Q9HNB3 - HALSA - GREMLIN Contacts

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Q9HNB3 - Uncharacterized protein

UniProt:	Q9HNB3	Sequences: MTADALPLADLEAYLADELGARVTDTEVLDGALNTMVAVSTESTEHAYVVRQASDMRDSGLFIDLDREYRVLAALTDTDVPAPAPVVYCEDESVLGDPFAVTTYREGEPVSVGSSLPERFQTPAGRRAVGEALVDTLADVHSVPTDPFEGVCERYEPLEQVEQFADRLDRATDASGRDVPELRRVVDWLREHAPPEHETRLTHGDFNSGNVCFADGTPPEITGVLDWETAALGEPRTELGYLLFYWRDDGDPTPGLDAIRARYGDDHPDAVAEVAAAAEHGFYRYANRPGSPSRRELIERYEARTGLAFDHGRFYRAHAALGLAAVWEDSHARRVAAGEPTDWEPLLDYTAAVTASIVDGEFEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	364 (321)
Sequences:	2796 (1930)
Seq/√Len:	107.7

BACSU - YCBJ
HALSA - Q9HNB3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
105_R	223_G	4.763	1.00
135_D	300_R	4.100	1.00
72_L	85_P	3.972	1.00
188_W	192_H	3.685	1.00
86_V	103_T	3.660	1.00
133_L	211_V	3.506	1.00
84_A	103_T	3.444	1.00
127_R	296_E	3.149	1.00
132_A	135_D	3.146	1.00
146_D	152_C	3.058	1.00
14_Y	87_V	3.013	1.00
69_Y	85_P	3.011	1.00
38_A	47_A	2.877	1.00
293_S	296_E	2.876	1.00
109_P	212_C	2.741	1.00
214_A	217_T	2.708	1.00
162_E	166_D	2.678	1.00
135_D	304_R	2.649	1.00
127_R	131_E	2.626	1.00
198_E	307_L	2.549	1.00
24_T	40_S	2.543	1.00
12_E	16_A	2.529	1.00
131_E	300_R	2.512	1.00
187_D	191_E	2.508	1.00
89_C	94_V	2.435	1.00
76_T	85_P	2.405	1.00
299_E	303_A	2.306	1.00
66_D	88_Y	2.300	1.00
122_T	125_G	2.243	1.00
105_R	222_T	2.224	1.00
47_A	104_Y	2.206	1.00
139_D	304_R	2.188	1.00
50_V	101_V	2.169	1.00
169_D	190_R	2.156	1.00
79_D	139_D	2.154	1.00
181_E	356_S	2.153	1.00
332_A	336_A	2.141	1.00
214_A	218_P	2.141	1.00
136_T	224_V	2.139	1.00
144_P	147_P	2.139	1.00
72_L	83_P	2.121	1.00
134_V	297_L	2.084	1.00
298_I	312_G	2.078	1.00
40_S	47_A	2.068	1.00
169_D	186_V	2.033	1.00
130_G	292_P	2.000	1.00
38_A	104_Y	1.975	1.00
242_L	297_L	1.955	1.00
26_T	38_A	1.921	1.00
10_D	13_A	1.903	1.00
47_A	106_E	1.887	1.00
145_T	201_L	1.870	1.00
8_L	25_D	1.838	1.00
132_A	136_T	1.770	1.00
154_R	230_A	1.759	1.00
170_R	174_A	1.746	1.00
52_Q	97_D	1.731	1.00
185_V	358_V	1.727	1.00
106_E	215_D	1.679	1.00
89_C	99_F	1.655	1.00
300_R	303_A	1.627	1.00
323_L	354_T	1.608	1.00
14_Y	89_C	1.605	1.00
33_L	228_E	1.595	1.00
240_G	319_A	1.578	1.00
243_L	312_G	1.575	1.00
186_V	321_L	1.569	1.00
140_V	224_V	1.567	1.00
41_T	44_T	1.565	1.00
76_T	84_A	1.561	1.00
214_A	220_E	1.556	1.00
295_R	299_E	1.545	1.00
200_R	235_P	1.544	1.00
199_T	232_L	1.537	1.00
69_Y	88_Y	1.535	1.00
173_D	183_R	1.489	1.00
