GREMLIN Database
Q9HNB2 - DNA repair protein
UniProt: Q9HNB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 592 (473)
Sequences: 6627 (4538)
Seq/√Len: 208.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
480_E483_F4.0491.00
477_T480_E3.6671.00
480_E485_L3.6321.00
479_E482_A3.5601.00
163_E194_F3.2661.00
336_K340_E2.7581.00
478_E481_I2.7181.00
480_E484_T2.4981.00
66_R69_E2.4901.00
477_T483_F2.3971.00
122_L125_D2.3911.00
364_T373_I2.3831.00
166_G177_L2.3791.00
67_L70_L2.3221.00
479_E483_F2.2861.00
504_E508_A2.2771.00
477_T485_L2.2691.00
506_T511_T2.2041.00
478_E483_F2.1891.00
336_K339_I2.1691.00
120_Q123_F2.1521.00
425_V428_D2.1441.00
71_L75_Q2.1321.00
41_C44_C2.1231.00
40_I43_D2.1081.00
75_Q78_E2.0981.00
72_F75_Q2.0781.00
81_T84_L2.0771.00
69_E72_F2.0751.00
512_V516_A2.0441.00
84_L87_E2.0121.00
229_G234_I2.0091.00
64_Q67_L1.9961.00
364_T409_V1.9771.00
511_T515_T1.9741.00
194_F226_I1.9641.00
83_L86_G1.9631.00
511_T514_G1.9271.00
40_I44_C1.9231.00
121_G125_D1.9111.00
481_I485_L1.9101.00
491_E494_V1.9021.00
538_L541_E1.9011.00
533_A537_L1.8881.00
478_E482_A1.8751.00
255_V295_Y1.8751.00
340_E343_L1.8741.00
531_K534_L1.8721.00
65_D68_E1.8671.00
382_R405_L1.8631.00
77_L80_V1.8531.00
482_A485_L1.8471.00
479_E485_L1.8261.00
71_L74_E1.8171.00
536_K540_Y1.8151.00
74_E80_V1.8021.00
76_D79_K1.7921.00
116_H168_H1.7901.00
493_V496_H1.7881.00
478_E484_T1.7501.00
499_E503_V1.7491.00
81_T85_G1.7361.00
70_L74_E1.7361.00
506_T510_V1.7261.00
64_Q68_E1.7201.00
66_R70_L1.7191.00
74_E77_L1.7151.00
506_T509_N1.7051.00
529_P533_A1.7021.00
364_T370_C1.6961.00
490_M496_H1.6861.00
181_V190_K1.6531.00
67_L71_L1.6291.00
504_E507_L1.6261.00
477_T482_A1.6171.00
507_L511_T1.6161.00
499_E502_A1.6131.00
85_G88_L1.5861.00
503_V509_N1.5851.00
510_V515_T1.5831.00
510_V514_G1.5801.00
425_V461_Y1.5781.00
478_E485_L1.5721.00
92_L96_D1.5651.00
470_Y473_S1.5491.00
500_D503_V1.5431.00
519_R522_D1.5341.00
504_E511_T1.5331.00
85_G89_D1.5321.00
74_E78_E1.5171.00
536_K539_E1.4991.00
80_V83_L1.4951.00
503_V510_V1.4901.00
367_R387_G1.4731.00
504_E510_V1.4681.00
82_G85_G1.4521.00
547_E550_D1.4521.00
553_R556_T1.4491.00
534_L538_L1.4321.00
537_L542_F1.4301.00
532_H536_K1.4281.00
70_L73_A1.4181.00
509_N514_G1.4171.00
162_G190_K1.4171.00
494_V497_Y1.4141.00
540_Y543_I1.4111.00
68_E72_F1.4061.00
87_E90_P1.4051.00
510_V513_G1.4041.00
522_D526_G1.4041.00
67_L73_A1.4011.00
76_D80_V1.3971.00
531_K535_G1.3941.00
95_Y98_V1.3881.00
