GREMLIN Database
Q9HNB4 - Uncharacterized protein
UniProt: Q9HNB4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 155 (122)
Sequences: 351 (135)
Seq/√Len: 12.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_A133_E7.0351.00
77_D134_P3.9340.99
36_L60_I3.3980.98
76_L80_A2.6550.92
39_R42_E2.5860.91
99_E132_D2.4460.88
27_V30_G2.3330.86
45_Y57_G2.3030.85
99_E130_D2.2250.83
101_T128_E2.1170.79
103_G106_G2.0510.77
47_D55_R2.0080.76
25_V30_G1.9620.74
95_V135_G1.8850.71
34_T66_A1.8590.70
99_E128_E1.8010.67
101_T130_D1.7990.67
127_Y135_G1.7270.64
25_V28_A1.7120.63
80_A103_G1.6090.58
81_R128_E1.6050.58
35_P43_I1.5700.56
96_L124_V1.5370.54
86_T90_E1.4990.53
85_H92_E1.4770.51
24_G28_A1.4670.51
61_D117_L1.4550.50
60_I67_P1.4490.50
84_E103_G1.4380.49
44_D55_R1.4250.49
97_A134_P1.4210.49
30_G66_A1.4180.48
24_G84_E1.3830.47
102_V125_H1.3400.45
24_G63_E1.3150.43
81_R132_D1.3150.43
23_V83_P1.2880.42
108_T125_H1.2640.41
45_Y55_R1.2240.39
47_D52_D1.1980.38
103_G130_D1.1860.37
24_G50_A1.1820.37
81_R99_E1.1770.37
86_T115_D1.1690.36
27_V31_Q1.1520.35
85_H102_V1.1260.34
61_D84_E1.1210.34
26_V31_Q1.1090.33
95_V138_I1.1080.33
23_V26_V1.0930.33
43_I52_D1.0720.32
89_V118_L1.0550.31
23_V138_I1.0500.31
85_H125_H1.0210.30
69_F105_E0.9970.29
82_V126_W0.9920.28
128_E132_D0.9870.28
95_V124_V0.9860.28
79_G135_G0.9860.28
38_R42_E0.9840.28
68_H85_H0.9630.27
80_A116_S0.9620.27
95_V121_A0.9510.27
95_V117_L0.9490.27
68_H108_T0.9230.26
28_A31_Q0.9210.26
23_V49_S0.9140.25
71_M75_E0.8780.24
28_A77_D0.8760.24
43_I46_A0.8630.23
92_E102_V0.8510.23
114_G119_I0.8490.23
95_V127_Y0.8470.23
78_P131_G0.8470.23
37_V42_E0.8450.23
102_V137_F0.8450.23
113_A133_E0.8410.23
21_W36_L0.8390.23
109_H119_I0.8380.22
102_V108_T0.8310.22
25_V31_Q0.8290.22
87_N92_E0.8250.22
32_Q63_E0.8240.22
37_V60_I0.8230.22
68_H92_E0.8220.22
100_Y137_F0.8160.22
51_G130_D0.8070.21
43_I71_M0.8050.21
42_E45_Y0.7950.21
101_T110_E0.7920.21
109_H135_G0.7800.20
57_G75_E0.7800.20
76_L94_Y0.7770.20
57_G112_S0.7740.20
57_G129_N0.7740.20
34_T67_P0.7710.20
33_P66_A0.7690.20
81_R112_S0.7580.20
32_Q53_G0.7570.20
32_Q138_I0.7500.20
72_R89_V0.7490.19
99_E110_E0.7470.19
32_Q46_A0.7440.19
110_E128_E0.7260.19
38_R43_I0.7160.18
27_V53_G0.7070.18
44_D47_D0.7030.18
26_V133_E0.7020.18
92_E137_F0.7020.18
39_R43_I0.7010.18
112_S130_D0.6980.18
26_V29_M0.6920.18
49_S83_P0.6910.18
74_F82_V0.6900.18
78_P104_I0.6880.18
42_E46_A0.6800.17
76_L82_V0.6740.17
18_P90_E0.6730.17
54_T82_V0.6720.17
92_E108_T0.6680.17
31_Q42_E0.6680.17
85_H137_F0.6670.17
43_I138_I0.6660.17
114_G121_A0.6650.17
19_V100_Y0.6580.17
100_Y133_E0.6570.17
59_L73_R0.6530.17
51_G132_D0.6520.17
37_V64_D0.6500.17
34_T123_A0.6450.16
124_V129_N0.6430.16
73_R104_I0.6420.16
57_G136_A0.6400.16
23_V114_G0.6380.16
90_E111_V0.6320.16
43_I57_G0.6290.16
92_E125_H0.6270.16
126_W135_G0.6200.16
21_W88_A0.6190.16
80_A118_L0.6190.16
44_D88_A0.6140.16
17_K27_V0.6070.15
41_S60_I0.6040.15
103_G116_S0.5940.15
110_E132_D0.5910.15
37_V62_G0.5780.15
68_H125_H0.5770.15
26_V30_G0.5750.15
69_F89_V0.5730.14
114_G136_A0.5670.14
17_K26_V0.5670.14
92_E122_G0.5640.14
32_Q35_P0.5570.14
109_H127_Y0.5540.14
50_A87_N0.5530.14
33_P68_H0.5510.14
93_Q135_G0.5500.14
38_R60_I0.5500.14
88_A121_A0.5490.14
41_S52_D0.5480.14
73_R137_F0.5470.14
40_A43_I0.5470.14
85_H108_T0.5470.14
24_G27_V0.5460.14
99_E134_P0.5460.14
87_N100_Y0.5450.14
79_G90_E0.5430.14
86_T94_Y0.5430.14
68_H137_F0.5370.14
25_V36_L0.5360.14
20_M105_E0.5300.13
57_G135_G0.5270.13
41_S63_E0.5250.13
59_L66_A0.5230.13
108_T137_F0.5160.13
52_D65_G0.5160.13
100_Y117_L0.5140.13
93_Q127_Y0.5120.13
106_G113_A0.5090.13
109_H126_W0.5090.13
60_I69_F0.5020.13
99_E112_S0.5000.13
116_S126_W0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sefA 5 0.9548 99.9 0.647 Contact Map
1rc6A 4 0.8903 99.9 0.663 Contact Map
1sq4A 5 0.9742 99.9 0.663 Contact Map
1sfnA 5 0.9355 99.9 0.669 Contact Map
4e2qA 6 0.929 99.8 0.687 Contact Map
3jzvA 5 0.8065 99.7 0.732 Contact Map
1vj2A 2 0.7226 99.7 0.734 Contact Map
3kgzA 2 0.8 99.6 0.737 Contact Map
3ibmA 2 0.8065 99.6 0.74 Contact Map
3ht1A 2 0.7871 99.6 0.741 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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