188_W	317_A	1.487	1.00
166_D	190_R	1.469	1.00
48_Y	86_V	1.458	1.00
81_P	136_T	1.457	1.00
214_A	222_T	1.455	1.00
91_D	94_V	1.440	1.00
140_V	201_L	1.431	1.00
41_T	48_Y	1.429	1.00
177_R	328_E	1.427	1.00
88_Y	98_P	1.413	1.00
69_Y	73_A	1.413	1.00
33_L	36_M	1.387	1.00
39_V	50_V	1.379	1.00
240_G	312_G	1.378	1.00
70_R	153_E	1.369	1.00
73_A	85_P	1.364	1.00
105_R	212_C	1.362	1.00
15_L	101_V	1.346	1.00
90_E	98_P	1.338	1.00
108_E	125_G	1.332	0.99
331_H	335_V	1.326	0.99
26_T	40_S	1.318	0.99
212_C	225_L	1.296	0.99
113_G	117_P	1.294	0.99
212_C	222_T	1.292	0.99
166_D	170_R	1.280	0.99
181_E	184_R	1.269	0.99
348_D	351_A	1.265	0.99
298_I	302_E	1.259	0.99
130_G	291_S	1.254	0.99
135_D	139_D	1.245	0.99
296_E	299_E	1.237	0.99
6_L	25_D	1.234	0.99
92_E	98_P	1.213	0.99
169_D	173_D	1.199	0.99
9_A	12_E	1.197	0.99
182_L	324_A	1.188	0.99
131_E	304_R	1.182	0.99
318_H	322_G	1.179	0.99
19_L	87_V	1.179	0.99
23_V	39_V	1.175	0.99
330_S	338_G	1.173	0.99
196_E	234_E	1.151	0.98
294_R	316_R	1.149	0.98
134_V	304_R	1.147	0.98
147_P	150_G	1.122	0.98
160_Q	237_T	1.102	0.98
162_E	193_A	1.095	0.98
247_R	294_R	1.094	0.98
240_G	316_R	1.086	0.98
229_T	326_V	1.085	0.98
133_L	242_L	1.079	0.98
182_L	325_A	1.074	0.98
339_E	344_E	1.070	0.98
132_A	221_I	1.069	0.98
165_A	318_H	1.065	0.97
142_S	305_T	1.059	0.97
141_H	301_Y	1.058	0.97
168_L	171_A	1.058	0.97
136_T	221_I	1.057	0.97
80_V	143_V	1.054	0.97
131_E	135_D	1.038	0.97
136_T	206_F	1.033	0.97
129_V	213_F	1.030	0.97
46_H	103_T	1.023	0.97
239_L	298_I	1.022	0.97
66_D	98_P	1.021	0.97
128_A	131_E	1.018	0.97
7_P	10_D	1.018	0.97
71_V	230_A	1.008	0.96
192_H	314_F	1.003	0.96
300_R	304_R	0.997	0.96
317_A	358_V	0.996	0.96
184_R	187_D	0.995	0.96
208_S	291_S	0.993	0.96
209_G	241_Y	0.987	0.96
132_A	220_E	0.983	0.96
138_A	305_T	0.968	0.96
145_T	149_E	0.959	0.95
145_T	152_C	0.953	0.95
59_S	175_S	0.948	0.95
243_L	316_R	0.943	0.95
357_I	360_G	0.942	0.95
109_P	225_L	0.931	0.95
181_E	355_A	0.924	0.94
137_L	206_F	0.917	0.94
331_H	348_D	0.912	0.94
66_D	70_R	0.910	0.94
66_D	90_E	0.909	0.94
334_R	344_E	0.905	0.94
145_T	232_L	0.903	0.94
28_V	49_V	0.900	0.93
308_A	311_H	0.899	0.93
12_E	22_R	0.890	0.93
302_E	309_F	0.886	0.93
138_A	304_R	0.883	0.93
144_P	150_G	0.882	0.93
15_L	87_V	0.880	0.93
173_D	186_V	0.880	0.93
10_D	93_S	0.880	0.93
334_R	345_P	0.878	0.93
185_V	317_A	0.874	0.92
23_V	41_T	0.873	0.92
299_E	302_E	0.873	0.92
70_R	73_A	0.869	0.92
168_L	325_A	0.868	0.92
184_R	359_D	0.859	0.92
234_E	315_Y	0.859	0.92