121_G124_E1.3841.00
500_D509_N1.3761.00
70_L75_Q1.3641.00
525_V529_P1.3611.00
180_L229_G1.3551.00
537_L541_E1.3531.00
526_G533_A1.3501.00
358_G424_Q1.3501.00
340_E344_V1.3471.00
537_L540_Y1.3431.00
321_P324_I1.3421.00
519_R523_R1.3371.00
120_Q124_E1.3321.00
336_K343_L1.3281.00
339_I342_T1.3261.00
503_V514_G1.3251.00
487_K490_M1.3231.00
477_T484_T1.3231.00
489_D493_V1.3221.00
503_V511_T1.3181.00
97_E101_T1.3141.00
490_M494_V1.3121.00
191_H195_Q1.3091.00
489_D492_N1.3061.00
75_Q81_T1.3031.00
78_E82_G1.3001.00
414_L418_V1.2981.00
523_R528_I1.2971.00
498_D506_T1.2931.00
224_A227_I1.2891.00
522_D533_A1.2851.00
395_S399_Q1.2851.00
477_T481_I1.2771.00
498_D502_A1.2761.00
481_I484_T1.2751.00
64_Q69_E1.2691.00
362_I427_F1.2681.00
73_A76_D1.2651.00
526_G537_L1.2601.00
534_L537_L1.2591.00
503_V506_T1.2571.00
535_G538_L1.2551.00
490_M493_V1.2531.00
473_S476_G1.2521.00
98_V102_T1.2511.00
77_L81_T1.2401.00
532_H538_L1.2361.00
92_L95_Y1.2351.00
335_E339_I1.2311.00
500_D504_E1.2291.00
80_V86_G1.2271.00
508_A511_T1.2251.00
544_D547_E1.2141.00
528_I532_H1.2041.00
550_D553_R1.2021.00
489_D496_H1.2021.00
529_P537_L1.1991.00
546_L550_D1.1921.00
304_G308_G1.1901.00
545_G550_D1.1881.00
65_D69_E1.1871.00
115_L118_D1.1841.00
533_A536_K1.1841.00
81_T87_E1.1821.00
479_E484_T1.1811.00
500_D510_V1.1771.00
117_P120_Q1.1741.00
527_D541_E1.1741.00
102_T106_D1.1741.00
534_L541_E1.1731.00
72_F76_D1.1731.00
551_R555_V1.1691.00
525_V532_H1.1671.00
191_H206_I1.1641.00
69_E73_A1.1571.00
96_D99_S1.1541.00
545_G548_P1.1461.00
79_K82_G1.1451.00
59_V81_T1.1401.00
500_D508_A1.1371.00
506_T512_V1.1331.00
535_G543_I1.1311.00
529_P540_Y1.1301.00
507_L514_G1.1291.00
73_A78_E1.1251.00
537_L543_I1.1241.00
446_L460_V1.1221.00
526_G534_L1.1211.00
508_A513_G1.1181.00
544_D549_T1.1141.00
527_D531_K1.1111.00
305_E310_L1.1051.00
82_G86_G1.1031.00
502_A508_A1.1031.00
528_I536_K1.0991.00
492_N496_H1.0961.00
531_K538_L1.0951.00
94_K98_V1.0921.00
526_G530_T1.0921.00
65_D77_L1.0911.00
80_V84_L1.0891.00
486_L497_Y1.0851.00
546_L549_T1.0851.00
533_A538_L1.0841.00
374_S409_V1.0811.00
84_L89_D1.0791.00
501_A504_E1.0771.00
94_K97_E1.0761.00
491_E495_T1.0711.00
68_E71_L1.0701.00
203_N223_A1.0701.00
507_L510_V1.0691.00
86_G89_D1.0671.00
76_D82_G1.0651.00
512_V515_T1.0611.00
539_E543_I1.0601.00
190_K193_D1.0581.00
552_G556_T1.0571.00
472_S475_E1.0561.00
69_E74_E1.0561.00
488_G494_V1.0531.00
101_T105_V1.0521.00
526_G529_P1.0511.00
119_V122_L1.0451.00
