GREMLIN Database
Q9HNB3 - Uncharacterized protein
UniProt: Q9HNB3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 364 (321)
Sequences: 2796 (1930)
Seq/√Len: 107.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_R223_G4.7631.00
135_D300_R4.1001.00
72_L85_P3.9721.00
188_W192_H3.6851.00
86_V103_T3.6601.00
133_L211_V3.5061.00
84_A103_T3.4441.00
127_R296_E3.1491.00
132_A135_D3.1461.00
146_D152_C3.0581.00
14_Y87_V3.0131.00
69_Y85_P3.0111.00
38_A47_A2.8771.00
293_S296_E2.8761.00
109_P212_C2.7411.00
214_A217_T2.7081.00
162_E166_D2.6781.00
135_D304_R2.6491.00
127_R131_E2.6261.00
198_E307_L2.5491.00
24_T40_S2.5431.00
12_E16_A2.5291.00
131_E300_R2.5121.00
187_D191_E2.5081.00
89_C94_V2.4351.00
76_T85_P2.4051.00
299_E303_A2.3061.00
66_D88_Y2.3001.00
122_T125_G2.2431.00
105_R222_T2.2241.00
47_A104_Y2.2061.00
139_D304_R2.1881.00
50_V101_V2.1691.00
169_D190_R2.1561.00
79_D139_D2.1541.00
181_E356_S2.1531.00
332_A336_A2.1411.00
214_A218_P2.1411.00
136_T224_V2.1391.00
144_P147_P2.1391.00
72_L83_P2.1211.00
134_V297_L2.0841.00
298_I312_G2.0781.00
40_S47_A2.0681.00
169_D186_V2.0331.00
130_G292_P2.0001.00
38_A104_Y1.9751.00
242_L297_L1.9551.00
26_T38_A1.9211.00
10_D13_A1.9031.00
47_A106_E1.8871.00
145_T201_L1.8701.00
8_L25_D1.8381.00
132_A136_T1.7701.00
154_R230_A1.7591.00
170_R174_A1.7461.00
52_Q97_D1.7311.00
185_V358_V1.7271.00
106_E215_D1.6791.00
89_C99_F1.6551.00
300_R303_A1.6271.00
323_L354_T1.6081.00
14_Y89_C1.6051.00
33_L228_E1.5951.00
240_G319_A1.5781.00
243_L312_G1.5751.00
186_V321_L1.5691.00
140_V224_V1.5671.00
41_T44_T1.5651.00
76_T84_A1.5611.00
214_A220_E1.5561.00
295_R299_E1.5451.00
200_R235_P1.5441.00
199_T232_L1.5371.00
69_Y88_Y1.5351.00
173_D183_R1.4891.00
188_W317_A1.4871.00
166_D190_R1.4691.00
48_Y86_V1.4581.00
81_P136_T1.4571.00
214_A222_T1.4551.00
91_D94_V1.4401.00
140_V201_L1.4311.00
41_T48_Y1.4291.00
177_R328_E1.4271.00
88_Y98_P1.4131.00
69_Y73_A1.4131.00
33_L36_M1.3871.00
39_V50_V1.3791.00
240_G312_G1.3781.00
70_R153_E1.3691.00
73_A85_P1.3641.00
105_R212_C1.3621.00
15_L101_V1.3461.00
90_E98_P1.3381.00
108_E125_G1.3320.99
331_H335_V1.3260.99
26_T40_S1.3180.99
212_C225_L1.2960.99
113_G117_P1.2940.99
212_C222_T1.2920.99
166_D170_R1.2800.99
181_E184_R1.2690.99
348_D351_A1.2650.99
298_I302_E1.2590.99
130_G291_S1.2540.99
135_D139_D1.2450.99
296_E299_E1.2370.99
6_L25_D1.2340.99
92_E98_P1.2130.99
169_D173_D1.1990.99
9_A12_E1.1970.99
182_L324_A1.1880.99
131_E304_R1.1820.99
318_H322_G1.1790.99
19_L87_V1.1790.99
23_V39_V1.1750.99
330_S338_G1.1730.99
196_E234_E1.1510.98