150_G	155_Y	0.858	0.92
244_F	319_A	0.856	0.92
231_A	237_T	0.855	0.92
18_E	87_V	0.850	0.91
182_L	355_A	0.847	0.91
190_R	193_A	0.844	0.91
171_A	329_D	0.844	0.91
341_T	344_E	0.835	0.91
74_A	150_G	0.834	0.91
33_L	54_S	0.833	0.91
89_C	92_E	0.831	0.90
177_R	352_A	0.825	0.90
125_G	219_P	0.822	0.90
53_A	66_D	0.822	0.90
40_S	44_T	0.821	0.90
25_D	39_V	0.816	0.90
16_A	21_A	0.811	0.89
123_P	289_P	0.810	0.89
39_V	101_V	0.808	0.89
129_V	208_S	0.808	0.89
326_V	330_S	0.807	0.89
143_V	149_E	0.803	0.89
147_P	152_C	0.801	0.89
134_V	300_R	0.796	0.88
346_L	349_Y	0.796	0.88
161_V	318_H	0.793	0.88
356_S	360_G	0.793	0.88
165_A	169_D	0.793	0.88
85_P	88_Y	0.790	0.88
59_S	171_A	0.788	0.88
9_A	13_A	0.788	0.88
79_D	142_S	0.787	0.88
209_G	212_C	0.786	0.88
75_L	143_V	0.783	0.88
131_E	296_E	0.782	0.88
6_L	37_V	0.782	0.88
14_Y	99_F	0.777	0.87
108_E	218_P	0.776	0.87
206_F	221_I	0.772	0.87
285_Y	288_R	0.770	0.87
118_E	121_Q	0.769	0.87
165_A	190_R	0.769	0.87
356_S	359_D	0.767	0.87
251_D	294_R	0.765	0.86
155_Y	159_E	0.763	0.86
244_F	320_A	0.763	0.86
133_L	297_L	0.762	0.86
211_V	221_I	0.760	0.86
181_E	352_A	0.758	0.86
355_A	358_V	0.756	0.86
74_A	149_E	0.752	0.86
145_T	199_T	0.752	0.86
54_S	229_T	0.751	0.85
106_E	214_A	0.750	0.85
121_Q	125_G	0.749	0.85
183_R	187_D	0.747	0.85
131_E	134_V	0.747	0.85
334_R	338_G	0.746	0.85
202_T	233_G	0.745	0.85
11_L	95_L	0.735	0.84
8_L	12_E	0.734	0.84
296_E	300_R	0.731	0.84
31_G	226_D	0.731	0.84
351_A	359_D	0.730	0.84
330_S	334_R	0.730	0.84
186_V	190_R	0.730	0.84
330_S	344_E	0.729	0.84
180_P	184_R	0.729	0.84
89_C	95_L	0.727	0.84
128_A	219_P	0.726	0.83
243_L	294_R	0.725	0.83
134_V	242_L	0.722	0.83
124_A	127_R	0.722	0.83
345_P	348_D	0.721	0.83
53_A	64_D	0.721	0.83
172_T	176_G	0.718	0.83
312_G	316_R	0.717	0.83
83_P	102_T	0.717	0.83
342_D	347_L	0.716	0.83
179_V	328_E	0.714	0.82
38_A	49_V	0.713	0.82
202_T	232_L	0.713	0.82
155_Y	232_L	0.712	0.82
142_S	307_L	0.710	0.82
332_A	338_G	0.708	0.82
49_V	104_Y	0.708	0.82
345_P	349_Y	0.706	0.82
35_T	53_A	0.705	0.82
316_R	361_E	0.703	0.81
210_N	226_D	0.702	0.81
115_S	284_R	0.699	0.81
317_A	361_E	0.697	0.81
179_V	351_A	0.697	0.81
133_L	213_F	0.696	0.81
198_E	234_E	0.696	0.81
78_T	201_L	0.695	0.81
78_T	149_E	0.694	0.81
176_G	328_E	0.690	0.80
32_A	341_T	0.688	0.80
156_E	159_E	0.686	0.80
34_N	51_R	0.684	0.80
167_R	171_A	0.683	0.80
193_A	314_F	0.682	0.79
41_T	45_E	0.681	0.79
198_E	305_T	0.674	0.79
58_D	61_L	0.674	0.79
179_V	352_A	0.671	0.78