508_A515_T1.0431.00
530_T537_L1.0421.00
75_Q80_V1.0401.00
59_V64_Q1.0391.00
499_E511_T1.0371.00
254_E448_R1.0351.00
508_A514_G1.0311.00
500_D507_L1.0271.00
334_A337_P1.0271.00
500_D511_T1.0251.00
501_A505_E1.0251.00
534_L540_Y1.0211.00
487_K491_E1.0211.00
142_L148_Q1.0191.00
471_H475_E1.0181.00
529_P532_H1.0151.00
95_Y100_A1.0151.00
373_I409_V1.0141.00
448_R451_R1.0131.00
531_K536_K1.0111.00
525_V537_L1.0091.00
505_E509_N1.0091.00
532_H537_L1.0081.00
509_N515_T1.0061.00
379_Y407_A1.0001.00
506_T515_T0.9981.00
113_L117_P0.9931.00
341_N345_R0.9921.00
169_R173_G0.9881.00
504_E514_G0.9821.00
501_A506_T0.9811.00
71_L76_D0.9791.00
546_L551_R0.9781.00
474_M478_E0.9761.00
552_G555_V0.9751.00
517_A520_L0.9721.00
530_T539_E0.9691.00
84_L88_L0.9681.00
64_Q70_L0.9681.00
328_V331_A0.9681.00
339_I343_L0.9671.00
333_G339_I0.9651.00
66_R72_F0.9631.00
472_S476_G0.9631.00
522_D529_P0.9631.00
83_L87_E0.9591.00
498_D503_V0.9591.00
142_L294_V0.9571.00
102_T105_V0.9551.00
533_A540_Y0.9551.00
78_E86_G0.9551.00
425_V430_L0.9510.99
68_E74_E0.9490.99
70_L77_L0.9480.99
75_Q79_K0.9440.99
80_V85_G0.9430.99
526_G532_H0.9390.99
505_E508_A0.9380.99
486_L489_D0.9380.99
548_P554_A0.9360.99
549_T552_G0.9350.99
551_R554_A0.9340.99
194_F228_V0.9330.99
522_D525_V0.9320.99
141_G148_Q0.9300.99
116_H119_V0.9290.99
122_L160_L0.9270.99
525_V531_K0.9270.99
423_N428_D0.9250.99
116_H121_G0.9220.99
526_G531_K0.9210.99
493_V497_Y0.9190.99
374_S381_S0.9190.99
41_C58_A0.9190.99
425_V429_T0.9170.99
536_K542_F0.9160.99
498_D508_A0.9130.99
205_T224_A0.9100.99
398_R402_D0.9100.99
532_H535_G0.9080.99
93_T97_E0.9080.99
511_T516_A0.9070.99
500_D514_G0.9060.99
470_Y474_M0.9040.99
525_V533_A0.9040.99
72_F86_G0.9010.99
526_G535_G0.8990.99
529_P534_L0.8990.99
178_L247_I0.8990.99
506_T514_G0.8980.99
549_T553_R0.8940.99
78_E84_L0.8940.99
545_G549_T0.8910.99
104_D107_P0.8910.99
72_F80_V0.8910.99
74_E89_D0.8880.99
548_P552_G0.8870.99
533_A539_E0.8870.99
534_L542_F0.8860.99
118_D123_F0.8830.99
133_V150_V0.8830.99
526_G543_I0.8820.99
523_R529_P0.8820.99
335_E338_D0.8810.99
538_L542_F0.8800.99
340_E345_R0.8760.99
190_K194_F0.8740.99
72_F78_E0.8740.99
183_L232_E0.8720.99
524_M531_K0.8710.99
500_D505_E0.8700.99
527_D536_K0.8670.99
81_T88_L0.8670.99
394_K398_R0.8660.99
498_D510_V0.8660.99
91_D98_V0.8630.99
471_H474_M0.8560.99
504_E509_N0.8560.99
532_H540_Y0.8550.99
529_P541_E0.8520.99
523_R530_T0.8490.99
389_D392_E0.8480.99
491_E497_Y0.8470.99
