99
283_A378_F0.6650.99
352_P358_T0.6640.99
110_V160_A0.6600.99
253_P257_A0.6600.99
98_A104_S0.6590.99
83_D87_R0.6590.99
288_L397_L0.6580.99
151_L196_A0.6560.99
237_G325_A0.6540.99
224_A229_D0.6530.99
29_A33_A0.6520.99
366_L397_L0.6500.99
49_T55_D0.6500.99
31_L61_L0.6500.99
40_L69_F0.6500.99
294_I358_T0.6470.99
30_S34_H0.6470.99
58_R68_V0.6460.99
234_H265_L0.6450.99
388_L396_I0.6440.99
223_T277_T0.6420.99
193_P253_P0.6400.99
81_A111_A0.6390.99
372_A375_A0.6370.99
323_A328_V0.6370.99
241_A245_A0.6360.99
28_D32_D0.6360.99
361_P366_L0.6360.99
213_N281_T0.6350.99
236_V240_A0.6340.99
288_L355_L0.6340.99
160_A179_A0.6320.99
388_L393_A0.6310.99
316_D320_D0.6310.99
242_G246_L0.6290.99
210_N282_H0.6280.99
308_L339_I0.6280.99
75_E103_S0.6270.99
213_N300_H0.6260.99
343_T353_A0.6260.99
145_V190_V0.6240.99
156_I268_Y0.6240.99
270_I278_L0.6240.99
25_R194_V0.6240.99
342_V346_R0.6240.99
19_F261_R0.6230.99
27_L60_G0.6210.99
216_I338_V0.6210.99
40_L91_T0.6190.99
305_P343_T0.6140.98
47_V54_M0.6120.98
88_V96_I0.6110.98
43_T48_G0.6080.98
355_L361_P0.6060.98
291_A365_E0.6040.98
18_R188_S0.6040.98
309_A312_F0.6030.98
82_F114_L0.6010.98
61_L66_A0.6000.98
388_L392_D0.5990.98
157_S267_E0.5980.98
298_V351_L0.5970.98
309_A340_D0.5970.98
222_A387_P0.5940.98
53_V195_L0.5940.98
29_A32_D0.5930.98
21_P254_E0.5930.98
321_R325_A0.5890.98
322_L326_L0.5890.98
238_T265_L0.5880.98
148_P191_A0.5850.98
220_Y319_R0.5850.98
216_I304_T0.5850.98
310_H389_T0.5830.98
122_A166_P0.5830.98
34_H145_V0.5820.98
361_P369_V0.5820.98
376_D380_D0.5820.98
110_V162_I0.5810.98
295_Q298_V0.5810.98
147_V190_V0.5800.98
148_P263_L0.5770.98
140_A183_R0.5770.98
246_L259_I0.5750.98
37_D65_L0.5740.98
113_A137_P0.5730.98
41_V99_V0.5730.98
48_G55_D0.5720.98
280_L283_A0.5720.98
42_V84_A0.5710.98
17_L189_V0.5700.98
47_V53_V0.5700.98
214_K266_V0.5690.97
316_D335_A0.5690.97
312_F332_P0.5680.97
219_L229_D0.5670.97
73_T293_P0.5660.97
197_A256_M0.5650.97
25_R63_D0.5630.97
97_V145_V0.5610.97
141_L187_A0.5610.97
317_G320_D0.5610.97
300_H303_V0.5600.97
43_T104_S0.5590.97
117_T141_L0.5580.97
28_D31_L0.5570.97
44_G49_T0.5570.97
117_T124_V0.5560.97
377_P380_D0.5540.97
316_D319_R0.5540.97
244_R345_V0.5530.97
25_R59_D0.5520.97
340_D343_T0.5490.97
221_A381_N0.5480.97
238_T242_G0.5470.97
116_G141_L0.5460.97
363_R366_L0.5460.97
332_P336_S0.5460.97
87_R93_A0.5450.97
236_V239_L0.5450.97
284_F373_A0.5440.97
301_A351_L0.5440.97
114_L118_T0.5440.97
325_A328_V0.5440.97
208_A239_L0.5430.97
310_H396_I0.5420.97
257_A261_R0.5380.96
373_A397_L0.5370.96
240_A345_V0.5360.96
216_I308_L0.5360.96
384_D392_D0.5350.96
95_A143_P0.5330.96
82_F121_R0.5300.96
43_T68_V0.5290.96
339_I343_T0.5290.96
57_V60_G0.5290.96
193_P260_L0.5270.96
288_L369_V0.5270.96
75_E289_S0.5260.96
370_A393_A0.5260.96
306_H396_I0.5260.96
302_V351_L0.5240.96
356_R363_R0.5220.96
213_N279_S0.5210.96
208_A247_G0.5210.96
54_M99_V0.5210.96
40_L84_A0.5200.96
214_K296_Q0.5190.96
35_D94_D0.5170.96
18_R190_V0.5150.96
334_P337_A0.5150.96
53_V99_V0.5150.96
48_G68_V0.5140.95
184_L187_A0.5140.95
235_G262_G0.5120.95
65_L91_T0.5110.95
181_D184_L0.5100.95
161_G210_N0.5090.95
39_A66_A0.5090.95
176_S296_Q0.5090.95
280_L382_A0.5090.95
224_A228_T0.5080.95
80_T107_V0.5080.95
243_L345_V0.5080.95
366_L370_A0.5070.95
319_R322_L0.5070.95
141_L183_R0.5070.95
205_A345_V0.5050.95
48_G58_R0.5050.95
117_T138_D0.5040.95
346_R351_L0.5030.95
346_R349_L0.5020.95
121_R124_V0.5010.95
133_T137_P0.5010.95
106_D296_Q0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ox4A 2 0.9352 100 0.147 Contact Map
3bfjA 5 0.9327 100 0.147 Contact Map
1rrmA 2 0.9302 100 0.166 Contact Map
1vljA 2 0.9576 100 0.167 Contact Map
4fr2A 2 0.9352 100 0.169 Contact Map
3zdrA 2 0.9451 100 0.186 Contact Map
4qgsA 2 0.9277 100 0.187 Contact Map
3w5sA 2 0.8579 100 0.211 Contact Map
3iv7A 2 0.8554 100 0.212 Contact Map
3jzdA 3 0.8678 100 0.214 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0123 seconds.