294_R316_R1.1490.98
134_V304_R1.1470.98
147_P150_G1.1220.98
160_Q237_T1.1020.98
162_E193_A1.0950.98
247_R294_R1.0940.98
240_G316_R1.0860.98
229_T326_V1.0850.98
133_L242_L1.0790.98
182_L325_A1.0740.98
339_E344_E1.0700.98
132_A221_I1.0690.98
165_A318_H1.0650.97
142_S305_T1.0590.97
141_H301_Y1.0580.97
168_L171_A1.0580.97
136_T221_I1.0570.97
80_V143_V1.0540.97
131_E135_D1.0380.97
136_T206_F1.0330.97
129_V213_F1.0300.97
46_H103_T1.0230.97
239_L298_I1.0220.97
66_D98_P1.0210.97
128_A131_E1.0180.97
7_P10_D1.0180.97
71_V230_A1.0080.96
192_H314_F1.0030.96
300_R304_R0.9970.96
317_A358_V0.9960.96
184_R187_D0.9950.96
208_S291_S0.9930.96
209_G241_Y0.9870.96
132_A220_E0.9830.96
138_A305_T0.9680.96
145_T149_E0.9590.95
145_T152_C0.9530.95
59_S175_S0.9480.95
243_L316_R0.9430.95
357_I360_G0.9420.95
109_P225_L0.9310.95
181_E355_A0.9240.94
137_L206_F0.9170.94
331_H348_D0.9120.94
66_D70_R0.9100.94
66_D90_E0.9090.94
334_R344_E0.9050.94
145_T232_L0.9030.94
28_V49_V0.9000.93
308_A311_H0.8990.93
12_E22_R0.8900.93
302_E309_F0.8860.93
138_A304_R0.8830.93
144_P150_G0.8820.93
15_L87_V0.8800.93
173_D186_V0.8800.93
10_D93_S0.8800.93
334_R345_P0.8780.93
185_V317_A0.8740.92
23_V41_T0.8730.92
299_E302_E0.8730.92
70_R73_A0.8690.92
168_L325_A0.8680.92
184_R359_D0.8590.92
234_E315_Y0.8590.92
150_G155_Y0.8580.92
244_F319_A0.8560.92
231_A237_T0.8550.92
18_E87_V0.8500.91
182_L355_A0.8470.91
190_R193_A0.8440.91
171_A329_D0.8440.91
341_T344_E0.8350.91
74_A150_G0.8340.91
33_L54_S0.8330.91
89_C92_E0.8310.90
177_R352_A0.8250.90
125_G219_P0.8220.90
53_A66_D0.8220.90
40_S44_T0.8210.90
25_D39_V0.8160.90
16_A21_A0.8110.89
123_P289_P0.8100.89
39_V101_V0.8080.89
129_V208_S0.8080.89
326_V330_S0.8070.89
143_V149_E0.8030.89
147_P152_C0.8010.89
134_V300_R0.7960.88
346_L349_Y0.7960.88
161_V318_H0.7930.88
356_S360_G0.7930.88
165_A169_D0.7930.88
85_P88_Y0.7900.88
59_S171_A0.7880.88
9_A13_A0.7880.88
79_D142_S0.7870.88
209_G212_C0.7860.88
75_L143_V0.7830.88
131_E296_E0.7820.88
6_L37_V0.7820.88
14_Y99_F0.7770.87
108_E218_P0.7760.87
206_F221_I0.7720.87
285_Y288_R0.7700.87
118_E121_Q0.7690.87
165_A190_R0.7690.87
356_S359_D0.7670.87
251_D294_R0.7650.86
155_Y159_E0.7630.86
244_F320_A0.7630.86
133_L297_L0.7620.86
211_V221_I0.7600.86
181_E352_A0.7580.86
355_A358_V0.7560.86
74_A149_E0.7520.86
145_T199_T0.7520.86
54_S229_T0.7510.85
106_E214_A0.7500.85
121_Q125_G0.7490.85
183_R187_D0.7470.85
131_E134_V0.7470.85
334_R338_G0.7460.85
202_T233_G0.7450.85
11_L95_L0.7350.84
8_L12_E0.7340.84
296_E300_R0.7310.84
31_G226_D0.7310.84
351_A359_D0.7300.84