256_H416_A0.8460.99
74_E79_K0.8460.99
334_A339_I0.8450.99
69_E75_Q0.8450.99
314_L317_F0.8440.99
79_K89_D0.8440.99
93_T96_D0.8440.99
501_A507_L0.8430.99
66_R71_L0.8430.99
101_T107_P0.8410.99
100_A105_V0.8390.99
424_Q430_L0.8360.99
96_D101_T0.8350.99
315_V318_E0.8350.99
100_A108_V0.8330.99
93_T98_V0.8320.99
94_K99_S0.8300.99
175_G248_G0.8280.99
70_L85_G0.8270.99
207_R237_A0.8270.99
324_I327_H0.8250.99
84_L90_P0.8240.99
525_V528_I0.8230.99
487_K494_V0.8220.99
73_A80_V0.8210.98
137_A161_V0.8210.98
382_R399_Q0.8200.98
531_K537_L0.8190.98
517_A522_D0.8180.98
130_L134_Q0.8180.98
95_Y101_T0.8160.98
532_H543_I0.8160.98
527_D532_H0.8150.98
410_T414_L0.8120.98
65_D76_D0.8100.98
139_E144_E0.8070.98
70_L81_T0.8070.98
66_R73_A0.8060.98
79_K84_L0.8050.98
325_E459_K0.8050.98
73_A83_L0.8050.98
76_D81_T0.8000.98
181_V187_A0.7970.98
530_T534_L0.7970.98
83_L89_D0.7960.98
377_L409_V0.7960.98
59_V70_L0.7920.98
522_D538_L0.7900.98
80_V88_L0.7900.98
72_F84_L0.7890.98
94_K102_T0.7890.98
517_A523_R0.7890.98
159_T190_K0.7880.98
521_N528_I0.7860.98
69_E78_E0.7840.98
64_Q75_Q0.7830.98
91_D94_K0.7830.98
520_L523_R0.7830.98
98_V101_T0.7810.98
489_D495_T0.7790.98
505_E511_T0.7790.98
508_A512_V0.7780.98
498_D501_A0.7760.98
100_A104_D0.7750.98
486_L490_M0.7740.98
75_Q82_G0.7740.98
548_P551_R0.7720.98
115_L119_V0.7680.98
529_P542_F0.7680.98
176_K246_D0.7670.98
382_R396_V0.7670.98
335_E341_N0.7670.98
78_E89_D0.7640.98
470_Y475_E0.7620.98
523_R526_G0.7600.98
183_L416_A0.7570.97
100_A103_D0.7550.97
359_Q422_A0.7540.97
74_E81_T0.7530.97
491_E496_H0.7530.97
91_D95_Y0.7530.97
74_E82_G0.7510.97
372_E376_K0.7510.97
544_D551_R0.7500.97
103_D107_P0.7500.97
113_L116_H0.7490.97
492_N495_T0.7480.97
176_K225_D0.7460.97
527_D537_L0.7450.97
113_L118_D0.7420.97
67_L74_E0.7390.97
76_D83_L0.7370.97
498_D505_E0.7360.97
70_L89_D0.7340.97
127_F160_L0.7330.97
99_S103_D0.7300.97
95_Y102_T0.7300.97
76_D85_G0.7300.97
503_V513_G0.7290.97
71_L82_G0.7290.97
529_P539_E0.7270.97
78_E81_T0.7250.97
108_V112_E0.7250.97
98_V103_D0.7240.97
332_D336_K0.7230.97
546_L552_G0.7210.97
81_T86_G0.7210.97
77_L84_L0.7200.97
64_Q72_F0.7190.97
316_E319_E0.7170.96
118_D122_L0.7170.96
498_D509_N0.7160.96
499_E506_T0.7150.96
500_D512_V0.7150.96
501_A515_T0.7120.96
524_M543_I0.7120.96
218_H221_D0.7110.96
506_T516_A0.7080.96
336_K341_N0.7060.96
215_D218_H0.7060.96
102_T107_P0.7050.96
67_L78_E0.7050.96
522_D539_E0.7050.96
550_D554_A0.7040.96
533_A543_I0.7030.96