133_L	221_I	0.669	0.78
33_L	82_A	0.668	0.78
350_T	357_I	0.667	0.78
136_T	139_D	0.667	0.78
197_H	307_L	0.667	0.78
34_N	53_A	0.665	0.78
13_A	16_A	0.665	0.78
245_Y	323_L	0.665	0.78
125_G	128_A	0.663	0.78
161_V	237_T	0.661	0.77
24_T	44_T	0.661	0.77
157_P	200_R	0.660	0.77
94_V	99_F	0.659	0.77
357_I	361_E	0.657	0.77
161_V	234_E	0.653	0.76
163_Q	231_A	0.653	0.76
211_V	224_V	0.651	0.76
170_R	173_D	0.650	0.76
320_A	358_V	0.646	0.76
71_V	229_T	0.643	0.75
61_L	160_Q	0.641	0.75
331_H	334_R	0.640	0.75
31_G	205_D	0.639	0.75
126_R	290_G	0.636	0.75
124_A	360_G	0.634	0.74
89_C	96_G	0.633	0.74
203_H	206_F	0.632	0.74
55_D	97_D	0.630	0.74
72_L	100_A	0.626	0.73
350_T	359_D	0.626	0.73
195_P	311_H	0.625	0.73
150_G	154_R	0.624	0.73
321_L	325_A	0.623	0.73
61_L	176_G	0.619	0.73
286_A	289_P	0.619	0.73
36_M	141_H	0.619	0.73
76_T	82_A	0.617	0.72
149_E	153_E	0.615	0.72
313_R	316_R	0.611	0.72
202_T	209_G	0.611	0.72
187_D	190_R	0.609	0.71
128_A	135_D	0.607	0.71
328_E	331_H	0.605	0.71
146_D	149_E	0.604	0.71
355_A	359_D	0.604	0.71
185_V	355_A	0.602	0.71
73_A	77_D	0.602	0.71
87_V	101_V	0.600	0.70
168_L	326_V	0.600	0.70
172_T	328_E	0.600	0.70
134_V	138_A	0.598	0.70
131_E	292_P	0.598	0.70
205_D	210_N	0.597	0.70
327_W	351_A	0.597	0.70
150_G	153_E	0.597	0.70
165_A	193_A	0.596	0.70
327_W	330_S	0.595	0.70
36_M	82_A	0.595	0.70
34_N	68_E	0.592	0.69
124_A	128_A	0.591	0.69
27_E	340_P	0.591	0.69
36_M	54_S	0.589	0.69
228_E	330_S	0.586	0.68
73_A	76_T	0.585	0.68
346_L	353_V	0.584	0.68
21_A	44_T	0.584	0.68
78_T	81_P	0.583	0.68
320_A	357_I	0.583	0.68
159_E	162_E	0.581	0.68
82_A	141_H	0.580	0.68
161_V	314_F	0.580	0.68
59_S	237_T	0.580	0.68
34_N	63_I	0.577	0.67
349_Y	360_G	0.575	0.67
252_P	357_I	0.575	0.67
164_F	168_L	0.573	0.67
207_N	244_F	0.573	0.67
78_T	143_V	0.572	0.67
302_E	307_L	0.572	0.67
16_A	22_R	0.571	0.66
65_L	97_D	0.569	0.66
182_L	186_V	0.568	0.66
62_F	329_D	0.568	0.66
46_H	86_V	0.568	0.66
91_D	96_G	0.567	0.66
100_A	228_E	0.567	0.66
135_D	138_A	0.567	0.66
342_D	346_L	0.566	0.66
284_R	287_N	0.565	0.66
83_P	225_L	0.564	0.66
165_A	186_V	0.564	0.66
285_Y	322_G	0.564	0.66
168_L	322_G	0.562	0.65
153_E	232_L	0.561	0.65
13_A	187_D	0.560	0.65
144_P	149_E	0.560	0.65
206_F	224_V	0.559	0.65
221_I	224_V	0.559	0.65
294_R	298_I	0.559	0.65
197_H	234_E	0.559	0.65
108_E	214_A	0.557	0.65
134_V	305_T	0.556	0.64
346_L	350_T	0.556	0.64
86_V	101_V	0.556	0.64
67_R	168_L	0.555	0.64
27_E	332_A	0.554	0.64
175_S	325_A	0.553	0.64