330_S334_R0.7300.84
186_V190_R0.7300.84
330_S344_E0.7290.84
180_P184_R0.7290.84
89_C95_L0.7270.84
128_A219_P0.7260.83
243_L294_R0.7250.83
134_V242_L0.7220.83
124_A127_R0.7220.83
345_P348_D0.7210.83
53_A64_D0.7210.83
172_T176_G0.7180.83
312_G316_R0.7170.83
83_P102_T0.7170.83
342_D347_L0.7160.83
179_V328_E0.7140.82
38_A49_V0.7130.82
202_T232_L0.7130.82
155_Y232_L0.7120.82
142_S307_L0.7100.82
332_A338_G0.7080.82
49_V104_Y0.7080.82
345_P349_Y0.7060.82
35_T53_A0.7050.82
316_R361_E0.7030.81
210_N226_D0.7020.81
115_S284_R0.6990.81
317_A361_E0.6970.81
179_V351_A0.6970.81
133_L213_F0.6960.81
198_E234_E0.6960.81
78_T201_L0.6950.81
78_T149_E0.6940.81
176_G328_E0.6900.80
32_A341_T0.6880.80
156_E159_E0.6860.80
34_N51_R0.6840.80
167_R171_A0.6830.80
193_A314_F0.6820.79
41_T45_E0.6810.79
198_E305_T0.6740.79
58_D61_L0.6740.79
179_V352_A0.6710.78
133_L221_I0.6690.78
33_L82_A0.6680.78
350_T357_I0.6670.78
136_T139_D0.6670.78
197_H307_L0.6670.78
34_N53_A0.6650.78
13_A16_A0.6650.78
245_Y323_L0.6650.78
125_G128_A0.6630.78
161_V237_T0.6610.77
24_T44_T0.6610.77
157_P200_R0.6600.77
94_V99_F0.6590.77
357_I361_E0.6570.77
161_V234_E0.6530.76
163_Q231_A0.6530.76
211_V224_V0.6510.76
170_R173_D0.6500.76
320_A358_V0.6460.76
71_V229_T0.6430.75
61_L160_Q0.6410.75
331_H334_R0.6400.75
31_G205_D0.6390.75
126_R290_G0.6360.75
124_A360_G0.6340.74
89_C96_G0.6330.74
203_H206_F0.6320.74
55_D97_D0.6300.74
72_L100_A0.6260.73
350_T359_D0.6260.73
195_P311_H0.6250.73
150_G154_R0.6240.73
321_L325_A0.6230.73
61_L176_G0.6190.73
286_A289_P0.6190.73
36_M141_H0.6190.73
76_T82_A0.6170.72
149_E153_E0.6150.72
313_R316_R0.6110.72
202_T209_G0.6110.72
187_D190_R0.6090.71
128_A135_D0.6070.71
328_E331_H0.6050.71
146_D149_E0.6040.71
355_A359_D0.6040.71
185_V355_A0.6020.71
73_A77_D0.6020.71
87_V101_V0.6000.70
168_L326_V0.6000.70
172_T328_E0.6000.70
134_V138_A0.5980.70
131_E292_P0.5980.70
205_D210_N0.5970.70
327_W351_A0.5970.70
150_G153_E0.5970.70
165_A193_A0.5960.70
327_W330_S0.5950.70
36_M82_A0.5950.70
34_N68_E0.5920.69
124_A128_A0.5910.69
27_E340_P0.5910.69
36_M54_S0.5890.69
228_E330_S0.5860.68
73_A76_T0.5850.68
346_L353_V0.5840.68
21_A44_T0.5840.68
78_T81_P0.5830.68
320_A357_I0.5830.68
159_E162_E0.5810.68
82_A141_H0.5800.68
161_V314_F0.5800.68
59_S237_T0.5800.68
34_N63_I0.5770.67
349_Y360_G0.5750.67
252_P357_I0.5750.67
164_F168_L0.5730.67
207_N244_F0.5730.67
78_T143_V0.5720.67
302_E307_L0.5720.67
16_A22_R0.5710.66
65_L97_D0.5690.66
182_L186_V0.5680.66
62_F329_D0.5680.66
46_H86_V0.5680.66
91_D96_G0.5670.66
100_A228_E0.5670.66