69_E80_V0.7030.96
95_Y105_V0.7030.96
72_F79_K0.7030.96
531_K541_E0.7030.96
83_L88_L0.7020.96
113_L125_D0.7020.96
264_G268_D0.7020.96
503_V507_L0.7000.96
520_L527_D0.6990.96
217_G220_F0.6980.96
488_G491_E0.6970.96
250_V274_L0.6960.96
205_T219_A0.6960.96
535_G540_Y0.6960.96
91_D101_T0.6960.96
76_D87_E0.6920.96
361_I410_T0.6920.96
91_D99_S0.6880.96
92_L100_A0.6880.96
64_Q71_L0.6870.96
73_A84_L0.6860.95
530_T533_A0.6850.95
77_L87_E0.6810.95
67_L72_F0.6800.95
503_V512_V0.6790.95
336_K344_V0.6770.95
500_D506_T0.6750.95
550_D555_V0.6750.95
371_N383_P0.6750.95
75_Q83_L0.6740.95
470_Y476_G0.6730.95
150_V161_V0.6710.95
94_K100_A0.6700.95
534_L543_I0.6700.95
502_A509_N0.6700.95
167_L198_Y0.6700.95
216_D219_A0.6700.95
491_E506_T0.6700.95
527_D533_A0.6670.95
417_G448_R0.6670.95
78_E83_L0.6660.95
326_R442_F0.6660.95
527_D542_F0.6660.95
549_T554_A0.6650.95
525_V536_K0.6640.95
65_D81_T0.6640.95
166_G251_V0.6630.95
521_N524_M0.6620.95
488_G492_N0.6620.95
545_G552_G0.6610.94
117_P123_F0.6610.94
341_N344_V0.6600.94
71_L86_G0.6580.94
154_T254_E0.6560.94
495_T506_T0.6560.94
521_N540_Y0.6530.94
544_D552_G0.6530.94
80_V89_D0.6500.94
379_Y405_L0.6490.94
342_T345_R0.6470.94
534_L539_E0.6470.94
535_G539_E0.6460.94
520_L532_H0.6460.94
527_D538_L0.6460.94
99_S106_D0.6450.94
504_E513_G0.6440.94
72_F81_T0.6440.94
503_V508_A0.6430.94
524_M530_T0.6430.94
116_H122_L0.6410.94
69_E81_T0.6400.93
502_A505_E0.6390.93
473_S477_T0.6330.93
73_A79_K0.6320.93
520_L529_P0.6310.93
250_V271_I0.6300.93
199_G202_A0.6300.93
547_E551_R0.6280.93
108_V111_S0.6260.93
71_L78_E0.6250.93
66_R80_V0.6240.93
95_Y99_S0.6230.93
256_H444_Q0.6220.93
97_E105_V0.6220.93
75_Q84_L0.6220.93
183_L256_H0.6200.92
520_L534_L0.6200.92
395_S398_R0.6180.92
546_L555_V0.6180.92
527_D535_G0.6170.92
503_V515_T0.6170.92
335_E340_E0.6160.92
546_L553_R0.6130.92
97_E100_A0.6130.92
75_Q86_G0.6120.92
498_D514_G0.6120.92
66_R88_L0.6120.92
97_E102_T0.6110.92
130_L133_V0.6110.92
327_H459_K0.6080.92
490_M497_Y0.6070.92
529_P535_G0.6060.92
43_D90_P0.6050.91
522_D534_L0.6040.91
145_G168_H0.6030.91
67_L76_D0.6030.91
191_H204_V0.6020.91
82_G88_L0.6020.91
162_G165_A0.6010.91
529_P538_L0.6010.91
78_E88_L0.6010.91
530_T536_K0.6000.91
71_L80_V0.6000.91
162_G296_L0.6000.91
507_L512_V0.5970.91
66_R75_Q0.5970.91
528_I540_Y0.5950.91
59_V67_L0.5940.91
69_E84_L0.5940.91
103_D106_D0.5940.91
67_L81_T0.5930.91
70_L76_D0.5910.90
544_D548_P0.5910.90
424_Q429_T0.5910.90
80_V90_P0.5880.90