108_E	219_P	0.552	0.64
67_R	231_A	0.551	0.64
115_S	118_E	0.551	0.64
246_W	251_D	0.549	0.63
54_S	63_I	0.547	0.63
130_G	243_L	0.546	0.63
353_V	356_S	0.546	0.63
36_M	63_I	0.546	0.63
324_A	354_T	0.544	0.63
145_T	200_R	0.544	0.63
205_D	226_D	0.544	0.63
34_N	231_A	0.543	0.63
329_D	333_R	0.542	0.62
347_L	351_A	0.542	0.62
32_A	330_S	0.542	0.62
33_L	204_G	0.540	0.62
292_P	297_L	0.539	0.62
242_L	253_T	0.536	0.62
205_D	228_E	0.534	0.61
198_E	311_H	0.534	0.61
121_Q	129_V	0.533	0.61
129_V	219_P	0.533	0.61
108_E	222_T	0.532	0.61
207_N	225_L	0.531	0.61
139_D	300_R	0.531	0.61
183_R	186_V	0.531	0.61
82_A	207_N	0.530	0.61
59_S	100_A	0.528	0.60
67_R	333_R	0.528	0.60
77_D	84_A	0.528	0.60
352_A	356_S	0.528	0.60
69_Y	87_V	0.528	0.60
34_N	164_F	0.527	0.60
13_A	17_D	0.527	0.60
34_N	163_Q	0.527	0.60
185_V	324_A	0.526	0.60
210_N	228_E	0.526	0.60
330_S	333_R	0.525	0.60
192_H	311_H	0.524	0.60
347_L	350_T	0.524	0.60
217_T	220_E	0.523	0.60
181_E	359_D	0.523	0.60
204_G	329_D	0.522	0.60
242_L	246_W	0.522	0.60
138_A	300_R	0.521	0.59
239_L	319_A	0.520	0.59
81_P	204_G	0.520	0.59
122_T	128_A	0.520	0.59
315_Y	325_A	0.520	0.59
73_A	84_A	0.520	0.59
35_T	97_D	0.520	0.59
36_M	330_S	0.518	0.59
298_I	309_F	0.518	0.59
65_L	88_Y	0.517	0.59
123_P	290_G	0.516	0.59
35_T	52_Q	0.515	0.59
81_P	126_R	0.515	0.59
80_V	139_D	0.514	0.58
233_G	238_E	0.514	0.58
145_T	157_P	0.513	0.58
20_G	177_R	0.511	0.58
356_S	361_E	0.510	0.58
126_R	291_S	0.510	0.58
248_D	295_R	0.509	0.58
203_H	234_E	0.509	0.58
164_F	318_H	0.509	0.58
95_L	99_F	0.509	0.58
160_Q	164_F	0.507	0.57
332_A	335_V	0.507	0.57
23_V	48_Y	0.506	0.57
241_Y	323_L	0.506	0.57
182_L	185_V	0.506	0.57
256_L	350_T	0.505	0.57
194_P	315_Y	0.505	0.57
302_E	305_T	0.505	0.57
344_E	351_A	0.505	0.57
294_R	312_G	0.505	0.57
172_T	183_R	0.504	0.57
246_W	294_R	0.502	0.57
257_D	353_V	0.502	0.57
74_A	80_V	0.501	0.57
185_V	313_R	0.501	0.57
316_R	319_A	0.501	0.57
171_A	326_V	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dxpA	2	0.8736	100	0.411	Contact Map
3w0oA	1	0.772	100	0.497	Contact Map
3atsA	1	0.8681	100	0.505	Contact Map
3csvA	2	0.794	100	0.617	Contact Map
4orkA	1	0.8022	100	0.625	Contact Map
4dcaA	1	0.7527	100	0.628	Contact Map
3i1aA	1	0.8049	100	0.633	Contact Map
4h05A	1	0.7005	100	0.634	Contact Map
3sg8A	2	0.7967	100	0.637	Contact Map
3tdwA	1	0.783	100	0.642	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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