135_D138_A0.5670.66
342_D346_L0.5660.66
284_R287_N0.5650.66
83_P225_L0.5640.66
165_A186_V0.5640.66
285_Y322_G0.5640.66
168_L322_G0.5620.65
153_E232_L0.5610.65
13_A187_D0.5600.65
144_P149_E0.5600.65
206_F224_V0.5590.65
221_I224_V0.5590.65
294_R298_I0.5590.65
197_H234_E0.5590.65
108_E214_A0.5570.65
134_V305_T0.5560.64
346_L350_T0.5560.64
86_V101_V0.5560.64
67_R168_L0.5550.64
27_E332_A0.5540.64
175_S325_A0.5530.64
108_E219_P0.5520.64
67_R231_A0.5510.64
115_S118_E0.5510.64
246_W251_D0.5490.63
54_S63_I0.5470.63
130_G243_L0.5460.63
353_V356_S0.5460.63
36_M63_I0.5460.63
324_A354_T0.5440.63
145_T200_R0.5440.63
205_D226_D0.5440.63
34_N231_A0.5430.63
329_D333_R0.5420.62
347_L351_A0.5420.62
32_A330_S0.5420.62
33_L204_G0.5400.62
292_P297_L0.5390.62
242_L253_T0.5360.62
205_D228_E0.5340.61
198_E311_H0.5340.61
121_Q129_V0.5330.61
129_V219_P0.5330.61
108_E222_T0.5320.61
207_N225_L0.5310.61
139_D300_R0.5310.61
183_R186_V0.5310.61
82_A207_N0.5300.61
59_S100_A0.5280.60
67_R333_R0.5280.60
77_D84_A0.5280.60
352_A356_S0.5280.60
69_Y87_V0.5280.60
34_N164_F0.5270.60
13_A17_D0.5270.60
34_N163_Q0.5270.60
185_V324_A0.5260.60
210_N228_E0.5260.60
330_S333_R0.5250.60
192_H311_H0.5240.60
347_L350_T0.5240.60
217_T220_E0.5230.60
181_E359_D0.5230.60
204_G329_D0.5220.60
242_L246_W0.5220.60
138_A300_R0.5210.59
239_L319_A0.5200.59
81_P204_G0.5200.59
122_T128_A0.5200.59
315_Y325_A0.5200.59
73_A84_A0.5200.59
35_T97_D0.5200.59
36_M330_S0.5180.59
298_I309_F0.5180.59
65_L88_Y0.5170.59
123_P290_G0.5160.59
35_T52_Q0.5150.59
81_P126_R0.5150.59
80_V139_D0.5140.58
233_G238_E0.5140.58
145_T157_P0.5130.58
20_G177_R0.5110.58
356_S361_E0.5100.58
126_R291_S0.5100.58
248_D295_R0.5090.58
203_H234_E0.5090.58
164_F318_H0.5090.58
95_L99_F0.5090.58
160_Q164_F0.5070.57
332_A335_V0.5070.57
23_V48_Y0.5060.57
241_Y323_L0.5060.57
182_L185_V0.5060.57
256_L350_T0.5050.57
194_P315_Y0.5050.57
302_E305_T0.5050.57
344_E351_A0.5050.57
294_R312_G0.5050.57
172_T183_R0.5040.57
246_W294_R0.5020.57
257_D353_V0.5020.57
74_A80_V0.5010.57
185_V313_R0.5010.57
316_R319_A0.5010.57
171_A326_V0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dxpA 2 0.8736 100 0.411 Contact Map
3w0oA 1 0.772 100 0.497 Contact Map
3atsA 1 0.8681 100 0.505 Contact Map
3csvA 2 0.794 100 0.617 Contact Map
4orkA 1 0.8022 100 0.625 Contact Map
4dcaA 1 0.7527 100 0.628 Contact Map
3i1aA 1 0.8049 100 0.633 Contact Map
4h05A 1 0.7005 100 0.634 Contact Map
3sg8A 2 0.7967 100 0.637 Contact Map
3tdwA 1 0.783 100 0.642 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.