71_L83_L0.5880.90
528_I535_G0.5870.90
77_L90_P0.5860.90
498_D511_T0.5860.90
523_R527_D0.5860.90
502_A506_T0.5850.90
321_P326_R0.5850.90
498_D504_E0.5850.90
521_N527_D0.5850.90
548_P555_V0.5840.90
424_Q428_D0.5830.90
84_L91_D0.5810.90
528_I531_K0.5810.90
525_V541_E0.5790.90
66_R74_E0.5770.89
65_D74_E0.5770.89
305_E309_K0.5770.89
82_G89_D0.5760.89
79_K87_E0.5760.89
521_N529_P0.5760.89
74_E88_L0.5740.89
526_G541_E0.5740.89
528_I541_E0.5730.89
522_D531_K0.5720.89
161_V165_A0.5700.89
67_L84_L0.5660.89
87_E91_D0.5660.89
117_P121_G0.5660.89
59_V76_D0.5650.88
532_H541_E0.5650.88
72_F77_L0.5640.88
74_E84_L0.5640.88
314_L319_E0.5640.88
551_R556_T0.5620.88
324_I450_G0.5610.88
58_A64_Q0.5600.88
325_E457_R0.5590.88
521_N525_V0.5560.88
74_E87_E0.5540.87
82_G96_D0.5540.87
510_V516_A0.5540.87
528_I538_L0.5530.87
75_Q89_D0.5510.87
77_L82_G0.5500.87
96_D100_A0.5500.87
546_L554_A0.5470.87
526_G540_Y0.5470.87
384_Y414_L0.5470.87
547_E552_G0.5470.87
520_L536_K0.5470.87
70_L79_K0.5460.87
374_S378_D0.5460.87
525_V530_T0.5420.86
162_G181_V0.5410.86
377_L407_A0.5410.86
444_Q448_R0.5400.86
520_L524_M0.5360.86
191_H228_V0.5360.86
499_E514_G0.5350.86
518_K523_R0.5330.85
208_V211_S0.5310.85
536_K543_I0.5300.85
99_S102_T0.5290.85
518_K522_D0.5280.85
504_E515_T0.5270.85
117_P125_D0.5240.84
154_T447_G0.5240.84
74_E90_P0.5210.84
92_L102_T0.5210.84
96_D106_D0.5200.84
192_E398_R0.5190.84
192_E196_D0.5190.84
320_R323_P0.5190.84
328_V332_D0.5170.84
436_W445_M0.5170.84
360_T425_V0.5150.83
64_Q73_A0.5150.83
337_P340_E0.5140.83
93_T99_S0.5130.83
215_D219_A0.5130.83
509_N512_V0.5130.83
65_D84_L0.5120.83
71_L81_T0.5120.83
500_D515_T0.5110.83
170_L173_G0.5110.83
522_D528_I0.5100.83
517_A531_K0.5090.83
82_G87_E0.5090.83
58_A70_L0.5090.83
489_D497_Y0.5080.83
492_N497_Y0.5070.82
538_L543_I0.5070.82
65_D72_F0.5050.82
212_R215_D0.5040.82
517_A528_I0.5030.82
549_T555_V0.5020.82
70_L84_L0.5020.82
522_D527_D0.5010.82
539_E542_F0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zj8A 2 0.7787 100 0.405 Contact Map
4qu4A 1 0.8074 100 0.41 Contact Map
4f92B 1 0.8801 100 0.415 Contact Map
2va8A 1 0.7584 100 0.415 Contact Map
2p6rA 1 0.7669 100 0.416 Contact Map
4bgdA 1 0.8463 100 0.423 Contact Map
5agaA 4 0.7889 100 0.425 Contact Map
4a4zA 1 0.7568 100 0.437 Contact Map
4nhoA 1 0.6841 100 0.44 Contact Map
4pxaA 1 0.6858 100 0.442 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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